#MindBlown Learning about impressive efficacy of the #degrader space from #GwennHansen #NurixTherapeutics #BTK #inducedproximity #E3Ligase

Congratulations to @craigmcrews.bsky.social and all others involved at @yale.edu, Arvinas and Pfizer. #InducedProximity should be at the top of many The Nobel Prize lists now.

#TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success #ChemSky #ChemBio

Excited to present our work on molecular glue degraders at the SMR Target to Patient conference in the Wellcome Genome Campus next month - looks like a very strong line-up. www.smr.org.uk/Meetings/202... #TargetedProteinDegradation #InducedProximity #MolecularGlues #DrugDiscovery #ChemicalBiology

A crystal structure of tubulin-RB3 bound to a colchicine site inhibitor showed another binding site at the RB3 interface. An optimized compound with no colchicine site affinity retained antimicrotubule activity through stathmin complex stabilization. #inducedproximity #molecularglues

Many additional exciting applications of #InducedProximity have already been shown in basic academic research (#PROTAC, #RIPTAC, #LYTAC, #AUTEC, #RIBOTAC, #PhosTAC, #PHICS, #OGTAC, #ACETAC, #ACETAG, #DUBTAC). Curious, which other therapeutic areas will most profit from this development. (2/3)

#TargetedProteinDegradation #InducedProximity #MolecularGlue #TPD #eTPD #PROTAC #LYTAC #MoDEA #KineTAC #PROTAB #AbTAC #EpiTAC #REULR #GlueTAC #TICTAC #AUTAC #ATTEC #AUTOTAC #TrogoTAC #RIPR #RIPTAC #AgnoTAC #FragTAC #SHEDTAC

#TargetedProteinDegradation #MolecularGlue #CRBN #CDK4 #ChemicalBiology #InducedProximity #DrugDiscovery #Proteomics