#TumorMicroenvironment
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mapjournals.bsky.social
#Targetome
Chinese herbal medicine remodels the desmoplastic, immunosuppressive pancreatic tumor microenvironment, suppressing PDAC growth and enhancing efficacy of conventional therapies.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0049
#TumorMicroenvironment #ChineseHerb
October 31, 2026 at 1:45 AM
norgenbiotek.bsky.social
Limited biopsy material? Maximize your molecular insights.
Join Norgen Biotek's FREE webinar on DNA, RNA & protein purification from precious tumor samples.
LIVE Q&A with Lohit Khera.
Register: register.gotowebinar.com/rt/384745662...
#CancerResearch #TumorMicroenvironment #NorgenBiotek
October 27, 2026 at 3:43 PM
theinnovation.bsky.social
Check out the latest issue of The Innovation Oncology!!! Volume 1, Issue 3 is now online!
#oncology #cancertherapy #oncolyticvirustherapy #cancerscreenings #ColorectalCancer #TumorMicroenvironment #Chemoradiotherapy #immunotherapy #breastcancer #deeplearning #Ferroptosis #PrecisionOncology
October 26, 2026 at 3:46 AM
bionewscentral.com
Blocking the #CD44 receptor alters tumor-promoting cells in the #TumorMicroenvironment and could improve prospects for treatment of #PancreaticCancer.
#PancreaticCancerTreatment
Pancreatic cancer: Researchers reprogram the tumor microenvironment – BioNews Central
Blocking the CD44 receptor alters tumor-promoting cells in the tumor microenvironment and could improve prospects for treatment of pancreatic cancer. ...
sbee.link
October 24, 2026 at 8:49 PM
themolecularbrief.substack.com
Some tumors have their own microbial neighborhoods
substack.com/@themolecula...
#CancerBiology #CancerResearch #Oncology #TumorMicroenvironment #ScienceCommunication
#microbiome
THE MOLECULAR BRIEF (@themolecularbrief)
Some Tumors Have Their Own Microbial Neighborhood Scientists have found evidence of bacteria and other microbes associated with certain tumors. These microbes may influence inflammation, interact wi...
substack.com
October 16, 2026 at 5:46 AM
theinnovation.bsky.social
Wang et al. developed an AI-assisted integrative analysis workflow by combining H3K27ac MobiChIP profiling with scRNA-seq data and applied it to an AOM/DSS-induced colorectal cancer model.
doi.org/10.59717/j.x...
#colorectalcancer #TumorMicroenvironment
October 15, 2026 at 4:55 AM
gpbees.bsky.social
5/5: Beyond immune cells
Attenuated CXCL12-CXCR4 and ICAM1-SPN signaling, together with a marrow-specific tumor metaprogram involving IGFBP3/NAMPT, points to disruption of hematopoietic niche support.
#CancerResearch #TumorMicroenvironment
October 9, 2026 at 2:55 AM
genesndiseases.bsky.social
#Hexokinase2 does more than fuel cancer metabolism.
This review shows how it regulates #CellDeath, reshapes the #TumorMicroenvironment and promotes immune evasion, highlighting HK2-targeting therapies as promising strategies.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
October 8, 2026 at 12:01 PM
thebabaklab.bsky.social
In a new Cell review, Douglas Hanahan revisits one of the most influential frameworks in cancer biology.

Link in the comments 👇

#HallmarksOfCancer #CancerResearch #Oncology #TumorMicroenvironment #CancerBiology #PrecisionMedicine
October 7, 2026 at 7:51 PM
plosbiology.org
#TrendingNow | Within the #TumorMicroenvironment, cells engage in dynamic metabolic competition. This Essay discusses metabolic crosstalk between #cancer cells and #TCells, highlighting metabolic targeting as a promising strategy to reprogram anti-tumor immune responses 🧪 #ICYMI plos.io/3U6RWir
Bi-directional metabolic reprogramming between cancer cells and T cells reshapes the anti-tumor immune response
Cancer cells and T cells engage in dynamic metabolic competition and adaptation within the tumor microenvironment. This Essay discusses bi-directional metabolic crosstalk between tumors and T cells,…
plos.io
October 7, 2026 at 6:09 AM
alicefrolov.bsky.social
The Vascular Normalization Window in Anti-VEGF Therapy

I am sharing a figure intended to communicate the transient nature of vascular normalization.

