Molecular Neurodegeneration
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molneurodegen.bsky.social
Molecular Neurodegeneration
@molneurodegen.bsky.social
The #1 open-access peer-reviewed neuroscience journal with a 2025 Impact Factor of 19.6 and a 5-year IF of 21.1. Official journal of BrightFocus Foundation
In vivo detection of pathologic α- #synuclein and #TDP43 in the skin and olfactory mucosa of a patient with #Parkinsons disease-like phenotype carrying the p.Thr272Serfs*10 GRN mutation

Paola Caroppo, Vittoria Aprea...Grazia Devigili

link.springer.com/article/10.1...
In vivo detection of pathologic α- synuclein and TDP-43 in the skin and olfactory mucosa of a patient with Parkinson’s disease-like phenotype carrying the p.Thr272Serfs*10 GRN mutation - Molecular Neu...
We describe a patient carrying the GRN p.Thr272Serfs*10 mutation, who presented with parkinsonism at onset and later developed prodromal frontotemporal dementia, in whom seed amplification assay on ol...
link.springer.com
October 5, 2026 at 2:16 PM
As part of our 'Lipids in Neurodegeneration' collection!

From mechanism to intervention: #lipoproteins and #AlzheimersDisease

Tetiana Poliakova, Lizi Zhang, Cheryl L. Wellington @dmcbrainhealth.bsky.social #cholesterol

link.springer.com/article/10.1...
From mechanism to intervention: lipoproteins and Alzheimer’s disease - Molecular Neurodegeneration
Alzheimer’s disease (AD) is the leading global cause of dementia, characterized by memory impairment and neuropathological hallmarks of amyloid and tau deposition. Several cardiovascular risk factors,...
link.springer.com
September 28, 2026 at 3:39 PM
Dynamic [18F]PI-2620 recording facilitates prediction of β- #amyloid positivity and simultaneous staging of tau and #neurodegeneration

Johannes Gnörich, Julia Kusche-Palenga, Agnes Kling...Matthias Brendel @lmu.de #neuroimaging #tauopathies

link.springer.com/article/10.1...
Dynamic [18F]PI-2620 recording facilitates prediction of β-amyloid positivity and simultaneous staging of tau and neurodegeneration - Molecular Neurodegeneration
Background Patients with Alzheimer’s disease (AD) and clinically overlapping neurodegenerative diseases are classified molecularly using the A/T/N classification system. Apart from fluid biomarkers an...
link.springer.com
September 24, 2026 at 2:56 PM
Explore the inaugural Review Collection from our sister journal, Molecular Neurodegeneration Advances
@molneurodegenadvnc.bsky.social

Led by Drs Lance Johnson, Julia TCW & Hui Zhang, it highlights emerging paradigms & therapeutic horizons in neurodegeneration

link.springer.com/collections/...
The Molecular Landscape of Neurodegeneration: Emerging Paradigms and Therapeutic Horizons
Rapid advances in molecular neuroscience have revealed new layers of complexity in the pathogenic mechanisms underlying neurodegenerative diseases. From the ...
link.springer.com
September 23, 2026 at 4:06 PM
#Astrocyte reactivity identifies p- #tau217 -positive individuals at elevated risk of cognitive decline across the #AlzheimersDisease continuum

Bruna Bellaver, Guilherme Povala, Pamela C. L. Ferreira...Tharick A. Pascoal @pittdeptofmed.bsky.social

link.springer.com/article/10.1...
September 23, 2026 at 3:21 PM
Reposted by Molecular Neurodegeneration
Happy to share a new review article I wrote with Fasih Ahsan and Tracy Young-Pearse @typlab.bsky.social is out today in @molneurodegen.bsky.social! Here, we provide an overview of tools and findings leveraging human cellular models to study lipid biology in AD!
September 21, 2026 at 2:01 PM
Reposted by Molecular Neurodegeneration
New TYP lab publication is out today! A phenomenal review by @heuerwego.bsky.social, Fasih Ahsan and Tracy providing a thorough overview of human cellular models to study AD lipid biology!
September 21, 2026 at 1:59 PM
Plasma GDF15 as a potential #biomarker and driver of #neuroinflammation and #dementia risk

José M. Izquierdo @uam.es

link.springer.com/article/10.1...
September 21, 2026 at 1:40 PM
CSF #proteomics and #machinelearning reveal distinct stages across the #AlzheimersDisease continuum

Saima Rathore...Nicholas T. Seyfried, Allan I. Levey @emorydeptofmed.bsky.social

link.springer.com/article/10.1...
September 14, 2026 at 1:23 PM
Intranasal drug delivery for #neurodegenerative diseases: #therapeutic opportunities across molecules, organelles, and cells

