Dear friends and colleagues,
I am excited to share a preprint describing my take on extracellular targeted protein degradation (eTPD) - a proximity modality termed Sheddase-Targeting Chimeras (SHEDTACs).
www.biorxiv.org/content/10.6... 👀
I am excited to share a preprint describing my take on extracellular targeted protein degradation (eTPD) - a proximity modality termed Sheddase-Targeting Chimeras (SHEDTACs).
www.biorxiv.org/content/10.6... 👀
www.biorxiv.org
February 9, 2026 at 11:37 PM
Dear friends and colleagues,
I am excited to share a preprint describing my take on extracellular targeted protein degradation (eTPD) - a proximity modality termed Sheddase-Targeting Chimeras (SHEDTACs).
www.biorxiv.org/content/10.6... 👀
I am excited to share a preprint describing my take on extracellular targeted protein degradation (eTPD) - a proximity modality termed Sheddase-Targeting Chimeras (SHEDTACs).
www.biorxiv.org/content/10.6... 👀
The ETPD is no joke
March 10, 2026 at 8:53 PM
The ETPD is no joke
Sen güleceksen neden olmasın
www.youtube.com/watch?v=etPD...
www.youtube.com/watch?v=etPD...
February 21, 2025 at 6:16 AM
Sen güleceksen neden olmasın
www.youtube.com/watch?v=etPD...
www.youtube.com/watch?v=etPD...
Hijacking Extracellular Targeted Protein Degrader–Drug Conjugates for Enhanced Drug Delivery
Open access 🔓
Open access 🔓
Hijacking Extracellular Targeted Protein Degrader–Drug Conjugates for Enhanced Drug Delivery
Antibody-based therapeutics encompass diverse modalities for targeting tumor cells. Among these, antibody–drug conjugates (ADCs) and extracellular targeted protein degradation (eTPD) specifically depe...
pubs.acs.org
November 3, 2025 at 11:15 AM
Hijacking Extracellular Targeted Protein Degrader–Drug Conjugates for Enhanced Drug Delivery
Open access 🔓
Open access 🔓
Happy to have contributed in a small way to this very cool study from Jim Wells lab, led by Fangzhu Zhao. They developed low-density lipoprotein receptor-targeting chimeras (LIPTACs) to promote induced extracellular protein degradation & ADC delivery. 👏
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Low-density lipoprotein receptor-targeting chimeras for membrane protein degradation and enhanced drug delivery
Antibody-based therapeutics encompass diverse modalities for targeting tumor cells. Among these, antibody-drug conjugates (ADCs) and extracellular targeted protein degradation (eTPD) specifically depe...
www.biorxiv.org
June 11, 2025 at 8:50 PM
Happy to have contributed in a small way to this very cool study from Jim Wells lab, led by Fangzhu Zhao. They developed low-density lipoprotein receptor-targeting chimeras (LIPTACs) to promote induced extracellular protein degradation & ADC delivery. 👏
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Dispar Bone Bolango terapkan sistem ETPD di pintu masuk kawasan wisata - https://www.antaranews.com/berita/4626217/dispar-bone-bolango-terapkan-sistem-etpd-di-pintu-masuk-kawasan-wisata
Dispar Bone Bolango terapkan sistem ETPD di pintu masuk kawasan wisata
Dinas Pariwisata (Dispar) Kabupaten Bone Bolango Provinsi Gorontalo menerapkan sistem Elektronik Transaksi Pemerintah Daerah (ETPD) di pintu masuk kawasan ...
www.antaranews.com
February 4, 2025 at 12:21 PM
Dispar Bone Bolango terapkan sistem ETPD di pintu masuk kawasan wisata - https://www.antaranews.com/berita/4626217/dispar-bone-bolango-terapkan-sistem-etpd-di-pintu-masuk-kawasan-wisata
Szerintem ez teljesen normális, hogy 2 szülőnél máshogy működnek a gyerekek, ne aggódj ezen szerintem. Nekem a 2 gyerekem nem ugyanúgy reagált dolgokra amikor kicsik voltak :)
De elmondja neked Bluey is:
www.youtube.com/watch?v=eTPD...
De elmondja neked Bluey is:
www.youtube.com/watch?v=eTPD...
Slow and Steady | Baby Race | Bluey
YouTube video by Bluey - Official Channel
www.youtube.com
April 2, 2025 at 3:18 PM
Szerintem ez teljesen normális, hogy 2 szülőnél máshogy működnek a gyerekek, ne aggódj ezen szerintem. Nekem a 2 gyerekem nem ugyanúgy reagált dolgokra amikor kicsik voltak :)
De elmondja neked Bluey is:
www.youtube.com/watch?v=eTPD...
