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🎓 From around the world to Vienna: #CeMM welcomes its 2026 cohort of international #PhD students! Ready to collaborate, discover & push the boundaries of #molecularmedicine together. 👩‍🔬👨🏿‍🔬
October 1, 2026 at 1:02 PM
mlopes0811.bsky.social
#tbt to when I received the fantastic news that I was selected as a winner of the 2025 International Journal of Molecular Sciences (IJMS) Young Investigator Award! 👨🏻‍🔬🏆

#IJMS #YoungInvestigator #MolecularMedicine #BiomedicalResearch
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www.mdpi.com/journal/ijms...
October 1, 2026 at 1:51 PM
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The Ohio State University is hiring:
Research Scientist - Molecular Medicine & Therapeutics

#researcher #medicine #molecularmedicine
September 28, 2026 at 9:32 AM
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USP2 inhibition destabilizes STUB1 to suppress pathological #Pexophagy in PEX1-deficient models, restoring peroxisome abundance while mitigating metabolic abnormalities, neuro-axonal pathology, and motor dysfunction.

#STTT #OpenAccess: doi.org/10.1038/s413...
#Neurobiology #MolecularMedicine
Inhibition of USP2 suppresses pathological pexophagy and rescues PEX1-deficient peroxisome biogenesis disorder
September 27, 2026 at 6:45 AM
northwell-journals.bsky.social
Molecular Medicine - Journal

Article in Press: Dysregulation of DNA replication licensing factors in cancer | #MolecularMedicine #Cancer #PrereplicativeComplex link.springer.com/article/10.1...
September 23, 2026 at 4:04 PM
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Molecular Medicine - Journal

Article in Press: Urinary collagen type I degradation products as common fibrosis biomarkers in chronic diseases | #MolecularMedicine #Fibrosis #Biomarkers #CKD link.springer.com/article/10.1...
Urinary collagen type I degradation products as common fibrosis biomarkers in chronic diseases - Molecular Medicine
Background Fibrosis, characterised by excessive accumulation of collagen type I (COL1), is a common feature of chronic diseases, including liver diseases (LDs), chronic kidney disease (CKD) and heart ...
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September 23, 2026 at 4:37 PM
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Molecular Medicine - Journal

Article in Press: Pericytes within tumour and other angiogenic microenvironments as potential targets for therapeutic viruses | #MolecularMedicine #Pericytes #CancerAngiogenesis #OncolyticViruses link.springer.com/article/10.1...
Fig. 1 Pericytes are infected by VSV following systemic VSV treatment. A Schematic of imaging experiment timeline.
September 23, 2026 at 4:03 PM
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Molecular Medicine - Journal
Article in Press: TGF-β1 signaling in Crohn’s disease | #MolecularMedicine #TGFbeta #CrohnsDisease link.springer.com/article/10.1...
TGF-β1 signaling in Crohn’s disease - Molecular Medicine
Crohn's disease (CD), a chronic inflammatory disorder of the gastrointestinal tract, arises from the intricate interplay among genetic predisposition, environmental triggers, and gut microbial communi...
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September 23, 2026 at 3:37 PM
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Molecular Medicine - Journal

Article in Press: Bacterial communication in the gut: interbacterial and bacteria-host crosstalk | #MolecularMedicine #BacterialCommunication #MicrobialCrosstalk #GutMicrobiome link.springer.com/article/10.1...
Fig. 3 Influencing factors on bacterial communication. Bacterial communication is regulated by diverse factors originating from bacteria, gut microenvironment and signaling molecules. A. Overview of factors influencing bacterial communication, in which bacterial-derived elements include population density and mutant strains, gut environmental regulators comprise antibiotics, pH, gut motility and host immunity, and signaling molecules are modulated by their diffusion mode and rate as well as competitive inhibition.
September 23, 2026 at 4:06 PM
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Molecular Medicine - Journal
Article in Press: Proteogenomic Analysis of HDAC4 and HDAC5 in Uveal Melanoma | #MolecularMedicine #HDAC #UvealMelanoma #Proteogenomics link.springer.com/article/10.1...
Proteogenomic Analysis of HDAC4 and HDAC5 in Uveal Melanoma - Molecular Medicine
Uveal melanoma (UM) is a rare but aggressive cancer arising from cells of the uveal tract that is highly resistant to therapy once it has metastasized. In drug screening experiments, we identified a h...
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September 23, 2026 at 4:36 PM
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Molecular Medicine - Journal