#TumorAngiogenesis #VascularNormalization #AntiVEGF #TumorMicroenvironment #Pericytes #TumorVasculature #AntiangiogenicTherapy #CancerBiology
The Vascular Normalization Window in Anti-VEGF Therapy I am sharing a figure intended to communicate the transient nature of vascular normalization during anti-angiogenic treatment, a concept that continues to shape dosing and combination strategy discussions. I want to emphasize at the outset that the underlying data are simulated; the curves are constructed to reproduce trends reported across the preclinical and clinical literature rather than to present novel measurements. The plot is a temporal contour band plot rendering two opposing envelopes against time following VEGF pathway blockade. The first envelope tracks pericyte coverage of the tumor microvasculature, expressed as fractional NG2/PDGFRβ-positive perivascular investment, which rises as VEGF withdrawal reduces the destabilizing pressure on nascent endothelium. The second envelope tracks microvessel density, which declines as immature, poorly perfused vessels regress. The shaded intersection identifies the normalization window, the interval during which pericyte recruitment and basement membrane maturation restore a more physiologically competent vascular phenotype before pruning progresses toward frank hypovascularity. Within this window the figure annotates the functional correlates that motivate combination scheduling: reduced interstitial fluid pressure, attenuated hypoxia, improved oxygen and drug delivery, and partial restoration of endothelial barrier integrity. The band widths encode illustrative uncertainty, reflecting the heterogeneity in window timing and duration observed across tumor models and dosing regimens. The mechanistic argument the figure supports is that therapeutic benefit from normalization is inherently self-limiting. Sustained or excessive VEGF inhibition drives the system past the window into a hypoxic, treatment-resistant state, whereas appropriately timed cytotoxic or immunotherapeutic delivery may exploit the transient perfusion gain.
October 2, 2026 at 5:01 PM
sigtrans-sttt.bsky.social
A multitarget strategy may help address #TNBC heterogeneity.

Opti-hTIF1γ suppresses β-catenin, TGFβ and STAT3 signaling while downregulating CD47 and CXCL5, enhancing #macrophage phagocytosis and #antitumoractivity.
#TumorMicroenvironment #CancerBiology
#STTT #OpenAccess: doi.org/10.1038/s413...
Transcriptional intermediary factor 1 gamma-based multitarget gene therapeutic strategy for triple-negative breast cancer
October 1, 2026 at 7:42 AM
svanuytven.eurosky.social
Weekly reads 21/09/26:
How tumors exploit cell states and how we're learning to engineer our own

behindthebioinformatics.substack.com/p/weekly-rea...

#CancerResearch #SingleCell #TumorMicroenvironment #SyntheticBiology
Weekly reads 21/09/26
How tumors exploit cell states and how we're learning to engineer our own
behindthebioinformatics.substack.com
September 30, 2026 at 8:50 AM
sigtrans-sttt.bsky.social
TKTL1-driven #Glycolysis increases lactate and promotes #Immunosuppressive dendritic-cell signaling in #HCC. Targeting the TKTL1–HIF-1α–HK2 axis and lactate reprograms the #TumorMicroenvironment to enhance PD-1 blockade.

#STTT #OpenAccess: doi.org/10.1038/s413...
Transketolase-like 1 potentiates PD-1 blockade in hepatocellular carcinoma by glycolysis to prime dendritic cell lactylation
September 29, 2026 at 9:15 AM
genesndiseases.bsky.social
#BrainMetastases are shaped by complex #TumorMicroenvironment interactions.
This study identifies the MIF–CD74 axis as a key tumor–myeloid hub and links pDC signatures to shorter survival, highlighting a potential target.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
September 27, 2026 at 1:30 AM
isev.org
📘Read in #JEV📘 Small Extracellular Vesicle-Derived Nidogen 1 Promotes HCC Carcinogenesis via Transglutaminase 3-Mediated YAP/TAZ Signalling #extracellularvesicles #hepatocellularcarcinoma #nidogen1 #tumormicroenvironment isevjournals.onlinelibrary.wiley.com/doi/epdf/10....
September 25, 2026 at 12:41 PM
ontarget-podcast.bsky.social
Mirna Jarosz, CEO of #LiquidCellDx, explains how her company's #liquidbiopsy captures information about the #tumormicroenvironment, providing critical treatment guidance.

🎧 Listen now → www.ontargetpodcast.com

#OnTarget #PrecisionMedicine #Oncology #Immunotherapy #CancerDiagnostics #AI
September 23, 2026 at 7:26 PM
cancers-mdpi.bsky.social
📣Check out some highly cited #SpecialIssues in 2025 related to our section "Tumor Microenvironment"

Explore here🔎 www.mdpi.com/about/announ...

