#Pericytes
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rridrobot.bsky.social
RRIDs were included in this in Diabetes paper. RRIDs improve reproducibility in scientific research. #reproducibility #OpenResearch #accelerateopenscience
HGF Endogenously Produced by Pancreatic Pericytes Regulates β-Cell Function
Read the full paper: HGF Endogenously Produced by Pancreatic Pericytes Regulates β-Cell Function
doi.org
October 28, 2026 at 7:00 AM
biorxiv-neursci.bsky.social
Brain pericytes are an oxidative stress-sensitive cell population damaged through ROS-1 dependent TRPA1 activation. https://www.biorxiv.org/content/10.64898/2026.10.19.760199v1
October 24, 2026 at 11:17 AM
prepub-neurodegen.bsky.social
Brain pericytes are an oxidative stress-sensitive cell population damaged through ROS-1 dependent TRPA1 activation. #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.10.19.760199v1
October 24, 2026 at 1:01 PM
biorxivpreprint.bsky.social
Brain pericytes are an oxidative stress-sensitive cell population damaged through ROS-1 dependent TRPA1 activation. https://www.biorxiv.org/content/10.64898/2026.10.19.760199v1
October 24, 2026 at 11:17 AM
rridrobot.bsky.social
The authors included RRIDs in their in Molecular Neurobiology paper! We value the author's support of reproducibility. #ReproducibleResearch #OpenScience #OpenResearch
Latent HIV Infection of BBB Pericytes Enhances Gap Junction-mediated Crosstalk with Endothelial Cells
Read the full paper: Latent HIV Infection of BBB Pericytes Enhances Gap Junction-mediated Crosstalk with Endothelial Cells
doi.org
October 23, 2026 at 7:00 AM
adapubs.bsky.social
⭐ 📖 Paper of the Month: Nov

HGF Endogenously Produced by Pancreatic Pericytes Regulates β-Cell Function ➡️ doi.org/10.2337/db26-0227

Articles chosen 🗓️ monthly & 🆓 online #paperofthemonth #diabetes
This image shows an article cover from the journal "Diabetes" by the American Diabetes Association. The title is about HGF produced by pancreatic pericytes regulating β-cell function. There are two diagrams: one labeled "Embryogenesis, Pregnancy" showing β-cell expansion, and the other labeled "Adulthood" depicting insulin production. The graphic is on a textured black background with the text "Paper of the Month" at the bottom.
October 21, 2026 at 7:15 PM
nature.com
Nature research paper: Capillary-selective vasodilation through myosin inhibition halts ischaemic cascades

go.nature.com/4dGCcwP
Capillary-selective vasodilation through myosin inhibition halts ischaemic cascades - Nature
R(+)2501 reverses capillary no-reflow by relaxing pericytes, restoring microvascular perfusion and improving survival in animal models of myocardial infarction and acute kidney injury.
go.nature.com
October 20, 2026 at 12:13 PM
topladave.bsky.social
Nature research paper: Capillary-selective vasodilation through myosin inhibition halts ischaemic cascades.

www.nature.com/articles/s41...
Capillary-selective vasodilation through myosin inhibition halts ischaemic cascades - Nature
R(+)2501 reverses capillary no-reflow by relaxing pericytes, restoring microvascular perfusion and improving survival in animal models of myocardial infarction and acute kidney injury.
www.nature.com
October 20, 2026 at 4:12 PM
bpodaily.bsky.social
Alzheimer's-associated gene variant APOE4 promotes change of pericytes to myofibroblasts in the brain due to a raise TGF-β signalling => vessel fibrosis + plaques

📸 Braxton Schuldt et al @joelwblanchard.bsky.social Icahn School of Medicine in @cp-cell.bsky.social

➡️ bpod.org.uk/archive/2026...
October 18, 2026 at 9:14 AM
thephoenix.community
🧵 2/3
The headline: 0 neurons changed, yet deleting APOE4 from capillary pericytes restored spatial memory in mice.
In 1,000+ Brazilian brains, carriers with high education and social support held onto cognition despite the same plaque burden as those who declined.
Flame hero stat slide. Removing APOE4 from vessel-wrapping pericytes restored spatial memory in mice, with zero neuron changes. Navy slide on the Brazilian brain study. Education and social support tracked with preserved cognition at equal plaque load. Light slide. In APOE4 mice a vessel growth signal fell about 45% at an age mapping to human 40s and 50s. Navy slide. APOE4 immune cells showed about 3x higher activation and stayed overreactive even after being replaced.
October 18, 2026 at 9:11 PM
cathy007.bsky.social
www.nature.com/articles/s41...
Capillary-selective vasodilation through myosin inhibition halts ischaemic cascades - Nature
R(+)2501 reverses capillary no-reflow by relaxing pericytes, restoring microvascular perfusion and improving survival in animal models of myocardial infarction and acute kidney injury.
www.nature.com
October 16, 2026 at 4:25 PM
www.nature.com/articles/s41...

