Congratulations to the IeDEA investigators who just learned they will be presenting their #HIV research at #CROI2025 in San Francisco in March!
We will post the abstract list when the conference starts.
The photo is from our meeting after this year's conference in Denver ❣️
We will post the abstract list when the conference starts.
The photo is from our meeting after this year's conference in Denver ❣️
November 19, 2024 at 3:54 AM
Our ICTU Statistician Louise-Rae Cherrill is at #CROI2025 for the presentation of exciting results of the ICTU-managed @riotrial.bsky.social with promising advances in #HIVTreatment driven by immune-based therapies www.imperial.ac.uk/news/261858/...
March 12, 2025 at 11:01 AM
Our ICTU Statistician Louise-Rae Cherrill is at #CROI2025 for the presentation of exciting results of the ICTU-managed @riotrial.bsky.social with promising advances in #HIVTreatment driven by immune-based therapies www.imperial.ac.uk/news/261858/...
While #CROI2025 was lovely because I got to see so many colleagues I love and respect, hearing their stories of their grants getting pulled and careers falling apart in real time was grim. We no longer are a place that fosters innovative research and academia. It’s being torn to shreds…
March 12, 2025 at 10:10 PM
While #CROI2025 was lovely because I got to see so many colleagues I love and respect, hearing their stories of their grants getting pulled and careers falling apart in real time was grim. We no longer are a place that fosters innovative research and academia. It’s being torn to shreds…
DoxyPrEP data next, with rectal microbiome being similar between the deferred and immediate arm. Again reassuring to see and shows DoxyPrEP may also be a possible preventative mechanism. #CROI2025
March 12, 2025 at 8:55 PM
DoxyPrEP data next, with rectal microbiome being similar between the deferred and immediate arm. Again reassuring to see and shows DoxyPrEP may also be a possible preventative mechanism. #CROI2025
Amazing reduction in the use of antimicrobials among DoxyPEP users overall, in a study in implementation in Italy, with decreased in doxycycline use when used prophylactically compared to baseline. This flies in the face of the concern that DoxyPEP would increase antimicrobial use! #CROi2025
March 12, 2025 at 8:53 PM
Amazing reduction in the use of antimicrobials among DoxyPEP users overall, in a study in implementation in Italy, with decreased in doxycycline use when used prophylactically compared to baseline. This flies in the face of the concern that DoxyPEP would increase antimicrobial use! #CROi2025
DoxyPEP Implementation talks next:
The PRIDOX study is looking at DoxyPEP in MSM in Spain
They saw significant decline in CT and syphilis
There were no increases in ESBL E coli or MRSA, nor an increase in doxy resistant NG
#CROi2025
The PRIDOX study is looking at DoxyPEP in MSM in Spain
They saw significant decline in CT and syphilis
There were no increases in ESBL E coli or MRSA, nor an increase in doxy resistant NG
#CROi2025
March 12, 2025 at 8:41 PM
DoxyPEP Implementation talks next:
The PRIDOX study is looking at DoxyPEP in MSM in Spain
They saw significant decline in CT and syphilis
There were no increases in ESBL E coli or MRSA, nor an increase in doxy resistant NG
#CROi2025
The PRIDOX study is looking at DoxyPEP in MSM in Spain
They saw significant decline in CT and syphilis
There were no increases in ESBL E coli or MRSA, nor an increase in doxy resistant NG
#CROi2025
LA injectable PrEP and contraception next, via In Situ Forming Implants, very exciting to see advancement in this space!!
CAB and MPA combined and studied in Macaques. Animal model studying showed that there was maintenance of ovulation suppression and no implant migration with good CAB PK #CROI2025
CAB and MPA combined and studied in Macaques. Animal model studying showed that there was maintenance of ovulation suppression and no implant migration with good CAB PK #CROI2025
March 12, 2025 at 6:31 PM
LA injectable PrEP and contraception next, via In Situ Forming Implants, very exciting to see advancement in this space!!
CAB and MPA combined and studied in Macaques. Animal model studying showed that there was maintenance of ovulation suppression and no implant migration with good CAB PK #CROI2025
CAB and MPA combined and studied in Macaques. Animal model studying showed that there was maintenance of ovulation suppression and no implant migration with good CAB PK #CROI2025
INSTI resistance was noted in 9/44 cases starting ART, the majority were started on non-INSTI ART, with 1/6 having been started on INSTI based regimen, and all suppressed
Interesting stuff!
