#MetabolicReprogramming
LightNews LightNews
genesndiseases.bsky.social
Understanding tumour metabolism could unlock new strategies against #ColorectalCancer resistance and recurrence.
This review explores #MetabolicReprogramming and emerging #biomarkers for earlier diagnosis and personalised therapy.
#GenesAndDiseases: doi.org/10.1016/j.ge...
November 5, 2026 at 9:01 AM
alicefrolov.bsky.social
Diverging log-scale lollipop chart ranking 54 tissues by PCK1 median expression relative to the cross-tissue median of 0.5 TPM, with tissues on one axis and fold difference on the other.

#Gluconeogenesis #PCK1 #GTEx #TumorMetabolism #HepaticMetabolism #MetabolicReprogramming #TissueTranscriptomics
I would like to share a visualization of PCK1 (phosphoenolpyruvate carboxykinase 1, cytosolic; GENCODE ENSG00000124253.10) expression across human tissues, with the aim of discussing how gluconeogenic capacity is distributed relative to cancer-relevant tissues. The figure is a diverging log-scale lollipop chart in which each tissue is ranked by its deviation from the cross-tissue median. The data are GTEx v8 median gene expression by tissue across 54 tissues, and these are bulk-tissue medians from postmortem donors, so cell-type composition differs between tissues. The cross-tissue median is 0.5 TPM (dashed line). Liver is the clear upper outlier at 530.0 TPM, which is 1052.7 times the median. At the other extreme, cultured fibroblasts show the lowest median at 0.04 TPM. A log axis is necessary here, because on a linear scale almost every tissue would collapse onto the baseline beside the hepatic value. Several points seem worth discussing. First, the magnitude of the hepatic signal is consistent with PCK1 being a core component of the hepatocyte gluconeogenic program, and high transcript abundance is associated with tissues that carry out net glucose production. Second, the very low values in cultured fibroblasts indicate that transcript abundance in this in vitro setting is far below the tissue median, which is relevant when PCK1 is interrogated in cell line models. Third, for tumor biology, a cancer-relevant tissue reading near or below the median is compatible with low basal PCK1 transcription, but bulk medians cannot resolve whether this reflects epithelial, stromal or immune contributions. Important limitations: TPM medians do not report enzymatic flux, protein abundance or post-translational regulation, and donor-level variance is not shown in this summary view. Matched tumor-normal comparisons would be needed before drawing any inference about metabolic rewiring in malignancy. I would like to share a visualization of PCK1 (phosphoenolpyruvate carboxykinase 1, cytosolic; GENCODE ENSG00000124253.10) expression across human tissues, with the aim of discussing how gluconeogenic capacity is distributed relative to cancer-relevant tissues. The figure is a diverging log-scale lollipop chart in which each tissue is ranked by its deviation from the cross-tissue median. The data are GTEx v8 median gene expression by tissue across 54 tissues, and these are bulk-tissue medians from postmortem donors, so cell-type composition differs between tissues. The cross-tissue median is 0.5 TPM (dashed line). Liver is the clear upper outlier at 530.0 TPM, which is 1052.7 times the median. At the other extreme, cultured fibroblasts show the lowest median at 0.04 TPM. A log axis is necessary here, because on a linear scale almost every tissue would collapse onto the baseline beside the hepatic value. Several points seem worth discussing. First, the magnitude of the hepatic signal is consistent with PCK1 being a core component of the hepatocyte gluconeogenic program, and high transcript abundance is associated with tissues that carry out net glucose production. Second, the very low values in cultured fibroblasts indicate that transcript abundance in this in vitro setting is far below the tissue median, which is relevant when PCK1 is interrogated in cell line models. Third, for tumor biology, a cancer-relevant tissue reading near or below the median is compatible with low basal PCK1 transcription, but bulk medians cannot resolve whether this reflects epithelial, stromal or immune contributions. Important limitations: TPM medians do not report enzymatic flux, protein abundance or post-translational regulation, and donor-level variance is not shown in this summary view. Matched tumor-normal comparisons would be needed before drawing any inference about metabolic rewiring in malignancy.
November 4, 2026 at 5:02 PM
genesndiseases.bsky.social
How does #MetabolicReprogramming drive kidney cancer?
This review explores altered glucose and lipid metabolism, amino acid use, and mitochondrial dysfunction in #ClearCellRenalCellCarcinoma, revealing new therapeutic opportunities.
#GenesAndDiseases: doi.org/10.1016/j.ge...
October 25, 2026 at 3:06 PM
sigtrans-sttt.bsky.social
Next-generation NK cell therapies are expanding beyond #Cancer. This review explores CAR-NK engineering, #MetabolicReprogramming, immune checkpoint disruption, and strategies to overcome #SolidTumor barriers.

