There are no shortcuts in drug discovery. And it takes incredible efforts to make sense of what you can find in the scientific literature. This is an excellent piece of work to quality check what has been claimed as a new avenue in targeted protein degradation (TPD). www.nature.com/articles/s41...
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
www.nature.com
November 25, 2024 at 10:09 PM
There are no shortcuts in drug discovery. And it takes incredible efforts to make sense of what you can find in the scientific literature. This is an excellent piece of work to quality check what has been claimed as a new avenue in targeted protein degradation (TPD). www.nature.com/articles/s41...
See kids, this is a real life example of the "drink ice cofie, panec attec" meme, never drink your iced coffee or have a panec attec!
December 7, 2024 at 12:48 PM
See kids, this is a real life example of the "drink ice cofie, panec attec" meme, never drink your iced coffee or have a panec attec!
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
Refreshing to see papers that go to great pains to set the record straight being published in a high profile setting
Refreshing to see papers that go to great pains to set the record straight being published in a high profile setting
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
www.nature.com
November 29, 2024 at 12:39 PM
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
Refreshing to see papers that go to great pains to set the record straight being published in a high profile setting
Refreshing to see papers that go to great pains to set the record straight being published in a high profile setting
A autophagosome-tethering compound (ATTEC) technology that utilises bifunctional small molecules for lysosomal trafficking is used, resulting in degradation of target mRNA located in the cytoplasm.
July 3, 2025 at 4:04 PM
A autophagosome-tethering compound (ATTEC) technology that utilises bifunctional small molecules for lysosomal trafficking is used, resulting in degradation of target mRNA located in the cytoplasm.
Quality control is often overlooked in novel pathways, and we demonstrate this using ATTECs (Autophagy Tethering Compounds) as a case study. Our new study highlights what’s frequently missing in research!
#ProteinDegradation
Just out in @naturecomms.bsky.social
www.nature.com/articles/s41...
#ProteinDegradation
Just out in @naturecomms.bsky.social
www.nature.com/articles/s41...
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
www.nature.com
December 6, 2024 at 10:24 AM
Quality control is often overlooked in novel pathways, and we demonstrate this using ATTECs (Autophagy Tethering Compounds) as a case study. Our new study highlights what’s frequently missing in research!
#ProteinDegradation
Just out in @naturecomms.bsky.social
www.nature.com/articles/s41...
#ProteinDegradation
Just out in @naturecomms.bsky.social
www.nature.com/articles/s41...
The paper
"Surprisingly none of the ligands used for the development of ATTECs showed measurable affinity for the proposed targets LC3/GABARAP using a diversity of biophysical methods, suggesting that reported LC3-ligand based degraders cause degradation not due to a LC3/GABARAP mediated mechanism"
"Surprisingly none of the ligands used for the development of ATTECs showed measurable affinity for the proposed targets LC3/GABARAP using a diversity of biophysical methods, suggesting that reported LC3-ligand based degraders cause degradation not due to a LC3/GABARAP mediated mechanism"
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
www.nature.com
December 11, 2024 at 10:22 AM
The paper
"Surprisingly none of the ligands used for the development of ATTECs showed measurable affinity for the proposed targets LC3/GABARAP using a diversity of biophysical methods, suggesting that reported LC3-ligand based degraders cause degradation not due to a LC3/GABARAP mediated mechanism"
"Surprisingly none of the ligands used for the development of ATTECs showed measurable affinity for the proposed targets LC3/GABARAP using a diversity of biophysical methods, suggesting that reported LC3-ligand based degraders cause degradation not due to a LC3/GABARAP mediated mechanism"
PAQ Therapeutics is turning the cell's own recycling system into a cancer drug - meet ATTEC.
Full story on https://yespress.io/paq-therapeutics?utm_source=bluesky&utm_medium=social
Full story on https://yespress.io/paq-therapeutics?utm_source=bluesky&utm_medium=social
yespress.io
August 29, 2026 at 9:31 AM
PAQ Therapeutics is turning the cell's own recycling system into a cancer drug - meet ATTEC.