#CROI2025
Interesting stuff!
#CROI2025
March 12, 2025 at 6:24 PM
INSTI resistance was noted in 9/44 cases starting ART, the majority were started on non-INSTI ART, with 1/6 having been started on INSTI based regimen, and all suppressed
Interesting stuff!
#CROI2025
Interesting stuff!
#CROI2025
HPTN 083 info on HIV treatment after CAB-LA
47 HIV Acquisitions occurred on trial
15/21 treated on INSTI based regimen saw viral suppression
21/26 saw viral suppression on other ART
All 6 cases that were diagnosed <6 months between last CAB and ART start saw suppression on INSTI based ART
#CROI2025
47 HIV Acquisitions occurred on trial
15/21 treated on INSTI based regimen saw viral suppression
21/26 saw viral suppression on other ART
All 6 cases that were diagnosed <6 months between last CAB and ART start saw suppression on INSTI based ART
#CROI2025
March 12, 2025 at 6:22 PM
HPTN 083 info on HIV treatment after CAB-LA
47 HIV Acquisitions occurred on trial
15/21 treated on INSTI based regimen saw viral suppression
21/26 saw viral suppression on other ART
All 6 cases that were diagnosed <6 months between last CAB and ART start saw suppression on INSTI based ART
#CROI2025
47 HIV Acquisitions occurred on trial
15/21 treated on INSTI based regimen saw viral suppression
21/26 saw viral suppression on other ART
All 6 cases that were diagnosed <6 months between last CAB and ART start saw suppression on INSTI based ART
#CROI2025
While HIV RNA testing is able to detect before developing resistance, 12 individuals had false positive HIV RNA test
False positive rate is 75%, up to 77% if last CAB LA in 6 months, and 100% if last CAB LA > 6 months
HIV RNA performed poorly for HIV Screening, blurring the picture more #CROI2025
False positive rate is 75%, up to 77% if last CAB LA in 6 months, and 100% if last CAB LA > 6 months
HIV RNA performed poorly for HIV Screening, blurring the picture more #CROI2025
March 12, 2025 at 6:09 PM
While HIV RNA testing is able to detect before developing resistance, 12 individuals had false positive HIV RNA test
False positive rate is 75%, up to 77% if last CAB LA in 6 months, and 100% if last CAB LA > 6 months
HIV RNA performed poorly for HIV Screening, blurring the picture more #CROI2025
False positive rate is 75%, up to 77% if last CAB LA in 6 months, and 100% if last CAB LA > 6 months
HIV RNA performed poorly for HIV Screening, blurring the picture more #CROI2025
All of this is to say that if taken as prescribed, TAF/FTC is effective for cis-women, and as effective as TDF/FTC in this study.
Secondary analysis showed that if individuals who took 2 or more pills showed odds of HIV acquisition were 89% lower (IMPRESSIVE!) #CROI2025
Secondary analysis showed that if individuals who took 2 or more pills showed odds of HIV acquisition were 89% lower (IMPRESSIVE!) #CROI2025
March 12, 2025 at 5:36 PM
All of this is to say that if taken as prescribed, TAF/FTC is effective for cis-women, and as effective as TDF/FTC in this study.
