Happy Friday! We're so thrilled to share our review on #trainedimmunity out in @elife.bsky.social today. We had a great time writing this. Honored to be included in the special issue of trained immunity. Always an absolute treat to write with @khannakm.bsky.social
elifesciences.org/articles/108...
elifesciences.org/articles/108...
November 14, 2025 at 6:08 PM
Happy Friday! We're so thrilled to share our review on #trainedimmunity out in @elife.bsky.social today. We had a great time writing this. Honored to be included in the special issue of trained immunity. Always an absolute treat to write with @khannakm.bsky.social
elifesciences.org/articles/108...
elifesciences.org/articles/108...
Paper alert:
Congratulations to PhD student, now Dr. Aryeh Solomon for this great work, published @elife.bsky.social
Can a BCG vaccine also protect from Gram-negative infection? #TrainedImmunity #BCG
Thanks also to long time collaborator Mihai Netea and other friends.
doi.org/10.7554/eLif...
Congratulations to PhD student, now Dr. Aryeh Solomon for this great work, published @elife.bsky.social
Can a BCG vaccine also protect from Gram-negative infection? #TrainedImmunity #BCG
Thanks also to long time collaborator Mihai Netea and other friends.
doi.org/10.7554/eLif...
January 8, 2025 at 8:54 AM
Paper alert:
Congratulations to PhD student, now Dr. Aryeh Solomon for this great work, published @elife.bsky.social
Can a BCG vaccine also protect from Gram-negative infection? #TrainedImmunity #BCG
Thanks also to long time collaborator Mihai Netea and other friends.
doi.org/10.7554/eLif...
Congratulations to PhD student, now Dr. Aryeh Solomon for this great work, published @elife.bsky.social
Can a BCG vaccine also protect from Gram-negative infection? #TrainedImmunity #BCG
Thanks also to long time collaborator Mihai Netea and other friends.
doi.org/10.7554/eLif...
#Medsky🧪 #IDsky #oncosky #immunosky #publichealth Review the Pros & Cons of #Trainedimmunity in chronic inflammatory diseases and #cancer . Immunological memory has traditionally been considered an exclusive property of #adaptiveimmunity,
February 2, 2025 at 5:43 AM
#Medsky🧪 #IDsky #oncosky #immunosky #publichealth Review the Pros & Cons of #Trainedimmunity in chronic inflammatory diseases and #cancer . Immunological memory has traditionally been considered an exclusive property of #adaptiveimmunity,
To my friends who are @keystonesymposia.bsky.social #hematopoiesis and #myeloid meetings— please check out two talks from my group TOMORROW: Ruoqiong Cao on central #trainedimmunity Thursday morning and Arushana Maknojia unravels #microbiome dependent hematopoiesis in the pm! 🔥🔥🔥
February 25, 2026 at 11:18 PM
To my friends who are @keystonesymposia.bsky.social #hematopoiesis and #myeloid meetings— please check out two talks from my group TOMORROW: Ruoqiong Cao on central #trainedimmunity Thursday morning and Arushana Maknojia unravels #microbiome dependent hematopoiesis in the pm! 🔥🔥🔥
unbelievable #trainedimmunity talks this morning (day 2)at the #KSinnateimmune25.
loved Kari Nadeau's talk about allergy and TI!!
loved Kari Nadeau's talk about allergy and TI!!
February 4, 2025 at 5:12 PM
unbelievable #trainedimmunity talks this morning (day 2)at the #KSinnateimmune25.
loved Kari Nadeau's talk about allergy and TI!!
loved Kari Nadeau's talk about allergy and TI!!
Hiya! I'll be at UVM (Burlington, VT) on this Friday (12/6) to give a talk for the VCIID seminar series and will talk about Resident #Macrophages in respiratory infections and #trainedimmunity. Would love to meet some macrophage enthusiasts and learn about your science. Esp trainees for lunch!
December 4, 2024 at 7:53 PM
Hiya! I'll be at UVM (Burlington, VT) on this Friday (12/6) to give a talk for the VCIID seminar series and will talk about Resident #Macrophages in respiratory infections and #trainedimmunity. Would love to meet some macrophage enthusiasts and learn about your science. Esp trainees for lunch!
This latest review synthesizes evidence on the complex relationship between metabolic dysregulation and innate #Immune memory and proposes that targeting #TrainedImmunity may offer novel strategies for diabetes intervention. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
November 29, 2025 at 2:56 AM
This latest review synthesizes evidence on the complex relationship between metabolic dysregulation and innate #Immune memory and proposes that targeting #TrainedImmunity may offer novel strategies for diabetes intervention. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
#OpenAccess: www.sciencedirect.com/science/arti...
