So then, this team at Stanford have looked at a particular DRT called DRT3. This has three component parts: an enzyme called DRT3a, which is bound to a second enzyme DRTb, and lastly a shortish noncoding RNA strand (noncoding because it doesn't encode a protein). /8
April 18, 2026 at 7:20 PM
So then, this team at Stanford have looked at a particular DRT called DRT3. This has three component parts: an enzyme called DRT3a, which is bound to a second enzyme DRTb, and lastly a shortish noncoding RNA strand (noncoding because it doesn't encode a protein). /8
Vacature: 60% assistentschap in mensenrechten bij UCLouvain Saint-Louis, binnen mijn onderzoekscentrum (CIRC) ⚖️ (meer informatie in link)
Een in hoofdzaak Franstalig mandaat, maar zeker Engels is ook belangrijk (en evt. wat NLs zou niet onhandig zijn voor mij ;)) 🇫🇷🇬🇧
shorturl.at/n8H5D
Een in hoofdzaak Franstalig mandaat, maar zeker Engels is ook belangrijk (en evt. wat NLs zou niet onhandig zijn voor mij ;)) 🇫🇷🇬🇧
shorturl.at/n8H5D
DRTB - Un mandat d'assistant·e (60%) - Droits humains (n°50048505)
DRTB - Un mandat d'assistant·e (60%) - Droits humains (n°50048505)
shorturl.at
May 12, 2025 at 8:14 AM
Vacature: 60% assistentschap in mensenrechten bij UCLouvain Saint-Louis, binnen mijn onderzoekscentrum (CIRC) ⚖️ (meer informatie in link)
Een in hoofdzaak Franstalig mandaat, maar zeker Engels is ook belangrijk (en evt. wat NLs zou niet onhandig zijn voor mij ;)) 🇫🇷🇬🇧
shorturl.at/n8H5D
Een in hoofdzaak Franstalig mandaat, maar zeker Engels is ook belangrijk (en evt. wat NLs zou niet onhandig zijn voor mij ;)) 🇫🇷🇬🇧
shorturl.at/n8H5D
In the manuscript, we argue that the primary endpoint in any DRTB platform trial should be microbiological (treatment failure or relapse)
Deaths in DRTB trials have mostly NOT been TB related
[8/n]
Deaths in DRTB trials have mostly NOT been TB related
[8/n]
September 10, 2024 at 2:42 PM
In the manuscript, we argue that the primary endpoint in any DRTB platform trial should be microbiological (treatment failure or relapse)
Deaths in DRTB trials have mostly NOT been TB related
[8/n]
Deaths in DRTB trials have mostly NOT been TB related
[8/n]
2010-2012 are our big Dresden Files Years. We finally, after five years of work, got the DFRPG released. We did some early publication partnerships. And our two big titles of the Dawn era, Spirit of the Century and Don't Rest Your Head, continued to chug along. We dipped a toe into tie-in fiction.
February 10, 2025 at 10:58 PM
2010-2012 are our big Dresden Files Years. We finally, after five years of work, got the DFRPG released. We did some early publication partnerships. And our two big titles of the Dawn era, Spirit of the Century and Don't Rest Your Head, continued to chug along. We dipped a toe into tie-in fiction.
Breaking News🗞️
On Monday 31 of March 2025, the #ASCENTDRTB Consortium Partner @treatmentactiongroup.org launched the update of community materials on #DRTB and a brand-new activists’ guide to shorter treatment for DR-TB.💫
🔗Learn more here: ascentdrtb.org/treatment-ac...
#TBSky #IDSky
On Monday 31 of March 2025, the #ASCENTDRTB Consortium Partner @treatmentactiongroup.org launched the update of community materials on #DRTB and a brand-new activists’ guide to shorter treatment for DR-TB.💫
🔗Learn more here: ascentdrtb.org/treatment-ac...
#TBSky #IDSky
Treatment Action Group – TAG Community Resources 2025 – ASCENT DR-TB
ascentdrtb.org
April 2, 2025 at 9:25 AM
Breaking News🗞️
On Monday 31 of March 2025, the #ASCENTDRTB Consortium Partner @treatmentactiongroup.org launched the update of community materials on #DRTB and a brand-new activists’ guide to shorter treatment for DR-TB.💫
🔗Learn more here: ascentdrtb.org/treatment-ac...