De elmondja neked Bluey is:
www.youtube.com/watch?v=eTPD...
In this video... What we think FDEV might be up to, what is likely just around the corner and why we think this year is so important for the longer term future of the game, and everyone that plays it.
#EliteDangerous o7
www.youtube.com/watch?v=etpd...
#EliteDangerous o7
www.youtube.com/watch?v=etpd...
Why the Elite Dangerous “Brand New Feature” might be so important
YouTube video by The Buur Pit
www.youtube.com
July 3, 2024 at 4:17 PM
In this video... What we think FDEV might be up to, what is likely just around the corner and why we think this year is so important for the longer term future of the game, and everyone that plays it.
#EliteDangerous o7
www.youtube.com/watch?v=etpd...
#EliteDangerous o7
www.youtube.com/watch?v=etpd...
Hijacking Extracellular Targeted Protein Degrader-Drug Conjugates for Enhanced Drug Delivery | JACS
@jacs.acspublications.org @ucsfcancer.bsky.social @jimwellsucsf.bsky.social
pubs.acs.org/doi/10.1021/...
@jacs.acspublications.org @ucsfcancer.bsky.social @jimwellsucsf.bsky.social
pubs.acs.org/doi/10.1021/...
Hijacking Extracellular Targeted Protein Degrader–Drug Conjugates for Enhanced Drug Delivery
Antibody-based therapeutics encompass diverse modalities for targeting tumor cells. Among these, antibody–drug conjugates (ADCs) and extracellular targeted protein degradation (eTPD) specifically depe...
pubs.acs.org
October 16, 2025 at 6:41 PM
Hijacking Extracellular Targeted Protein Degrader-Drug Conjugates for Enhanced Drug Delivery | JACS
@jacs.acspublications.org @ucsfcancer.bsky.social @jimwellsucsf.bsky.social
pubs.acs.org/doi/10.1021/...
@jacs.acspublications.org @ucsfcancer.bsky.social @jimwellsucsf.bsky.social
pubs.acs.org/doi/10.1021/...
Efficiency in clearing amyloid-β (Aβ) in Alzheimer's is enhanced by SPYTACs, a new eTPD platform, offering a safer alternative to anti-Aβ immunotherapy. PMID:41785850, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00162-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00162-5
No description available
www.cell.com
April 16, 2026 at 5:10 AM
New preprint from stellar UCSF grad student Kaan Kumru and @jimwellsucsf.bsky.social!
A cytokine receptor-targeting chimera (kineTAC) toolbox for expanding extracellular targeted protein degradation | bioRxiv
www.biorxiv.org/content/10.1...
A cytokine receptor-targeting chimera (kineTAC) toolbox for expanding extracellular targeted protein degradation | bioRxiv
www.biorxiv.org/content/10.1...
A cytokine receptor-targeting chimera (kineTAC) toolbox for expanding extracellular targeted protein degradation.
Extracellular targeted protein degradation (eTPD) is as an important new modality for manipulating the extracellular proteome. However, most eTPD receptors are expressed broadly or are restricted to t...
www.biorxiv.org
September 4, 2025 at 8:22 PM
New preprint from stellar UCSF grad student Kaan Kumru and @jimwellsucsf.bsky.social!
A cytokine receptor-targeting chimera (kineTAC) toolbox for expanding extracellular targeted protein degradation | bioRxiv
www.biorxiv.org/content/10.1...
A cytokine receptor-targeting chimera (kineTAC) toolbox for expanding extracellular targeted protein degradation | bioRxiv
www.biorxiv.org/content/10.1...
Check out this new work from Fangzhu Zhao with @jimwellsucsf.bsky.social presenting new modalities for targeted membrane protein degradation (LIPTACs) and drug-degrader conjugates (DDCs)!
www.biorxiv.org/content/10.1...
@ucsfcancer.bsky.social @ucsfhealth.bsky.social @ucberkeleyofficial.bsky.social
www.biorxiv.org/content/10.1...
@ucsfcancer.bsky.social @ucsfhealth.bsky.social @ucberkeleyofficial.bsky.social
Low-density lipoprotein receptor-targeting chimeras for membrane protein degradation and enhanced drug delivery
Antibody-based therapeutics encompass diverse modalities for targeting tumor cells. Among these, antibody-drug conjugates (ADCs) and extracellular targeted protein degradation (eTPD) specifically depe...
www.biorxiv.org
June 11, 2025 at 2:18 AM
Check out this new work from Fangzhu Zhao with @jimwellsucsf.bsky.social presenting new modalities for targeted membrane protein degradation (LIPTACs) and drug-degrader conjugates (DDCs)!
www.biorxiv.org/content/10.1...
