#CTNNB1
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mirlrim.bsky.social
Imbuída de Espírito Natalicio, se quiserem fazer uma boa acção este Natal e que vai realmente fazer a diferença na vida de alguém, pensem fazer uma doação nesta campanha de gofund me.

www.gofundme.com/f/terapia-ge...
Donate to Terapia Génica para a cura da Síndrome CTNNB1, organized by Mariana Esteves
Olá a todos. Esta é a nossa Mafaldinha. A Mafalda tem Síndrome CTNNB1,… Mariana Esteves needs your support for Terapia Génica para a cura da Síndrome CTNNB1
www.gofundme.com
December 22, 2025 at 11:59 AM
nature.com
Nature research paper: Hepatic zonation determines tumorigenic potential of mutant β-catenin

go.nature.com/4o83OgL
Hepatic zonation determines tumorigenic potential of mutant β-catenin - Nature
Zonal positioning in the liver determines whether the CTNNB1 oncogene can induce liver cancer.
go.nature.com
November 21, 2025 at 6:48 PM
csemple.bsky.social
Delighted to contribute to this seminal study of a critical oncogene! A long journey but worth it in the end :-)
www.nature.com/articles/s41...
Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling - Nature Genetics
Saturation genome editing of a cancer mutation hotspot in CTNNB1, the gene encoding β-catenin, reveals a gradient of effects of missense mutations on Wnt signaling.
www.nature.com
February 2, 2026 at 4:11 PM
radar360.bsky.social
Empieza la segunda parte de la jornada con la Asociación CTNNB1
November 25, 2024 at 10:55 AM
onehealthgenomics.bsky.social
New Publication:
Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling

@roslininstitute.bsky.social @uoe-igc.bsky.social @edinuni-irr.bsky.social @cruk-si.bsky.social

www.nature.com/articles/s41...
Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling - Nature Genetics
Saturation genome editing of a cancer mutation hotspot in CTNNB1, the gene encoding β-catenin, reveals a gradient of effects of missense mutations on Wnt signaling.
www.nature.com
March 30, 2026 at 3:15 PM
kevin-dean.bsky.social
New preprint! Using multiscale ExM/OPM/ASLM, we show that oncogenic drivers leave distinct 3D architectural fingerprints in intact liver tissue: NRAS primarily remodels cell shape, whereas CTNNB1 shifts mitochondrial architecture toward a pericentral-like state. tinyurl.com/kepy33m6
Deciphering the Multiscale Morphology of Somatic Oncogenic Alterations in Hepatocellular Carcinoma
Somatic oncogenic mutations are typically defined by their molecular alterations, yet how they reorganize cellular architecture within intact tissues remain largely unknown. Here, we demonstrate that ...
www.biorxiv.org
July 16, 2026 at 2:15 PM
albacalvo.bsky.social
¡Ayudemos a la pequeña Nora y a otros peques en su misma situación! ¡Visibilicemos las enfermedades raras! ♡

+ Info aquí:
asociacionctnnb1.org/sindrome-ctn...

rarediseases.org/es/rare-dise...

fundacioncolumbus.org/ejes-de-actu...
CTNNB1
May 14, 2025 at 8:13 AM
haoyin.bsky.social
Calcifying nested stromal-epithelial tumor of the liver with recurrence in a transplanted liver

rare tumor < 50 cases reported

FoundationOne CDx genomic sequencing on FFPE tumor➡️
CTNNB1 T41I
PIK3CA R38H
TERT promoter c.-124C>T

Wenyi Luo lab #HumPathRep 2022
www.sciencedirect.com/science/arti...
March 24, 2025 at 8:09 PM
vetcancerhealth.bsky.social
Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat #Aldosterone-Secreting Tumors.
#veterinary #oncology
www.ahajournals.org/doi/10.1161/...
Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors | Hypertension
BACKGROUND: Primary aldosteronism (PA) is a common cause of human hypertension. Somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 are found in at least 80% of aldosterone-producing adenomas, whi...
www.ahajournals.org
November 24, 2024 at 8:38 PM
genesndiseases.bsky.social
This study shows that #CRISPR/CasRx-mediated Ctnnb1 and Smo knockdown inhibits Wnt/b-catenin and Ihh signaling to mitigate #osteoarthritis progression in a mice model.

#OpenAccess: https://buff.ly/3PNKYMY
CRISPR/CasRx-mediated RNA knockdown targeting β-catenin and Ihh signaling alleviates osteoarthritis
January 21, 2025 at 1:00 PM
zee207702.bsky.social
www.cbc.ca/news/canada/...
'We have to do it': Family of girl with ultra-rare disease prepares to test experimental treatment | CBC News
Harper Tanton will be the fourth child in the world to participate in the clinical trial for kids who have CTNNB1 syndrome. She largely depends on a wheelchair and has developmental and speech delays.
www.cbc.ca
August 4, 2026 at 10:26 PM
genesndiseases.bsky.social
CRISPR/CasRx-mediated dual knockdown of Ctnnb1 and Smo effectively suppresses Wnt/β-catenin and Ihh signaling to reduce #osteoarthritis progression, highlighting a promising RNA-targeting #GeneTherapy strategy for OA treatment.