#Medsky🧪 #IDsky #immunosky #publichealth #Trainedimmunity-based mucosal #immunotherapies for the prevention of respiratory infections
Nonspecific properties of #vaccines extend protection beyond the targeted diseases. These effects, mediated by trained immunity – a memory process …
dlvr.it/TK4g0d
Nonspecific properties of #vaccines extend protection beyond the targeted diseases. These effects, mediated by trained immunity – a memory process …
dlvr.it/TK4g0d
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections
The devastating impact of respiratory infections demonstrates the critical need for
novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies
as a complementary t...
dlvr.it
April 11, 2025 at 10:48 PM
#Medsky🧪 #IDsky #immunosky #publichealth #Trainedimmunity-based mucosal #immunotherapies for the prevention of respiratory infections
Nonspecific properties of #vaccines extend protection beyond the targeted diseases. These effects, mediated by trained immunity – a memory process …
dlvr.it/TK4g0d
Nonspecific properties of #vaccines extend protection beyond the targeted diseases. These effects, mediated by trained immunity – a memory process …
dlvr.it/TK4g0d
🚨 New paper alert!
Our team at CIC bioGUNE has just published a new study in "Immunology" exploring how adjuvants can induce innate immune memory and reshape hematopoiesis.
Let’s dive in 👇
#InnateMemory #TrainedImmunity #Immunology
@anguitalab.bsky.social @cicbiogune.bsky.social
🧵1/6
Our team at CIC bioGUNE has just published a new study in "Immunology" exploring how adjuvants can induce innate immune memory and reshape hematopoiesis.
Let’s dive in 👇
#InnateMemory #TrainedImmunity #Immunology
@anguitalab.bsky.social @cicbiogune.bsky.social
🧵1/6
October 2, 2025 at 3:36 PM
🚨 New paper alert!
Our team at CIC bioGUNE has just published a new study in "Immunology" exploring how adjuvants can induce innate immune memory and reshape hematopoiesis.
Let’s dive in 👇
#InnateMemory #TrainedImmunity #Immunology
@anguitalab.bsky.social @cicbiogune.bsky.social
🧵1/6
Our team at CIC bioGUNE has just published a new study in "Immunology" exploring how adjuvants can induce innate immune memory and reshape hematopoiesis.
Let’s dive in 👇
#InnateMemory #TrainedImmunity #Immunology
@anguitalab.bsky.social @cicbiogune.bsky.social
🧵1/6
#Medsky🧪 #IDsky #immunosky #Publichealth Understanding the #Trainedimmunity, #inatedimmunity in infection @cellpress.bsky.social
www.cell.com/trends/immun...
journals.asm.org/doi/full/10....
www.ijmb.in/doi/IJMB/pdf...
www.researchgate.net/profile/Muha...
link.springer.com/article/10.1...
www.cell.com/trends/immun...
journals.asm.org/doi/full/10....
www.ijmb.in/doi/IJMB/pdf...
www.researchgate.net/profile/Muha...
link.springer.com/article/10.1...
Lactate trains immunity
Understanding the mechanisms implicated in the establishment of trained immunity could
aid the design of novel therapeutic approaches. By studying Bacille Calmette-Guerin
(BCG) vaccination in a human ...
www.cell.com
May 27, 2025 at 6:32 PM
Check out this beautiful and comprehensive review by Juan Diego and Michael Schotsaert about "Helminth infections affect host immune responses to viral infections and vaccines" in FemsMicroReview. #TrainedImmunity
@jgbd.bsky.social @mschotsaert.bsky.social
academic.oup.com/femsre/advan...
@jgbd.bsky.social @mschotsaert.bsky.social
academic.oup.com/femsre/advan...
Helminth infections affect host immune responses to viral infections and vaccines
Abstract. Helminths are highly prevalent in many regions of the world. Due to the chronic nature of most helminth infections, these parasites are proficien
academic.oup.com
August 14, 2025 at 6:51 PM
Check out this beautiful and comprehensive review by Juan Diego and Michael Schotsaert about "Helminth infections affect host immune responses to viral infections and vaccines" in FemsMicroReview. #TrainedImmunity
@jgbd.bsky.social @mschotsaert.bsky.social
academic.oup.com/femsre/advan...