fantastic work describing a new inhibitor that targets smooth muscle myosin
Capillary-selective vasodilation through myosin inhibition halts ischaemic cascades - Nature
R(+)2501 reverses capillary no-reflow by relaxing pericytes, restoring microvascular perfusion and improving survival in animal models of myocardial infarction and acute kidney injury.
www.nature.com
October 15, 2026 at 4:30 PM
rridrobot.bsky.social
RRIDs were included in this in Nature Communications paper. Thanks for making your methods matter! #OpenResearch #BetterScience #OpenScience
Blood flow patterns in mice are regulated by interpericyte tunneling nanotubes connecting functionally-opposite neuronal areas - Nature Communications
Although central nervous system’s function depends on blood flow patterns, the mechanism behind their formation is unknown. Here the authors show that specialized pericytes connected by tunneling nanotubes control flux patterns in the mouse retina.
doi.org
October 11, 2026 at 7:01 AM
ajpathology.bsky.social
Retinal Pericytes and Their Role in Proliferative Retinopathies

Full text: https://ajp.amjpathol.org/article/S0002-9440(26)00158-6/fulltext
October 8, 2026 at 1:27 PM
joelwblanchard.bsky.social
One of the most exciting applications of #miBrains in the Blanchard Lab is the prospect of personalized medicine.

Because miBrains start from human cells, they can be engineered to match an individual donor's genetic profile – starting from something as simple as a skin biopsy.
This picture depicts two primary cell types in the miBrain, the endothelial cell vasculature (red) and the pericytes (green). This miBrain was aged in culture for 3 weeks, allowing for complex 3D morphology to arise, and notably, the pericytes are wrapping themselves around the vasculature to support their stability, growth and barrier function.
October 6, 2026 at 3:43 PM
schalleklab.bsky.social
#FluorescenceFriday
Pericytes are tiny cells that surround microvessels. Here we show how single cells wrap their "tentacles" around retinal capillaries 👁️

Color: renders depth

bit.ly/3TFifQe

@flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social @urochester.bsky.social
October 2, 2026 at 12:25 PM
schalleklab.bsky.social
not only imaging pericytes/endothelial connectome at EM level, but we have high interest in capturing and quantifying pericyte mitochondria as well. this would be super fun to do this with you and @choroidlab.bsky.social
how difficult would it be to see/send a small snippet of EM volume ?
October 2, 2026 at 8:50 PM
shihcheng.bsky.social
Discover key findings: Unique fibrotic pericyte cluster identified in pulmonary fibrosis using single-cell RNA-seq in human lungs and mouse models, unlocking DNA regulation insights. PMID:42373667, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74910-3 #Medsky #Pharmsky #RNA 🧪
Emergence of fibrotic pericytes and their transcriptional regulation in pulmonary fibrosis | Nature Communications
Multiple cell types have been implicated in pathogenesis of pulmonary fibrosis with pericytes emerging as a new focus due to their role in promoting fibrotic remodeling. Fibrotic environment changes normal pericyte functions, but transcriptional programs regulating pericyte transition towards fibrotic state remain unclear. Utilizing single cell RNA-sequencing of human pulmonary fibrotic lungs and mouse genetic models, we identified a unique cluster of fibrosis-associated pericytes which was not present in normal lungs and exhibited a distinctive transcriptional signature indicating transition of normal pericytes to a fibrotic state. FOXF1 was identified as one of the transcription factors decreased in fibrotic pericytes. Pericyte-specific deletion of Foxf1 increased severity of pulmonary fibrosis in bleomycin mouse model as demonstrated by reduced survival, impaired lung functions, increased body weight loss and increased fibrotic remodeling. Pericyte-specific overexpression of Foxf1 a
doi.org
October 2, 2026 at 9:00 AM
prof-clark.bsky.social
MAC in the ageing choroid may be more widespread than expected—highest on macrophages, pericytes & smooth muscle cells. #AMD #Complement #Ophthalmology buff.ly/hhhvX3U
https://pubmed.ncbi.nlm.nih.gov/42818647/?utm_source=Chrome&utm_medium=rss&utm_campaign=pubmed-2&utm_content=12GmDGiSiGA9an3uAk7xg5WeD6SUYkvXu9hh-tydPALMY8vQtD&fc=20241229120800&ff=20261001125438&v=2.20.1
buff.ly
October 2, 2026 at 9:00 AM
alicefrolov.bsky.social
The Vascular Normalization Window in Anti-VEGF Therapy

I am sharing a figure intended to communicate the transient nature of vascular normalization.