#STTT #OpenAccess: doi.org/10.1038/s413...
Next-generation natural killer cell therapy: bench to bedside and beyond
October 23, 2026 at 2:30 AM
genesndiseases.bsky.social
#TCellExhaustion can protect grafts but weaken immunity.
This review explores metabolic and #epigenetic regulation of exhaustion, highlighting strategies to promote graft tolerance while limiting risks. #MetabolicReprogramming
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
October 15, 2026 at 11:30 AM
sigtrans-sttt.bsky.social
How does macrophage zinc accumulation worsen #MASLD progression?

Macrophage zinc trapping activates IRE1α–XBP1s signaling, promoting IL-1β-driven #MetabolicReprogramming and lipid transfer to hepatocytes, driving liver inflammation.

#STTT #OpenAccess: doi.org/10.1038/s413...
Zinc accumulation in macrophages exacerbates metabolic dysfunction-associated steatotic liver disease progression
September 30, 2026 at 12:15 PM
mapjournals.bsky.social
#Targetome
Respiratory chain complexes as programmable therapeutic nodes: beyond ATP bioenergetics toward context-dependent metabolic reprogramming.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0037
#RespiratoryChain #Mitochondria #MetabolicReprogramming #DrugDiscovery
September 29, 2026 at 5:03 AM
sigtrans-sttt.bsky.social
Myeloid-derived suppressor cells promote immune escape and tumor progression through #MetabolicReprogramming, altered differentiation and interactions within the #TumorMicroenvironment, highlighting their theranostic potential.

#STTT #OpenAccess: doi.org/10.1038/s413...
Myeloid-derived suppressor cells in cancer: biology, regulatory networks and theranostic prospects
September 11, 2026 at 12:30 PM
bojmarlab.bsky.social
His research integrates stable isotope tracing, mass spectrometry, and systems biology to increase translational relevance while reducing animal use. #CancerMetabolism #SystemsBiology #TranslationalResearch #MetabolicReprogramming
November 14, 2025 at 2:05 PM
medcomm.bsky.social
#Review in #MedComm_Oncology
Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies doi.org/10.1002/mog2...

#ImmuneResponse #immunotherapy #MetabolicReprogramming #TME
November 20, 2025 at 9:16 AM
medcomm.bsky.social
#Review in #MedComm
Trained Immunity in Health and Disease doi.org/10.1002/mco2...

#EpigeneticInheritance #Immunotherapy #ImmuneCell #MetabolicReprogramming #TrainedImmunity
Trained Immunity in Health and Disease
Growth and timescale of medical publications on trained immunity and its related health and disease. This figure illustrates the number of published papers over time, from 2000 to 2025 (by August 14,...
doi.org
November 14, 2025 at 2:09 AM
moloncology.bsky.social
🗣️New meeting announced

🟨 "Cancer Metabolism"🟨

📅 It's not too late to plan ahead

Submit abstracts by Jun 29 2026

⌛️Register by Sept 7 2026

🗓️Oct 6-8 2026

🖱️https://buff.ly/s88vxNH

#CancerMetabolism #Metabolism
#MetabolicReprogramming #CancerResearch
November 4, 2025 at 9:00 AM
americanaging.bsky.social
🧬 Meet Dr. Hanane Hadj-Moussa
Discover how re-engineering acetyl-CoA metabolism could unlock constitutive healthy aging—only at #AGEAnnualMeeting2025!
🔗 bit.ly/4cJx8Gd
#HealthyAging #AcetylCoA #MetabolicReprogramming #MitochondriaMatters #AGE2025
April 29, 2025 at 2:54 PM
andreamorandi.bsky.social
Here is an exciting weekly selection of #anticancer #therapy and #metabolicreprogramming! Enjoy (pardon, running a bit late this week 😅)

biomed.news/bims-meract/...

🙏 @biomednews.bsky.social
the white rabbit from alice in wonderland is running with a clock on his back and says sorry running a little late
ALT: the white rabbit from alice in wonderland is running with a clock on his back and says sorry running a little late
media.tenor.com
March 3, 2026 at 6:06 AM
andreamorandi.bsky.social
Here we go again! A weekly selection of #anticancer #metabolicreprogramming
! Enjoy 🙂 biomed.news/bims-meract/...