@jgbd.bsky.social @mschotsaert.bsky.social
academic.oup.com/femsre/advan...
9/9 I'd love to connect if you're interested in trained immunity, eosinophils, allergy, or infection-driven inflammation @science.org
#ScienceImmunology #PhDResearch #TrainedImmunity #Eosinophils #Asthma #Allergy #SkinInfection
#ScienceImmunology #PhDResearch #TrainedImmunity #Eosinophils #Asthma #Allergy #SkinInfection
April 4, 2025 at 6:18 PM
9/9 I'd love to connect if you're interested in trained immunity, eosinophils, allergy, or infection-driven inflammation @science.org
#ScienceImmunology #PhDResearch #TrainedImmunity #Eosinophils #Asthma #Allergy #SkinInfection
#ScienceImmunology #PhDResearch #TrainedImmunity #Eosinophils #Asthma #Allergy #SkinInfection
Excited about the upcoming Innate Imm Memory Keystone meeting in Vancouver in Feb2025. Looking forward to sharing my postdoc work with the community, get some feedback and learn about cutting edge discoveries in #TrainedImmunity field. #LungresMacs ftw!
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
Innate Immune Memory: Mechanisms and Consequences | Keystone Symposia
Join us at the Keystone Symposia on Innate Immune Memory: Mechanisms and Consequences, February 2025, in Vancouver, with field leaders!
www.keystonesymposia.org
December 9, 2024 at 11:38 PM
Excited about the upcoming Innate Imm Memory Keystone meeting in Vancouver in Feb2025. Looking forward to sharing my postdoc work with the community, get some feedback and learn about cutting edge discoveries in #TrainedImmunity field. #LungresMacs ftw!
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
Aging may dull your immune system, but trained immunity could boost its response to inflammation.
📄 Full article: https://food-medicine-protocol.ghost.io/the-role-of-trained-immunity-in-aging-associated-inflammation-implications-for-longevity/
#trainedimmunity #ShrineLongevity
📄 Full article: https://food-medicine-protocol.ghost.io/the-role-of-trained-immunity-in-aging-associated-inflammation-implications-for-longevity/
#trainedimmunity #ShrineLongevity
September 24, 2026 at 3:56 AM
Aging may dull your immune system, but trained immunity could boost its response to inflammation.
📄 Full article: https://food-medicine-protocol.ghost.io/the-role-of-trained-immunity-in-aging-associated-inflammation-implications-for-longevity/
#trainedimmunity #ShrineLongevity
📄 Full article: https://food-medicine-protocol.ghost.io/the-role-of-trained-immunity-in-aging-associated-inflammation-implications-for-longevity/
#trainedimmunity #ShrineLongevity
Nargis Khan and Maz Divangahi show that β-glucan reprograms HSCs in the bone marrow to generate ‘regulatory’ neutrophils (IL-10hi) which are required for promoting #diseasetolerance and lung tissue integrity against IAV challenge. [1/n]
www.nature.com/articles/s41...
#TrainedImmunity #RegNeuts
www.nature.com/articles/s41...
#TrainedImmunity #RegNeuts
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus - Nature Immunology
Divangahi and colleagues report that β-glucan pretreatment before influenza A virus challenge can increase survival by inducing long-term reprogramming of neutrophils, promoting disease tolerance irre...
www.nature.com
February 21, 2025 at 3:39 AM
Nargis Khan and Maz Divangahi show that β-glucan reprograms HSCs in the bone marrow to generate ‘regulatory’ neutrophils (IL-10hi) which are required for promoting #diseasetolerance and lung tissue integrity against IAV challenge. [1/n]
www.nature.com/articles/s41...
#TrainedImmunity #RegNeuts
www.nature.com/articles/s41...
#TrainedImmunity #RegNeuts
New publication!!! Together Carlos Del Fresno Lab, we discussed how mucosal hashtag#vaccines based on trained immunity (TIbVs) work to prevent respiratory infections — including MV130, developed by
Inmunotek #AMR #TrainedImmunity #immunosky www.cell.com/trends/immun...
Inmunotek #AMR #TrainedImmunity #immunosky www.cell.com/trends/immun...
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections
The devastating impact of respiratory infections demonstrates the critical need for
novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies
as a complementary t...
www.cell.com
March 21, 2025 at 4:59 PM
New publication!!! Together Carlos Del Fresno Lab, we discussed how mucosal hashtag#vaccines based on trained immunity (TIbVs) work to prevent respiratory infections — including MV130, developed by
Inmunotek #AMR #TrainedImmunity #immunosky www.cell.com/trends/immun...