#TumorAngiogenesis #VascularNormalization #AntiVEGF #TumorMicroenvironment #Pericytes #TumorVasculature #AntiangiogenicTherapy #CancerBiology
The Vascular Normalization Window in Anti-VEGF Therapy I am sharing a figure intended to communicate the transient nature of vascular normalization during anti-angiogenic treatment, a concept that continues to shape dosing and combination strategy discussions. I want to emphasize at the outset that the underlying data are simulated; the curves are constructed to reproduce trends reported across the preclinical and clinical literature rather than to present novel measurements. The plot is a temporal contour band plot rendering two opposing envelopes against time following VEGF pathway blockade. The first envelope tracks pericyte coverage of the tumor microvasculature, expressed as fractional NG2/PDGFRβ-positive perivascular investment, which rises as VEGF withdrawal reduces the destabilizing pressure on nascent endothelium. The second envelope tracks microvessel density, which declines as immature, poorly perfused vessels regress. The shaded intersection identifies the normalization window, the interval during which pericyte recruitment and basement membrane maturation restore a more physiologically competent vascular phenotype before pruning progresses toward frank hypovascularity. Within this window the figure annotates the functional correlates that motivate combination scheduling: reduced interstitial fluid pressure, attenuated hypoxia, improved oxygen and drug delivery, and partial restoration of endothelial barrier integrity. The band widths encode illustrative uncertainty, reflecting the heterogeneity in window timing and duration observed across tumor models and dosing regimens. The mechanistic argument the figure supports is that therapeutic benefit from normalization is inherently self-limiting. Sustained or excessive VEGF inhibition drives the system past the window into a hypoxic, treatment-resistant state, whereas appropriately timed cytotoxic or immunotherapeutic delivery may exploit the transient perfusion gain.
October 2, 2026 at 5:01 PM
adapubs.bsky.social
Pericytes are a significant endogenous source of hepatocyte growth factor, coupling the islet microvasculature to insulin production and glucose homeostasis.

Read here ➡️ doi.org/10.2337/db26-0227
Diagram comparing embryogenesis, pregnancy, and adulthood stages in relation to β-cells. In both stages, pericytes release HGF, activating c-Met on β-cells. During embryogenesis and pregnancy, this interaction promotes β-cell expansion, shown by a red circular arrow. In adulthood, it facilitates insulin production, with Pdx1, Insa, and Slc2a2 involved in the process.
October 1, 2026 at 8:20 PM
febsj.bsky.social
🔬 Burkhard et al. discussed how pericytes contribute to the synthesis and remodelling of the ECM in different pathophysiological conditions, and shared an atlas of the pericyte matrisome:
📕 Proteolytic remodelling of the extracellular matrix by pericytes ➡️ buff.ly/NhJzFIi
#pericyte #ECM #matrisome
September 28, 2026 at 11:40 AM
wirepulleroo.bsky.social
🌱 APOE4 may do more than raise Alzheimer's risk. A Cell study links it to a vascular shift: pericytes become myofibroblast-like cells, secrete fibronectin and promote vascular amyloid. Blocking TGF-beta reversed this in models. www.cell.com/cell/fulltex...
#Neuroscience #cell #neuroskyence #art
A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration
APOE4 causes a pericyte-to-myofibroblast transition that promotes cerebrovascular fibrosis and perivascular amyloid accumulation. TGF-β inhibition reverses this pathological remodeling and thus presen...
www.cell.com
September 28, 2026 at 8:08 AM
biologist077.bsky.social
the apoe4 gene, a major alzheimer's risk, damages brain blood vessels by turning pericytes (vessel-stabilizing cells) into scar-formers, leading to amyloid buildup. blocking a protein called tgf-beta protected these cells!
September 27, 2026 at 2:05 PM
kalmialatifolia.bsky.social
It helps to provide a URL.

www.genengnews.com/topics/trans...
APOE4 Linked to Potentially Reversible Mechanisms of Brain Blood Vessel Damage in Alzheimer’s
The team found mechanisms by which APOE4 changed pericytes and caused cholesterol to accumulate in astrocytes to promote neurodegeneration.
www.genengnews.com
September 28, 2026 at 10:23 AM