November 17, 2024 at 3:16 AM
LFI a annoncé ce matin le dépôt d’une nouvelle motion de destitution du président de la République. La présidente du groupe, Mathilde Panot, a alors souligné que celle-ci compte « déjà 86 signataires », soit plus que le nombre de députés FI.
➡️ https://l.humanite.fr/d2B
➡️ https://l.humanite.fr/d2B
September 9, 2025 at 2:15 PM
LFI a annoncé ce matin le dépôt d’une nouvelle motion de destitution du président de la République. La présidente du groupe, Mathilde Panot, a alors souligné que celle-ci compte « déjà 86 signataires », soit plus que le nombre de députés FI.
➡️ https://l.humanite.fr/d2B
➡️ https://l.humanite.fr/d2B
This is the time to support the arts, specifically the terrific New York Foundation for the Arts (NYFA). Bid here — great art at bargain prices, mine included.
event.auctria.com/cdf452c5-d2b...
event.auctria.com/cdf452c5-d2b...
March 6, 2025 at 3:47 PM
This is the time to support the arts, specifically the terrific New York Foundation for the Arts (NYFA). Bid here — great art at bargain prices, mine included.
event.auctria.com/cdf452c5-d2b...
event.auctria.com/cdf452c5-d2b...
D2B stuff while I'm at it 😼 though I'm assuming there's barely a wg fandom on this app lmao #wordgirl #Dr.Two-Brains
January 8, 2025 at 6:54 PM
D2B stuff while I'm at it 😼 though I'm assuming there's barely a wg fandom on this app lmao #wordgirl #Dr.Two-Brains
The Los Angeles County Commission on Human Relations (LACCHR) today released its inaugural Hate Incident Report.
The number of ‘hate incidents’ in Los Angeles County increased from 609 in 2022 to 821 in 2023 — a 35% increase. assets-us-01.kc-usercontent.com/0234f496-d2b...
The number of ‘hate incidents’ in Los Angeles County increased from 609 in 2022 to 821 in 2023 — a 35% increase. assets-us-01.kc-usercontent.com/0234f496-d2b...
April 4, 2025 at 1:54 AM
The Los Angeles County Commission on Human Relations (LACCHR) today released its inaugural Hate Incident Report.
The number of ‘hate incidents’ in Los Angeles County increased from 609 in 2022 to 821 in 2023 — a 35% increase. assets-us-01.kc-usercontent.com/0234f496-d2b...
The number of ‘hate incidents’ in Los Angeles County increased from 609 in 2022 to 821 in 2023 — a 35% increase. assets-us-01.kc-usercontent.com/0234f496-d2b...
Ouverture du procès de l’ex-PDG de Casino Jean-Charles Naouri, jugé pour manipulation de cours et corruption
➡️ https://l.humanite.fr/d2b
➡️ https://l.humanite.fr/d2b
October 1, 2025 at 12:15 PM
Ouverture du procès de l’ex-PDG de Casino Jean-Charles Naouri, jugé pour manipulation de cours et corruption
➡️ https://l.humanite.fr/d2b
➡️ https://l.humanite.fr/d2b
An interesting article by Jonathan Powell about the power of direct-to-biology approaches in Drug Discovery.
www.linkedin.com/pulse/direct...
#DrugDiscovery #D2B #DirectToBiology #ChemSky #ChemBio
www.linkedin.com/pulse/direct...
#DrugDiscovery #D2B #DirectToBiology #ChemSky #ChemBio
Direct-to-Biology: From Emerging Technology to a Core Drug Discovery Workflow
In early 2025, we asked a simple question: "D2B or not D2B?" From the published literature to 2025 much of the disclosed campaigns and platforms centred on PROTAC® hit finding and covalent drug discov...
www.linkedin.com
August 22, 2026 at 2:39 PM
An interesting article by Jonathan Powell about the power of direct-to-biology approaches in Drug Discovery.
www.linkedin.com/pulse/direct...
#DrugDiscovery #D2B #DirectToBiology #ChemSky #ChemBio
www.linkedin.com/pulse/direct...
#DrugDiscovery #D2B #DirectToBiology #ChemSky #ChemBio
This drawing is up for auction for NYFA’s annual benefit! Here’s a link to the online platform event.auctria.com/cdf452c5-d2b...
