Furosemide (lasix) is a loop diuretic. It works via a threshold effect: to achieve diuresis, the concentration of furosemide at the site of action must EXCEED the diuretic threshold, which varies based on a number of factors.
More pharmacology in this excellent IBCC post: emcrit.org/ibcc/diurese/
More pharmacology in this excellent IBCC post: emcrit.org/ibcc/diurese/
Diuretics & Deresuscitation
CONTENTS Specific diuretics Acetazolamide SGLT2 inhibitors Loop diuretics Loop diuretic infusion Thiazides Amiloride (Spironolactone) General approach to diuresis in acute care medicine Intro Large-vo...
emcrit.org
January 17, 2025 at 6:19 PM
Furosemide (lasix) is a loop diuretic. It works via a threshold effect: to achieve diuresis, the concentration of furosemide at the site of action must EXCEED the diuretic threshold, which varies based on a number of factors.
More pharmacology in this excellent IBCC post: emcrit.org/ibcc/diurese/
More pharmacology in this excellent IBCC post: emcrit.org/ibcc/diurese/
Fluid deresuscitation: A narrative review
CCR Journal Watch - tracking the critical care literature daily
https://criticalcarereviews.com/latest-evidence/journal-watch
CCR Journal Watch - tracking the critical care literature daily
https://criticalcarereviews.com/latest-evidence/journal-watch
May 18, 2025 at 8:22 PM
Fluid deresuscitation: A narrative review
CCR Journal Watch - tracking the critical care literature daily
https://criticalcarereviews.com/latest-evidence/journal-watch
CCR Journal Watch - tracking the critical care literature daily
https://criticalcarereviews.com/latest-evidence/journal-watch
Today's Paper of the Day is:
Advances in resuscitation and deresuscitation
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
Advances in resuscitation and deresuscitation
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
July 16, 2025 at 6:53 AM
Today's Paper of the Day is:
Advances in resuscitation and deresuscitation
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
Advances in resuscitation and deresuscitation
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
Heading to #CHEST2026? Find me in Phoenix! 🌵
Sun 4 PM: Deresuscitation in Critical Illness (W101A)
Mon 9:15 AM: Improv in MedEd (W101A)
Mon 12:15 PM & Tue 1:50 PM: Swipe Right on Shock, a 20-min MCS game (Exhibit Hall)
Mon 3:15 PM: NIV to Phrenic Pacing (W104B)
Sun 4 PM: Deresuscitation in Critical Illness (W101A)
Mon 9:15 AM: Improv in MedEd (W101A)
Mon 12:15 PM & Tue 1:50 PM: Swipe Right on Shock, a 20-min MCS game (Exhibit Hall)
Mon 3:15 PM: NIV to Phrenic Pacing (W104B)
October 2, 2026 at 8:23 PM
Heading to #CHEST2026? Find me in Phoenix! 🌵
Sun 4 PM: Deresuscitation in Critical Illness (W101A)
Mon 9:15 AM: Improv in MedEd (W101A)
Mon 12:15 PM & Tue 1:50 PM: Swipe Right on Shock, a 20-min MCS game (Exhibit Hall)
Mon 3:15 PM: NIV to Phrenic Pacing (W104B)
Sun 4 PM: Deresuscitation in Critical Illness (W101A)
Mon 9:15 AM: Improv in MedEd (W101A)
Mon 12:15 PM & Tue 1:50 PM: Swipe Right on Shock, a 20-min MCS game (Exhibit Hall)
Mon 3:15 PM: NIV to Phrenic Pacing (W104B)
💧 Should fluid therapy in #ICU pts be shorter & more strategic?
🔹 Excessive fluid resuscitation=worse outcomes;
🔹#ROSE model & deresuscitation strategies aim to balance perfusion+ 💧 overload;
🔹Tools like US & bioimpedance can guide safe fluid removal
criticalcarescience.org/article/flui...
🔹 Excessive fluid resuscitation=worse outcomes;
🔹#ROSE model & deresuscitation strategies aim to balance perfusion+ 💧 overload;
🔹Tools like US & bioimpedance can guide safe fluid removal
criticalcarescience.org/article/flui...
June 14, 2025 at 1:50 PM
💧 Should fluid therapy in #ICU pts be shorter & more strategic?
🔹 Excessive fluid resuscitation=worse outcomes;
🔹#ROSE model & deresuscitation strategies aim to balance perfusion+ 💧 overload;
🔹Tools like US & bioimpedance can guide safe fluid removal
criticalcarescience.org/article/flui...
