#Colchicine
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mementomorty.bsky.social
this is what ohioians really want
a map that shows soon to be ohio, upper ohio, lower ohio, future ohio, colchicine, Hawaii, gulf of ohio, ohiocean, ohio, florida
November 2, 2026 at 7:42 PM
rheumcat.bsky.social
non inferiority trial of colchicine discontinuation

placebo was NOT non inferior to colchicine for gout flares

#2026GCAN #ACR26
12 month non inferiority trial colchicine or placebo months 0 to 6 and then follow up til month 12 more flares in the placebo group than colchicine group
November 5, 2026 at 1:29 PM
rheumcat.bsky.social
Lisa Stamp - colchicine ppx for gout (prerecorded because it's 2am in NZ)

#2026GCAN #ACR26
colchicine is an ancient remedy isolated in the early 1800s from the Colchicum autumnale plant
November 5, 2026 at 1:24 PM
stewieeee.bsky.social
I’ve got Losartan, Colchicine, and Metoprolol. Can’t cool those up.
November 2, 2026 at 10:53 PM
rheumcat.bsky.social
Colchicine flare ppx and reduced CVE

Colchicine vs NSAID flare ppx and CVE - favors colchicine

#2026GCAN #ACR26
Lancet Rheumatology 2025 A&R 2025
November 5, 2026 at 2:09 PM
rheumcat.bsky.social
More omics - colchicine and gene expression

#2026GCAN #ACR26
Wheeler et al ACR25 gene expression and colchicine
November 5, 2026 at 1:15 PM
rheumcat.bsky.social
Lessons learned: you can either have your flares early or late

But have a gout flare plan!

#2026GCAN #ACR26
Colchicine prevents gout flares with ULT Gout flares rise after stopping ppx You can have your flares early or late Have a gout flare plan Can restart ppx Colchicine ppx may reduce CVD events
November 5, 2026 at 1:38 PM
rheumcat.bsky.social
Colchicine as flare ppx for gout when starting ULT

But do we really need it??

#2026GCAN #ACR26
people hate having gout flares starting ULT can precipitate flares this can lead to loss of trust guidelines recommend anti inflammatory prophylaxis do we really need colchicine ppx? most trials are of short duration and don't have follow up for ppx discontinuation
November 5, 2026 at 1:28 PM
hswapnil.medsky.social
Department of 🥱
Colchicine doesn’t prevent periop AKI

www.ajkd.org/article/S027... in @ajkd.bsky.social
Colchicine and Perioperative Acute Kidney Injury: A Substudy of the COP-AF Randomized Clinical Trial
Perioperative inflammation may result in organ injury, including acute kidney injury (AKI). Colchicine, an anti-inflammatory drug, may help protect the organs from inflammation. This clinical trial su...
www.ajkd.org
October 30, 2026 at 11:54 PM
rheumcat.bsky.social
The UK group on CV risk and colchicine ppx for gout

pubmed.ncbi.nlm.nih.gov/39708831/

#2026GCAN #ACR26
Cipolletta et al 2024 - reduced risk of CVD events if colchicine vs no ppx
November 5, 2026 at 1:35 PM
rheumcat.bsky.social
2020/2021 - pandemic; but colchicine ppx RCT conducted through this time period

#GCAN2026 #ACR26
is colchicine ppx required with start low go slow allopurinol dose escalation in gout?
November 5, 2026 at 7:26 PM
rheumcat.bsky.social
✨Shareef Tubeileh (MS2 at VCU) - TriNetX study of age at gout dx

Later onset gout:

- higher risk of inpatient admission but lower risk of colchicine Rx.

- higher risk of MACE, ESKD, mortality

Can all be explained by comorbidity burden and age.

