Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 25, 2026 at 2:03 PM
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 24, 2026 at 7:00 AM
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 24, 2026 at 7:01 AM
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 23, 2026 at 1:26 AM
Metal-free cycloaddition reactions of an Si📷Si triple bond with terminal alkynes
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Cycloaddition Reactions
May 13, 2025 at 1:51 AM
Cycloaddition Reactions
[6+4] Cycloadditions! Introducing our first dive into this fascinating subject in a very enjoyable collaboration with Ken Houk and his team. Congrats to Harrison and Tufan!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Synthesis of Collinoketones via Biomimetic [6 + 4] Cycloaddition
Cycloadditions are among the most powerful reactions for constructing molecular complexity. The archetypal example is the [4 + 2] (Diels–Alder) cycloaddition, which efficiently furnishes cyclohexene d...
pubs.acs.org
November 15, 2025 at 11:11 PM
[6+4] Cycloadditions! Introducing our first dive into this fascinating subject in a very enjoyable collaboration with Ken Houk and his team. Congrats to Harrison and Tufan!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Cycloaddition of epoxides and atmospheric CO2 in aqueous catalyzed by an upper-rim functionalized calix[4]arene organocatalyst
Cycloaddition of epoxides and atmospheric CO2 in aqueous catalyzed by an upper-rim functionalized calix[4]arene organocatalyst
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
May 21, 2025 at 11:50 PM
Cycloaddition of epoxides and atmospheric CO2 in aqueous catalyzed by an upper-rim functionalized calix[4]arene organocatalyst
Bifunctional reagents and strain-release cycloaddition – one reagent for the best of both worlds! 🫱🏼🫲🏽
Check out our latest publication on cyclic bifunctional reagents and in situ generated 2H-azirines in @jacs.acspublications.org:
pubs.acs.org/doi/10.1021/...
#OrganicChemistry #ChemTwitter
Check out our latest publication on cyclic bifunctional reagents and in situ generated 2H-azirines in @jacs.acspublications.org:
pubs.acs.org/doi/10.1021/...
#OrganicChemistry #ChemTwitter
April 14, 2025 at 12:14 PM
Bifunctional reagents and strain-release cycloaddition – one reagent for the best of both worlds! 🫱🏼🫲🏽
Check out our latest publication on cyclic bifunctional reagents and in situ generated 2H-azirines in @jacs.acspublications.org:
pubs.acs.org/doi/10.1021/...
#OrganicChemistry #ChemTwitter
Check out our latest publication on cyclic bifunctional reagents and in situ generated 2H-azirines in @jacs.acspublications.org:
pubs.acs.org/doi/10.1021/...
#OrganicChemistry #ChemTwitter
Endo-selective [2+2] cycloaddition of norbornadienes enables the synthesis of homocubanes #chemsky
Endo-selective [2+2] cycloaddition of norbornadienes enables the synthesis of homocubanes
Nature Chemistry, Published online: 10 July 2026; doi:10.1038/s41557-026-02201-xThe [2+2] cycloaddition of norbornadienes and alkynes usually favours the formation of the exo adducts. Now, a nickel-catalysed endo-selective [2+2] cycloaddition has been developed, which has been used to generate otherwise elusive endo-tricyclononadienes, and further derivatized via intramolecular [2+2] photocycloaddition to synthesize homocubanes.
dlvr.it
July 10, 2026 at 10:18 AM
Endo-selective [2+2] cycloaddition of norbornadienes enables the synthesis of homocubanes #chemsky
Really pleased to see this work published. We helped out with the crystallography which helped to better understand how these cations function. #ChemSky
@pubs.acs.org
pubs.acs.org/doi/10.1021/...
@pubs.acs.org
pubs.acs.org/doi/10.1021/...