@ucsfcancer.bsky.social @ucsfhealth.bsky.social @ucberkeleyofficial.bsky.social
www.biorxiv.org/content/10.1...
@ucsfcancer.bsky.social @ucsfhealth.bsky.social @ucberkeleyofficial.bsky.social
Build live and customizable data tools with marimo's built-in data editor, like this financial tracker:
youtube.com/shorts/eTPd...
youtube.com/shorts/eTPd...
Ditch Excel for This Marimo Finance Tool
Feel free to play around with the code/tool here: https://molab.marimo.io/notebooks/nb_Wq6zCfAURWbbd7YdvSVLZq
www.youtube.com
October 1, 2025 at 4:00 PM
Build live and customizable data tools with marimo's built-in data editor, like this financial tracker:
youtube.com/shorts/eTPd...
youtube.com/shorts/eTPd...
🦠🔬 Recently we reported the development of a new class of sensors to directly monitor live-cell protein trafficking and provide a sensitive indication of delivery to functional, enzymatically active lysosomes. A quick 🧵for #FluorescenceFriday www.biorxiv.org/content/10.1...
Monitoring lysosomal catabolism: a sensitive probe for assessing targeted lysosomal degradation of extracellular proteins
Extracellular targeted protein degradation (eTPD) is an emerging therapeutic field. The Lysosome targeting chimera (LYTAC) is a therapeutic modality that promotes degradation of extracellular drivers ...
www.biorxiv.org
February 21, 2025 at 10:05 PM
🦠🔬 Recently we reported the development of a new class of sensors to directly monitor live-cell protein trafficking and provide a sensitive indication of delivery to functional, enzymatically active lysosomes. A quick 🧵for #FluorescenceFriday www.biorxiv.org/content/10.1...
BI: 267 Pemda Gunakan Kartu Kredit Indonesia, Total Transaksi Rp 665 Miliar - https://katadata.co.id/finansial/keuangan/69a8fa8e96663/bi-267-pemda-gunakan-kartu-kredit-indonesia-total-transaksi-rp-665-miliar
BI: 267 Pemda Gunakan Kartu Kredit Indonesia, Total Transaksi Rp 665 Miliar - Keuangan Katadata.co.id
Untuk mendukung digitalisasi keuangan daerah BI telah menghadirkan berbagai inovasi sistem pembayaran yang memperkuat implementasi Elektronifikasi Transaksi Pemerintah Daerah (ETPD).
katadata.co.id
March 5, 2026 at 3:47 AM
BI: 267 Pemda Gunakan Kartu Kredit Indonesia, Total Transaksi Rp 665 Miliar - https://katadata.co.id/finansial/keuangan/69a8fa8e96663/bi-267-pemda-gunakan-kartu-kredit-indonesia-total-transaksi-rp-665-miliar
Well I tried to write a multi message response but the goddamn app crashed again. So just watch this instead it makes most of my points but with charts and a lot more words.
youtu.be/etPD-9Ng5H8?...
youtu.be/etPD-9Ng5H8?...
The Big Reset and Chaos in 2025 || Peter zeihan
YouTube video by BEC Finance
youtu.be
January 26, 2025 at 3:33 AM
Well I tried to write a multi message response but the goddamn app crashed again. So just watch this instead it makes most of my points but with charts and a lot more words.
youtu.be/etPD-9Ng5H8?...
youtu.be/etPD-9Ng5H8?...
Kemendagri Dorong Pemda Terapkan ETPD Guna Tingkatkan Pendapatan Asli Daerah https://www.klikwarta.com/kemendagri-dorong-pemda-terapkan-etpd-guna-tingkatkan-pendapatan-asli-daerah
Kemendagri Dorong Pemda Terapkan ETPD Guna Tingkatkan Pendapatan Asli Daerah
Klikwarta.com, Jakarta - Kementerian Dalam Negeri (Kemendagri) melalui Direktorat Jenderal (Ditjen) Bina Keuangan Daerah (Keuda) mendorong pemerintah daerah (Pemda) untuk mengimplementasikan Elektronifikasi Transaksi Pemerintah Daerah (ETPD) dan digitalisasi dalam pengelolaan pendapatan daerah. Upaya ini diharapkan mampu mendorong peningkatan Pendapatan Asli Daerah (PAD).