#2026GCAN #ACR26
November 5, 2026 at 5:19 PM
rheumcat.bsky.social
✨Colchicine Exposure Induces DNA Methylation and Expression Changes in Genes – Austin Wheeler

#2026GCAN #ACR26
1 - quantify DNA methylation changes a/w colchicine exposure with ULT initiation - Stamp study 2 - compare genes near differentially methylated sites to those differentially expressed with colchicine in STOP Gout 67 CpGs mapped to 45 genes 10 genes overlapped with differentially expressed transcripts from STOP gout study 10 genes overlapping
November 5, 2026 at 9:54 PM
bibliotecahuvh.bsky.social
Colchicine and Perioperative Acute Kidney Injury: A Substudy of the COP-AF Randomized Clinical Trial. www.sciencedirect.com/science/arti... #hvhebron #anest
www.sciencedirect.com
November 5, 2026 at 12:19 PM
laurafrost.bsky.social
I finally found out why the govt in Ontario won't cover colchicine. They say it's for pain duh, guess who made the decision in the govt has never had chronic pericarditis or gout.
November 2, 2026 at 1:51 AM
sonulesanika8-06.bsky.social
www.linkedin.com/pulse/colchi...
Colchicine Market: Deep-Dive Analysis, 2025–2034 Outlook, Global and Regional Dynamics
Colchicine Market size was valued at 189.36 Million USD in 2025 and is poised to grow from 199.
www.linkedin.com
November 3, 2026 at 6:11 AM
glbryson.bsky.social
COP-AF sub study.
0.5mg colchicine BID has no effect on atrial fib or AKI following thoracic surgery.
It does, however, give one the shits.
1/2
October 31, 2026 at 1:51 AM
minouette.bsky.social
with geneticist C. D. Darlington, they wrote monumental Chromosome Atlas of Cultivated Plants.

As a cytologist at Royal Horticultural Society at Wisley from ‘45-‘51 she researched effects of colchicine on magnolia which caused a doubling of chromosomes, giving heavier leaves, variable flowers with
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minouette.etsy.com
November 4, 2026 at 1:11 PM
rheumcat.bsky.social
💉Firsekibart - anti IL-1b akin to canakinumab, already approved in China

Phase 2 trial - used as flare ppx against colchicine

#2026GCAN #ACR26
November 4, 2026 at 1:20 PM
rheumcat.bsky.social
Other things learned from STOP GOUT

Can also learn about subclinical inflammation in gout

#2026GCAN #ACR26
91% achieved SU <6.8mg/dl at 48 weeks colchicine ppx in 90% reduced CRP median dose of 400mg allopurinol needed similar rash rates Wheeler et al 2025 - PCA to cluster analytes among gout participants not having flares to look at systemic inflammation
November 5, 2026 at 1:11 PM
rheumcat.bsky.social
✨Brian Coburn - gout tx discontinuation among hospitalized gout pts

VA - looked at allopurinol, colchicine users

outcomes: discontinuation at admission; at discharge

factors a/w discontinuation - AKI, unit of admission

#2026GCAN #ACR26
November 5, 2026 at 6:30 PM
rheumcat.bsky.social
This UK study pointed towards colchicine flare ppx and higher risk of MI??

Could the limitations of the study design explain the results?

#2026GCAN #ACR26
under ascertainment of AEs exposure definition
November 5, 2026 at 2:11 PM
drnikhilshah.bsky.social
🔬 In nearly 3,000 patients having noncardiac thoracic surgery, colchicine did not reduce perioperative acute kidney injury compared with placebo, including in those with chronic kidney disease.

🎧 This Week in Nephrology: free AI briefing 👇
audioscholar.cc/feed/nephrology?w=2026-W45
Nephrology Weekly — AudioScholar
A ~10-minute, PubMed-sourced audio briefing of the week's nephrology literature. Free, every week.
audioscholar.cc
November 4, 2026 at 11:51 AM
rheumcat.bsky.social
Using UK CPRD they also did a self controlled case series study - results were null, there was no increased CV event risk after stopping flare ppx

pubmed.ncbi.nlm.nih.gov/42671134/

#2026GCAN #ACR26
first ever CV event = outcome gout flare prophylaxis = prescription for colchicine or NSAID on same day as ULT start n=707 IRR 1.05 (95% CI 0.74-1.52) overall
November 5, 2026 at 1:37 PM
nijkerknieuwsnl.bsky.social
Jichtmiddel colchicine nu ook tegen hartinfarct en beroerte

Lees hier het hele bericht
https://nijkerk.nieuws.nl/gezondheidspagina/jichtmiddel-colchicine-nu-ook-tegen-hartinfarct-en-beroerte

#Nijkerk #Nijkerkerveen #Hoevelaken #gezondheid
October 29, 2026 at 2:38 PM