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kidneyint.bsky.social
Meeting Report
Outcomes from the International Society of Nephrology forum on complement therapeutics in C3 glomerulopathy and IgA nephropathy

doi.org/10.1016/j.kint.2026.08.007

#NephSky #MedSky #OpenAccess #C3G #C3Glomerulopathy #IgAN #IgANephropathy #ComplementSystem #GlomerularDisease
October 2, 2026 at 5:00 PM
hemehub.bsky.social
🔍✨Final questions for PNH & Breakthrough Hemolysis!

Swipe to see the answers and explanations!

#PNH #ParoxysmalNocturnalHemoglobinuria #BreakthroughHemolysis #ComplementSystem #FactorBInhibition #Iptacopan #C5Inhibitors #Hematology #HemeOnc #RareDisease #Thrombosis #BoneMarrowFailure #Hemolysis
May 28, 2026 at 7:48 PM
hemehub.bsky.social
🩸 Facts about #PNH & Breakthrough Hemolysis:

Survival outcomes, #BTH definition variability, biosimilars, and next-generation complement inhibitors.

#ComplementSystem #C5Inhibition #BoneMarrowFailure #Thrombosis #Hemolysis #RenalFailure #Hematology #HemeOnc #MedicalEducation #MedEd #HEMEHUB
May 28, 2026 at 7:46 PM
hemehub.bsky.social
🩸🚀Today’s clinical questions!

Swipe to see the answers and explanations.

#PNH #Eculizumab #Ravulizumab #C5Inhibition #ComplementSystem #BreakthroughHemolysis #PKBreakthrough #Pregnancy #DrugClearance #PlasmaVolume #MaternalHealth #ThrombosisRisk #Hematology #HemeOnc #MedEd #HEMEHUB
May 26, 2026 at 2:59 PM
hemehub.bsky.social
🩸 Facts about PNH & Breakthrough Hemolysis:

Surgical complement activation, renal complications from chronic hemolysis, transplant as the only curative option, and thrombosis risk during BTH.

#PNH #BTH #ComplementSystem #C5Inhibition #Thrombosis #Hemolysis #Hematology #HemeOnc #MedEd #HEMEHUB
May 26, 2026 at 2:56 PM
hemehub.bsky.social
🔎 💬Today’s questions!

Swipe to see the answers and explanations!

#PNH #Hemolysis #CellFreeHemoglobin #NitricOxide #NOScavenging #SmoothMuscleDystonia #EsophagealSpasm #AbdominalPain #ComplementSystem #C5Inhibition #ExtravascularHemolysis #EVH #Hemoglobin #Hematology #HemeOnc #HEMEHUB
May 21, 2026 at 9:11 PM
hemehub.bsky.social
🩸 Facts about #PNH & Breakthrough Hemolysis:

Breakthrough risk on #eculizumab, improved PK control with #ravulizumab, #EVH markers despite #LDH control, and Hb drops signaling marrow failure.

#BTH #ComplementSystem #C5Inhibition #BoneMarrowFailure #Hemoglobin #Hematology #RareDiseases #HEMEHUB
May 21, 2026 at 9:10 PM
hemehub.bsky.social
🌟🔎Today’s questions!

Swipe to see the answers and explanations!

#PNH #BreakthroughHemolysis #IVH #LDH #Haptoglobin #Bilirubin #HemolysisMarkers #ComplementSystem #C5 #Eculizumab #ComplementInhibition #Hematology #HemeOnc #RareDisease #ClinicalMedicine #MedicalEducation #MedEd #HEMEHUB
May 18, 2026 at 9:11 PM
hemehub.bsky.social
🩸 Facts about #PNH & Breakthrough Hemolysis:

Alternative pathway tick-over (C3), C5a-driven inflammation in #BTH, pregnancy as a complement trigger, #crovalimab SC dosing, and #LDH targets with terminal inhibition.

#ComplementSystem #C3 #C5a #Hematology #HemeOnc #RareDiseases #MedEd #HEMEHUB
May 18, 2026 at 9:06 PM
hemehub.bsky.social
🩸✨Today’s questions!

Swipe to see the answers and explanations!

#PNH #Hematopoiesis #Granulocytes #BreakthroughHemolysis #BTH #RedBloodCells #ComplementSystem #C5Inhibitors #Ravulizumab #Eculizumab #ComplementBlockade #Hematology #HemeOnc #RareDiseases #BoneMarrowFailure #HEMEHUB
May 14, 2026 at 8:57 PM
hemehub.bsky.social
🩸 Facts about #PNH & Breakthrough Hemolysis:

Iron loss from chronic IVH, meningococcal infection risk with complement blockade, and factors driving breakthrough hemolysis severity.

#ComplementSystem #C3Inhibitors #BreakthroughHemolysis #BoneMarrowFailure #RareDiseases #Hematology #HemeOnc #HEMEHUB
May 14, 2026 at 8:55 PM
hemehub.bsky.social
🩸 Facts about PNH & Breakthrough Hemolysis:

Proximal inhibition, complement regulation, and evolving strategies in disease control.