#TBSky #IDSky
On Monday 31 of March 2025, the #ASCENTDRTB Consortium Partner @treatmentactiongroup.org launched the update of community materials on #DRTB and a brand-new activists’ guide to shorter treatment for DR-TB.💫
🔗Learn more here: ascentdrtb.org/treatment-ac...
#TBSky #IDSky
In Russian prisons, Drug Resistant Tuberculosis (DRTB) runs rampant and inmates are routinely paroled into the general population, infected. That is what a state which practices depraved indifference to public health looks like. We're not far behind. shorturl.at/nK7Gg
Evolution: Library: Threat of Tuberculosis
shorturl.at
April 18, 2025 at 12:28 AM
In Russian prisons, Drug Resistant Tuberculosis (DRTB) runs rampant and inmates are routinely paroled into the general population, infected. That is what a state which practices depraved indifference to public health looks like. We're not far behind. shorturl.at/nK7Gg
Big Scary (Alida) inexplicably fascinated on sight with the Easily Exploitable Ingenue (Phae)
(shhh, I know it isn't Like That in the movie, but this particular scene wormed its way into my brain when i was a kid. Those buttons got installed EARLY.)
www.youtube.com/watch?v=DRtb...
(shhh, I know it isn't Like That in the movie, but this particular scene wormed its way into my brain when i was a kid. Those buttons got installed EARLY.)
www.youtube.com/watch?v=DRtb...
March 4, 2025 at 5:31 PM
Big Scary (Alida) inexplicably fascinated on sight with the Easily Exploitable Ingenue (Phae)
(shhh, I know it isn't Like That in the movie, but this particular scene wormed its way into my brain when i was a kid. Those buttons got installed EARLY.)
www.youtube.com/watch?v=DRtb...
(shhh, I know it isn't Like That in the movie, but this particular scene wormed its way into my brain when i was a kid. Those buttons got installed EARLY.)
www.youtube.com/watch?v=DRtb...
In Belfast. Im Mai 2024. Bruce tanzt auch auf "Hungry Hearts" und "Nightshift".
www.youtube.com/watch?v=dRTb...
www.youtube.com/watch?v=dRTb...
Hungry Heart + Nightshift - Audience Belfast, Northern Ireland - May 9, 2024 - Bruce Springsteen
May 2024, Belfast (Boucher Road) 0:00 Hungry Heart extracts 2:35 Nightshift extracts
www.youtube.com
June 8, 2024 at 3:47 PM
In Belfast. Im Mai 2024. Bruce tanzt auch auf "Hungry Hearts" und "Nightshift".
www.youtube.com/watch?v=dRTb...
www.youtube.com/watch?v=dRTb...
This will be a bit of a crossover with my threads! I loved Tanya's song, "Dreams to Dream" in An American Tail: Fievel Goes West! m.youtube.com/watch?v=DRtb...
An American Tail: Fievel Goes West (1991) - Dreams To Dream Scene (7/10) | Movieclips
YouTube video by Movieclips
m.youtube.com
September 28, 2024 at 4:28 PM
This will be a bit of a crossover with my threads! I loved Tanya's song, "Dreams to Dream" in An American Tail: Fievel Goes West! m.youtube.com/watch?v=DRtb...
youtube.com/watch?v=drtB...
“Republicans think it’s a dream”he says. Republicans think that somebody protecting a criminal international sex network is the guy that Michigan needs? Send rogers back to Florida. Ps the Democrats will come together. You can trust on that.
“Republicans think it’s a dream”he says. Republicans think that somebody protecting a criminal international sex network is the guy that Michigan needs? Send rogers back to Florida. Ps the Democrats will come together. You can trust on that.
El-Sayed stuns Michigan in razor-thin Democratic Senate primary win
YouTube video by Scripps News
youtube.com
August 5, 2026 at 3:43 PM
youtube.com/watch?v=drtB...
“Republicans think it’s a dream”he says. Republicans think that somebody protecting a criminal international sex network is the guy that Michigan needs? Send rogers back to Florida. Ps the Democrats will come together. You can trust on that.
“Republicans think it’s a dream”he says. Republicans think that somebody protecting a criminal international sex network is the guy that Michigan needs? Send rogers back to Florida. Ps the Democrats will come together. You can trust on that.
