September 29, 2026 at 09:43PM Terverifikasi Administratif dan Faktual oleh Dewan Pers Home Bulu Tangkis Selasa, 29 September 2026 | 20:15 WIB Ganda putra China, Liang Wei Keng/Wang Chang, akan dipisah setelah Asian Games 2026 Aichi-Nagoya pada turnamen Korea Open 2026. (SAJJAD HUSSAIN/AFP) BOLASPORT.COM - Ganda putra nomor satu China, Liang Wei Keng/Wang Chang, terpantau akan dipisahkan setelah…

This Review considers developments in enzymes, biosynthetic pathways and cellular engineering that enable their use in catalysis for new chemistry and beyond.

TSMC became a global chip powerhouse by manufacturing chips for other companies and never competing with them. Founded by Morris Chang on 21 February 1987, it took the process lead around 7nm in 2018 and began 2nm volume production in late 2025. See how it unfolded, 1987–2026, milestone by milestone — the complete TSMC history, including Taiwan Semiconductor Manufacturing Company and pure-play foundry. Explore the full timeline.

Ruské finále v Chang-čou vyhrál Daniil Medveděv. Bývalý první tenista světového žebříčku porazil 7:5 a 6:4 Andreje Rubljova a získal třetí letošní titul, celkově na okruhu ATP ovládl 24. turnaj.

A single vote has blocked a nearly 10 million-franc construction loan for a new sports hall in Häggenschwil, leaving the village divided over what should happen next, SRF reports. The final count was 336 votes against and 335 in favour. The ballots were counted again, but the result did not chang…

September 29, 2026 at 07:40PM Terverifikasi Administratif dan Faktual oleh Dewan Pers Home Bulu Tangkis Selasa, 29 September 2026 | 17:52 WIB Leo Rolly Carnando/Daniel Marthin bikin China kembali sulit juara di sektor ganda putra sepanjang sejarah Asian Games setelah mengalahkan Liang Wei Keng/Wang Chang di final tahun ini. (NOC INDONESIA) BOLASPORT.COM - Keberhasilan Leo Rolly Carnando/Daniel Marthin…

September 29, 2026 at 07:46PM Terverifikasi Administratif dan Faktual oleh Dewan Pers Home Bulu Tangkis Selasa, 29 September 2026 | 19:15 WIB Ganda putra China, Liang Wei Keng/Wang Chang, pada final Asian Games 2026 Aichi-Nagoya, di Jepang, Selasa (29/9/2026). (YUICHI YAMAZAKI/AFP) BOLASPORT.COM - Target China menyapu bersih tujuh medali emas di cabang olahraga bulu tangkis Asian Games 2026 Aichi-Nagoya gagal total.

by Lei Zhu, Guan Zhang, Yingying Pu, Wenyu Wang, Zhanyan Zhang, Jiasai Kang, Haoshu Zhang, Lingling Chang, Le Shi, Yong Huang, Dewen Tong, Qian Du Circoviruses are the smallest known mammalian viruses with a single-stranded circular genome, whose replication capacity is highly dependent on host factors. Although the virus-encoded replication-associated protein (Rep/Rep’) plays a critical role in circovirus DNA replication, it lacks polymerase activity. Here, we uncovered a mechanism by which circoviruses hijack the host proliferating cell nuclear antigen (PCNA) via their Rep to recruit POLD1, the catalytic subunit of host DNA polymerase δ, thereby driving viral DNA synthesis. POLD1 was identified to be the major polymerase in the replication of circovirus DNA, and the virus infection promoted POLD1 expression. Further, it had been found that the Rep of Circoviruses bound to host sliding clamp protein PCNA to indirectly recruit POLD1 to viral replication centers, and the N-terminal motif LIXXG of Rep and the C-terminal motif NXNXK of PCNA were identified to be corresponding conservative binding sites. As PCV2 is the most clinically significant circovirus, a small-molecule drug R428 was screened to effectively block the binding between PCV2 Rep and porcine PCNA. R428 could significantly suppress the formation of the Rep/PCNA complex in cells, and effectively suppress PCV2 replication and alleviate PCV2 infection-induced tissue damage in mice and piglets. In conclusion, we elucidated the novel mechanism by which circoviruses hijack host PCNA-POLD1 to facilitate their DNA replication via Rep, and identified R428 as a potential anti-PCV2 agent for the prevention and control of circovirus-associated diseases.

YouTube video by Pernelle.