www.klikwarta.com
January 19, 2025 at 2:52 PM
Kemendagri Dorong Pemda Terapkan ETPD Guna Tingkatkan Pendapatan Asli Daerah https://www.klikwarta.com/kemendagri-dorong-pemda-terapkan-etpd-guna-tingkatkan-pendapatan-asli-daerah
Kemendagri Minta Daerah Susun Roadmap Elektronifikasi Transaksi - https://ekonomi.republika.co.id/berita/tb1z5y416/kemendagri-minta-daerah-susun-roadmap-elektronifikasi-transaksi
Kemendagri Minta Daerah Susun Roadmap Elektronifikasi Transaksi |Republika Online
Implementasi ETPD kini memasuki periode kedua.
republika.co.id
February 26, 2026 at 6:28 AM
Kemendagri Minta Daerah Susun Roadmap Elektronifikasi Transaksi - https://ekonomi.republika.co.id/berita/tb1z5y416/kemendagri-minta-daerah-susun-roadmap-elektronifikasi-transaksi
Feed: "South Jersey Media"
By: Submitted Content on Friday, December 26, 2025
By: Submitted Content on Friday, December 26, 2025
Applications open for part time officer
The Evesham Township Police Department (ETPD) is recruiting for the position of part-time Special Law Enforcement Officer l (SLEO).The SLEO l Position is a
southjersey.media
December 27, 2025 at 6:19 PM
Feed: "South Jersey Media"
By: Submitted Content on Friday, December 26, 2025
By: Submitted Content on Friday, December 26, 2025
Pasaman Barat Komitmen Transformasi Digital, Ihpan Hadiri High Level Meeting TP2DD di Bukittinggi
INGATLAH - Pemerintah Kabupaten Pasaman Barat (Pasbar) menegaskan komitmennya terhadap akselerasi digitalisasi keuangan daerah. Wakil Bupati Pasaman Barat, M. Ihpan, menghadiri kegiatan High Level…
INGATLAH - Pemerintah Kabupaten Pasaman Barat (Pasbar) menegaskan komitmennya terhadap akselerasi digitalisasi keuangan daerah. Wakil Bupati Pasaman Barat, M. Ihpan, menghadiri kegiatan High Level…
Pasaman Barat Komitmen Transformasi Digital, Ihpan Hadiri High Level Meeting TP2DD di Bukittinggi
INGATLAH - Pemerintah Kabupaten Pasaman Barat (Pasbar) menegaskan komitmennya terhadap akselerasi digitalisasi keuangan daerah. Wakil Bupati Pasaman Barat, M. Ihpan, menghadiri kegiatan High Level Meeting (HLM) Tim Percepatan dan Perluasan Digitalisasi Daerah (TP2DD) serta Asistensi Penyusunan Roadmap Elektronifikasi Transaksi Pemerintah Daerah (ETPD) Tahun 2025. Acara strategis yang bertujuan memperkuat koordinasi implementasi transaksi nontunai ini diselenggarakan oleh Kantor Perwakilan Bank Indonesia Provinsi Sumatera Barat di The Balcone Hotel, Bukittinggi, dan berlangsung selama dua hari, mulai 28 hingga 29 Oktober 2025. Pertemuan tingkat tinggi ini dipimpin langsung oleh Gubernur Sumatera Barat dan diikuti oleh seluruh kepala daerah se-Sumatera Barat, bersama tim teknis digitalisasi transaksi daerah.
www.ingatlah.com
October 29, 2025 at 5:27 AM
Pasaman Barat Komitmen Transformasi Digital, Ihpan Hadiri High Level Meeting TP2DD di Bukittinggi
INGATLAH - Pemerintah Kabupaten Pasaman Barat (Pasbar) menegaskan komitmennya terhadap akselerasi digitalisasi keuangan daerah. Wakil Bupati Pasaman Barat, M. Ihpan, menghadiri kegiatan High Level…
INGATLAH - Pemerintah Kabupaten Pasaman Barat (Pasbar) menegaskan komitmennya terhadap akselerasi digitalisasi keuangan daerah. Wakil Bupati Pasaman Barat, M. Ihpan, menghadiri kegiatan High Level…
Kemendagri perkuat Elektronifikasi Transaksi Pemerintah Daerah - https://www.antaranews.com/berita/5439206/kemendagri-perkuat-elektronifikasi-transaksi-pemerintah-daerah
Kemendagri perkuat Elektronifikasi Transaksi Pemerintah Daerah
Direktorat Jenderal Bina Keuangan Daerah Kementerian Dalam Negeri dorong penguatan implementasi Elektronifikasi Transaksi Pemerintah Daerah (ETPD) melalui ...
www.antaranews.com
February 26, 2026 at 6:59 AM
Kemendagri perkuat Elektronifikasi Transaksi Pemerintah Daerah - https://www.antaranews.com/berita/5439206/kemendagri-perkuat-elektronifikasi-transaksi-pemerintah-daerah