#MetabolicDysfunction
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andrewtosolini.bsky.social
Really pleased for David and Chloe to see this published. Was a great collaboration

#ALS #MND #SOD1 #metabolicdysfunction

@uclqsion.bsky.social
braincomms.bsky.social Brain Communications @braincomms.bsky.social · 5d
Thompson et al. report the generation and characterization of novel gene-edited mice expressing the human superoxide dismutase 1 (SOD1) gene and carrying the pathogenic SOD1A5V mutation associated with amyotrophic lateral sclerosis.

Read it at 👉https://buff.ly/J8mz8dt

#neuroscience #ALS
September 28, 2026 at 12:20 AM
sigtrans-sttt.bsky.social
Inotodiol activates LXRβ and promotes PPARδ-dependent #SIRT3 transcription, engaging the LXRβ/SIRT3/PGC-1α pathway to restore mitochondrial function and counter age-associated #MuscleWasting and #MetabolicDysfunction.

#STTT #OpenAccess: doi.org/10.1038/s413...
Inotodiol prevents age-related muscle wasting by restoring mitochondrial function through liver X receptor beta signaling
September 29, 2026 at 5:38 AM
itmat.bsky.social
Establishing #Fruitfly model to discern #MolecularMechanisms of #Sleep & #CircadianClock related #MetabolicDysfunction for developing #TherapeuticOpportunities elifesciences.org/articles/108... @weljielab #Metabolomics #TranslationalScience
Integrated respirometry and metabolomics unveil circadian metabolic dynamics in Drosophila
Wild-type flies anticipate daily respiratory demands by coordinating substrate use, whereas short-sleep and clock-deficient mutants shift toward reactive fuel use and altered redox metabolism.
elifesciences.org
September 29, 2026 at 6:40 PM
ilona-n.bsky.social
Who are these people?!?!?
Seems like it’s time for Dr. Ilona to conjure her bitch endocrinologist mode.

#metabolicdysfunction
#endocrinology
#MedSky
mementomorty.bsky.social Memento (artemis) Morty 🌙 @mementomorty.bsky.social · Apr 1
The vast majority of people don't hate on drugs like Ozempic out of concern for others. They're hating on it because they don't want fat people do feel good or be happy and think that there is some moral failing associated with obesity and those drugs are "cheating"
cait.bsky.social cait (and adonis) @cait.bsky.social · Apr 1
it's fine and even understandable that people would have concerns about various aspects of Ozempic but I keep seeing people gleefully anticipating some sort of horrific long-term side effects and that's really really weird
April 3, 2025 at 8:20 PM
itmat.bsky.social
#MechanicalStress to #MetabolicDysfunction & #Contractile impairment with #Cytoskeletal #Remodeling & #AMPK #Signaling as potential #TherapeuticTargets in #HeartFailure doi.org/10.1016/j.ce... @MarguliesLab #TranslationalScience
Redirecting
doi.org
June 23, 2026 at 8:39 PM
ntumeta.bsky.social
@ntumeta.bsky.social had a great time at #SFEBES2026 sharing work via talks & posters on #AdiposeBiology, #developmentalProgramming & #metabolicDysfunction. Proud of everyone who presented—great science & collaborations! @mark-christian-lab.bsky.social @nkalender.bsky.social @jhobbs22.bsky.social
March 8, 2026 at 10:29 AM
dagette.bsky.social
2/3 Menstrual cycle difficulties, such as irregular periods or severe PMS, may be linked to underlying metabolic dysfunction. Conditions like insulin resistance or thyroid imbalances can exacerbate these issues, highlighting the need for a holistic approach to women’s health. #MetabolicDysfunction
December 25, 2024 at 8:56 PM
bionewscentral.com
A study in mice found that #HighFatDiets cause #MetabolicEnzyme #dysregulation leading to #WeightGain and higher #DiabetesRisk, which can be reversed by #AntioxidantTreatment.
#MetabolicDysfunction
A high-fat diet sets off metabolic dysfunction in cells, leading to weight gain – BioNews Central
A study in mice found that high-fat diets cause metabolic enzyme dysregulation leading to weight gain and higher diabetes risk, which can be reversed by antioxidant treatment. ...
sbee.link
May 30, 2025 at 7:55 PM
liversmdpi.bsky.social
📢 Article in #LiversMDPI

🧬 In midlife women, menopause predicted reduced QoL and higher MASLD rates.
🩺 MASLD did not independently impact QoL despite metabolic links.

📖 Read more: www.mdpi.com/2673-4389/6/...

#menopause #MASLD #QualityOfLife #MetabolicDysfunction
July 20, 2026 at 1:38 PM
gastroadvisor.bsky.social
#MetabolicDysfunction does not increase risk for mortality in severe #AlcoholAssociatedHepatitis. #GastroSky
Metabolic Dysfunction Does Not Increase Mortality in Severe Alcohol-Associated Hepatitis
Metabolic dysfunction is not associated with increased mortality among individuals with severe alcohol-associated hepatitis.
www.gastroenterologyadvisor.com
June 5, 2026 at 10:10 PM
currentmedscience.bsky.social
An overview of the #Neuroprotective role of #Naringin and #Naringenin, elucidating their potency in targeting #AlzheimersDisease #Pathophysiology by modulating amyloid-β and #MetabolicDysfunction while addressing delivery limitations.