#PNH #ComplementSystem #ComplementInhibition #C3Inhibitors #Pegcetacoplan #Iptacopan #BoneMarrowFailure #RareDiseases #Hematology #HemeOnc #MedicalEducation #HEMEHUB
May 12, 2026 at 1:40 AM
hemehub.bsky.social
💡🚀Today’s clinical questions!

Swipe to see the answers and explanations!

#PNH #ComplementSystem #BreakthroughHemolysis #C5Inhibitors #Ravulizumab #ComplementInhibition #ExtravascularHemolysis #Pegcetacoplan #Danicopan #Iptacopan #Eculizumab #Hematology #HemeOnc #HEMEHUB
May 9, 2026 at 10:44 PM
hemehub.bsky.social
🩸 Facts about #PNH & Breakthrough #Hemolysis:

Breakthrough hemolysis may occur from low drug levels (PK-BTH) or excess complement activation (PD-BTH), while C3-mediated extravascular hemolysis can still contribute to ongoing anemia despite treatment.

#ComplementSystem #HemeOnc #Hematology #HEMEHUB
May 9, 2026 at 10:43 PM
castltrastondrs.medsky.network
Recap
The #complementsystem plays a crucial role in chronic inflammation, tissue damage & microvascular clotting in #longCOVID. @virusesimmunity.bsky.social et al indicates that complement activation, which is significantly heightened during acute #COVID persists for months or even years
September 2, 2025 at 2:29 PM
castltrastondrs.medsky.network
In this Review @virusesimmunity.bsky.social et al examine the evidence linking #complementsystem dysregulation to LC & explore its potential role in driving disease pathology.
@jci-insight.bsky.social
insight.jci.org/articles/vie...
The complement cascade can be initiated by three distinct pathways: the classical, lectin, and alternative pathways. The classical and lectin pathways are triggered when recognition molecules bind to structures such as antibody complexes and carbohydrates on pathogen surfaces, leading to the activation of their associated proteases C1s/C1r and MASP-1/2. These proteases cleave C4 and C2, generating the C3 convertase (C4b2b), which then processes C3 into the anaphylatoxin C3a and the opsonin C3b. Accumulation of C3b induces the formation of the C5 convertase, which cleaves C5 into C5a and C5b. The subsequent interaction of C5b with C6, C7, C8, and C9 leads to the assembly of a lytic pore, known as the terminal complement complex (TCC). The alternative pathway is initiated when factor B (FB) interacts either with water-hydrolyzed C3, C3(H2O), or with deposited C3b to form the C3(H2O)Bb or C3bBb C3 convertases following factor D (FD) cleavage. These proteases, and in particular, the surface-bound and properdin/factor P–stabilized (FP-stabilized) C3bBbP C3 convertase act as an amplification loop for complement, generating most of the activated C3 fragments regardless of the initiating pathway. SARS-CoV-2 infection triggers activation of the complement cascade through direct interaction with viral components or virus-specific antibodies, typically resolving once the infection is cleared. However, in patients with long COVID, this activation may persist, potentially contributing to ongoing symptoms. Several proposed mechanisms of long COVID can directly activate the complement system. For example, antiherpesvirus antibodies, likely the result of herpesvirus reactivation, or autoantibodies may drive activation via the classical pathway. Insertion of TCC in the endothelial cell wall causes activation and cell damage, causing the release of TSP1 and vWF. TSP1 promotes formation of monocyte-platelet aggregates, while vWF release — coupled with reduced levels of ADAMTS13, the metalloproteinase responsible for processing vWF multimers — leads to the accumulation of large or ultralarge vWF multimers on the endothelial surface. This, in turn, promotes platelet recruitment and thrombus formation. Additionally, vWF multimers on the endothelium, along with properdin and P selectin on activated platelets, can trap C3b, fueling complement activation via the amplification loop of the alternative pathway. Uncontrolled complement activation in the vasculature leads to red blood cell lysis, causing the release of heme and activation of the alternative pathway. Finally, tissue damage resulting from acute COVID-19, autoimmunity, or viral antigen reservoirs may all contribute to the persistent complement activation observed in patients with long COVID.
August 26, 2025 at 12:58 PM
castltrastondrs.medsky.network
#Medsky🧪 #IDsky #immunosky #publichealth Recent studies suggest that dysregulation of the #complementsystem, a key component of the innate immune response, may contribute to the pathogenesis of #longCOVID, particularly in connection with #coagulation, #inflammation & #vascularinjury.
August 26, 2025 at 12:53 PM
prof-clark.bsky.social
It's pretty cool to finally see a method capable of generating practical amounts of functional, full-length complement factor H. buff.ly/xwEz6YD