See this and next few messages for results of endTB-q
Find this hard to interpret - BCDL is NOT non inferior to hodgepodge of regimens of slightly longer duration
I think we need a PRACTical design platform trial in DRTB - no need for messy SOC arms, as can compare multiple regimens in same trial
Find this hard to interpret - BCDL is NOT non inferior to hodgepodge of regimens of slightly longer duration
I think we need a PRACTical design platform trial in DRTB - no need for messy SOC arms, as can compare multiple regimens in same trial
Lorenzo Guglielmetti on endTB-q interim results. RCT for pre-XDR TB.
November 17, 2024 at 11:49 AM
See this and next few messages for results of endTB-q
Find this hard to interpret - BCDL is NOT non inferior to hodgepodge of regimens of slightly longer duration
I think we need a PRACTical design platform trial in DRTB - no need for messy SOC arms, as can compare multiple regimens in same trial
Find this hard to interpret - BCDL is NOT non inferior to hodgepodge of regimens of slightly longer duration
I think we need a PRACTical design platform trial in DRTB - no need for messy SOC arms, as can compare multiple regimens in same trial
Ooh - Early DRTB and how we ended up at 18 to 24 months regimens would be perfect.
May 15, 2025 at 1:55 AM
Ooh - Early DRTB and how we ended up at 18 to 24 months regimens would be perfect.
#Globalfund #TB Innovation update just released - opportunity to find out about innovations in TB care in Global Fund supported countries. This update focusing on DRTB innovations including BPaLM scale up in Sierra Leone and the modified Short regimen in EECA. www.theglobalfund.org/media/15331/...
www.theglobalfund.org
December 20, 2024 at 10:15 AM
#Globalfund #TB Innovation update just released - opportunity to find out about innovations in TB care in Global Fund supported countries. This update focusing on DRTB innovations including BPaLM scale up in Sierra Leone and the modified Short regimen in EECA. www.theglobalfund.org/media/15331/...
Kicking off #TB #JournalClub 2025 with great discussion of shorturl.at/AGD8l Duong &al 2024 meta-analysis of VQUIN & TB-CHAMP RCTs. In our closing poll, 54% of audience members would take levo TPT if their household contact had quinolone-sensitive #DRTB - the rest chose another regimen/no TPT #tbsky
February 20, 2025 at 5:41 PM
Kicking off #TB #JournalClub 2025 with great discussion of shorturl.at/AGD8l Duong &al 2024 meta-analysis of VQUIN & TB-CHAMP RCTs. In our closing poll, 54% of audience members would take levo TPT if their household contact had quinolone-sensitive #DRTB - the rest chose another regimen/no TPT #tbsky
Join us at the TB GAPS ECHOHub on Thurs, 13 March, for part one of a lecture series on #DRTB, presented by Dr Jennifer Furin, who will share knowledge and experiences on best practices for clinical management to prevent and treat DRTB in patients.
Register here: buff.ly/jQVfK7m
#TBSky
Register here: buff.ly/jQVfK7m
#TBSky
March 9, 2025 at 1:52 PM
Join us at the TB GAPS ECHOHub on Thurs, 13 March, for part one of a lecture series on #DRTB, presented by Dr Jennifer Furin, who will share knowledge and experiences on best practices for clinical management to prevent and treat DRTB in patients.
Register here: buff.ly/jQVfK7m
#TBSky
Register here: buff.ly/jQVfK7m
#TBSky
❗Final #TBJC of 2024
🕓Thurs November 28, 4pm UK
🏛️Hosts: SGUL. Chair: Sean Wasserman. Presenter: Sharenja Ratnakumar.
💊 shorturl.at/jcijg long-term efficacy & safety from STREAM2 trial of shorter regimens for #DRTB
✉️ eepurl.com/hO4D79 to join mailing list for monthly #tuberculosis journal clubs!
🕓Thurs November 28, 4pm UK
🏛️Hosts: SGUL. Chair: Sean Wasserman. Presenter: Sharenja Ratnakumar.
💊 shorturl.at/jcijg long-term efficacy & safety from STREAM2 trial of shorter regimens for #DRTB
✉️ eepurl.com/hO4D79 to join mailing list for monthly #tuberculosis journal clubs!
Long-term efficacy and safety of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): extended follow-up of an open-label, multicentre, randomised, ...