Enhanced CO2/Epoxide Cycloaddition Catalyzed by Pyridine-Substituted Triazole-Quaternary Ammonium Bromide
A series of ionic quaternary ammonium bromides featuring triazole moieties, QAS-trzBn4, QAS-trzPic4, and QAS-trzBn2Pic2, were synthesized via Cu-catalyzed azide–alkyne cycloaddition (CuAAC) between pr...
pubs.acs.org
October 3, 2025 at 6:49 AM
Really pleased to see this work published. We helped out with the crystallography which helped to better understand how these cations function. #ChemSky
@pubs.acs.org
pubs.acs.org/doi/10.1021/...
@pubs.acs.org
pubs.acs.org/doi/10.1021/...
TRIPLE Triplet Triplet EnT catalysis in one pot —wondering how??😃
Dearomative [5+4] cycloaddition -> formal [3,3]-sigmatropic rearrangement ->[2+2] cycloaddition of bicyclic azaarenes to access unique pyridine fused/bridged pentacyclic products.
www.nature.com/articles/s41...
Dearomative [5+4] cycloaddition -> formal [3,3]-sigmatropic rearrangement ->[2+2] cycloaddition of bicyclic azaarenes to access unique pyridine fused/bridged pentacyclic products.
www.nature.com/articles/s41...
Triple energy transfer-enabled dearomative cycloaddition/rearrangement cascade of bicyclic azaarenes to structurally complex products - Nature Catalysis
Energy transfer (EnT) catalysed dearomative cycloadditions of bicyclic azaarenes are largely limited to [4+2] pathways, with higher-order cycloadditions being difficult to achieve. Now, the authors ci...
www.nature.com
July 10, 2026 at 8:16 AM
TRIPLE Triplet Triplet EnT catalysis in one pot —wondering how??😃
Dearomative [5+4] cycloaddition -> formal [3,3]-sigmatropic rearrangement ->[2+2] cycloaddition of bicyclic azaarenes to access unique pyridine fused/bridged pentacyclic products.
www.nature.com/articles/s41...
Dearomative [5+4] cycloaddition -> formal [3,3]-sigmatropic rearrangement ->[2+2] cycloaddition of bicyclic azaarenes to access unique pyridine fused/bridged pentacyclic products.
www.nature.com/articles/s41...
The review of Emma Robert on cycloaddition and annulation reactions with Donor-Acceptor cyclobutanes has now appeared in @helvchimacta.bsky.social !
doi.org/10.1002/hlca...
doi.org/10.1002/hlca...
October 5, 2025 at 2:56 PM
The review of Emma Robert on cycloaddition and annulation reactions with Donor-Acceptor cyclobutanes has now appeared in @helvchimacta.bsky.social !
doi.org/10.1002/hlca...
doi.org/10.1002/hlca...
The latest from the team, and the first for (Bluesky-less) Emeric Schubert 🥳
He uncovered unexpected Ge-H reactivity in the coordination sphere of Ni: dehydrocoupling of Ge-H w/ Si-H bonds, and some neat cycloaddition chem! 🧪 Very cool.
Find it here:
tinyurl.com/4jbwh62e
He uncovered unexpected Ge-H reactivity in the coordination sphere of Ni: dehydrocoupling of Ge-H w/ Si-H bonds, and some neat cycloaddition chem! 🧪 Very cool.
Find it here:
tinyurl.com/4jbwh62e
GeII–H/SiIV–H dehydrocoupling and cycloaddition chemistry of a Ni0 bis(hydridogermylene) complex
We report the high-yielding synthesis of a bis(hydridogermylene) complex of Ni0 (2). In contrast to known hydridotetrylene chemistry, this complex demonstrates a unique GeII–H/SiIV–H dehydrocoupling r...
tinyurl.com
April 23, 2026 at 9:48 AM
The latest from the team, and the first for (Bluesky-less) Emeric Schubert 🥳
He uncovered unexpected Ge-H reactivity in the coordination sphere of Ni: dehydrocoupling of Ge-H w/ Si-H bonds, and some neat cycloaddition chem! 🧪 Very cool.
