Seasoning powders are widely used to enhance food flavour but can be contaminated with aflatoxins, toxic compounds that pose health risks. This study …

Carbonyl compounds generated through lipid peroxidation and Maillard-type reactions are relevant markers of food quality and safety due to their potential toxicity and prevalence in processed plant-based beverages. This work presents the development and validation of a green, ultrasound-assisted dispersive liquid–liquid microextraction (UA-DLLME) method using sustainable extractant (isobutyl acetate) and dispersant (isopropanol) solvents for the simultaneous determination of 12 carbonyl compounds across multiple chemical families (aldehydes, ketones, furans, and dicarbonyls). The method integrates in situ derivatization with O-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine hydrochloride and gas chromatography–mass spectrometry (GC–MS) analysis. Method optimization was performed using a multivariable approach using an asymmetrical 26·31 screening design and a central composite design for response surface methodology. Analytical performance was validated according to Food and Drug Administration guidelines, achieving great linearity (r2 ≥ 0.9991), accuracy (90–107% recovery), precision (<7.5% RSD) and detection limits suitable for trace-level analysis in complex matrixes. The approach was applied to 51 commercial plant-based beverage samples (almond, soy, oat, rice, coconut, seed and mixed formulations). Greenness assessment was performed using AGREEprep (0.69/1) and BAGI (77.5/100) metrics, confirming the method’s alignment with green chemistry principles. This workflow provides a reliable and sustainable strategy for routine monitoring of carbonyls in food systems, with relevance to both quality control and exposure assessment.

Sample preparation is a crucial and challenging step for determining veterinary drug residues (VDRs) in animal products. This study aimed to develop t…

An innovative analytical method integrating QuEChERS with dispersive liquid–liquid microextraction using solidified floating organic droplets (DLLME-SFO) and ultra-high-performance liquid chromatogra...

Abstract. Synthetic cannabinoid receptor agonists (SCRAs) comprise a class of new psychoactive substances (NPS) that rank second in terms of notified subst

Development and validation of an extraction method based on dispersive liquid–liquid microextraction for the analysis by GC–MS of propofol in three different biological samples (blood, urine, and hai....

A sensitive, straightforward, and environmentally sustainable method was developed and validated for the quantification of 13 PBDEs in chicken eggs us…

The presence of polyaromatic hydrocarbons (PAHs) in river waters was analyzed over a period of four seasons. The DLLME method was employed to analyze samples collected from 21 different stations. The...

This work presents a greener approach for ultrasound-assisted (UA) dispersive liquid-liquid microextraction (DLLME) of carbonyl compounds from coffee …

Anal. Methods, 2025, Advance Article DOI: 10.1039/D5AY01089F, PaperBaoqing Bai, Xiaojie Li, Siyuan Meng, Ying Zhang, Tao Bo, Jinhua Zhang, Yukun Yang A new method, salting-out vortex-assisted dispersive liquid–liquid microextraction (SO-VA-DLLME), was developed for extracting amide herbicides (AHs) from food samples. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

ABSTRACT An innovative analytical method integrating QuEChERS with dispersive liquid–liquid microextraction using solidified floating organic droplets (DLLME-SFO) and ultra-high-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry (UHPLC-Q/Orbitrap HRMS) was developed for the rapid screening of 25 environmental hormones (EHs) in aquatic products. The method systematically optimized key parameters, including extraction solvent selection (1-undecanol), water volume (5 mL), pH (native pH 6.5), adsorbent combination (C18/PSA, 20 mg each), and salt addition (0% NaCl), achieving high sensitivity with detection limits of 0.1–0.4 µg/kg and recoveries of 68.2%–112.8%. The method demonstrated excellent linearity (R 2 > 0.995) across a concentration range of 0.4–40 µg/kg, with precision (intra- and inter-day RSDs < 15%) and manageable matrix effects (−19.5% to 10.9%).  The environmental impact assessment, conducted using the Analytical GREEnness Metric for Sample Preparation (AGREEprep score: 0.59) and Blue Applicability Grade Index (BAGI score: 80), confirmed that the proposed method satisfies both sustainability and practicality criteria for EHs analysis. Enhanced matrix purification and dual-polarity HRMS detection enabled accurate identification and quantification of structurally diverse EHs, including pesticides and pharmaceuticals. Validated in 60 commercial samples, the method detected prometryn residues in 11.7% of cases, demonstrating its practicality for monitoring EH contamination in complex aquatic matrices. This approach represents a significant advancement in multi-residue analysis, combining efficiency, sensitivity, and environmental compatibility.