New study shows that miR-101a regulates #ChondrocyteHypertrophy via Cox-2 & Col10a1, leading to delayed #Hypertrophy & #CartilageDegeneration, spotlighting it as a negative regulator of #Osteoarthritis. #medsky @uchicagocancer.bsky.social
#OpenAccess:
www.sciencedirect.com/science/arti...

A new therapeutic strategy for osteoarthritis emerges by targeting the AMPK–β-catenin–Runx2 signaling axis.
#Osteoarthritis #AMPK #BetaCatenin #Runx2 #CartilageDegeneration #OAPathogenesis
doi.org/10.1016/j.ge...

This review highlights the dual role of #LacticAcid in #Osteoarthritis (OA), driving #CartilageDegeneration while aiding #Inflammation resolution, and emphasizes redirecting lactate flux as a novel #therapeutic strategy for OA. #medsky
To read: doi.org/10.1007/s115...