Article in Press: Multi-omics in systemic sclerosis with emphasis on extracellular vesicles | #MolecularMedicine #ExtracellularVesicles #Multiomics #SystemicSclerosis link.springer.com/article/10.1...
Fig. 2 Schematic summary of the major metabolic pathways that are dysregulated in SSc. In each pathway (amino acid metabolism, lipid metabolism, mitochondrial metabolism, carbohydrate metabolism), the metabolites whose expression has been found to be modulated in patients’ plasma are listed. The impacted pathophysiological pathways are indicated (fibrosis in orange, immune alteration in violet and vascular dysfunction in red). TCA: Tricarboxylic Acid Cycle; GLUT-1: Glutamate Transporter-1
September 23, 2026 at 4:05 PM
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Molecular Medicine - Journal

Article in Press: Dopamine alters macrophage metabolism promoting intracellular Mycobacterium tuberculosis survival | #MolecularMedicine #dopamine #tuberculosis #macrophages link.springer.com/article/10.1...
Fig. 1 Dopamine induces accumulation of iron in macrophages. A-C Cellular labile iron pool evaluated in macrophages using Calcein AM staining and flowcytometry. (A) THP-1 macrophages and (B) mice primary peritoneal macrophages (PMQ). THP-1 and PMQ were treated with different concentrations of dopamine for 24 h in culture. The intracellular labile iron pool is significantly increased upon incubation with 250 µM DA. Data is presented as MFI ± SD (upper panels). Statistical significance was evaluated using unpaired t-test (n = 3 *p < 0.05, **p < 0.01). All Experiments were repeated three times and one representative data is presented. Lower panels depict one representative FACS overlay histograms plotted for data from n = 104 cells per histogram using flowjo software. C The labile iron pool is also significantly elevated in PMQ isolated from mice administered DA for 3 days. C57 BL/6 mice were injected i.p with 5 mg/kg DA in 200 ul PBS every 12 h for 3 days. Control represents cell....
September 23, 2026 at 3:38 PM
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Molecular Medicine - Journal
Article in Press: Oxidative stress and endothelial dysfunction: linking cellular damage to cardiovascular disease and erectile dysfunction | #MolecularMedicine #CVD #ED #OxidativeStress #EndothelialDysfunction link.springer.com/article/10.1...
Fig. 1 Cardiovascular sources of ROS. The primary sources of reactive oxygen species (ROS) in the cardiovascular system include mitochondrial dysfunction, NADPH oxidases (NOX), xanthine oxidase (XO), and uncoupled endothelial nitric oxide synthase (eNOS). A Triggers, such as chronic inflammation and hyperglycemia, cause mitochondrial membrane potential loss, which induces leakage of free radicals like superoxide anions and hydroxyl radicals. B In the presence of xanthine oxidase, hypoxic conditions may also activate the conversion of xanthine and hypoxanthine to uric acid, which is a potent pro-oxidant. C In addition, inflammatory mediators activates NADPH oxidases (NOX) to produce free radicals. D Under pathological conditions, such as dyslipidaemia or renal impairment, eNOS becomes uncoupled and produce superoxide instead of nitric oxide, in the presence of cofactors like as tetrahydrobiopterin (BH4). (E) Metabolic and inflammatory pathological amplifiers, such as diabetes and ......
September 23, 2026 at 4:35 PM
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Molecular Medicine - Journal
Bioengineered microtissue model of the human nigrostriatal pathway featuring centimeter-scale axon tracts and structural maturation over 6 months in vitro | #MolecularMedicine #Bioengineering #iPSC #inVitroModels #DopaminergicNeurons link.springer.com/article/10.1...
Fig. 1 Assessment and comparison of aggregated human iPSC-derived DA neuronal cultures on different coating surfaces. Representative confocal images show comparison of neurite growth pattern of DA neurons (110,000 cells/aggregate) on ... D- Immunocytochemistry (ICC) images validate DA neuronal markers such as βIII-tubulin (all axons, green), MAP2 (Microtubule-Associated Protein 2; soma and dendrites, gray) and TH (Tyrosine Hydroxylase; DA axons, red). E -Magnified images shown in the inset: enlarged overlay image (top) and individual channel images (bottom) highlight robust DA neuronal markers in the aggregate. F -Magnified images of peripheral neurites shown in the inset demonstrate individual channel images of TH and βIII-tubulin.
September 23, 2026 at 4:34 PM
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UT Southwestern Medical Center is hiring:
Tenure Track Assistant Professor in Molecular Medicine