Find it here:
tinyurl.com/4jbwh62e
He uncovered unexpected Ge-H reactivity in the coordination sphere of Ni: dehydrocoupling of Ge-H w/ Si-H bonds, and some neat cycloaddition chem! 🧪 Very cool.
Find it here:
tinyurl.com/4jbwh62e
New paper from our group out in JCTC! We introduce CYCLO70 — a benchmarking set of 70 challenging cycloaddition reactions (Diels–Alder, dipolar, sigmatropic).
👉 doi.org/10.1021/acs.... (1/6)
👉 doi.org/10.1021/acs.... (1/6)
CYCLO70: A New Challenging Pericyclic Benchmarking Set for Kinetics and Thermochemistry Evaluation
Here, a new challenging benchmarking data set for cycloaddition reactions, CYCLO70, is presented and analyzed. CYCLO70 has been generated with the specific aim of being representative of the most chal...
doi.org
September 12, 2025 at 5:20 PM
New paper from our group out in JCTC! We introduce CYCLO70 — a benchmarking set of 70 challenging cycloaddition reactions (Diels–Alder, dipolar, sigmatropic).
👉 doi.org/10.1021/acs.... (1/6)
👉 doi.org/10.1021/acs.... (1/6)
What an exciting time at Green IUPAC 2026 in Lisbon!
Fantastic event highlighting green chemistry research. Huge congrats to Madina Lenz on her poster prize for interrupted energy transfer cycloaddition! Thanks to all for the great vibe.
#GreenIUPAC2026 #GreenChemistry
Fantastic event highlighting green chemistry research. Huge congrats to Madina Lenz on her poster prize for interrupted energy transfer cycloaddition! Thanks to all for the great vibe.
#GreenIUPAC2026 #GreenChemistry
September 25, 2026 at 12:35 PM
What an exciting time at Green IUPAC 2026 in Lisbon!
Fantastic event highlighting green chemistry research. Huge congrats to Madina Lenz on her poster prize for interrupted energy transfer cycloaddition! Thanks to all for the great vibe.
#GreenIUPAC2026 #GreenChemistry
Fantastic event highlighting green chemistry research. Huge congrats to Madina Lenz on her poster prize for interrupted energy transfer cycloaddition! Thanks to all for the great vibe.
#GreenIUPAC2026 #GreenChemistry
New paper out in #BJOC @beilstein-institut.bsky.social
Solid state #photochemistry for a change😉⚗️"Visible light-initiated topochemical [2+2] cycloaddition in a #bimane dye" great collaboration with #MikhailFilatov @TUDubChemBPharm
funded by @researchireland.bsky.social doi.org/10.3762/bjoc...
Solid state #photochemistry for a change😉⚗️"Visible light-initiated topochemical [2+2] cycloaddition in a #bimane dye" great collaboration with #MikhailFilatov @TUDubChemBPharm
funded by @researchireland.bsky.social doi.org/10.3762/bjoc...
![Bimanes, a class of molecules based on the 1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione scaffold, were first introduced by E. M. Kosower in 1978. In this study, we report the topochemical cycloaddition of diethyl 2,6-dichloro-1,7-dioxo-1H,7H-pyrazolo[1,2-a]pyrazole-3,5-dicarboxylate (Cl2B), initiated by visible light. Crystal structure analysis confirmed that the reactive double bonds are parallel and coplanar, in line with the Schmidt criteria for topochemical cycloaddition. Additionally, two other bimane derivatives with different substitution patterns were synthesized and investigated. Our findings suggest that functionalizing bimanes to redshift their absorption maxima into the visible-light spectrum provides a promising strategy for synthesizing substituted cyclobutanes without the need for ultraviolet irradiation.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ls54voiihm3bxde2dkgrxbm3/bafkreidduymtzhb44xcfbfd46fwrtmmzmgmj7u6dbks42otca4k5xfa37i)
March 5, 2025 at 8:34 PM
New paper out in #BJOC @beilstein-institut.bsky.social
Solid state #photochemistry for a change😉⚗️"Visible light-initiated topochemical [2+2] cycloaddition in a #bimane dye" great collaboration with #MikhailFilatov @TUDubChemBPharm
funded by @researchireland.bsky.social doi.org/10.3762/bjoc...
