Captura de alias Gomelo en Medellín: la Policía lo señala como cabecilla de narcotráfico del EGC y le atribuye una trayectoria de 11 años.

Captura de alias Melechas durante la Operación DEALER. El señalado integrante del GDO Cordillera abastecería expendios de droga en Pereira y Dosquebradas.

Clear the chess board until only the king remains

A Volkswagen T-Roc komolyabb lett az elődjénél, a Renault Captur viszont teljes értékű hibridként is jóval olcsóbb. A Telex összehasonlítása azt vizsgálja, melyik szabadidő-autó kínál jobb vételt.

Beauty brands have long turned to rising stars to freshen up their ambassador rosters, banking on genuine cultural momentum rather than simple star power alone. Few partnerships this year have captur…

AbstractG protein-coupled receptors (GPCRs) are central physiological signal transducers and represent a primary class of therapeutic targets. While emerging evidence highlights a critical link between ligand-induced receptor conformations and pharmacological outcomes, the structural diversity dictating GPCR-G protein interface interactions remains incompletely understood. High-resolution structural studies reveal discrete, ligand-stabilized states, but these static snapshots do not fully capture the dynamic processes underlying GPCR activation and ligand efficacy. To address this, we established a native mass spectrometry (nMS) platform to probe ligand-induced conformational heterogeneity at the GPCR intracellular interface. Using the β1-adrenergic receptor (β1AR) as a model, we demonstrated a strong correlation between ligand efficacy and receptor complex formation with diverse active-state-specific nanobodies. Notably, leveraging the quantitative capacity of nMS, we uncovered distinct propensities of two highly similar nanobodies, Nb80 and Nb6B9, and showed that Nb6B9 engages weak-agonist-stabilized receptor states more effectively than Nb80. These interactions indicate that Nb6B9 recognizes ligand-specific conformations distinct from active states induced by full agonists. To gain structural insights, we utilized Nb6B9 chimeras with exchanged complementarity-determining regions (CDRs) and identified CDR1 and CDR3 as the primary drivers for ligand-specific recognition, implicating the involvement of receptor transmembrane motifs TM5 and TM6 in this conformational diversity. Finally, we demonstrated that nanobody-based nMS can distinguish receptor responses induced by the two salbutamol enantiomers, implying stereochemistry-dependent intracellular interface heterogeneity. Together, our study highlights the utility of nanobody-based nMS for evaluating the structural heterogeneity and dynamic landscapes of GPCRs.

El alcalde municipal de Juchitán, Miguel Sánchez Altamirano, fue detenido por su posible relación con el grupo delictivo "Los Cromos", según informó la Fiscalía General del Estado de Oaxaca. La captur… · Photo : Campaign Against Arms Trade · CC BY-SA · Flickr

An interactive investigation into Big Tech and AI companies' funding relationships with journalism and media organizations.

Filmed last year, the show captured the moment Coleen began to return to work, having previously been a stay-at-home mum while Wayne travelled the country for football.

As Michigan continues to examine its options for meeting its 100% clean energy goal, members of the state House gathered to consider a slate of bills to give the state authority over efforts to captur...

Yeni Renault Captur için merak edilenler belli oluyor. 2027 sonu beklenen SUV'un tasarımı, motorları, teknolojileri ve çıkış tarihi burada.

As Michigan continues to examine its options for meeting its 100% clean energy goal, members of the state House gathered to consider a slate of bills to give the state authority over efforts to captur...

More than 100,000 people took to central London yesterday (September 13) to join a march organised by right-wing activist Tommy Robinson, whose real name is Stephen Yaxley-Lennon. One witness captur...

802 likes, 80 comments - hilde_angel on September 23, 2026: "Vivemos um golpe de estado, que representa lá por debaixo dos anos, se desenvolve no silêncio dos e-mails e portas fechadas. O golpe captur...

Alias “DT”, señalado como presunto integrante de “El Salacho”, fue capturado en zona rural de Concordia. Le incautaron un revólver y seis cartuchos.

As Michigan continues to examine its options for meeting its 100% clean energy goal, members of the state House gathered to consider a slate of bills to give the state authority over efforts to captur...

Team portraits come with their own set of challenges. Matching lighting across four different people, keeping posing consistent, and making sure everyone looks equally polished, all while still captur...

Renault is preparing to take the successful Captur into its third generation. Originally launched in 2019 and significantly facelifted in 20...

Renault Captur, B-SUV segmentindeki başarısını yeni nesliyle sürdürmeye hazırlanıyor. İlk kez 2019 yılında satışa sunulan ve 2024'te kapsaml...