Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform | Yong Tae Kwon lab | #N-degron www.biorxiv.org/content/10.1...
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons and the cytoplasmic aggregation of misfolded proteins in the spinal cord...
www.biorxiv.org
September 8, 2025 at 11:07 AM
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform | Yong Tae Kwon lab | #N-degron www.biorxiv.org/content/10.1...
Targeted degradation of pathologic tau aggregates via AUTOTAC ameliorates tauopathy https://www.biorxiv.org/content/10.1101/2025.09.10.675324v1
September 13, 2025 at 7:15 AM
Targeted degradation of pathologic tau aggregates via AUTOTAC ameliorates tauopathy https://www.biorxiv.org/content/10.1101/2025.09.10.675324v1
AUTOTAC-mediated targeted degradation of transthyretin aggregates ameliorates hereditary transthyretin amyloidosis https://www.biorxiv.org/content/10.64898/2026.02.23.707350v1
February 24, 2026 at 2:30 PM
AUTOTAC-mediated targeted degradation of transthyretin aggregates ameliorates hereditary transthyretin amyloidosis https://www.biorxiv.org/content/10.64898/2026.02.23.707350v1
Targeted degradation of pathologic tau aggregates via AUTOTAC ameliorates tauopathy https://www.biorxiv.org/content/10.1101/2025.09.10.675324v1
September 13, 2025 at 7:15 AM
Targeted degradation of pathologic tau aggregates via AUTOTAC ameliorates tauopathy https://www.biorxiv.org/content/10.1101/2025.09.10.675324v1
AUTOTAC-mediated targeted degradation of transthyretin aggregates ameliorates hereditary transthyretin amyloidosis https://www.biorxiv.org/content/10.64898/2026.02.23.707350v1
February 24, 2026 at 2:30 PM
AUTOTAC-mediated targeted degradation of transthyretin aggregates ameliorates hereditary transthyretin amyloidosis https://www.biorxiv.org/content/10.64898/2026.02.23.707350v1
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform https://www.biorxiv.org/content/10.1101/2025.08.31.673396v1
September 3, 2025 at 4:15 PM
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform https://www.biorxiv.org/content/10.1101/2025.08.31.673396v1
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform https://www.biorxiv.org/content/10.1101/2025.08.31.673396v1
September 3, 2025 at 4:15 PM
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform https://www.biorxiv.org/content/10.1101/2025.08.31.673396v1
Targeted degradation of pathologic tau aggregates via AUTOTAC ameliorates tauopathy #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.09.10.675324v1
https://www.biorxiv.org/content/10.1101/2025.09.10.675324v1
September 13, 2025 at 4:02 PM
Targeted degradation of pathologic tau aggregates via AUTOTAC ameliorates tauopathy #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.09.10.675324v1
https://www.biorxiv.org/content/10.1101/2025.09.10.675324v1
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.08.31.673396v1
https://www.biorxiv.org/content/10.1101/2025.08.31.673396v1
September 4, 2025 at 7:02 AM
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.08.31.673396v1
https://www.biorxiv.org/content/10.1101/2025.08.31.673396v1
Preprint: An Oral AUTOTAC Degrader for Pathologic Tau Aggregates Ameliorates Tauopathy
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....
An Oral AUTOTAC Degrader for Pathologic Tau Aggregates Ameliorates Tauopathy
Tau aggregates cause the most prevalent forms of neurodegeneration including Alzheimer’s disease (AD) and progressive supranuclear palsy (PSP), but their select
papers.ssrn.com
December 5, 2025 at 1:13 AM
Preprint: An Oral AUTOTAC Degrader for Pathologic Tau Aggregates Ameliorates Tauopathy
papers.ssrn.com/sol3/papers....
papers.ssrn.com/sol3/papers....