Full story on https://yespress.io/paq-therapeutics?utm_source=bluesky&utm_medium=social
Full story on https://yespress.io/paq-therapeutics?utm_source=bluesky&utm_medium=social
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
www.nature.com
November 30, 2024 at 10:58 PM
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pemerintah Bidik Investasi China untuk Perkuat UMKM dan Industri Nasional
PUNGGAWANEWS, TIONGKOK - Pemerintah Indonesia mendorong penguatan kerja sama ekonomi dengan Tiongkok melalui penyelenggaraan Indonesia-China Investment Forum di Beijing pada 1 April 2026. Forum ini merupakan bagian dari…
PUNGGAWANEWS, TIONGKOK - Pemerintah Indonesia mendorong penguatan kerja sama ekonomi dengan Tiongkok melalui penyelenggaraan Indonesia-China Investment Forum di Beijing pada 1 April 2026. Forum ini merupakan bagian dari…
Pemerintah Bidik Investasi China untuk Perkuat UMKM dan Industri Nasional
PUNGGAWANEWS, TIONGKOK - Pemerintah Indonesia mendorong penguatan kerja sama ekonomi dengan Tiongkok melalui penyelenggaraan Indonesia-China Investment Forum di Beijing pada 1 April 2026. Forum ini merupakan bagian dari rangkaian misi dagang yang ditujukan untuk menarik aliran investasi sekaligus memperluas akses pasar bagi pelaku usaha nasional. Kegiatan yang berlangsung di China World Hotel, Beijing tersebut diinisiasi oleh Asian Trade, Tourism, and Economics Council (ATTEC) dan dihadiri oleh pejabat pemerintah kedua negara, pelaku industri, serta investor.
punggawanews.com
April 4, 2026 at 12:01 PM
Pemerintah Bidik Investasi China untuk Perkuat UMKM dan Industri Nasional
PUNGGAWANEWS, TIONGKOK - Pemerintah Indonesia mendorong penguatan kerja sama ekonomi dengan Tiongkok melalui penyelenggaraan Indonesia-China Investment Forum di Beijing pada 1 April 2026. Forum ini merupakan bagian dari…
PUNGGAWANEWS, TIONGKOK - Pemerintah Indonesia mendorong penguatan kerja sama ekonomi dengan Tiongkok melalui penyelenggaraan Indonesia-China Investment Forum di Beijing pada 1 April 2026. Forum ini merupakan bagian dari…
Mendag: ATTEC jadi jembatan investor Asia masuk ke Indonesia - https://www.antaranews.com/berita/5360758/mendag-attec-jadi-jembatan-investor-asia-masuk-ke-indonesia
Mendag: ATTEC jadi jembatan investor Asia masuk ke Indonesia
Menteri Perdagangan (Mendag) Budi Santoso menilai keberadaan Asian Trade, Tourism, and Economics Council (ATTEC) menjadi jembatan penting bagi pelaku usaha ...
www.antaranews.com
January 19, 2026 at 12:28 PM
Mendag: ATTEC jadi jembatan investor Asia masuk ke Indonesia - https://www.antaranews.com/berita/5360758/mendag-attec-jadi-jembatan-investor-asia-masuk-ke-indonesia
For aficionados of #fragments, #degraders & #ATTECs. Learn how biophysics approaches - spectral shift detection on #NanoTemper Dianthus characterised LC3/GABARAP interactions.
From #GoetheUniversity, #SGC, #DKTK, #DKFZ. #Fraunhofer #TUM #DiamondLightSource, Nathan Adams & Ivana Jaser
rdcu.be/d22DS
From #GoetheUniversity, #SGC, #DKTK, #DKFZ. #Fraunhofer #TUM #DiamondLightSource, Nathan Adams & Ivana Jaser
rdcu.be/d22DS
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
Nature Communications - Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to...
rdcu.be
December 10, 2024 at 8:04 PM
For aficionados of #fragments, #degraders & #ATTECs. Learn how biophysics approaches - spectral shift detection on #NanoTemper Dianthus characterised LC3/GABARAP interactions.
From #GoetheUniversity, #SGC, #DKTK, #DKFZ. #Fraunhofer #TUM #DiamondLightSource, Nathan Adams & Ivana Jaser
rdcu.be/d22DS
From #GoetheUniversity, #SGC, #DKTK, #DKFZ. #Fraunhofer #TUM #DiamondLightSource, Nathan Adams & Ivana Jaser
rdcu.be/d22DS