Both of the bedaquiline-containing regimens maintained superiority to the control
regimen, without evidence of increased mortality, providing two additional evidence-based
treatment options for patien...
shorturl.at
November 18, 2024 at 12:07 PM
❗Final #TBJC of 2024
🕓Thurs November 28, 4pm UK
🏛️Hosts: SGUL. Chair: Sean Wasserman. Presenter: Sharenja Ratnakumar.
💊 shorturl.at/jcijg long-term efficacy & safety from STREAM2 trial of shorter regimens for #DRTB
✉️ eepurl.com/hO4D79 to join mailing list for monthly #tuberculosis journal clubs!
🕓Thurs November 28, 4pm UK
🏛️Hosts: SGUL. Chair: Sean Wasserman. Presenter: Sharenja Ratnakumar.
💊 shorturl.at/jcijg long-term efficacy & safety from STREAM2 trial of shorter regimens for #DRTB
✉️ eepurl.com/hO4D79 to join mailing list for monthly #tuberculosis journal clubs!
That is so funny. We did receive a really interesting one on the landmark TB trials that underpin our regimens today. I learned a ton in a very concise read. It's also going through peer review now. Not specifically on DRTB but, hmm, that could be another submission from...you? 🤓😈
#IDSky #TBSky
#IDSky #TBSky
May 15, 2025 at 5:19 AM
People with DRTB deserve robust, effective, short and tolerable treatment regimens, informed by data from adequately powered RCTs
The tuberculosis community should come together, so the next DRTB trials can report results this decade, rather than the next
[14/n]
The tuberculosis community should come together, so the next DRTB trials can report results this decade, rather than the next
[14/n]
September 10, 2024 at 2:48 PM
People with DRTB deserve robust, effective, short and tolerable treatment regimens, informed by data from adequately powered RCTs
The tuberculosis community should come together, so the next DRTB trials can report results this decade, rather than the next
[14/n]
The tuberculosis community should come together, so the next DRTB trials can report results this decade, rather than the next
[14/n]
Drug-resistant TB. Doesn’t. Stop. At. Borders.
Cuts to global funding put lives at risk.
Read more via @wbur.org ⬇️
www.wbur.org/cognoscenti/...
#DRTB #GlobalHealth #HealthJustice #CareCantWait
Cuts to global funding put lives at risk.
Read more via @wbur.org ⬇️
www.wbur.org/cognoscenti/...
#DRTB #GlobalHealth #HealthJustice #CareCantWait
Tuberculosis doesn't respect borders
Tuberculosis kills 1.3 million people each year, making it the deadliest infectious disease in the world, write KJ Seung and Kunda Kwabisha Mikanda. Eliminating U.S. funding to combat it around the…
www.wbur.org
July 2, 2025 at 10:22 PM
Drug-resistant TB. Doesn’t. Stop. At. Borders.
Cuts to global funding put lives at risk.
Read more via @wbur.org ⬇️
www.wbur.org/cognoscenti/...
#DRTB #GlobalHealth #HealthJustice #CareCantWait
Cuts to global funding put lives at risk.
Read more via @wbur.org ⬇️
www.wbur.org/cognoscenti/...
#DRTB #GlobalHealth #HealthJustice #CareCantWait
NEW PAPER!
In this month's Bulletin of the WHO, a group of us from UK Academics and Professionals to end TB have a paper calling for a platform trial to evaluate new drug resistant TB (DRTB) treatment regimens
ncbi.nlm.nih.gov/pmc/articles...
This thread outlines some of our key arguments
[1/n]
In this month's Bulletin of the WHO, a group of us from UK Academics and Professionals to end TB have a paper calling for a platform trial to evaluate new drug resistant TB (DRTB) treatment regimens
ncbi.nlm.nih.gov/pmc/articles...
This thread outlines some of our key arguments
[1/n]
Drug-resistant tuberculosis treatments, the case for a phase III platform trial
Most phase III trials in drug-resistant tuberculosis have either been underpowered to quantify differences in microbiological endpoints or have taken up to a decade to complete. Composite primary endp...
ncbi.nlm.nih.gov
September 10, 2024 at 2:38 PM
NEW PAPER!
In this month's Bulletin of the WHO, a group of us from UK Academics and Professionals to end TB have a paper calling for a platform trial to evaluate new drug resistant TB (DRTB) treatment regimens
ncbi.nlm.nih.gov/pmc/articles...