#ComplementTherapeutics #ComplementSystem #Immunology #InnateImmunity #DrugDevelopment #BiotechInnovation #TranslationalMedicine #PrecisionMedicine
Moss-derived recombinant Factor H, CPV-104, effectively antagonizes alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy - PubMed
CPV-104 effectively limits both stabilization and formation of AP C3 convertases in NeF-positive C3G, demonstrating superior functional activity compared with sd-FH. By restoring physiological AP…
buff.ly
July 28, 2026 at 9:01 AM
prof-clark.bsky.social
New study reveals FHR-1 as both a driver of complement-mediated injury in IgAN and a novel therapeutic target, reshaping disease biology and treatment strategies. #IgAN #Nephrology #ComplementSystem #Immunology #MedTwitter
buff.ly/giVErnc
Dual Role of Factor H-Related Protein 1 in IgA Nephropathy Kidney Injury - PubMed
FHR-1 exacerbates kidney injury in IgAN by accelerating complement activation and inflammation. FHR-1<sub>SCR1-2</sub> effectively attenuated FHR-1-induced inflammation, demonstrating promising…
buff.ly
April 9, 2026 at 9:00 AM
prof-clark.bsky.social
Study of 156 dengue patients shows distinct complement signatures by disease severity, with soluble CR1 emerging as an independent early predictor of severe outcomes. #Dengue #Immunology #ComplementSystem #Biomarkers #GlobalHealth #Science buff.ly/da4fIQb
Aberrant systemic acute-phase complement responses in conjunction with soluble CR1 attribute to varying grades of dengue disease severity - PubMed
Our findings show that aberrant complement activation and levels of sCR1 could attribute to varying grades of dengue severity. Given its inverse association, the levels of sCR1 could likely render…
buff.ly
February 4, 2026 at 10:00 AM
prof-clark.bsky.social
New study shows deleting FHR1 reduces atherosclerosis, inflammation, and plaque formation in mice—revealing a novel immune-lipid axis in cardiovascular disease.
#Atherosclerosis #CardioScience #Immunology #ComplementSystem #TranslationalResearch buff.ly/QEVu3ct
Deletion of the Mouse Homolog of Human FHR1 (muFHR1) Alleviates Atherosclerosis in ApoE-/- mice - PubMed
Atherosclerosis is the leading cause of heart attack and stroke worldwide. The key characteristic of atherosclerosis is accumulation of LDL cholesterol in artery walls, the subsequent infiltration by...
buff.ly
January 27, 2026 at 10:00 AM
prof-clark.bsky.social
New research reveals systemic complement activation, specially elevated Factor B (Bb), is tightly linked to reduced choroidal thickness in advanced nnAMD. #AMD #Ophthalmology #ComplementSystem #Biomarkers #MedTwitter #SciComm #ResearchNews buff.ly/WQP6t8H
Association between systemic complement levels and choroidal thickness in advanced non-neovascular age-related macular degeneration - PubMed
To investigate associations between systemic complement activation and choroidal thickness (CT) in advanced non-neovascular age-related macular degeneration (nnAMD). Cross-sectional study of 96…
buff.ly
December 8, 2025 at 10:00 AM
prof-clark.bsky.social
New Mendelian randomization study reveals FHR1 and FD as causal drivers in IgA and diabetic nephropathy #Nephrology #KidneyDisease #PrecisionMedicine #Genomics #ComplementSystem #DrugDiscovery #Innovation #ScienceNews #AI #Bioinformatics buff.ly/tfat5dy
Identification of potential therapeutic targets for complement-associated glomerular diseases using Mendelian randomization - PubMed
The complement system is a crucial part of the innate immune response, involved in various glomerular diseases through its activation in different pathways. Uncontrolled complement activation plays a…
buff.ly
October 14, 2025 at 9:01 AM
prof-clark.bsky.social
New discovery: FHR1, a complement system protein, plays a surprising role in helping macrophages clear dead cells (efferocytosis). #FHR1 #Immunology #Macrophages #Proteomics #Biotech #ComplementSystem #SingleCell
buff.ly/KkCkG9e
Developing serum proteomics based prediction models of disease progression in ADPKD - PubMed
Autosomal Dominant Polycystic Kidney Disease is the most common genetic cause of kidney failure. Outcome prediction is essential to guide therapeutic decisions. However, currently available models…
buff.ly
July 21, 2025 at 2:53 AM
prof-clark.bsky.social
New insights into AMD: A recent study maps the retinal sialome and finds reduced sialic acid at the Bruch's membrane–choroid interface in AMD eyes—potentially impacting complement regulation via factor H (FH). #AMD #Ophthalmology #ComplementSystem buff.ly/jvrGu4F
The Sialome of the Retina, Alteration in Age-Related Macular Degeneration Pathology, and Potential Impacts on Complement Factor H - PubMed
The sialome of the human retina is altered in AMD. This may affect FH binding and, consequently, alternative complement pathway regulation.
pubmed.ncbi.nlm.nih.gov
June 30, 2025 at 2:55 AM