Tumors of the peripheral nervous system: treatment and risk of metastasis #nervoussystem #metastasis

Un consorcio científico internacional desvela que la SUMOilación de la proteína RAC1 es imprescindible para la invasión metastásica en subtipos agresivos como HER2+ y triple negativo, y demuestra la e...

Published in Nature Cancer: Researchers at the Université libre de Bruxelles (ULB) have discovered that immune cells build distinct "neighborhoods" around cancer cells. In one of these neighborhoods, immune cells communicate with cancer cells to promote their ability to spread to distant organs and mediate metastasis formation. This research could eventually help develop new therapies to target metastasis. Most cancer deaths are not caused by the original tumor, but by metastases, which correspond to the cancer cells that leave the original tumor and disseminate to other organs. To do so, cancer cells must loosen their attachment with the other cancer cells and become more motile, to be able to move away from the tumors, a process called epithelial-to-mesenchymal transition, or EMT. EMT is a progressive phenomenon and cancer cells go through an intermediate "hybrid" stage, which is the best at forming metastases. The study, published in the prestigious journal Nature Cancer, was led by Prof. Cédric Blanpain, MD/PhD, investigator at the WEL Research Institute, director of the Laboratory of Stem Cells and Cancer and professor at the Université libre de Bruxelles. The cancer is made of cancer cells and different normal cells, such as immune cells and blood vessels, which...

Primary tumors of the brain and meninges: treatment and risk of metastasis #tumor #metastasis #brain

Mansouri and colleagues show that basophils protect from early lung metastasis by suppressing regulatory T cells through the release of mast cell protease 8 and histamine.