Secondary analysis showed that if individuals who took 2 or more pills showed odds of HIV acquisition were 89% lower (IMPRESSIVE!) #CROI2025
Secondary analysis showed that if individuals who took 2 or more pills showed odds of HIV acquisition were 89% lower (IMPRESSIVE!) #CROI2025
Next is F/TAF in cis women, part of PURPOSE 1
A reminder PURPOSE 1 looked at LEN in cis women but also had a TAF/FTC and TDF/FTC arms
39 HIV infections occurred in F/TAF group but was not statistically different from background incidence or F/TDF
Adherence information below (it was low)
#CROI2025
A reminder PURPOSE 1 looked at LEN in cis women but also had a TAF/FTC and TDF/FTC arms
39 HIV infections occurred in F/TAF group but was not statistically different from background incidence or F/TDF
Adherence information below (it was low)
#CROI2025
March 12, 2025 at 5:33 PM
Next is F/TAF in cis women, part of PURPOSE 1
A reminder PURPOSE 1 looked at LEN in cis women but also had a TAF/FTC and TDF/FTC arms
39 HIV infections occurred in F/TAF group but was not statistically different from background incidence or F/TDF
Adherence information below (it was low)
#CROI2025
A reminder PURPOSE 1 looked at LEN in cis women but also had a TAF/FTC and TDF/FTC arms
39 HIV infections occurred in F/TAF group but was not statistically different from background incidence or F/TDF
Adherence information below (it was low)
#CROI2025
IMPREP CAB Brasil next:
Impressive uptake with >90% adherence, and 95% coverage in CAB-LA cohort. No seroconversions in the CAB-LA cohort 4% switched to oral PrEP. #CROI2025
Impressive uptake with >90% adherence, and 95% coverage in CAB-LA cohort. No seroconversions in the CAB-LA cohort 4% switched to oral PrEP. #CROI2025
March 12, 2025 at 5:17 PM
IMPREP CAB Brasil next:
Impressive uptake with >90% adherence, and 95% coverage in CAB-LA cohort. No seroconversions in the CAB-LA cohort 4% switched to oral PrEP. #CROI2025
Impressive uptake with >90% adherence, and 95% coverage in CAB-LA cohort. No seroconversions in the CAB-LA cohort 4% switched to oral PrEP. #CROI2025
Impressive data but just re-emphasizing that uptake in Cab-LA is low, and not surprisingly, pts were more likely to have public insurance which is what we are seeing in other clinics too
#CROI2025
#CROI2025
March 12, 2025 at 5:09 PM
Impressive data but just re-emphasizing that uptake in Cab-LA is low, and not surprisingly, pts were more likely to have public insurance which is what we are seeing in other clinics too
#CROI2025
#CROI2025
>80% of injections were on time, with higher rate of late doses in the initial 4 week follow up dose compared to 8 week follow up dose. Probability of persisting at 87.9% at 6 months and 74.9% at 12 months
34.3% switched back to oral prep
No new incident HIV infections #CROI2025
34.3% switched back to oral prep
No new incident HIV infections #CROI2025
March 12, 2025 at 5:09 PM
>80% of injections were on time, with higher rate of late doses in the initial 4 week follow up dose compared to 8 week follow up dose. Probability of persisting at 87.9% at 6 months and 74.9% at 12 months
34.3% switched back to oral prep
No new incident HIV infections #CROI2025
34.3% switched back to oral prep
No new incident HIV infections #CROI2025
March 12, 2025 at 1:23 AM
122 individuals enrolled in open-label arm. 43% living with HIV, 26% with uncontrolled HIV. Median time to clinical resolution was 14 days, which is longer than PALM007 study. Little to no difference with randomized arm. Older AGE and HIV status assoc with lower rate of resolution. #CROI2025
March 11, 2025 at 6:40 PM
122 individuals enrolled in open-label arm. 43% living with HIV, 26% with uncontrolled HIV. Median time to clinical resolution was 14 days, which is longer than PALM007 study. Little to no difference with randomized arm. Older AGE and HIV status assoc with lower rate of resolution. #CROI2025
STOMP Trial results next for open label arm. The open label arm was for individuals with progression or severe pain, or any of the following: age <18, pregnant or breastfeeding, severe Mpox, immunosuppression with HIV VL>1000 or CD4 <200, or exfoliative skin conditions. #CROI2025
March 11, 2025 at 6:40 PM
STOMP Trial results next for open label arm. The open label arm was for individuals with progression or severe pain, or any of the following: age <18, pregnant or breastfeeding, severe Mpox, immunosuppression with HIV VL>1000 or CD4 <200, or exfoliative skin conditions. #CROI2025
Ok we moved, and now covering On-Demand TDF/FTC in Women for HIV Prevention. 2-1-1 on demand regimen received 8% above target at 5 days after sex, protection increased 8-15% if 2-2-2-2. #CROI2025
March 11, 2025 at 6:25 PM
Ok we moved, and now covering On-Demand TDF/FTC in Women for HIV Prevention. 2-1-1 on demand regimen received 8% above target at 5 days after sex, protection increased 8-15% if 2-2-2-2. #CROI2025