#assistantprofessor #medicine #molecularmedicine
September 18, 2026 at 10:42 PM
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Molecular Medicine - Journal
Article in Press: Development and validation of a 10-metabolite prognostic model for 4-year all-cause mortality in heart failure with preserved ejection fraction in the Chinese Han population | #MolecularMedicine #HeartFailure #HFpEF link.springer.com/article/10.1...
Fig. 4 The core part of metabolic responses extracted from the metabolic network (Supplementary Figure S9 and S10) constructed based on metabolomics and transcriptomics
September 16, 2026 at 6:50 PM
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Molecular Medicine - Journal
Article in Press: USP7-mediated stabilization of Snail1 drives macrophage-to-myofibroblast transition and promotes postoperative peritoneal adhesions | #MolecularMedicine #PostoperativePeritonealAdhesions #Surgery #Olaparib link.springer.com/article/10.1...
USP7-mediated stabilization of Snail1 drives macrophage-to-myofibroblast transition and promotes postoperative peritoneal adhesions - Molecular Medicine
Background Postoperative peritoneal adhesions (PPAs) are a common and serious complication following abdominal surgery. The key pathological basis is the excessive accumulation of myofibroblasts durin...
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September 16, 2026 at 6:45 PM
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Molecular Medicine - Journal
Article in Press: Metabolism-guided precision oncology in hepatocellular carcinoma: vascular, stromal and immune crosstalk | #MolecularMedicine #HepatocelluarCarcinoma #HCC #Metabolomics link.springer.com/article/10.1...
Fig. 6 Therapeutic strategies targeting metabolic–vascular interactions in HCC. This schematic summarizes therapeutic concepts that arise from metabolism–vascular crosstalk in HCC. The figure is organized into four modules: tumor-intrinsic metabolic targets, endothelial cell metabolism and angiogenesis, stromal and myeloid targeting, and rational combination strategies. Tumor-intrinsic metabolic interventions include inhibition of lactate production, lactate transport, glycolytic enzymes, glutamine metabolism, fatty-acid oxidation, and lactylation-associated signaling. Endothelial-directed strategies include anti-VEGF/VEGFR therapies, PFKFB3 inhibition, and modulation of endothelial barrier function. Stromal and myeloid strategies include TAM repolarization, lactylation-related targeting, TGF-β inhibition, CAF modulation, and periostin blockade. The combination module illustrates how metabolic interventions may be paired with anti-angiogenic therapy or PD-1/PD-L1 blockade to enhance vascular normalization and anti-tumor immunity. Approved anti-angiogenic and immunecheckpoint therapies are shown as established clinical backbones, whereas metabolic, stromal, lactylation-associated, and CAF/TAM-directed strategies should be interpreted as investigational or preclinical candidates for biomarker-enriched testing rather than as established treatment options. Approved agents are shown in solid blue boxes, whereas investigational and preclinical strategies are shown in gray boxes with dashed outlines.
September 16, 2026 at 6:49 PM
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Molecular Medicine - Journal
Article in Press: Meta-transcriptomic analysis identifies suppressed FGF/FGFR signaling as a consistent molecular feature of impaired angiogenic repair in Diabetic Foot Ulcers | #MolecularMedicine #DiabeticFootUlcers #FGF link.springer.com/article/10.1...
Fig. 12 1) Integrated transcriptomic analysis of each microarray and RNA-seq cohort reveals convergent DFU signature with downregulated DEGs enriched for epidermal differentiation, keratinization and extracellular matrix organization gene ontology terms; 2) Gene set variation analysis (GSVA) and Protein–protein interaction networks (PPIN) indicated FGF/FGFR network components are downregulated in DFU; 3) Weighted gene co-expression network analysis (WGCNA) showed a module associated with inflammatory activation positively correlated with DFU status in the microarray cohort, while FGF/FGFR signaling modules were negatively correlated with DFU status in the RNA-seq cohort, Cell-type enrichment analysis revealed reduced stromal and reparative cell populations in the wound microenvironment.; 4) DFU diagnostic model tested and validated across microarray and RNA-seq cohorts identified nine marker genes in a random forest classifier. Among commonly up-regulated DEGs, SERPINE1 was highlig...
September 16, 2026 at 6:46 PM
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Molecular Medicine-Journal
Article in Press: The nutrition–microbiota–gut–kidney axis in acute kidney injury: molecular mechanisms, candidate biomarkers, and investigational intervention strategies #MolecularMedicine #Nutrition #GutMicrobiota #AcuteKidneyInjury link.springer.com/article/10.1...
September 10, 2026 at 3:50 PM
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Molecular Medicine - Journal
Article in Press: Endoplasmic reticulum stress-mediated PPARα-DDX3X interaction promotes immune-induced liver injury | #MolecularMedicine #PPAR #EndoplasmicReticulum #ImmuneSystem #LiverInjury
September 10, 2026 at 3:55 PM
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Molecular Medicine - Journal
Article in Press: Transmembrane glycoprotein GPNMB is a candidate predictive biomarker and target in metastatic renal cell carcinoma | #MolecularMedicine #Biomarkers #RenalCellCarcinoma #mRCC link.springer.com/article/10.1...
September 10, 2026 at 3:54 PM
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Molecular Medicine - Journal

