#TrainedImmunity
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parsemusfoundation.bsky.social
Vaccines are designed to protect against specific diseases, but research shows some may also influence the immune system’s response to unrelated infections.

Tell me about the nonspecific effects of vaccines: www.parsemus.org/project/non-...

#Vaccines #VaccineResearch #Immunology #TrainedImmunity
November 2, 2026 at 11:08 PM
ocasapiens.bsky.social
#trainedimmunity
#genetics
#homeostasis

Experiments with genetically modified mice (+ non gm control group) confirm retrospective studies of cancer patients: The BCG vaccine reduces dementia symptoms & risks, especially in ♀️ mice.
Limits well explained in "Discussion", imo.

Press release:
November 2, 2026 at 1:32 PM
genesndiseases.bsky.social
#Diabetes may leave a lasting imprint on immunity.
This review explores how #TrainedImmunity links metabolic dysregulation to diabetes and its complications, highlighting therapeutic opportunities to target innate immune memory.
#GenesAndDiseases: doi.org/10.1016/j.ge...
October 14, 2026 at 8:30 AM
lauboye.bsky.social
Our new paper in @Nature communications: Bacterial toxins induce transient trained immunity via NLRP3 inflammasome, improving survival in experimental sepsis.

Congrats to joint first authors Cédric Torre & Valentine Marion

nature.com/articles/s41...

#TrainedImmunity #Sepsis
Bacterial toxin sensing induces transient inflammasome-dependent innate immune memory that improves survival during sepsis - Nature Communications
This study shows that the bacterial toxin CNF1 can train innate immune cells to respond more effectively to subsequent infections, revealing a form of immune memory that improves survival during sepsi...
nature.com
October 12, 2026 at 9:13 AM
prblg.bsky.social
Tired of the annual "sick-day cycle"? 🛑

Join Here: tinyurl.com/3cm978h7

📖 Read the full post to learn more & register:
healthfitnessregime.com/fewer-sick-d...

#ImmuneHealth #TrainedImmunity #EvidenceBased #ColdAndFlu
September 29, 2026 at 6:07 PM
shrinelongevity.bsky.social
Aging may dull your immune system, but trained immunity could boost its response to inflammation.

📄 Full article: https://food-medicine-protocol.ghost.io/the-role-of-trained-immunity-in-aging-associated-inflammation-implications-for-longevity/

#trainedimmunity #ShrineLongevity
Exploring the role of trained immunity in aging and inflammation.
September 24, 2026 at 3:56 AM
gmj-georgia.bsky.social
🧠 New study: BCG vaccine may reshape brain immunity to protect against Alzheimer's disease. Mass General Brigham investigators found sustained chan…

#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedimmunity #Vaccineimmunology

#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedim…
BCG Vaccine Reshapes Brain Immunity, May Protect Against Alzheimer's
🧠 New study: BCG vaccine may reshape brain immunity to protect against Alzheimer's disease. Mass General Brigham investigators found sustained chan… #Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedimmunity #Vaccineimmunology
news.gmj.ge
September 15, 2026 at 5:26 AM
gmj-georgia.bsky.social
🧠 New study: BCG vaccine may reshape brain immunity to protect against Alzheimer's disease. Mass General Brigham investigators found sustained chan…

#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedimmunity #Vaccineimmunology

#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedim…
BCG Vaccine Reshapes Brain Immunity, May Protect Against Alzheimer's
🧠 New study: BCG vaccine may reshape brain immunity to protect against Alzheimer's disease. Mass General Brigham investigators found sustained chan… #Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedimmunity #Vaccineimmunology
news.gmj.ge
September 4, 2026 at 8:42 AM
claudio-oliveira93.bsky.social
β-Glucan treatment reduces morbidity & mortality in Influenza A virus (IAV) infection though enhanced neutrophil recruitment via RoRγt+ T cells & type I IFN-driven granulopoiesis, generating a unique subset of IL-10-producing neutrophils.