Solid state #photochemistry for a change😉⚗️"Visible light-initiated topochemical [2+2] cycloaddition in a #bimane dye" great collaboration with #MikhailFilatov @TUDubChemBPharm
funded by @researchireland.bsky.social doi.org/10.3762/bjoc...
We’re particularly keen to highlight great articles published by members of the #ChemSky community.
This one is by @gloriusfrank.bsky.social and colleagues at @uni-muenster.de
'Lewis acid-catalyzed [2π+2σ] cycloaddition of dihydropyridines with bicyclobutanes'
pubs.rsc.org/en/content/a...
This one is by @gloriusfrank.bsky.social and colleagues at @uni-muenster.de
'Lewis acid-catalyzed [2π+2σ] cycloaddition of dihydropyridines with bicyclobutanes'
pubs.rsc.org/en/content/a...
Lewis acid-catalyzed [2π+2σ] cycloaddition of dihydropyridines with bicyclobutanes
Herein we report a simple BF3-catalyzed cycloaddition of dihydropyridines with bicyclobutanes for the expedient synthesis of novel three-dimensional azacycle-fused bicyclo[2.1.1]hexane scaffolds. The ...
pubs.rsc.org
February 28, 2025 at 10:04 AM
We’re particularly keen to highlight great articles published by members of the #ChemSky community.
This one is by @gloriusfrank.bsky.social and colleagues at @uni-muenster.de
'Lewis acid-catalyzed [2π+2σ] cycloaddition of dihydropyridines with bicyclobutanes'
pubs.rsc.org/en/content/a...
This one is by @gloriusfrank.bsky.social and colleagues at @uni-muenster.de
'Lewis acid-catalyzed [2π+2σ] cycloaddition of dihydropyridines with bicyclobutanes'
pubs.rsc.org/en/content/a...
This study demonstrates a visible-light-induced topochemical #cycloaddition of a bimane derivative.
➡️ https://www.beilstein-journals.org/bjoc/articles/21/37?B=y
#bimanes #cycloaddition #cyclobutanes. #fluorescence #BJOC 💎🔓
@mathiassenge.bsky.social
➡️ https://www.beilstein-journals.org/bjoc/articles/21/37?B=y
#bimanes #cycloaddition #cyclobutanes. #fluorescence #BJOC 💎🔓
@mathiassenge.bsky.social
April 22, 2025 at 8:03 AM
This study demonstrates a visible-light-induced topochemical #cycloaddition of a bimane derivative.
➡️ https://www.beilstein-journals.org/bjoc/articles/21/37?B=y
#bimanes #cycloaddition #cyclobutanes. #fluorescence #BJOC 💎🔓
@mathiassenge.bsky.social
➡️ https://www.beilstein-journals.org/bjoc/articles/21/37?B=y
#bimanes #cycloaddition #cyclobutanes. #fluorescence #BJOC 💎🔓
@mathiassenge.bsky.social
Carbene–catalyzed mesoionization via formal [3+2] cycloaddition for mesoionic insecticide discovery
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
July 13, 2026 at 1:16 PM
Carbene–catalyzed mesoionization via formal [3+2] cycloaddition for mesoionic insecticide discovery
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
![A black hat with an illustration of the transition state of the 6+4 cycloaddition between tropone and dimethylfulvene, and a black beanie that reads "55 years of the [6 + 4] reaction"](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:vyc7btogzsuabjp5bmcgfdg5/bafkreibfz5stv4z7d5g2rijtx6kpj3jpi4yiov4qaryhxxfx4hzmuwa3mq)
We also like small rings now. Check out Robert’s work on the reaction of benzocyclobutanones with norbornadienes through Ni-catalyzed C–C bond activation in Organic Letters. Congrats! pubs.acs.org/doi/full/10....
