Read the full paper: SIRT7 Inhibits Adipose Tissue Browning Through Deacetylation of PPARγ2 at K382

A 356-patient Japanese trial found the selective PPARα modulator pemafibrate reduced liver enzymes in a dose-dependent manner and preserved kidney function better than fenofibrate in patients with

Lamin A/C proteins, integral to the nuclear lamina and present throughout the nucleoplasm, contribute to the mechanical stability of the nucleus and influence transcription as seen in laminopathies…

Abstract Objectives To investigate the effects of naringenin on pathological, molecular, and behavioural alterations in a cuprizone-induced mouse model of demyelination, with particular emphasis on peroxisome proliferator-activated receptor (PPAR) gamma expression, NOD-like receptor family pyrin ...

AbstractWhile exposure to PPAR active compounds can lead to various adverse health effects, studies on the environmental contaminants and their transformation products with PPAR activity remain limited. This study employed PPARγ protein affinity selection-mass spectrometry (AS-MS) to comprehensively identify and prioritize PPARγ-active contaminants in the Yangtze and Yellow Rivers, key drinking water sources in China. From wastewater treatment plant effluents, river, and source water samples, 61 PPARγ ligands were identified, including 18 antagonists not reported previously. Notably, a novel biodegradation product of di-2-ethylhexyl phthalate (DEHP), phthalic acid 1-(2-ethylhexyl) 2-(2-ethyl-5-carboxypentyl) ester (5CX-DEHP), was discovered and characterized as a potent PPARγ antagonist (IC50 = 8.5 μM). Semi-quantification revealed total concentrations of 61 chemicals ranging from 965.2 to 5748 ng/L in source waters, with priority agonistic chemicals such as 4-dodecylbenzenesulfonic acid and priority antagonistic chemicals such as 2-amino-6-methylmercaptopurine and 5CX-DEHP posing high ranking. This study comprehensively revealed the widespread occurrence of PPARγ agonistic and antagonistic chemicals in the water samples and identified a previously overlooked transformation product of DEHP as a relatively strong PPARγ antagonist.

2026.10.01 東北大学 プレスリリース 【発表のポイント】肥満症が胃噴門部腺がん(注 1)を進展させる機序として、腸内環境異常によるプログラム細胞死(注 2) (...

Interdomain interactions by the disordered N-terminal region in PPAR transcription factors lead to autoinhibition of DNA binding. The effect is strongest for the monomer suggesting inhibition of untimely DNA binding prior to heterodimer formation.

Farmworkers face disproportionate risks of metabolic syndrome with chronic exposure to organophosphate pesticides.

Pterostilbene, a compound found naturally in some foods, affects how skeletal muscles process fats by stabilizing a protein called PPARδ and increasing its signaling activity. Pterostilbene, a natura...