RRIDs were included in this in Journal of Advanced Research paper. RRIDs improve reproducibility in scientific research. #OpenScience #BetterScience #STMpublishing

Many additional exciting applications of #InducedProximity have already been shown in basic academic research (#PROTAC, #RIPTAC, #LYTAC, #AUTEC, #RIBOTAC, #PhosTAC, #PHICS, #OGTAC, #ACETAC, #ACETAG, #DUBTAC). Curious, which other therapeutic areas will most profit from this development. (2/3)

Instead of recruiting a ubiquitin ligase to a target protein, DUBTAC recruits a ubiquitin-removing enzyme to a protein and prevents its degradation 🧵 5/6

A Novel FXR-Targeted DUBTAC and Its Applications in Cholestasis Therapy

Super interesting: Deubiquitinase-targeting chimeras (DUBTAC) for targeted protein stabilization
DUBTAC is the anti-PROTAC strategy!
https://www.nature.com/articles/s41589-022-00971-2

While the findings demonstrate the versatility of the PRO-DUBTAC platform, further research is needed to fully explore its clinical applications and address potential limitations.

This study introduces the innovative PRO-DUBTAC platform, which stabilizes tumor-suppressive E3 ubiquitin ligases, VHL and KEAP1, by conjugating them with a deubiquitinase (OTUB1) ligand.