Stereoselective [2 + 2 + 2] Cycloaddition of Benzocyclobutanones and Norbornadienes through Nickel-Catalyzed C–C Bond Activation
We report a nickel-catalyzed stereoselective [2 + 2 + 2] cycloaddition between norbornadienes and benzocyclobutanones via C–C activation. This transformation generates four stereocenters, producing no...
pubs.acs.org
May 25, 2025 at 7:27 PM
We also like small rings now. Check out Robert’s work on the reaction of benzocyclobutanones with norbornadienes through Ni-catalyzed C–C bond activation in Organic Letters. Congrats! pubs.acs.org/doi/full/10....
Cu-MOF catalysts for the cycloaddition of CO2 with epoxides to cyclic carbonates: needs, current trends, and future perspectives https://www.sciencedirect.com/science/article/pii/S0020169326004056
September 26, 2026 at 1:05 PM
Cu-MOF catalysts for the cycloaddition of CO2 with epoxides to cyclic carbonates: needs, current trends, and future perspectives https://www.sciencedirect.com/science/article/pii/S0020169326004056
Dihydropyridines are attractive building blocks (and products). Their Lewis acid-catalyzed [2π+2σ] cycloaddition with bicyclobutanes is now reported in @ChemCommun
👏👏 Yujie and Ronewa!
pubs.rsc.org/en/content/a...
👏👏 Yujie and Ronewa!
pubs.rsc.org/en/content/a...
Lewis acid-catalyzed [2π+2σ] cycloaddition of dihydropyridines with bicyclobutanes
Herein we report a simple BF3-catalyzed cycloaddition of dihydropyridines with bicyclobutanes for the expedient synthesis of novel three-dimensional azacycle-fused bicyclo[2.1.1]hexane scaffolds. The ...
pubs.rsc.org
January 14, 2025 at 4:41 PM
Dihydropyridines are attractive building blocks (and products). Their Lewis acid-catalyzed [2π+2σ] cycloaddition with bicyclobutanes is now reported in @ChemCommun
👏👏 Yujie and Ronewa!
pubs.rsc.org/en/content/a...
👏👏 Yujie and Ronewa!
pubs.rsc.org/en/content/a...
🏆 Thrilled to share this highly regioselective synthesis of SF5-phenols and aminophenols via [4+2] Diels-Alder cycloaddition of electron rich dienes with SF5-alkynes. pubs.acs.org/doi/10.1021/...
🙏 Very grateful to @cnrs.fr for the "Emergence" funding and to @pubs.acs.org for this Rising ⭐ Award! 🎉🎊
🙏 Very grateful to @cnrs.fr for the "Emergence" funding and to @pubs.acs.org for this Rising ⭐ Award! 🎉🎊
Straightforward Access to Pentafluorosulfanylated Phenols and Aminophenols via [4 + 2] Diels–Alder Cycloaddition Reaction
Here is described a theoretical and experimental study of regioselective [4 + 2] Diels–Alder cycloaddition reactions between electron-rich dienes and SF5-alkynes. These methods give straightforward an...
pubs.acs.org
June 16, 2025 at 5:36 AM
🏆 Thrilled to share this highly regioselective synthesis of SF5-phenols and aminophenols via [4+2] Diels-Alder cycloaddition of electron rich dienes with SF5-alkynes. pubs.acs.org/doi/10.1021/...
🙏 Very grateful to @cnrs.fr for the "Emergence" funding and to @pubs.acs.org for this Rising ⭐ Award! 🎉🎊
🙏 Very grateful to @cnrs.fr for the "Emergence" funding and to @pubs.acs.org for this Rising ⭐ Award! 🎉🎊