#TrainedImmunity #β-Glucan #Neutrophils #InfluenzaA

🧵 (1/7)
February 22, 2025 at 7:16 PM
medcomm.bsky.social
#Review in #MedComm
Trained Immunity in Health and Disease doi.org/10.1002/mco2...

#EpigeneticInheritance #Immunotherapy #ImmuneCell #MetabolicReprogramming #TrainedImmunity
Trained Immunity in Health and Disease
Growth and timescale of medical publications on trained immunity and its related health and disease. This figure illustrates the number of published papers over time, from 2000 to 2025 (by August 14,...
doi.org
November 14, 2025 at 2:09 AM
castltrastondrs.medsky.network
- 💉 as a layer of protection: #COVID19vaccination provides specific immunity against #Covid , further bolstering the protection afforded by #trainedimmunity & reducing the likelihood of infection or #Longcovid & the development of severe diseases.
@bmj.com
bmjpaedsopen.bmj.com/content/7/1/...
Frontiers | The underlying mechanism behind the different outcomes of COVID-19 in children and adults
Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has affected hundreds of millions of people globally, resulting in millions of deaths. During this...
www.frontiersin.org
August 11, 2025 at 6:10 PM
castltrastondrs.medsky.network
The data show that induction of TRIM ( #Trainedimmunity) by certain vaccines confers broad beneficial effects that can protect beyond the target pathogen.

www.nature.com/articles/s41...
These insights suggest that prior #Covid19vaccines prevents overactivation of #innateimmune responses
Trained immunity in chronic inflammatory diseases and cancer - Nature Reviews Immunology
Besides its beneficial effects against infection, trained immunity has recently been implicated in inflammation-related disorders and is being exploited in cancer immunotherapy. These advances may ena...
www.nature.com
May 27, 2025 at 7:03 PM
castltrastondrs.medsky.network
#Medsky🧪 #IDsky #immunosky #Publichealth Understanding the #Trainedimmunity, #inatedimmunity in infection @cellpress.bsky.social

www.cell.com/trends/immun...

journals.asm.org/doi/full/10....

www.ijmb.in/doi/IJMB/pdf...

www.researchgate.net/profile/Muha...

link.springer.com/article/10.1...
Lactate trains immunity
Understanding the mechanisms implicated in the establishment of trained immunity could aid the design of novel therapeutic approaches. By studying Bacille Calmette-Guerin (BCG) vaccination in a human ...
www.cell.com
May 27, 2025 at 6:32 PM
castltrastondrs.medsky.network
#Medsky🧪 #IDsky #immunosky #publichealth #Trainedimmunity-based mucosal #immunotherapies for the prevention of respiratory infections
Nonspecific properties of #vaccines extend protection beyond the targeted diseases. These effects, mediated by trained immunity – a memory process …

dlvr.it/TK4g0d
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections
The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary t...
dlvr.it
April 11, 2025 at 10:48 PM
castltrastondrs.medsky.network
#Medsky🧪 #IDsky #oncosky #immunosky #publichealth Review the Pros & Cons of #Trainedimmunity in chronic inflammatory diseases and #cancer . Immunological memory has traditionally been considered an exclusive property of #adaptiveimmunity,
February 2, 2025 at 5:43 AM
castltrastondrs.medsky.network
MedSky #Immunology #viralimmunology Differences in #immuneresponses in males and females can sometimes favour one or the other sex. A sex bias in #trainedimmunity, where females displayed decreased inflammatory responsiveness & survival from opportunistic infection compared vs males.
August 23, 2023 at 11:45 AM
roi1avraham.bsky.social
Paper alert:
Congratulations to PhD student, now Dr. Aryeh Solomon for this great work, published @elife.bsky.social

Can a BCG vaccine also protect from Gram-negative infection? #TrainedImmunity #BCG
Thanks also to long time collaborator Mihai Netea and other friends.