🙏 @biomednews.bsky.social
a cartoon drawing of a girl reading a book
ALT: a cartoon drawing of a girl reading a book
media.tenor.com
April 27, 2025 at 7:39 PM
andreamorandi.bsky.social
Sharing a curated list of papers on #MetabolicReprogramming and #CancerTherapy - key insights into how metabolism drives treatment innovations. Follow for more updates! 🧬📚

biomed.news/bims-meract/...

Thanks @biomednews.bsky.social
a man wearing a michigan shirt is holding a book in his hand
ALT: a man wearing a michigan shirt is holding a book in his hand
media.tenor.com
December 2, 2024 at 8:07 AM
microbelab.bsky.social
We are so thankful as we congratulate former lab member and outstanding scientist @npokorzynski.bsky.social on his appointment as Assistant Professor of Microbiology @oregonstate.edu #MetabolicReprogramming #proteolysis #antibioticsusceptibility microbiology.oregonstate.edu/directory/ni...
Nick Pokorzynski | Department of Microbiology
microbiology.oregonstate.edu
August 29, 2025 at 4:53 PM
cp-trendsbiochem.bsky.social
Available online - the Review "The HIF axes in cancer: #angiogenesis, metabolism, and immune-modulation" from Karen Acuña-Pilarte and Mei Yee Koh.

#Hypoxia #HIF #TumorMicroenvironment #MetabolicReprogramming #Therapeutics

Read it here: authors.elsevier.com/sd/article/S...
July 14, 2025 at 1:27 PM
oncogenesisnature.bsky.social
#Cancer #CancerResearch #CancerMetabolism #Oncology #NatureReviews #TranslationalResearch #TherapeuticOpportunities #MetabolicReprogramming
June 11, 2026 at 11:27 AM
sigtrans-sttt.bsky.social
This review explores how post-translational modifications regulate #Cancer #MetabolicReprogramming and immune responses, highlighting phosphorylation, acetylation, lactylation and other modifications as #TherapeuticTargets.

#STTT #OpenAccess: doi.org/10.1038/s413...
Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer
August 14, 2026 at 12:45 PM
sigtrans-sttt.bsky.social
How does #Hypoglycemia drive #Neurodegeneration?

This study identifies the SRF–MRTF-A signaling axis as a driver of brain #MetabolicReprogramming and neurodegeneration, revealing a potential #TherapeuticTarget.

#OpenAccess: doi.org/10.1038/s413...
Hypoglycemia induces brain metabolic reprogramming and neurodegeneration via serum response factor and myocardin-related transcription factor-A
August 10, 2026 at 2:15 AM
sigtrans-sttt.bsky.social
PD-1/LAG-3 co-signaling rewires T-cell metabolism by inhibiting MYC, linking immune checkpoint activity to transcriptional and #metabolicreprogramming, and providing insights into overcoming immune checkpoint blockade resistance.

#STTT #OpenAccess: doi.org/10.1038/s413...
PD-1/LAG-3 signaling rewires T-cells via MYC inhibition
June 25, 2026 at 11:55 AM
sigtrans-sttt.bsky.social
Researchers show that high fructose intake promotes effector T cell generation through #MetabolicReprogramming, thereby amplifying #Inflammation and revealing a direct link between dietary fructose and immune dysregulation.
#STTT #OpenAccess: doi.org/10.1038/s413...
High fructose consumption aggravates inflammation by promoting effector T cell generation via inducing metabolic reprogramming
June 13, 2026 at 1:50 AM
sigtrans-sttt.bsky.social
Researchers show that TACC3-mediated lipid #MetabolicReprogramming suppresses CD8+ T-cell cytotoxicity in #HepatocellularCarcinoma, revealing a key mechanism of tumor #ImmuneEvasion and a potential #TherapeuticTarget.

#STTT #OpenAccess: doi.org/10.1038/s413...
Transforming acidic coiled-coil-containing protein 3-mediated lipid metabolism reprogramming impairs CD8+ T-cell cytotoxicity in hepatocellular carcinoma
June 10, 2026 at 6:58 AM
sigtrans-sttt.bsky.social
This study details how mitochondrial #MetabolicReprogramming drives #Cancer growth, highlighting innovative therapeutic strategies targeting these metabolic dependencies to improve outcomes in precision cancer treatment.
#STTT #OpenAccess: doi.org/10.1038/s413...
Mitochondrial metabolism and cancer therapeutic innovation
June 2, 2026 at 2:30 PM