Microglia clear intraneuronal α-synuclein aggregates
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis
Microglia clear intraneuronal α-synuclein aggregates.
www.science.org
October 8, 2026 at 1:36 AM
Microglia clear intraneuronal α-synuclein aggregates
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Replacing old immune cells called microglia with fresh ones holds promise for addressing brain conditions such as Alzheimer’s disease @nature.com @heidiledford.bsky.social
nature.com/articles/d41...
nature.com/articles/d41...
Swapping old immune cells in the brain with fresh ones could treat disease
Replacing immune cells called microglia holds promise for addressing brain conditions such as Alzheimer’s disease.
nature.com
September 26, 2025 at 4:39 PM
Replacing old immune cells called microglia with fresh ones holds promise for addressing brain conditions such as Alzheimer’s disease @nature.com @heidiledford.bsky.social
nature.com/articles/d41...
nature.com/articles/d41...
Neurons on fire 🔥 ? Check how these microglia 🟡 interact with neurons 🔵 accumulating phospho-Tau 🔴, one of the hallmarks in #Alzheimer's disease.
What is happening there? Are these microglia making things better or worse?
#FluorescenceFriday #Neuroinflammation
What is happening there? Are these microglia making things better or worse?
#FluorescenceFriday #Neuroinflammation
July 25, 2025 at 5:47 AM
Neurons on fire 🔥 ? Check how these microglia 🟡 interact with neurons 🔵 accumulating phospho-Tau 🔴, one of the hallmarks in #Alzheimer's disease.
What is happening there? Are these microglia making things better or worse?
#FluorescenceFriday #Neuroinflammation
What is happening there? Are these microglia making things better or worse?
#FluorescenceFriday #Neuroinflammation
My latest paper, deep proteomic analysis of mouse and human microglia: www.cell.com/cell-reports...
Deep proteomic analysis of microglia reveals fundamental biological differences between model systems
Lloyd et al. generated a comprehensive microglia proteome database, identifying over
11,000 proteins. Fundamental differences between ex vivo and in vitro microglia associated
with protein synthesis, ...
www.cell.com
November 13, 2024 at 9:24 AM
My latest paper, deep proteomic analysis of mouse and human microglia: www.cell.com/cell-reports...
2024 #FluorescenceFriday retrospective: It was a great year in science for microglia, the brain's immune cells! The brain is much more than neurons; these little cells are essential, particularly in inflammatory processes. Check them interacting below! Markers: neurons (🔵 MAP2), microglia (🟡 IBA1)
December 27, 2024 at 7:35 PM
2024 #FluorescenceFriday retrospective: It was a great year in science for microglia, the brain's immune cells! The brain is much more than neurons; these little cells are essential, particularly in inflammatory processes. Check them interacting below! Markers: neurons (🔵 MAP2), microglia (🟡 IBA1)
👻 "Dark Forest Within" 🧠
What if the brain is a creepy forest? Our neurons are the 🌲, old (as old as we are!), and without mobility. Suddenly, comes the microglia, our brain's immune cells. Everything lights up when they move around.
🟢microglia🟣neurons
#FluorescenceFriday 🎃
What if the brain is a creepy forest? Our neurons are the 🌲, old (as old as we are!), and without mobility. Suddenly, comes the microglia, our brain's immune cells. Everything lights up when they move around.
🟢microglia🟣neurons
#FluorescenceFriday 🎃
October 3, 2025 at 9:44 PM
👻 "Dark Forest Within" 🧠
What if the brain is a creepy forest? Our neurons are the 🌲, old (as old as we are!), and without mobility. Suddenly, comes the microglia, our brain's immune cells. Everything lights up when they move around.
🟢microglia🟣neurons
#FluorescenceFriday 🎃
What if the brain is a creepy forest? Our neurons are the 🌲, old (as old as we are!), and without mobility. Suddenly, comes the microglia, our brain's immune cells. Everything lights up when they move around.
🟢microglia🟣neurons
#FluorescenceFriday 🎃
I see an icy microglia!
January 30, 2025 at 2:54 PM
I see an icy microglia!
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease
This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease - Nature Communications
The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...
www.nature.com
December 6, 2024 at 6:44 AM
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease
This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
#fluorescencefriday distribution of microglia in the whole brain
February 6, 2026 at 7:28 PM
#fluorescencefriday distribution of microglia in the whole brain
Happy holidays everyone, from my microglia to yours.
November 27, 2024 at 4:54 PM
Happy holidays everyone, from my microglia to yours.
Check this neuron infected with #SARSCoV2 being attacked by a microglia. Is this process beneficial or detrimental? Do we want therapies to inhibit microglia activation/neuroinflammation, but what if it means more neurons infecting other neurons? Neurovirology is fascinating! #FluorescenceFriday
August 8, 2025 at 7:21 PM
Check this neuron infected with #SARSCoV2 being attacked by a microglia. Is this process beneficial or detrimental? Do we want therapies to inhibit microglia activation/neuroinflammation, but what if it means more neurons infecting other neurons? Neurovirology is fascinating! #FluorescenceFriday
For #FluorescenceFriday, RhoA (blue) and the actin cytoskeleton (magenta) are shown in a set of primary microglia 🔬 #Neuroscience #Microscopy
October 3, 2025 at 1:07 PM
For #FluorescenceFriday, RhoA (blue) and the actin cytoskeleton (magenta) are shown in a set of primary microglia 🔬 #Neuroscience #Microscopy
Our study is out in @cp-immunity.bsky.social: Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments, and sedation following alcohol abuse. Grateful to lab members, collaborators, funders, reviewers, @kavithascranton.bsky.social www.cell.com/immunity/ful...
Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments, and sedation following alcohol abuse
Alcohol’s brain effects are attributed to neurons, leaving microglial functional involvement
untested. Paouri, Stanko, et al. show that microglia drive alcohol-induced sedation,
motor impairment, and ...
www.cell.com
October 9, 2026 at 7:10 PM
Our study is out in @cp-immunity.bsky.social: Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments, and sedation following alcohol abuse. Grateful to lab members, collaborators, funders, reviewers, @kavithascranton.bsky.social www.cell.com/immunity/ful...
Microglia community, let’s start the discussion 🧠 follow the Microglia Starter Pack and ask @mancusorenzo.bsky.social to add your colleagues as they join Bluesky 🦋
go.bsky.app/DT3Cp4A
go.bsky.app/DT3Cp4A
November 17, 2024 at 12:52 PM
Microglia community, let’s start the discussion 🧠 follow the Microglia Starter Pack and ask @mancusorenzo.bsky.social to add your colleagues as they join Bluesky 🦋
go.bsky.app/DT3Cp4A
go.bsky.app/DT3Cp4A
An innovative method to reduce neurodegenerative disease: replace the microglial brain immune cells. Worked in a rare lysosomal storage disease, mouse model, efficient, without immune rejection
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Therapeutic genetic restoration through allogeneic brain microglia replacement - Nature
Nature - Therapeutic genetic restoration through allogeneic brain microglia replacement
www.nature.com
August 6, 2025 at 3:33 PM
An innovative method to reduce neurodegenerative disease: replace the microglial brain immune cells. Worked in a rare lysosomal storage disease, mouse model, efficient, without immune rejection
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🧠 Daily Feed of Brain Damage 🧠 in 2 parts with @davidjoffe64.bsky.social and @ejustin46.bsky.social
#SARSCoV2 can infect the immune cells of the brain, microglia, and contribute to neuroinflammation in #NeuroCovid. What do we know so far?
Review just published www.sciencedirect.com/science/arti...
#SARSCoV2 can infect the immune cells of the brain, microglia, and contribute to neuroinflammation in #NeuroCovid. What do we know so far?
Review just published www.sciencedirect.com/science/arti...
December 1, 2024 at 4:23 AM
🧠 Daily Feed of Brain Damage 🧠 in 2 parts with @davidjoffe64.bsky.social and @ejustin46.bsky.social
#SARSCoV2 can infect the immune cells of the brain, microglia, and contribute to neuroinflammation in #NeuroCovid. What do we know so far?
Review just published www.sciencedirect.com/science/arti...
#SARSCoV2 can infect the immune cells of the brain, microglia, and contribute to neuroinflammation in #NeuroCovid. What do we know so far?
Review just published www.sciencedirect.com/science/arti...
Sharing the latest from the lab. Led by Yunlong Liu, this work explores how microglia and engram neurons interact during fear extinction in the hippocampus.
rdcu.be/fgNH7
rdcu.be/fgNH7
Microglia-dependent regulation of fear memory extinction
Nature Neuroscience - Liu et al. show in mice that microglia are recruited to the soma and dendritic processes of fear engram neurons during extinction learning and that they weaken fear memories...
rdcu.be
May 4, 2026 at 10:46 AM
Sharing the latest from the lab. Led by Yunlong Liu, this work explores how microglia and engram neurons interact during fear extinction in the hippocampus.
rdcu.be/fgNH7
rdcu.be/fgNH7
Exquisite study characterizing morphological differences between plaque-associated microglia and coffin-like microglia and their association with astrocytes in AD 😳
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus - Acta Neuropathologica
In Alzheimer’s disease (AD), microglia form distinct cellular aggregates that play critical roles in disease progression, including Aβ plaque-associated microglia (PaM) and the newly identified coffin...
link.springer.com
February 18, 2025 at 12:23 AM
Exquisite study characterizing morphological differences between plaque-associated microglia and coffin-like microglia and their association with astrocytes in AD 😳
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Mice lacking microglia (Csf1r∆FIRE/∆FIRE) have normal
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression
www.nature.com/articles/s41...
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression
www.nature.com/articles/s41...
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience
Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...
www.nature.com
January 7, 2025 at 2:34 PM
Mice lacking microglia (Csf1r∆FIRE/∆FIRE) have normal
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression
www.nature.com/articles/s41...
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression
www.nature.com/articles/s41...
The potential role of dark microglia, a distinct subset of the primary immune cells in the brain, in Alzheimer's disease
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
December 23, 2024 at 4:30 PM
The potential role of dark microglia, a distinct subset of the primary immune cells in the brain, in Alzheimer's disease
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Analyzing how neurons🔵 and microglia🟡 (brain immune cells) interact and I vote for 3D microscopy videos with appropriate soundtracks 🤘 👩🎤🔬 #FluorescenceFriday
August 1, 2025 at 7:26 PM
Analyzing how neurons🔵 and microglia🟡 (brain immune cells) interact and I vote for 3D microscopy videos with appropriate soundtracks 🤘 👩🎤🔬 #FluorescenceFriday
But neurons are the most important cell type in the brain, right?
August 7, 2025 at 8:20 PM
But neurons are the most important cell type in the brain, right?
Could inhaling Xenon be used someday to prevent or treat Alzheimer's disease? An intriguing experimental model study shows its effect on modulating brain microglia and reducing inflammation
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy
Xenon inhalation modulates microglial responses in mice and is a potential therapeutic agent for treating Alzheimer’s disease.
www.science.org
January 15, 2025 at 7:37 PM
Could inhaling Xenon be used someday to prevent or treat Alzheimer's disease? An intriguing experimental model study shows its effect on modulating brain microglia and reducing inflammation
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...