#OpenAccess: doi.org/10.1016/j.ge...
March 30, 2026 at 6:00 PM
ctgct.bsky.social
Understanding CTNNB1 Syndrome has advanced rapidly through genotype-phenotype studies, preclinical models & natural history tracking. These foundations are essential for developing targeted therapies that address the root causes of the disorder.
🧪 #ATMP
🧬#GeneticResearch
Common features observed in individuals with CTNNB1 syndrome.
February 28, 2025 at 11:28 AM
ferl67.bsky.social
She has an ultra-rare disease. Now this Nova Scotia girl will be one of the first to test a possible cure | CBC News

www.cbc.ca/news/canada/...

#Medical #Canada #Health
'We have to do it': Family of girl with ultra-rare disease prepares to test experimental treatment | CBC News
Harper Tanton will be the fourth child in the world to participate in the clinical trial for kids who have CTNNB1 syndrome. She largely depends on a wheelchair and has developmental and speech delays.
www.cbc.ca
August 4, 2026 at 11:50 AM
wntuk.bsky.social
Beautiful new UK Wnt paper out now in @natgenet.nature.com
by Peter Hohenstein, Andrew Wood and Derya Ozdemir
@unileiden.bsky.social @edinburgh-uni.bsky.social and Koc University characterising the impact of numerous CTNNB1 mutational variants in human cancer.

www.nature.com/articles/s41...
Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling - Nature Genetics
Saturation genome editing of a cancer mutation hotspot in CTNNB1, the gene encoding β-catenin, reveals a gradient of effects of missense mutations on Wnt signaling.
www.nature.com
February 17, 2026 at 12:38 PM
genesndiseases.bsky.social
This study shows that #CRISPR/CasRx-mediated Ctnnb1 and Smo knockdown inhibits Wnt/b-catenin and Ihh signaling to mitigate #osteoarthritis progression in a mice model.

#OpenAccess: www.sciencedirect.co...
January 10, 2025 at 2:00 PM
farodevigo.es
🏃 La Carreira de Leo apura las horas para superar la barrera de los 2.400 participantes

📌 La prueba se celebrará el 4 de octubre en Mosteiro de Meis

📌 Los beneficios se destinarán a la Asociación CTNNB1 y a la Asociación Galega de Osteoplasia Ósea Progresiva
La Carreira de Leo apura las horas para superar la barrera de los 2.400 participantes
www.farodevigo.es
September 26, 2026 at 7:31 PM
davidusharauli.bsky.social
Notable paper

TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid tumors

#tumor
#immunology

buff.ly/L23yhOe
TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid tumors - Nature Immunology
TCR-T cells are T cells engineered to express a specific T cell receptor. Here the authors present a TCR-T cell that targets CTNNB1-S37F, corresponding to a shared cancer driver mutation. This…
www.nature.com
August 28, 2025 at 4:58 PM
haoyin.bsky.social
Prime Editing for patient-derived Liver or Intestinal Organoids

Alleles edited
CTNNB1 in-frame 6bpΔ
ABCB11 D482G or R1153H
ATP7B S430fs
SERPINA1 E342K
DGAT1 S210Δ

WGS of 4 prime-edited clonal organoid lines▶️absence of genome-wide off-target effects

#NatComm 2020
www.nature.com/articles/s41...
January 8, 2026 at 8:50 PM
jeffmold.bsky.social
Looks interesting! www.nature.com/articles/s41...
TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid tumors - Nature Immunology
TCR-T cells are T cells engineered to express a specific T cell receptor. Here the authors present a TCR-T cell that targets CTNNB1-S37F, corresponding to a shared cancer driver mutation. This immunot...
www.nature.com
September 1, 2025 at 8:44 PM
yalecancer.bsky.social
Quantitative #MRI + #AI can predict key molecular markers in #livercancer like p53, PD-L1, and CTNNB1. This noninvasive approach could guide personalized #HCC therapy without a biopsy.
➡️ pubs.rsna.org/doi/10.1148/...
@rsnasky.bsky.social
September 3, 2025 at 1:23 PM
radar360.bsky.social
¿Qué es el Síndrome CTNNB1? Nos lo explica Marta:
November 25, 2024 at 10:58 AM
rridrobot.bsky.social
RRIDs were included in this in Molecular Oncology paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #RRID #OpenScience
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Read the full paper: Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
doi.org
April 12, 2026 at 7:00 AM
biorxiv-cancer.bsky.social
CD73 restrains mutant β-catenin oncogenic activity in endometrial carcinomas https://www.biorxiv.org/content/10.1101/2024.11.18.624183v1
CD73 restrains mutant β-catenin oncogenic activity in endometrial carcinomas https://www.biorxiv.org/content/10.1101/2024.11.18.624183v1
Missense mutations in exon 3 of CTNNB1, the gene encoding {beta}-catenin, are associated with poor o
www.biorxiv.org
November 19, 2024 at 1:48 AM
wntlab.bsky.social
We're hiring! The vacancy for a PhD student position in our lab, working on a KWF-funded project "Targeting WNT/CTNNB1 signaling in breast cancer" is now open.

Check it out (or forward it) if you are (or know) someone who might be interested and a good fit:

werkenbij.uva.nl/en/vacancies...
Vacancy — PhD student Developmental, Stem Cell & Cancer Biology
<p><span>Do you want to develop new personalized treatment solutions for breast cancer? </span></p>
werkenbij.uva.nl
March 10, 2026 at 3:52 PM