doi.org/10.7554/eLif...
January 8, 2025 at 8:54 AM
the-14.com
COVID caused cancer tumours to shrink in mice – new study
#Health #COVID19 #Cancer #CancerResearch #Tumours #COVIDAndCancer #Immunotherapy #ScientificDiscovery #CancerTreatment #ImmuneSystem #MedicalBreakthrough #TrainedImmunity #HealthResearch
the-14.com/covid-caused...
COVID caused cancer tumours to shrink in mice – new study | The-14
New research shows severe COVID can trigger immune responses that shrink cancer tumors in mice, offering hope for innovative treatments while stressing safety.
the-14.com
November 23, 2024 at 6:13 PM
pat-ogger.bsky.social
Check out our new review discussing novel immunometabolic mechanisms underlying inflammation, metabolomic techniques and potential metabolite biomarkers of chronic inflammatory disease!

Special focus is on #efferocytosis #IL-10 and #trainedimmunity

link.springer.com/article/10.1...
Dissecting inflammation in the immunemetabolomic era - Cellular and Molecular Life Sciences
The role of immune metabolism, specific metabolites and cell-intrinsic and -extrinsic metabolic states across the time course of an inflammatory response are emerging knowledge. Targeted and untargete...
link.springer.com
April 28, 2025 at 9:08 PM
aizepellon.bsky.social
🔚 Bottom line:
SAS induces a context-dependent innate immune memory that enhances protection but is reversible.
This opens doors to smarter vaccine design using adjuvants as immune trainers.

Read the full paper 👉 doi.org/10.1111/imm....
#Vaccines #TrainedImmunity
🧵5/6
Challenge Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory
We utilised a commercially available adjuvant formulation to study the induction, maintenance, and consequences of innate immune memory. Using functional assays on bone marrow-derived innate cells, e...
doi.org
October 2, 2025 at 3:36 PM
aizepellon.bsky.social
🚨 New paper alert!

Our team at CIC bioGUNE has just published a new study in "Immunology" exploring how adjuvants can induce innate immune memory and reshape hematopoiesis.

Let’s dive in 👇

#InnateMemory #TrainedImmunity #Immunology
@anguitalab.bsky.social @cicbiogune.bsky.social

🧵1/6
October 2, 2025 at 3:36 PM
aizepellon.bsky.social
Here, we discuss IIM (in all its variants: #TrainedImmunity, #Tolerance, etc) in the context of host-microbiota interactions and as a mechanism of control of homeostasis and regulation of excessive inflammation
January 10, 2025 at 3:06 PM
aizepellon.bsky.social
Back to working full-time on #InnateImmuneMemory, so I'll start posting papers (mostly new, but also older ones that I re-read) on the topic. Hope this helps everyone (me too 😅) keeping up-to-date with this fast-growing field 😄

#TrainedImmunity #Tolerance #InnateImmunity #Immunity
November 15, 2024 at 11:02 AM
haoyin.bsky.social
Not only #TrainedImmunity, but also trained #SmoothMuscleCell!?

#YAP/TAZ in epigenetic control of Arterial mechanics

LINC (nesprin/SUN) to transduce rigidity to nucleoskeleton & gene transcription

Stéphane Laurent lab Annual Rev Physiol 2024
www.annualreviews.org/content/jour...
May 22, 2024 at 7:21 PM
jlbjournal.bsky.social
Xiaoya Wang, Yunpeng Jia, Xinyi Yan & Youwei Wang discuss the metabolic and epigenetic mechanisms that govern #TrainedImmunity, immune #Tolerance and immune #Exhaustion in the context of #Microglia
Metabolic and epigenetic regulation of microglia memory in neurological disorders
Microglial innate immune memory in the CNS is governed by metabolic and epigenetic mechanisms that drive 3 distinct phenotypes, namely trained immunity, im
doi.org
July 28, 2026 at 4:06 PM