ClpP is a mitochondrial protease and a validated cancer target. Here, the authors develop quinazolinone compounds that bind to the same site as the FDA-approved activator ClpP dordaviprone, yet they inhibit ClpP, reducing tumor burden in leukemia mouse models.

Tissue expansion mass spectrometry imaging enables the mapping of lipids, metabolites, proteins, peptides and N-glycans at high spatial resolution.

Mass Spectrometry Reviews, EarlyView.

AbstractThe field of proteomics is one of the fastest-growing scientific disciplines in the world today. Beginning in 2020, ambitious market predictions anticipated proteomics to more than double in market size in 4–6 years and to even surpass the well-established genomic sciences industry in 8–12 years. While the market is still growing, it has not come close to matching the initial projections. To better understand the root cause of this, the author has collected field surveys and direct interviews of over 200 scientists actively involved in proteomics research today. While ultimately incomplete, it is worth noting that over 68% of respondents received their technical training in proteomics during either their doctoral or postdoctoral training. In stark contrast, only 4.3% of students obtained training during their undergraduate education. Given the 5.7-to-9.4-year average cycle for traditional doctoral and postdoctoral training in the life sciences, it appears the limiting factor in growing the proteomics field may be linked directly to current practices in training a qualified workforce.

Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00083

Analytical ChemistryDOI: 10.1021/acs.analchem.5c01417

Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00321

In most bioanalytical laboratories, high-resolution mass spectrometry (HRMS) systems with electrospray ionization (ESI) are hyphenated to liquid chromatography platforms. The latter typically operate ...