#TumorMicroenvironment #metastasis #angiogenesis #IntercellularCommunication @mdpiopenaccess.bsky.social
September 23, 2026 at 8:38 AM
nabalabuic.bsky.social
📣 Hot off the press: our review, “Understanding and targeting the tumour matrisome,” is now published in @natrevclinonc.nature.com!
🔗 doi.org/10.1038/s415...

#ExtracellularMatrix #Matrisome #Matrisomics #Matritherapies #HallmarksOfCancer #TumorMicroenvironment
September 21, 2026 at 2:25 PM
cancers-mdpi.bsky.social
🧬Spatial #Transcriptomics in #LungCancer and Pulmonary Diseases: A Comprehensive Review

🧑‍🔬by Da Hyun Kang, Yoonjoo Kim et al. from Chungnam National University

📊Cited 19 times!

Read it here🔗 www.mdpi.com/2072-6694/17...

#SpatialTranscriptomics #PulmonaryDisease #TumorMicroenvironment
Figure 4. Spatial transcriptomic signatures across pulmonary diseases: cellular niches and molecular pathways.
September 17, 2026 at 10:17 AM
biomedicines.bsky.social
⚕️ The tumor microenvironment of pancreatic cancer remains a major obstacle. This review examines strategies to enhance immune activation and improve the effectiveness of immunotherapy combinations. #PancreaticCancer #TumorMicroenvironment
www.mdpi.com/2227-9059/12...
September 16, 2026 at 7:19 AM
alicefrolov.bsky.social
Sharing a visualization from our ongoing modeling work on intratumoral oxygen dynamics and the HIF-1α-driven transcriptional response.

#TumorHypoxia #HIF1alpha #TumorMicroenvironment #Angiogenesis #OxygenSensing #VEGF #ComputationalOncology #CancerMetabolism
Sharing a visualization from our ongoing modeling work on intratumoral oxygen dynamics and the HIF-1α-driven transcriptional response. Figure: "Oxygen tension collapse drives coordinated hypoxia-angiogenesis program across the tumor radius" Subtitle: "Simulated intratumoral pO₂ gradient from vessel wall to necrotic core with HIF-target activation" The figure uses a horizon-style stacked area representation (layered oxygen-gradient contour strip) to render pO₂ as a function of radial distance from the perfused vessel wall toward the necrotic core. Each contour band encodes a discrete oxygen tension interval, with marker overlays indicating the activation thresholds of canonical HIF-1α target loci. I want to emphasize that the underlying data are simulated; the parameterization reflects diffusion-limited oxygen distributions consistent with published Krogh-cylinder estimates and the well-characterized ~100–200 µm diffusion limit. The central observation is the coordinated character of the transcriptional program along the radial axis. Proximal to the vessel wall, pO₂ remains above the threshold for prolyl hydroxylase domain (PHD/EGLN) activity, sustaining VHL-mediated HIF-1α degradation. As oxygen tension declines toward the intermediate perinecrotic zone, PHD activity becomes substrate-limited, HIF-1α escapes hydroxylation and proteasomal turnover, and it accumulates to drive HRE-dependent transcription. The marker overlays illustrate the staggered engagement of glycolytic effectors (SLC2A1, LDHA), pH-regulatory targets (CA9), and pro-angiogenic signaling (VEGFA) as the gradient steepens. The horizon-strip format was chosen deliberately to compress the steep radial pO₂ decay into a legible vertical encoding while preserving the coincidence between tension thresholds and target activation.
September 14, 2026 at 5:03 PM
sigtrans-sttt.bsky.social
Myeloid-derived suppressor cells promote immune escape and tumor progression through #MetabolicReprogramming, altered differentiation and interactions within the #TumorMicroenvironment, highlighting their theranostic potential.

#STTT #OpenAccess: doi.org/10.1038/s413...
Myeloid-derived suppressor cells in cancer: biology, regulatory networks and theranostic prospects
September 11, 2026 at 12:30 PM
genesndiseases.bsky.social
Better #CancerImmunotherapy requires tackling hidden immune barriers.
This review highlights how dysfunctional #Bcells suppress anti-tumor immunity and outlines strategies to reprogram the #TumorMicroenvironment.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
September 11, 2026 at 2:00 AM
genesndiseases.bsky.social
Precision medicine is transforming #cholangiocarcinoma care.
This review highlights advances in targeted therapies and #immunotherapy while addressing challenges such as drug resistance and biomarker discovery. #TumorMicroenvironment
#GenesAndDiseases: doi.org/10.1016/j.ge...
https://doi.org/10.1016/j.gendis.2026.102124
doi.org
September 9, 2026 at 12:30 PM