Background: There are limited options for aerobic exercise options that improve cardiorespiratory fitness and that manage cardiometabolic health, that are age-appropriate and suitable for children with mobility disabilities. Children with disabilities require exercise programs that incorporate adapted movements to meet various functional needs, which offer brief training durations to accommodate busy schedules, and utilize remote training methods at home to bypass logistical transportation barriers. Objective: Test the potential effects and safety of a sprint-intensity arm-exercise interval training program, combined with music and telehealth, on cardiorespiratory fitness and cardiometabolic health in a child with cerebral palsy. Methods: Pre-to post-trial with a 12-week exercise intervention for a single child with cerebral palsy (male, age 17 years). The intervention was conducted at the participants homes. The participants exercised three times per week while following along with YouTube exercise videos. Videos included four-second maximal sprint bouts followed by periods of rest, which were repeated 30 times during a single exercise session (total of ~2 minutes of maximal exercise). Exercise sessions were supervised by research staff using videoconferencing. Cardiorespiratory fitness was indicated by peak oxygen consumption (pVO2)that was measured by a portable metabolic cart during a graded exercise test. Cardiometabolic health outcomes included body composition by dual-energy X-ray absorptiometry scan (DXA) and a cardiometabolic blood profile by a dried blood spot test. Outcomes were descriptively analyzed. Results: The participant achieved a 33.6% increase in pVO2 (14.6 to 19.5 mL/kg -1 /min -1 ), 37.8% improvement in blood triglycerides (82 to 51 mg/dL), and a 15.4% improvement in total cholesterol to high-density lipoprotein ratio (6.5 to 5.5). Additionally, he had a 5.9% reduction in body weight (171 to 161 lbs) and a 9.6% reduction in total body fat (61.35 to 55.48 lbs) from the arms, legs, and trunk. The participants experienced no adverse events or problems during the intervention. After completing the program, the participant elicited a maximal intensity of exercise using armbands, as demonstrated through pVO2. Conclusions: Sprint-intensity interval training, which involves the arms, may be safe and potentially effective for enhancing cardiorespiratory fitness and cardiometabolic health in children with physical disabilities. Further research is needed to verify the outcomes of this case report.