1/3 Embryogenesis requires fit cells. Here, following work from @miguel-torres-1963.bsky.social & @tristanrodriguez72.bsky.social and led by @joshifrenster.bsky.social we develop a #gastruloid model of #CellCompetition
www.biorxiv.org/content/10.1...
showing it recapitulates much of the embryo 🧵

Ever wonder how cells in our epithelia fight for space? 🤔

Let's dive into the fascinating world of mechanical cell competition! #EpithelialMechanics

Hello, I am @akshar21.bsky.social and I'll be your guide through this thread on mechanical #CellCompetition

The Frenster Lab is here! 🍾 I am so excited to start my #EmmyNoether funded group at @uni-freiburg.de this summer. Our group studies #CellCompetition dynamics during embryonic development using #gastruloids from multiple species. Thanks to the @dfg.de for creating this opportunity! FrensterLab.com

🥳 I am happy to share our latest manuscript published in @natcellbio.nature.com We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that this is highly pronounced in our system but also tightly restricted in time. (1/12) www.nature.com/articles/s41...

🚨Last days to apply!🚨
The Frenster Lab is hiring to study how cell competition is regulated in early embryonic development. We use 3D Gastruloids from multiple species and have exciting crossovers of developmental and cancer biology! Join us at University of Freiburg #cellcompetition #gastruloid

☕ @joshifrenster.bsky.social @amartinezarias.bsky.social & co utilize mosaic mouse #gastruloids as a model of cell fitness & competition, identifying a temporal window between primed pluripotency and early gastrulation during which #CellCompetition occurs in mammalian #embryogenesis.
bit.ly/4cBmfGK

Cells compete to maintain tissue health. A #research team from #MPZPM, @ijmonod.bsky.social & #NielsBohrInstitute found that force transmission decides the winner, challenging classical #CellCompetition views.

Learn more 👉 mpzpm.mpg.de/news/news-de...

#science #cellbiology

📸 Lucas Anger

EXCITED to share our new paper in Nat Commun @natureportfolio.bsky.social "Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development”, identifying a potential marker of cell competition. #zebrafish #cellcompetition
www.nature.com/articles/s41...

Landmark revisit
#Angiogenesis #CellCompetition VEGFR1/2 NOTCH

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

#NatureCellBio 2010
www.nature.com/articles/ncb...

We believe human #epithelioids could serve as a new experimental #platform to study epithelial #biology, #clonalevolution, #cellcompetition, tissue responses to #clinical #therapies, and molecular #cancerprevention.