Read: doi.org/10.1007/s115...
Naringin and Naringenin: Potential Multi-Target Agents for Alzheimer’s Disease
March 4, 2026 at 6:30 AM
stephscythes.bsky.social
"Evidence from 50 countries links high #UPF consumption to #obesity & #metabolicdysfunction such as #Parkinson’sdisease. ...both industries had used similar strategies to evade #regulation and increase product appeal, which “collectively hijack human biology”. ”
#medsky
apple.news/APfcgwc9HRoy...
Ultra-processed foods have more in common with cigarettes than vegetables, study finds — The Independent
UPF consumption has been linked to obesity, type 2 diabetes, cardiovascular disease and mental health issues
apple.news
February 3, 2026 at 11:48 AM
robertlufkinmd.bsky.social
As a medical school professor, I taught that psychiatric drugs fix "chemical imbalances." But a new Nature Mental Health paper from Stanford just flipped that model.

Dr. Sh...
#MetabolicPsychiatry #MentalHealth #MetabolicDysfunction #BrainHealth #Longevity
https://doi.org/10.1038/s44220-026-00609-5
April 3, 2026 at 1:42 PM
robertlufkinmd.bsky.social
Low testosterone + high fructose = a liver disaster hiding in plain sight.

As a medical school professor, I teach that metabolic risk factors rarely act alone. A n... https://www.omu.ac.jp/en/info/research-news/entry-105164.html

#LiverHealth #Testosterone #Fructose #GutHealth #MetabolicDysfunction
March 18, 2026 at 12:41 PM
4040rec.bsky.social
#BoehringerIngelheim #Survodutide #weightloss #glucagonGLP1dualagonist #obesity #Synchronize1trial #metabolicdysfunction #metabolicliverdisease #type2diabetes #cardiovasculardisease #obesityassociatedmetabolicliverdiseases #MASLD #MASH #SynchronizeMASLDtrial #liverfatnormalisation
zurl.co/rDKvG
Survodutide trial data show targeted visceral and liver fat reductions - PharmaTimes
Phase 3 results highlight metabolic benefits alongside weight loss
pharmatimes.com
June 8, 2026 at 8:53 AM
apspublications.bsky.social
Function 🚨 New Article Alert! Baily SM reviews the literature to examine the relationship between #alcohol, #CircadianRegulation, and #MetabolicDysfunction & #OrganInjury. 🍷🛏️🫀Read doi.org/10.1152/func...
February 25, 2026 at 2:30 PM
tenuretracker.bsky.social
Karolinska Institute (@ki.se) is hiring:
Postdoctoral Studies in Integrative Metabolism

#postdoc #medicine #metabolicdysfunction
July 4, 2026 at 10:43 PM
achronicvoice.com
" #MetabolicDysfunction -associated steatotic #LiverDisease (MASLD) affects up to 70 percent of patients who have type 2 #diabetes or #obesity, yet reliable, routine screening for liver disease is anything but commonplace.": buff.ly/1m7AKlA

via kevinmd
#metabolism
The liver's role in metabolic disease
MASLD is a critical driver of metabolic disease, not just a complication. Routine liver screening is essential for early intervention in diabetes and cardiovascular disease. Learn why.
buff.ly
December 9, 2025 at 7:30 AM
bionewscentral.com
A new mouse study suggests the #LongTerm #KetogenicDiet may harm #MetabolicHealth—disrupting #fat and #carbohydrate processing—and raises concerns about its #safety and #effectiveness. 
#MetabolicDysfunction #GlucoseIntolerance #FattyLiverDisease
Study in mice reveals long-term metabolic risks of ketogenic diet – BioNews Central
A new mouse study suggests the long-term ketogenic diet may harm metabolic health—disrupting fat and carbohydrate processing—and raises concerns about its safety and effectiveness. ...
sbee.link
October 22, 2025 at 6:23 PM
bionewscentral.com
A study of people with #Type2Diabetes found that nearly sixty percent had #FattyLiver, a small percentage developed severe #LiverDisease, and those with both type 2 diabetes and #obesity were at higher risk of disease progression.
#MetabolicDysfunction #MASLD
Fatty liver, but not liver damage, is common among individuals with type 2 diabetes – BioNews Central
A study of people with type 2 diabetes found that nearly sixty percent had fatty liver, a small percentage developed severe liver disease, and those with both type 2 diabetes and obesity were at higher risk of disease progression. ...
sbee.link
June 18, 2025 at 3:15 AM
sigtrans-sttt.bsky.social
Researchers identified that myeloid Mas promotes #Inflammatory #Senescence in #MASLD through PKM2-mediated Spi1 lactylation, revealing a potential #TherapeuticTarget for controlling hepatic inflammation and #MetabolicDysfunction.
#STTT #OpenAccess: doi.org/10.1038/s413...
Myeloid Mas drives pyruvate kinase M2-mediated Spi1 lactylation to fuel inflammatory senescence in MASLD
May 21, 2026 at 1:30 PM
genesndiseases.bsky.social
Tirzepatide shows promise in alleviating metabolic dysfunction-associated steatotic liver disease, supporting its potential as a treatment for metabolic liver disorders.
www.sciencedirect.com/science/arti...
#Tirzepatide #MASLD #MetabolicDysfunction #SteatoticLiverDisease #MetabolicHealth
June 30, 2026 at 8:29 AM
genesndiseases.bsky.social
This study shows that #tirzepatide reduces liver fat accumulation in #MetabolicDysfunction-associated steatohepatitis (#MASLD) by downregulating #CD36 and OBP2A, suggesting its potential as a #therapeutic strategy for MASLD. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
September 17, 2025 at 12:30 AM