Tu Chen Guan...Yun Cheng Wu, Eng King Tan, Zhi Dong Zhou

link.springer.com/article/10.1...
September 14, 2026 at 1:19 PM
#Inflammasomes: central mediators of neuroinflammatory #neurodegeneration in #Alzheimers and #Parkinsons disease

Clémence Tropis, Janna Jernigan Posey, Malú Gámez Tansey, @malutansey.bsky.social Michael T. Heneka

link.springer.com/article/10.1...
September 8, 2026 at 2:55 PM
The YTHDF proteins modulate #AlzheimersDisease -associated brain gene signatures

Shinya Tasaki, Denis R. Avey, Nicola A. Kearns...Yanling Wang @rushmedical.bsky.social

link.springer.com/article/10.1...
September 8, 2026 at 2:51 PM
Reposted by Molecular Neurodegeneration
Another moment of pride! 🎉 Emily Tom’s PhD work is finally published! Her work reveals a fascinating consequence of aging: plasma membrane damage increases, and lysosomes step in to repair the membrane and keep cells alive. Let us know what you think, and repost it! link.springer.com/article/10.1...
Lipid-driven membrane remodeling engages a lysosome-dependent adaptive repair program during retinal aging - Molecular Neurodegeneration
Age-associated remodeling of membrane lipid composition has been implicated in cellular dysfunction, yet the mechanisms linking lipid changes to membrane integrity and disease remain poorly defined. I...
link.springer.com
August 29, 2026 at 8:26 PM
#Lipid- driven membrane remodeling engages a
#lysosome -dependent adaptive repair program during retinal aging

Emily Tom, Fangyuan Gao, Carolina N. Franco...Dorota Skowronska-Krawczyk @drdorotask.bsky.social #retina #neurodegeneration

link.springer.com/article/10.1...
August 31, 2026 at 2:54 PM
Reposted by Molecular Neurodegeneration
Proud to see this new research from the BBRC and collaborators!

The study finds that amyloid-β pathology is the strongest predictor of future grey matter loss in preclinical AD, beyond tau-related pathology and other biological processes.

Congratulations to the team! 👏 @molneurodegen.bsky.social
Happy to share our latest work, published Molecular Neurodegeneration!

We studied associations between latent components from CSF #biomarkers with #longitudinal grey matter changes in preclinical AD, using data from @barcelonabeta.bsky.social and the University of Wisconsin @gsalvado.bsky.social
August 28, 2026 at 6:43 AM
Neurobiological correlates of longitudinal
#greymatter volume changes in preclinical #AlzheimersDisease

Wiesje Pelkmans...Gemma Salvadó, Sterling C. Johnson, Juan Domingo Gispert @barcelonabeta.bsky.social #amyloid #biomarkers

link.springer.com/article/10.1...
August 27, 2026 at 2:25 PM
GFAP upregulation by #astrocytes attenuates tau neurofibrillary tangle pathology in a mouse model of #tauopathy

Clara Muñoz-Castro, Molly A. Healey, Ayush Noori...Alberto Serrano-Pozo @harvardmed.bsky.social #AlzheimersDisease

link.springer.com/article/10.1...
August 25, 2026 at 2:12 PM
Iron dysregulation: implications for pathology in #multiplesclerosis

Dorsa Moezzi, Rianne Gorter, Atefeh Rayatpour, Rui Li, V. Wee Yong @ucalgary.bsky.social @hotchkissbrain.bsky.social #ferroptosis #oxidativestress

link.springer.com/article/10.1...
August 24, 2026 at 3:04 PM
Advancing a systems-level understanding of neurodegeneration: the BrightFocus #AlzheimersDisease research portfolio

Sharyn L. Rossi & Diane E. Bovenkamp @dianebovenkamp.bsky.social @brightfocus.bsky.social

link.springer.com/article/10.1...
August 24, 2026 at 2:59 PM
Reposted by Molecular Neurodegeneration
🚨 DON'T MISS OUT! 🚨 There’s less than one week until the ISMND 2026 Early Bird Registration deadline!

💰 Save on registration by securing the Early Bird rate by August 24.

We can’t wait to welcome you to Hong Kong!

🔗 Register now: ismnd2026.org
August 19, 2026 at 2:26 PM
Reposted by Molecular Neurodegeneration
We are excited to announce Dr Hui Zheng
@bcmhouston.bsky.social as our next ISMND webinar speaker!

Talk title: Beyond degradation: #Lysosomal sensing and signaling in #AlzheimersDisease

August 27, 2026
11am-12 pm (ET)

Host: Dr Joanna Jankowsky, WashU
Register: bit.ly/4bVXshg
August 17, 2026 at 3:33 PM