#Cytochrome
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loujsutcliffe.bsky.social
I come bearing geese!
shows.acast.com/cytochrome-h...
The Man in the Moone - Episode 1 | Cytochrome Hear Presents
shows.acast.com
March 28, 2025 at 9:45 PM
thesix.bsky.social
This cytochrome P450 inhibiting motherfucker.
December 17, 2024 at 4:27 PM
jftollefson.bsky.social
Day 23 - #copper

A Coppery-chested Jacamar (Galbula pastazae) considering the role that copper atoms play in ATP production for all aerobic organisms.

Ref 📷 eBird David Pereksta, Ref for Cytochrome c oxidase complex IV: Klaus Hoffmeier
#SciArtSeptember #birdart #biochemistry #alllifeisconnected
Watercolor and colored pencil illustration of a jacamar (bird) sitting on a twig facing right. The bird has a long dark bill, a blue and green head and a coppery chest. The painting sits on a schematic of a small portion of the cytochrome c oxidase complex, highlighting the roll of 2 copper (Cu) atoms in the transferring of electrons during aerobic cellular respiration.
September 23, 2026 at 12:02 PM
ninaippolito.bsky.social
Is…is this a cytochrome P450 joke?
June 30, 2026 at 5:39 PM
chercheurjuteux.com
Moi j'aime bien les threads sur la pharmaco, et les enzymes et le cytochrome p450 et CYP3A4 et cette SALOPERIE QU'EDT LE PAMPLEMOUSSE AVEC 393993 TRAITEMENTS.

Bref, lisez ce thread.
epitomax.bsky.social Epitomax 💊 🐍 @epitomax.bsky.social · Dec 6
Pourquoi le pamplemousse est-il le cauchemar du pharmacien ?

Parce qu’il est un inhibiteur enzymatique puissant et à ce titre, il est à l’origine de nombreuses interactions médicamenteuses !

Pamplemousse et médicaments, a thread 🧵👇🏻
December 7, 2024 at 12:01 AM
sigalalab.bsky.social
Happy to share a new preprint exploring the unusual biochemistry of a "weirdly" diverged cytochrome c in malaria parasites that exemplifies a lineage common to many apicomplexan parasites. @uofubiochem.bsky.social @uuhsresearch.bsky.social @uofutahcihd.bsky.social
www.biorxiv.org/content/10.6...
A Divergent Cytochrome c in Malaria Parasites with an Anomalously Low Redox Potential
Eukaryotic cytochrome (cyt) c is a highly conserved mitochondrial protein central to cellular respiration, featuring a covalently attached hexacoordinate heme whose redox potential is tuned by axial H...
www.biorxiv.org
December 26, 2025 at 4:37 PM
frezzalab.bsky.social
Cytosolic cytochrome c represses ferroptosis: Cell Metabolism www.cell.com/cell-metabol...
Cytosolic cytochrome c represses ferroptosis
Song et al. demonstrated that the cytosolic CYCS-INPP4A complex inhibits ferroptosis by promoting phosphatidylinositol-3-phosphate synthesis and preventing phospholipid peroxidation. The small molecul...
www.cell.com
April 17, 2025 at 5:54 PM
lambrechtslab.bsky.social
🦟🦠 Check out our latest article in @natcomms.nature.com on the genetic basis of #dengue virus susceptibility in #mosquitoes! Collaborative work brillantly led by @merklinglab.bsky.social and @elodiecouderc.bsky.social @pasteur.fr and primarily supported by @agencerecherche.bsky.social rdcu.be/eBbg7
Dengue virus susceptibility in Aedes aegypti linked to natural cytochrome P450 promoter variants
Nature Communications - Genetic factors affecting Aedes aegypti susceptibility to dengue virus infection aren’t well studied. Here the authors show that a cytochrome P450 gene, typically...
rdcu.be
August 18, 2025 at 10:08 AM
frezzalab.bsky.social
Cytosolic cytochrome c represses ferroptosis: Cell Metabolism www.cell.com/cell-metabol...
Cytosolic cytochrome c represses ferroptosis
Song et al. demonstrated that the cytosolic CYCS-INPP4A complex inhibits ferroptosis by promoting phosphatidylinositol-3-phosphate synthesis and preventing phospholipid peroxidation. The small molecul...
www.cell.com
June 5, 2025 at 2:41 PM
frezzalab.bsky.social
Tissue-specific adaptations to cytochrome c oxidase deficiency shape physiological outcomes 🧪

www.sciencedirect.com/science/arti...

