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News Release 30-Apr-2025
"Long COVID biomarkers found – associated with respiratory problems"
www.eurekalert.org/news-release...

Research paper:
"Identification of soluble biomarkers that associate with distinct manifestations of long COVID"
www.nature.com/articles/s41...

#LongCovid #CovidLung
News Release 30-Apr-2025 Long COVID biomarkers found – associated with respiratory problems Peer-Reviewed Publication Karolinska Institutet Researchers at Karolinska Institutet have identified biomarkers in the blood associated with symptoms of long COVID, particularly severe respiratory disorders. The discovery can pave the way for future diagnosis and treatment. The results are published in the top-ranking scientific journal Nature Immunology. Long COVID, also known as Post COVID, is a condition characterised by persistent symptoms of previous COVID-19. A new study from Karolinska Institutet, Sweden, and Cardiff University, UK, led by Marcus Buggert, docent at the Department of Medicine, Karolinska Institutet (Huddinge), has identified a set of proteins in the blood of people with Long COVID. “The proteins were mainly found in patients with Long COVID and severe respiratory problems,” says Dr Buggert. “This is a biomarker pattern that we know to be linked to inflammatory signal pathways involved in cell death and lung damage and that has also been observed in other patient groups with severe pulmonary disorders.”
May 1, 2025 at 12:27 PM
tomkindlon.bsky.social
From Germany:

A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID

www.nature.com/articles/s41...

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#LongCovid #CovidLung
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID — Kumar et al. "We also defined a distinct circulating CD14⁺ monocyte state (LC-Mo) associated with LC […] showed increased TGFβ/WNT–β-catenin signaling that increased over time and exhibited interindividual variability."
January 23, 2026 at 3:37 AM
tomkindlon.bsky.social
From China

Longitudinal assessment of pulmonary perfusion and ventilation defects in long COVID

www.sciencedirect.com/science/arti...

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#LongCovid #Covidlung
Longitudinal assessment of pulmonary perfusion and ventilation defects in long COVID: A one-year study using phase-resolved functional lung (PREFUL) MRI — Ouyang et al. "We found ventilation defects normalizing by six months, while perfusion defects persisted for up to one year. Severe perfusion defects at the acute phase were associated with a higher risk of long COVID, persistent dyspnea, and fatigue."
November 27, 2025 at 1:48 AM
tomkindlon.bsky.social
From Sweden

Longitudinal epigenetic rewiring in lung immune cells in patients with post COVID-19 condition

link.springer.com/article/10.1...

s4me.info/threads/long...

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#LongCovid #COVIDLung #PASC #PwLC #postcovid #postcovid19
Longitudinal epigenetic rewiring in lung immune cells in patients with post COVID-19 condition — Nikesjö et al "Distinct DNAm patterns were observed across pulmonary immune cell fractions, with longitudinal changes primarily detected in neutrophil- and macrophage-enriched populations, while alterations were not evident in PBMCs." "This divergence between lung and blood suggests tissue-specific epigenetic remodeling following SARS-CoV-2 infection and underscores the limitations of relying solely on peripheral blood to capture disease-relevant molecular changes in PCC." Article | Thread
September 22, 2026 at 12:40 AM
tomkindlon.bsky.social
From the US

Bronchovascular texture pattern on quantitative CT reveals airway and vascular remodeling in post-COVID-19 Lungs

link.springer.com/article/10.1...

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#LongCovid #CovidLung
Bronchovascular texture pattern on quantitative CT reveals airway and vascular remodeling in post-COVID-19 Lungs — Zhang et al "our findings are consistent with an alveolar–vascular mechanism whereby persistent microcirculatory dysfunction and perfusion heterogeneity contribute to impaired gas transfer." "Multiple imaging biomarkers further indicated that airway and pulmonary vascular remodeling, along with increased ventilation heterogeneity, persisted and were strongly associated with self-reported symptoms and validated questionnaires." Article | Thread
July 7, 2026 at 12:40 AM
tomkindlon.bsky.social
From the UK

Using hyperpolarised xenon magnetic resonance imaging to explore breathlessness in long COVID: results from the EXPLAIN study

publications.ersnet.org/content/erjo...

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#LongCovid #CovidLung
Using hyperpolarised xenon magnetic resonance imaging to explore breathlessness in long COVID: results from the EXPLAIN study — Ng et al "Our results show that in the majority of never-hospitalised LC participants, gas transfer measurements using 129Xe-MRI were similar to those of fully recovered controls." Article | Thread
September 10, 2026 at 9:55 PM
tomkindlon.bsky.social
Interrogating pulmonary diffusing capacity in long COVID: insights from DLCO and DLNO testing

www.frontiersin.org/journals/phy...

"between group analysis revealed that only in females, not in males, was DLNO and Vc significantly lower in those with LC"

#LongCovid #CovidLung
Frontiers | Interrogating pulmonary diffusing capacity in long COVID: insights from DLCO and DLNO testing
IntroductionThe lingering respiratory effects of COVID-19, particularly in patients with Long COVID, remain poorly understood, prompting a comprehensive eval...
www.frontiersin.org
December 15, 2025 at 11:19 PM
tomkindlon.bsky.social
From the US

Clinical, Radiographic, and Physiological Correlates of Post-COVID-19 Dyspnea in Military Health System Beneficiaries

dx.doi.org/10.1093/ofid...

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#LongCovid #Covidlung
Clinical, Radiographic, and Physiological Correlates of Post-COVID-19 Dyspnea in Military Health System Beneficiaries: Results From the Chronic Impairment With Pulmonary Symptoms (ChIPS) Sub-study — Goertzen et al. "Overall, this study demonstrates both subjective and objective differences between those with ongoing dyspnea following COVID-19 infection that are not explained by standard investigations typically ordered in clinical care for chronic dyspnea."
November 27, 2025 at 1:42 AM
mrweaverface.bsky.social
Psalm 20:7 "Some trust in chariots and some in horses, but we trust in the name of the LORD our God."

God can heal you straight up!

#running #covidlung #afib #healing #praisethelord
August 28, 2025 at 2:24 PM
chrisjohns.me
Had a #LongCovid #CovidLung attack tonight. I forgot to take my #Symbicort this morning, and it came back to bite me.
Thankfully, the symptom was being unable to catch my breath, and nothing much worse; apart from the mini panic attack that came after.
November 17, 2024 at 4:26 AM
tomkindlon.bsky.social
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"We also assessed lung parenchymal involvement at chest CT. More than two thirds of patients showed CT abnormalities, such as fibrotic alterations or persisting ground grass opacities, among both in- and out-patients."

#CovidLung #PostCovid19 #PwLC
September 23, 2024 at 5:27 PM