Inmunotek #AMR #TrainedImmunity #immunosky www.cell.com/trends/immun...
The data show that induction of TRIM ( #Trainedimmunity) by certain vaccines confers broad beneficial effects that can protect beyond the target pathogen.
www.nature.com/articles/s41...
These insights suggest that prior #Covid19vaccines prevents overactivation of #innateimmune responses
www.nature.com/articles/s41...
These insights suggest that prior #Covid19vaccines prevents overactivation of #innateimmune responses
Trained immunity in chronic inflammatory diseases and cancer - Nature Reviews Immunology
Besides its beneficial effects against infection, trained immunity has recently been implicated in inflammation-related disorders and is being exploited in cancer immunotherapy. These advances may ena...
www.nature.com
May 27, 2025 at 7:03 PM
The data show that induction of TRIM ( #Trainedimmunity) by certain vaccines confers broad beneficial effects that can protect beyond the target pathogen.
www.nature.com/articles/s41...
These insights suggest that prior #Covid19vaccines prevents overactivation of #innateimmune responses
www.nature.com/articles/s41...
These insights suggest that prior #Covid19vaccines prevents overactivation of #innateimmune responses
Check out our new review discussing novel immunometabolic mechanisms underlying inflammation, metabolomic techniques and potential metabolite biomarkers of chronic inflammatory disease!
Special focus is on #efferocytosis #IL-10 and #trainedimmunity
link.springer.com/article/10.1...
Special focus is on #efferocytosis #IL-10 and #trainedimmunity
link.springer.com/article/10.1...
Dissecting inflammation in the immunemetabolomic era - Cellular and Molecular Life Sciences
The role of immune metabolism, specific metabolites and cell-intrinsic and -extrinsic metabolic states across the time course of an inflammatory response are emerging knowledge. Targeted and untargete...
link.springer.com
April 28, 2025 at 9:08 PM
Check out our new review discussing novel immunometabolic mechanisms underlying inflammation, metabolomic techniques and potential metabolite biomarkers of chronic inflammatory disease!
Special focus is on #efferocytosis #IL-10 and #trainedimmunity
link.springer.com/article/10.1...
Special focus is on #efferocytosis #IL-10 and #trainedimmunity
link.springer.com/article/10.1...
Not only #TrainedImmunity, but also trained #SmoothMuscleCell!?
#YAP/TAZ in epigenetic control of Arterial mechanics
LINC (nesprin/SUN) to transduce rigidity to nucleoskeleton & gene transcription
Stéphane Laurent lab Annual Rev Physiol 2024
www.annualreviews.org/content/jour...
#YAP/TAZ in epigenetic control of Arterial mechanics
LINC (nesprin/SUN) to transduce rigidity to nucleoskeleton & gene transcription
Stéphane Laurent lab Annual Rev Physiol 2024
www.annualreviews.org/content/jour...
May 22, 2024 at 7:21 PM
Not only #TrainedImmunity, but also trained #SmoothMuscleCell!?
#YAP/TAZ in epigenetic control of Arterial mechanics
LINC (nesprin/SUN) to transduce rigidity to nucleoskeleton & gene transcription
Stéphane Laurent lab Annual Rev Physiol 2024
www.annualreviews.org/content/jour...
#YAP/TAZ in epigenetic control of Arterial mechanics
LINC (nesprin/SUN) to transduce rigidity to nucleoskeleton & gene transcription
Stéphane Laurent lab Annual Rev Physiol 2024
www.annualreviews.org/content/jour...
MedSky #Immunology #viralimmunology Differences in #immuneresponses in males and females can sometimes favour one or the other sex. A sex bias in #trainedimmunity, where females displayed decreased inflammatory responsiveness & survival from opportunistic infection compared vs males.
August 23, 2023 at 11:45 AM
MedSky #Immunology #viralimmunology Differences in #immuneresponses in males and females can sometimes favour one or the other sex. A sex bias in #trainedimmunity, where females displayed decreased inflammatory responsiveness & survival from opportunistic infection compared vs males.
Innate immunity was long thought to be devoid of immunological memory until a landmark study a decade ago introduced the concept of #TrainedImmunity.
Today, we’re inviting research to a new Focus Issue on Trained Immunity. Find out more and spread the word: elifesciences.org/inside-elife...