Congratulations to Milica Popovic and Lea Isermann from the Trifunovic lab for this nice work!
Tissue-specific adaptations to cytochrome c oxidase deficiency shape physiological outcomes
It becomes increasingly clear that the tissue specificity of mitochondrial diseases might in part rely on their ability to compensate for mitochondria…
www.sciencedirect.com
December 3, 2024 at 9:00 AM
risettemd.bsky.social
Ok but this is a cytochrome P450 stimulator and will increase metabolism of other medications
September 18, 2026 at 5:09 AM
bejalab.bsky.social
Cytochrome b5 occurrence in giant and other viruses belonging to the phylum Nucleocytoviricota www.nature.com/articles/s44...
Cytochrome b5 occurrence in giant and other viruses belonging to the phylum Nucleocytoviricota - npj Viruses
npj Viruses - Cytochrome b5 occurrence in giant and other viruses belonging to the phylum Nucleocytoviricota
www.nature.com
February 18, 2025 at 6:36 AM
rebeleinlab.bsky.social
Fantastic work by the Ward lab to repurpose cytochrome #P450 enzymes for a new-to-nature asymmetric metal-catalysed H atom transfer! Just released
@Nature
: doi.org/10.1038/s415.... A must read!🧪
Repurposing haemoproteins for asymmetric metal-catalysed H atom transfer - Nature
Cytochrome P450 enzymes can be repurposed to catalyse asymmetric metal–hydride hydrogen atom transfer, a new-to-nature reaction.
doi.org
July 31, 2025 at 11:37 PM
frezzalab.bsky.social
Mitochondrial contact site and cristae organizing system promotes modular assembly of cytochrome c oxidase: Cell Reports www.cell.com/cell-reports...
Mitochondrial contact site and cristae organizing system promotes modular assembly of cytochrome c oxidase
Colina-Tenorio et al. show that MICOS interacts with the Cox1 and Cox3 assembly modules and facilitates respiratory complex IV biogenesis. By recruiting assembly factors and the mitochondrial multifun...
www.cell.com
January 1, 2026 at 1:39 PM
chemshell.bsky.social
High resolution structural biology approaches and ChemShell QM/MM simulations reveal an unusual structural feature in a cytochrome P460 enzyme, in research published in @chemicalscience.rsc.org

For more details: chemshell.org/mcp460-doubl...
Identifying an unusual structural feature in a cytochrome P460 enzyme - ChemShell
Structural and computational studies indicate the presence of a haem-lysine double crosslink in Methylococcus capsulatus cytochrome P460.
chemshell.org
September 24, 2025 at 1:02 PM
huguesrenault.bsky.social
The cytochrome P450 enzyme MpCYP78E1 inhibits meristem initiation and activity in Marchantia polymorpha

www.biorxiv.org/content/10.1...
April 30, 2025 at 11:12 AM
c0nc0rdance.bsky.social
I love that everyone seems to be aware of the inhibitory effects on cytochrome P450 drug metabolism!

A thread on the history of that discovery, and implications:
c0nc0rdance.bsky.social c0nc0rdance @c0nc0rdance.bsky.social · Oct 10
Hopefully you know that GRAPEFRUIT JUICE can inhibit liver enzymes that break down the active ingredients in certain therapeutic drugs, which can result in dangerous overdosing (or underdosing) with certain drugs.

A few surprising insights (thread):
https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix
February 21, 2024 at 12:35 PM
docseuss.bsky.social
Not surprising, as someone with cfs, my doctor told me in 2010 it was the result of hypomethylation and something to do with cytochrome p450 dysfunction
tomkindlon.bsky.social Tom Kindlon @tomkindlon.bsky.social · Jul 12
Interesting new UK research:

Brain and muscle chemistry in ME/chronic fatigue syndrome ( #MECFS) & #longCOVID: a 7T magnetic resonance spectroscopy study

www.nature.com/articles/s41...

