#DigestiveAutoimmunity
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The bidirectional Thymus-Gut Axis: redefining central tolerance in digestive autoimmunity #MolecularMedicine #DigestiveAutoimmunity #IBD #PSC #AIH #CeliacDisease link.springer.com/article/10.1...
Figure 1. Therapeutic strategies and Clinical models of thymus-gut axis in digestive autoimmunity. This figure illustrates three main therapeutic approaches targeting the thymus-gut axis. (1) Thymic rejuvenation: Using agents like KGF, RANKL, or rapamycin to promote thymic epithelial cell proliferation, restoring thymic function and naïve T cell output. (2) Antigen-specific tTreg therapy: Engineered tTregs generated via TCR/CAR engineering or extracellular vesicle (EV) platforms precisely home to digestive tissues to locally suppress autoreactive T cells. (3) Clinical thymectomy: Serving as a natural clinical model, it can cure thymoma-associated paraneoplastic digestive syndromes but impairs tTreg generation and increases long-term autoimmunity risk. Restoring the balance of this axis ultimately aims to re-establish immune tolerance and achieve disease remission.
August 13, 2026 at 6:41 PM