Today, we’re inviting research to a new Focus Issue on Trained Immunity. Find out more and spread the word: elifesciences.org/inside-elife...
March 6, 2024 at 3:24 PM
Innate immunity was long thought to be devoid of immunological memory until a landmark study a decade ago introduced the concept of #TrainedImmunity.
Today, we’re inviting research to a new Focus Issue on Trained Immunity. Find out more and spread the word: elifesciences.org/inside-elife...
Today, we’re inviting research to a new Focus Issue on Trained Immunity. Find out more and spread the word: elifesciences.org/inside-elife...
🧠 New study: BCG vaccine may reshape brain immunity to protect against Alzheimer's disease. Mass General Brigham investigators found sustained chan…
#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedimmunity #Vaccineimmunology
#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedim…
#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedimmunity #Vaccineimmunology
#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedim…
BCG Vaccine Reshapes Brain Immunity, May Protect Against Alzheimer's
🧠 New study: BCG vaccine may reshape brain immunity to protect against Alzheimer's disease. Mass General Brigham investigators found sustained chan…
#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedimmunity #Vaccineimmunology
news.gmj.ge
September 4, 2026 at 8:42 AM
🧠 New study: BCG vaccine may reshape brain immunity to protect against Alzheimer's disease. Mass General Brigham investigators found sustained chan…
#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedimmunity #Vaccineimmunology
#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedim…
#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedimmunity #Vaccineimmunology
#Alzheimersdisease #BCGvaccine #Neuroinflammation #Trainedim…
Back to working full-time on #InnateImmuneMemory, so I'll start posting papers (mostly new, but also older ones that I re-read) on the topic. Hope this helps everyone (me too 😅) keeping up-to-date with this fast-growing field 😄
#TrainedImmunity #Tolerance #InnateImmunity #Immunity
#TrainedImmunity #Tolerance #InnateImmunity #Immunity
November 15, 2024 at 11:02 AM
Back to working full-time on #InnateImmuneMemory, so I'll start posting papers (mostly new, but also older ones that I re-read) on the topic. Hope this helps everyone (me too 😅) keeping up-to-date with this fast-growing field 😄
#TrainedImmunity #Tolerance #InnateImmunity #Immunity
#TrainedImmunity #Tolerance #InnateImmunity #Immunity
The gut trains the bone marrow.
Microbial signals → trained immunity → systemic inflammation control. 🦠🦴
Discover the gut–bone marrow axis at
📍 Global Microbiome Congress 2026 | Boston
🗓 June 15–16, 2026
🔗 microbiomecongress.org
#TrainedImmunity #Microbiome #GMC2026
Microbial signals → trained immunity → systemic inflammation control. 🦠🦴
Discover the gut–bone marrow axis at
📍 Global Microbiome Congress 2026 | Boston
🗓 June 15–16, 2026
🔗 microbiomecongress.org
#TrainedImmunity #Microbiome #GMC2026
January 13, 2026 at 4:09 AM
The gut trains the bone marrow.
Microbial signals → trained immunity → systemic inflammation control. 🦠🦴
Discover the gut–bone marrow axis at
📍 Global Microbiome Congress 2026 | Boston
🗓 June 15–16, 2026
🔗 microbiomecongress.org
#TrainedImmunity #Microbiome #GMC2026
Microbial signals → trained immunity → systemic inflammation control. 🦠🦴
Discover the gut–bone marrow axis at
📍 Global Microbiome Congress 2026 | Boston
🗓 June 15–16, 2026
🔗 microbiomecongress.org
#TrainedImmunity #Microbiome #GMC2026
Sina Bohnacker and Julia Esser-von Bieren identify key roles of heGDH in immune evasion, parasite chronicity, and tissue repair during helminth infections in this new study. Huge fan of Julia's work! #type2 #helminths #trainedimmunity #heGDH
www.science.org/doi/epdf/10.... [20/n]
www.science.org/doi/epdf/10.... [20/n]
A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis
You have to enable JavaScript in your browser's settings in order to use the eReader.
www.science.org
December 19, 2024 at 3:28 AM
Sina Bohnacker and Julia Esser-von Bieren identify key roles of heGDH in immune evasion, parasite chronicity, and tissue repair during helminth infections in this new study. Huge fan of Julia's work! #type2 #helminths #trainedimmunity #heGDH
www.science.org/doi/epdf/10.... [20/n]
www.science.org/doi/epdf/10.... [20/n]