"changes in lactate in ME/CFS are consistent with the presence of energetic stress & mitochondrial dysfunction"
Abstract Myalgic encephalitis/chronic fatigue syndrome (ME/CFS) is a common debilitating medical condition, whose main symptoms - fatigue, post-exertional malaise and cognitive dysfunction – are also present in many cases of long COVID. Magnetic resonance spectroscopy (MRS) allows the insight into their pathophysiology through exploration of a range of biochemicals putatively relevant to aetiological processes, in particular mitochondrial dysfunction and energy metabolism. 24 patients with ME/CFS, 25 patients with long COVID and 24 healthy controls (HC) underwent brain (pregenual and dorsal anterior cingulate cortex, respectively, pgACC and dACC) and calf muscle MRS scanning at 7 Tesla, followed by a computerised cognitive assessment. Compared to HC, ME/CFS patients had elevated levels of lactate in both pgACC and dACC, while long COVID patients had lowered levels of total choline in dACC. By contrast, skeletal muscle metabolites at rest did not significantly differ between the groups. The changes in lactate in ME/CFS are consistent with the presence of energetic stress and mitochondrial dysfunction. A reduction in total choline in long COVID is of interest in the context of the recently reported association between blood clots and ‘brain fog’, and earlier animal studies showing that choline might prevent intravascular coagulation. Importantly, differences in findings between ME/CFS and long COVID suggest that the underlying neurobiological mechanisms, while leading to similar clinical presentations, may differ. An important implication is that patients with ME/CFS and those with fatigue in the course of long COVID should not be studied as a single group, at least until the mechanisms are better understood.
July 12, 2025 at 7:51 PM
plantphys.bsky.social
Insights into plastocyanin–cytochrome b6f complex formation: The role of plastocyanin phosphorylation (Yuval Milrad, Daniel Wegemann, Sebastian Kuhlgert, Martin Scholz, Muhammad Younas, André Vidal-Meireles, Michael Hippler) doi.org/10.1093/plph... #PlantScience
Insights into plastocyanin–cytochrome b6f complex formation: The role of plastocyanin phosphorylation
Structural proteomics uncovers the role of plastocyanin phosphorylation in regulating electron transfer between cytochrome b6f and PSI.
doi.org
September 23, 2025 at 6:49 PM
jcamthrash.bsky.social
A Cytochrome c‐Containing Periplasmic Nitrate Reductase in the Acetogen Sporomusa ovata - Waschinger enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/... #jcampubs
A Cytochrome c‐Containing Periplasmic Nitrate Reductase in the Acetogen Sporomusa ovata
Sporomusa ovata, a cytochrome-containing, acetogenic bacterium, conserves energy by reduction of carbon dioxide to acetate. Nitrate serves as additional electron acceptor and is reduced to ammonium, ...
enviromicro-journals.onlinelibrary.wiley.com
January 8, 2026 at 2:52 PM
garantes.bsky.social
First preprint post here 🧪 🧬, on the molecular mechanism of proton transport and coenzyme-Q reactivity catalyzed by respiratory complex III. Check it out if you are into #bioenergetics, #enzymes or #compchem

www.biorxiv.org/content/10.1...
Redox-Activated Proton Transfer through a Redundant Network in the Qo Site of Cytochrome bc1
Proton translocation catalyzed by cytochrome bc 1 (respiratory complex III) during coenzyme-Q redox cycling is a critical bioenergetic process, yet its detailed molecular mechanism remains incompletel...
www.biorxiv.org
November 24, 2024 at 2:50 AM
cvasilescu.bsky.social
Here it is! 😉 A new collection of papers on #Mitochondria in #Health & #Disease! 📚
biomed.news/bims-mitdis/...

👉 SLC25A3 exports mitochondrial copper to metalate cytochrome c oxidase and prevent cuproptosis

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
SLC25A3 exports mitochondrial copper to metalate cytochrome c oxidase and prevent cuproptosis
June 21, 2026 at 3:15 PM
martinstoermer.bsky.social
Cytochrome P450 contains no chromium
September 15, 2024 at 12:05 PM
stephanhacker2.bsky.social
Great paper by the group of @larsjeuken.bsky.social in J. Biol. Chem. with first author Tijn van der Velden. Cytochrome bd of M. tuberculosis is RedOx-regulated through a disulfide with potential important implications for survival in the phagosome #chemsky #ChemBio (1/2)
www.jbc.org/article/S002...
Menaquinone-specific turnover by Mycobacterium tuberculosis cytochrome bd is redox regulated by the Q-loop disulfide bond
Cytochrome bd from Mycobacterium tuberculosis (Mtbd) is a menaquinol oxidase that has gained interest as an antibiotic target because of its importance in survival under infectious conditions. Mtbd co...
www.jbc.org
January 17, 2025 at 7:34 AM