🔹 Excessive fluid resuscitation=worse outcomes;
🔹#ROSE model & deresuscitation strategies aim to balance perfusion+ 💧 overload;
🔹Tools like US & bioimpedance can guide safe fluid removal
criticalcarescience.org/article/flui...
Advances in resuscitation and deresuscitation
CCR Journal Watch - tracking the critical care literature daily
https://criticalcarereviews.com/latest-evidence/journal-watch
CCR Journal Watch - tracking the critical care literature daily
https://criticalcarereviews.com/latest-evidence/journal-watch
May 15, 2025 at 9:24 PM
Advances in resuscitation and deresuscitation
CCR Journal Watch - tracking the critical care literature daily
https://criticalcarereviews.com/latest-evidence/journal-watch
CCR Journal Watch - tracking the critical care literature daily
https://criticalcarereviews.com/latest-evidence/journal-watch
#SCCM2026
#SurvivingSepsis arguing for active deresuscitation, admitting the data are very scant so far
#SurvivingSepsis arguing for active deresuscitation, admitting the data are very scant so far
March 23, 2026 at 3:14 PM
#SCCM2026
#SurvivingSepsis arguing for active deresuscitation, admitting the data are very scant so far
#SurvivingSepsis arguing for active deresuscitation, admitting the data are very scant so far
What I find it most useful for at the moment is in weaning patients/deresuscitation, but in the context of echo/lung ultrasound, fluid balance.
May 12, 2026 at 8:44 PM
What I find it most useful for at the moment is in weaning patients/deresuscitation, but in the context of echo/lung ultrasound, fluid balance.
Give diuretics as boluses
look at Chloride, k+ and pH
Multimodal diuresis
Not every form of "heart failure" need diuretics in the firsts hours
#EMIMCC
#DiuresisJedi
#Deresuscitation
look at Chloride, k+ and pH
Multimodal diuresis
Not every form of "heart failure" need diuretics in the firsts hours
#EMIMCC
#DiuresisJedi
#Deresuscitation
August 9, 2025 at 3:17 PM
Give diuretics as boluses
look at Chloride, k+ and pH
Multimodal diuresis
Not every form of "heart failure" need diuretics in the firsts hours
#EMIMCC
#DiuresisJedi
#Deresuscitation
look at Chloride, k+ and pH
Multimodal diuresis
Not every form of "heart failure" need diuretics in the firsts hours
#EMIMCC
#DiuresisJedi
#Deresuscitation
I never started a "Bumex drip" (but I used "nephron bomb")
I never gave albumin to "enhance diuresis"
I never checked "serial labs"
We should not be afraid of diuresis and decongestion
I kept it simple here but if you want to read more, please check @pulmcrit.bsky.social
emcrit.org/ibcc/diurese/
I never gave albumin to "enhance diuresis"
I never checked "serial labs"
We should not be afraid of diuresis and decongestion
I kept it simple here but if you want to read more, please check @pulmcrit.bsky.social
emcrit.org/ibcc/diurese/
Diuretics & Deresuscitation
CONTENTS Specific diuretics Acetazolamide SGLT2 inhibitors Loop diuretics Loop diuretic infusion Thiazides Amiloride (Spironolactone) General approach to diuresis in acute care medicine Introduction t...
emcrit.org
June 29, 2026 at 1:52 PM
I never started a "Bumex drip" (but I used "nephron bomb")
I never gave albumin to "enhance diuresis"
I never checked "serial labs"
We should not be afraid of diuresis and decongestion
I kept it simple here but if you want to read more, please check @pulmcrit.bsky.social
emcrit.org/ibcc/diurese/
I never gave albumin to "enhance diuresis"
I never checked "serial labs"
We should not be afraid of diuresis and decongestion
I kept it simple here but if you want to read more, please check @pulmcrit.bsky.social
emcrit.org/ibcc/diurese/
Today's Paper of the Day is:
Advances in resuscitation and deresuscitation
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2026
Advances in resuscitation and deresuscitation
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2026
May 15, 2026 at 6:45 AM
Today's Paper of the Day is:
Advances in resuscitation and deresuscitation
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2026
Advances in resuscitation and deresuscitation
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2026
Doppler tell us when to remove fluids in the ICU.
Discontinuous IRVF = 4× higher success in deresuscitation, with 87% S.
VExUS 2–3 is Sp but not S.
IRVF = a real-time marker of readiness, not long-term outcomes.