March 11, 2025 at 2:18 PM
This drawing is up for auction for NYFA’s annual benefit! Here’s a link to the online platform event.auctria.com/cdf452c5-d2b...
The "Measure G" task force is interviewing six candidates (including a former LA City Council member, Michael Woo) for the county's new Ethics Commission this afternoon
You can read their applications here:
assets-us-01.kc-usercontent.com/0234f496-d2b...
You can read their applications here:
assets-us-01.kc-usercontent.com/0234f496-d2b...
September 16, 2026 at 6:47 PM
The "Measure G" task force is interviewing six candidates (including a former LA City Council member, Michael Woo) for the county's new Ethics Commission this afternoon
You can read their applications here:
assets-us-01.kc-usercontent.com/0234f496-d2b...
You can read their applications here:
assets-us-01.kc-usercontent.com/0234f496-d2b...
Yea~ These are the only four from the looks of things
January 30, 2025 at 6:25 PM
Yea~ These are the only four from the looks of things
Factors to Consider for Synthesis in 1536-Well Plates─An Amide Coupling Case Study for PROTAC Synthesis
Factors to Consider for Synthesis in 1536-Well Plates─An Amide Coupling Case Study for PROTAC Synthesis
Ultra high-throughput chemistry carried out in 1536-well plates is increasingly utilized for reaction optimization protocols and direct-to-biology (D2B) platforms, where nanomolar quantities of the fi...
pubs.acs.org
February 24, 2025 at 10:56 AM
Factors to Consider for Synthesis in 1536-Well Plates─An Amide Coupling Case Study for PROTAC Synthesis
So in case you missed it, I'll be at
@thoughtbubbleuk.bsky.social
this weekend, at table D2b, right by the entrance! Featuring collaborations with @windlass.bsky.social @comicnerdsam.bsky.social
@iraganaart.bsky.social @turbomiracle.bsky.social @lexa.bsky.social and @bamccray.bsky.social
@thoughtbubbleuk.bsky.social
this weekend, at table D2b, right by the entrance! Featuring collaborations with @windlass.bsky.social @comicnerdsam.bsky.social
@iraganaart.bsky.social @turbomiracle.bsky.social @lexa.bsky.social and @bamccray.bsky.social
November 14, 2024 at 7:00 PM
So in case you missed it, I'll be at
@thoughtbubbleuk.bsky.social
this weekend, at table D2b, right by the entrance! Featuring collaborations with @windlass.bsky.social @comicnerdsam.bsky.social
@iraganaart.bsky.social @turbomiracle.bsky.social @lexa.bsky.social and @bamccray.bsky.social
@thoughtbubbleuk.bsky.social
this weekend, at table D2b, right by the entrance! Featuring collaborations with @windlass.bsky.social @comicnerdsam.bsky.social
@iraganaart.bsky.social @turbomiracle.bsky.social @lexa.bsky.social and @bamccray.bsky.social
Check-out the first paper from @farnabygroup.bsky.social developing novel chemistry for plate-based PROTAC assembly that in a single Direct-to-Biology (D2B) screen delivers a potent hit that degrades the target protein in the brain of a mouse. Delighted to see this out and kudos to all co-authors
March 10, 2025 at 6:21 PM
Check-out the first paper from @farnabygroup.bsky.social developing novel chemistry for plate-based PROTAC assembly that in a single Direct-to-Biology (D2B) screen delivers a potent hit that degrades the target protein in the brain of a mouse. Delighted to see this out and kudos to all co-authors
I think D2B is particularly challenging for degrader read-outs. The problem is that there are many mechanisms that can lead to reduced protein level, both direct and indirect. Careful controls and validations experiments need to be run which can compromise the efficiency gains of D2B.
November 28, 2025 at 6:25 AM
I think D2B is particularly challenging for degrader read-outs. The problem is that there are many mechanisms that can lead to reduced protein level, both direct and indirect. Careful controls and validations experiments need to be run which can compromise the efficiency gains of D2B.
Today, Wednesday Aug 26, at 11:30 cities of the Valley and North County will elect their Metro rep - via the little known City Selection Committee. Meeting agenda posted here: assets-us-01.kc-usercontent.com/0234f496-d2b...
assets-us-01.kc-usercontent.com
August 26, 2026 at 4:12 PM
Today, Wednesday Aug 26, at 11:30 cities of the Valley and North County will elect their Metro rep - via the little known City Selection Committee. Meeting agenda posted here: assets-us-01.kc-usercontent.com/0234f496-d2b...