Article in Press: Glucose-dependent regulation of hepatic adipsin controls glucose uptake and tolerance | #MolecularMedicine #Glucose #Adipsin #Hepatocytes #Liver #Diabetes #MASLD link.springer.com/article/10.1...
September 10, 2026 at 3:42 PM
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Molecular Medicine - Journal

Article in Press: HEATR1 deficiency enhanced gastric cancer cell PANoptosis to boost anti-tumor immunity | #MolecularMedicine #GastricCancer #PANoptosis #HEATR1 #ImmuneCheckpointInhibitor link.springer.com/article/10.1...
Fig. 6 HEATR1 knockdown PDOs were prone to PANoptosis and enhanced DC-primed CD8+ T cell expansion. A PDOs and PMBC-derived CD8+ T cells and immature DCs were obtained from the same patient. After pulsing with PDO supernatants, mature DCs were cocultured with CD8+ T cells.
September 10, 2026 at 3:38 PM
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Molecular Medicine - Journal
Article in Press: Recent advances in delivery strategies for CRISPR-based genome editing | #MolecularMedicine #CRISPR #GenomeEditing link.springer.com/article/10.1...
Fig. 2 Multiple strategies for CRISPR delivery. A Clinical CRISPR-based genome editing can be accomplished by either in vivo or ex vivo delivery strategies. The ex vivo strategy entails the extraction of target cells from the patient, followed by precision genome editing within a controlled biomanufacturing environment, and concludes with the reinfusion or engraftment of the modified cells. Conversely, the in vivo strategy involves the direct administration of the CRISPR machinery into the patient, requiring the diverse delivery methods to successfully navigate physiological barriers to reach the designated tissues. B Four primary categories of vectors utilized for the intracellular CRISPR delivery. Viral vectors leverage the highly evolved infectious pathways of viruses, such as adenovirus, adeno-associated virus, and lentivirus. Physical methods actively induce transient cellular porosity, encompassing microinjection and electroporation. Nanoparticle-based methods, provide high....
September 10, 2026 at 3:52 PM