#POCUS #Ultrasound #CriticalCare #IRVF #VExUS #FluidManagement #ICU #MedSci
Discontinuous IRVF = 4× higher success in deresuscitation, with 87% S.
VExUS 2–3 is Sp but not S.
IRVF = a real-time marker of readiness, not long-term outcomes.
#POCUS #Ultrasound #CriticalCare #IRVF #VExUS #FluidManagement #ICU #MedSci
December 13, 2025 at 10:30 PM
Doppler tell us when to remove fluids in the ICU.
Discontinuous IRVF = 4× higher success in deresuscitation, with 87% S.
VExUS 2–3 is Sp but not S.
IRVF = a real-time marker of readiness, not long-term outcomes.
#POCUS #Ultrasound #CriticalCare #IRVF #VExUS #FluidManagement #ICU #MedSci
Discontinuous IRVF = 4× higher success in deresuscitation, with 87% S.
VExUS 2–3 is Sp but not S.
IRVF = a real-time marker of readiness, not long-term outcomes.
#POCUS #Ultrasound #CriticalCare #IRVF #VExUS #FluidManagement #ICU #MedSci
Deresuscitation has become more and more ubiquitous within ICU practice. But what tools can we use to do it? Over the next 2 Tweetorials, i’ll explain some pharmacological methods. Focussing on the JICS mix!
My talk from #ACCS2023
#FOAMed #POCUS #FOAMcc #medtwitter
My talk from #ACCS2023
#FOAMed #POCUS #FOAMcc #medtwitter
November 18, 2024 at 5:53 PM
Deresuscitation has become more and more ubiquitous within ICU practice. But what tools can we use to do it? Over the next 2 Tweetorials, i’ll explain some pharmacological methods. Focussing on the JICS mix!
My talk from #ACCS2023
#FOAMed #POCUS #FOAMcc #medtwitter
My talk from #ACCS2023
#FOAMed #POCUS #FOAMcc #medtwitter
I think the last decades of Critical Care Medicine research has shifted to an emphasis on deresuscitation from an emphasis on resuscitation and to me this makes sense
(Although obviously they both are important)
(Although obviously they both are important)
November 29, 2024 at 3:03 PM
I think the last decades of Critical Care Medicine research has shifted to an emphasis on deresuscitation from an emphasis on resuscitation and to me this makes sense
(Although obviously they both are important)
(Although obviously they both are important)
This PM lots of POCUS hands on
And a lesson on bioimpedance analysis for fluid assessment
pubmed.ncbi.nlm.nih.gov/25432557/
And a lesson on bioimpedance analysis for fluid assessment
pubmed.ncbi.nlm.nih.gov/25432557/
The use of bio-electrical impedance analysis (BIA) to guide fluid management, resuscitation and deresuscitation in critically ill patients: a bench-to-bedside review - PubMed
The impact of a positive fluid balance on morbidity and mortality has been well established. However, little is known about how to monitor fluid status and fluid overload. This narrative review summarises the recent literature and discusses the different parameters related to bio-electrical impedanc …
pubmed.ncbi.nlm.nih.gov
November 20, 2025 at 2:48 PM
This PM lots of POCUS hands on
And a lesson on bioimpedance analysis for fluid assessment
pubmed.ncbi.nlm.nih.gov/25432557/
And a lesson on bioimpedance analysis for fluid assessment
pubmed.ncbi.nlm.nih.gov/25432557/
Come along and here all about ‘deresuscitation’ with myself, @icmteaching and @ICUltrasonica.
I’m going to talk about excess fluid removal, the JICS mix way at #ACCS2023 Manchester. #FOAMed #POCUS #FOAMcc #medtwitter @veerappan91050 @iceman_ex
I’m going to talk about excess fluid removal, the JICS mix way at #ACCS2023 Manchester. #FOAMed #POCUS #FOAMcc #medtwitter @veerappan91050 @iceman_ex
November 18, 2024 at 5:54 PM
Come along and here all about ‘deresuscitation’ with myself, @icmteaching and @ICUltrasonica.
I’m going to talk about excess fluid removal, the JICS mix way at #ACCS2023 Manchester. #FOAMed #POCUS #FOAMcc #medtwitter @veerappan91050 @iceman_ex
I’m going to talk about excess fluid removal, the JICS mix way at #ACCS2023 Manchester. #FOAMed #POCUS #FOAMcc #medtwitter @veerappan91050 @iceman_ex