WILL WE EVER STOP DOING THESE? MAYBE ONE DAY!
The 2025-2026 Non-NCAA National Championships (Part 8) presented by the Sickos Committee!
Check out all the Non-NCAA Champions from the past year! All other parts quoted like a Russian Nesting doll. 🪆
The 2025-2026 Non-NCAA National Championships (Part 8) presented by the Sickos Committee!
Check out all the Non-NCAA Champions from the past year! All other parts quoted like a Russian Nesting doll. 🪆
August 13, 2026 at 1:50 PM
WILL WE EVER STOP DOING THESE? MAYBE ONE DAY!
The 2025-2026 Non-NCAA National Championships (Part 8) presented by the Sickos Committee!
Check out all the Non-NCAA Champions from the past year! All other parts quoted like a Russian Nesting doll. 🪆
The 2025-2026 Non-NCAA National Championships (Part 8) presented by the Sickos Committee!
Check out all the Non-NCAA Champions from the past year! All other parts quoted like a Russian Nesting doll. 🪆
🤖¡Cómo usar #ChatGPT (versión gratuita) paso a paso! youtube.com/watch?v=D2b-... por Xavier Mitjana.
January 6, 2025 at 1:29 PM
🤖¡Cómo usar #ChatGPT (versión gratuita) paso a paso! youtube.com/watch?v=D2b-... por Xavier Mitjana.
@savilltech.com has a new #GitHub #Devcontainer + #Codespaces video. I am a massive champion of this amazing tech for open source, I've contributed a PR to enable it for #PowerShell and do most of my personal module development in devcontainers now. Learn more here!
www.youtube.com/watch?v=-D2B...
www.youtube.com/watch?v=-D2B...
May 13, 2025 at 4:30 PM
@savilltech.com has a new #GitHub #Devcontainer + #Codespaces video. I am a massive champion of this amazing tech for open source, I've contributed a PR to enable it for #PowerShell and do most of my personal module development in devcontainers now. Learn more here!
www.youtube.com/watch?v=-D2B...
www.youtube.com/watch?v=-D2B...
And I don't think d2B is obvious at all to be honest! Takes serious work and alignment from multiple angles compared to putting a pure compound in an assay. I guess it depends on your perspective
November 25, 2025 at 11:11 PM
And I don't think d2B is obvious at all to be honest! Takes serious work and alignment from multiple angles compared to putting a pure compound in an assay. I guess it depends on your perspective
【お知らせ🦓】
しまうまマルシェβ版の審査に通りましたので、画集を委託販売させて頂いています🐉（しまうま出版様が印刷、販売、発送して下さります）
marche.n-pri.jp/products/d2b...
先行利用者を募集中だそうなので、気軽に画集を出したい方は応募されてはいかがでしょうか？
※応募数が規定に達し次第、受付終了だそう
#しまうま出版
#イラスト
#龍
しまうまマルシェβ版の審査に通りましたので、画集を委託販売させて頂いています🐉（しまうま出版様が印刷、販売、発送して下さります）
marche.n-pri.jp/products/d2b...
先行利用者を募集中だそうなので、気軽に画集を出したい方は応募されてはいかがでしょうか？
※応募数が規定に達し次第、受付終了だそう
#しまうま出版
#イラスト
#龍
April 14, 2025 at 8:19 AM
【お知らせ🦓】
しまうまマルシェβ版の審査に通りましたので、画集を委託販売させて頂いています🐉（しまうま出版様が印刷、販売、発送して下さります）
marche.n-pri.jp/products/d2b...
先行利用者を募集中だそうなので、気軽に画集を出したい方は応募されてはいかがでしょうか？
※応募数が規定に達し次第、受付終了だそう
#しまうま出版
#イラスト
#龍
しまうまマルシェβ版の審査に通りましたので、画集を委託販売させて頂いています🐉（しまうま出版様が印刷、販売、発送して下さります）
marche.n-pri.jp/products/d2b...
先行利用者を募集中だそうなので、気軽に画集を出したい方は応募されてはいかがでしょうか？
※応募数が規定に達し次第、受付終了だそう
#しまうま出版
#イラスト
#龍