This thread outlines some of our key arguments
[1/n]
In this month's Bulletin of the WHO, a group of us from UK Academics and Professionals to end TB have a paper calling for a platform trial to evaluate new drug resistant TB (DRTB) treatment regimens
ncbi.nlm.nih.gov/pmc/articles...
This thread outlines some of our key arguments
[1/n]
Webinar alert! 🚨
Part I will focus on WHO guidelines and treatment options.
Part II will focus on how to address extensively drug-resistant TB, including treatment guidelines, compassionate use, and more.
🔗 www.treatmentactiongroup.org/drtb-webinar...
Part I will focus on WHO guidelines and treatment options.
Part II will focus on how to address extensively drug-resistant TB, including treatment guidelines, compassionate use, and more.
🔗 www.treatmentactiongroup.org/drtb-webinar...
August 10, 2026 at 2:32 PM
Webinar alert! 🚨
Part I will focus on WHO guidelines and treatment options.
Part II will focus on how to address extensively drug-resistant TB, including treatment guidelines, compassionate use, and more.
🔗 www.treatmentactiongroup.org/drtb-webinar...
Part I will focus on WHO guidelines and treatment options.
Part II will focus on how to address extensively drug-resistant TB, including treatment guidelines, compassionate use, and more.
🔗 www.treatmentactiongroup.org/drtb-webinar...
When @who.int recommended the use of a 6-months all-oral #BPaL (bedaquiline, pretomanid and linezolid) regimen under #OperationalResearch conditions for selected people with #DrugResistant #tuberculosis ( #DRTB) in 2020, we took action.
Read our recent publication: journals.plos.org/plosone/arti...
Read our recent publication: journals.plos.org/plosone/arti...
Introducing BPaL: Experiences from countries supported under the LIFT-TB project
Background Previously, drug-resistant tuberculosis (DR-TB) patients were treated with long, toxic, and relatively ineffective regimens. However, in recent years, there have been major improvements mad...
journals.plos.org
December 6, 2024 at 3:40 PM
When @who.int recommended the use of a 6-months all-oral #BPaL (bedaquiline, pretomanid and linezolid) regimen under #OperationalResearch conditions for selected people with #DrugResistant #tuberculosis ( #DRTB) in 2020, we took action.
Read our recent publication: journals.plos.org/plosone/arti...
Read our recent publication: journals.plos.org/plosone/arti...
This #WorldTBDay, we’re highlighting the DRTB-HDT trial – testing 2 host-directed therapies for drug-resistant #tuberculosis.
With enrolment nearly complete, the study is moving closer to insights that could improve treatment outcomes & reduce long-term lung damage.
Learn more in the video 👇🏾
With enrolment nearly complete, the study is moving closer to insights that could improve treatment outcomes & reduce long-term lung damage.
Learn more in the video 👇🏾
The DR TB-HDT project
YouTube video by The Aurum Institute
youtu.be
March 24, 2025 at 12:10 PM
This #WorldTBDay, we’re highlighting the DRTB-HDT trial – testing 2 host-directed therapies for drug-resistant #tuberculosis.
With enrolment nearly complete, the study is moving closer to insights that could improve treatment outcomes & reduce long-term lung damage.
Learn more in the video 👇🏾
With enrolment nearly complete, the study is moving closer to insights that could improve treatment outcomes & reduce long-term lung damage.
Learn more in the video 👇🏾
WHO recommend more regimens for DRTB but still limited data on relative efficacy and safety
Article from UK Academics and Professionals to End TB calling for a platform trial currently in press (see cdn.who.int/media/docs/d...)
Anyone know if the BEAT-TB data have been made public yet?
#IDsky
Article from UK Academics and Professionals to End TB calling for a platform trial currently in press (see cdn.who.int/media/docs/d...)
Anyone know if the BEAT-TB data have been made public yet?
#IDsky
cdn.who.int
August 20, 2024 at 9:08 PM
WHO recommend more regimens for DRTB but still limited data on relative efficacy and safety
Article from UK Academics and Professionals to End TB calling for a platform trial currently in press (see cdn.who.int/media/docs/d...)
Anyone know if the BEAT-TB data have been made public yet?
#IDsky
Article from UK Academics and Professionals to End TB calling for a platform trial currently in press (see cdn.who.int/media/docs/d...)
Anyone know if the BEAT-TB data have been made public yet?
#IDsky