Microtubule comets in human iPSCs to kick off my first week of grad school! ☄️💫
June 3, 2026 at 10:40 PM
Microtubule comets in human iPSCs to kick off my first week of grad school! ☄️💫
CRISPR mRNA iPSCs
These are world changing inventions.
These are world changing inventions.
October 19, 2025 at 9:04 AM
CRISPR mRNA iPSCs
These are world changing inventions.
These are world changing inventions.
Some beautiful IPSCs for your Friday! #patchclamp
May 16, 2025 at 5:42 PM
Some beautiful IPSCs for your Friday! #patchclamp
Researchers at Osaka University developed an experimental stem cell treatment for severe corneal damage. They reprogrammed blood cells from healthy donors into iPSCs and used them to create corneal tissue intended for transplantation.
September 19, 2026 at 1:00 PM
Researchers at Osaka University developed an experimental stem cell treatment for severe corneal damage. They reprogrammed blood cells from healthy donors into iPSCs and used them to create corneal tissue intended for transplantation.
I moved from on iPSCs and organoids in ~2012 to systems neuro and then deep learning (~’16/17). I vividly remember when interviewing for faculty positions someone asking me “is deep learning really the way to go/why give up my successful start in iPSCs”…
~10 years on ... yes, for me, yes!
~10 years on ... yes, for me, yes!
The further a researcher or inventor moves from their previous work, the less cited their latest work will be
https://go.nature.com/44VjEW9
https://go.nature.com/44VjEW9
Shifting research focus comes with the risk of reduced impact
An analysis of millions of scientific papers and patents shows that the further a researcher or inventor moves from their previous work, the less cited their latest work will be.
go.nature.com
June 1, 2025 at 6:40 PM
I moved from on iPSCs and organoids in ~2012 to systems neuro and then deep learning (~’16/17). I vividly remember when interviewing for faculty positions someone asking me “is deep learning really the way to go/why give up my successful start in iPSCs”…
~10 years on ... yes, for me, yes!
~10 years on ... yes, for me, yes!
Awesome talk from @akshayjg.bsky.social at the Jornades de Bioinformàtica i Genòmica presenying our work on Alzheimer's disease using iPSCs and scRNAseq.
December 19, 2025 at 11:06 AM
Awesome talk from @akshayjg.bsky.social at the Jornades de Bioinformàtica i Genòmica presenying our work on Alzheimer's disease using iPSCs and scRNAseq.
🤩 A successful first day of our SNE Thematic Days, with symposia on iPSCs, neuroimmunoendocrinology and thyroid hormones, as well as short talks and posters from our ECRs.
We ended the day with a welcome reception and the introduction of our new SNE Honorary Presidents.
Looking forward to Day 2!
We ended the day with a welcome reception and the introduction of our new SNE Honorary Presidents.
Looking forward to Day 2!
September 24, 2026 at 6:59 PM
🤩 A successful first day of our SNE Thematic Days, with symposia on iPSCs, neuroimmunoendocrinology and thyroid hormones, as well as short talks and posters from our ECRs.
We ended the day with a welcome reception and the introduction of our new SNE Honorary Presidents.
Looking forward to Day 2!
We ended the day with a welcome reception and the introduction of our new SNE Honorary Presidents.
Looking forward to Day 2!
One of these trials has been funded by NIH.
The other in Japan (where the Yamanaka work originated); this country made a big bet on iPSCs, leading the world
www.nature.com/articles/d41...
@nature.com editorial on stem cells in this week's issue
www.nature.com/articles/d41...
The other in Japan (where the Yamanaka work originated); this country made a big bet on iPSCs, leading the world
www.nature.com/articles/d41...
@nature.com editorial on stem cells in this week's issue
www.nature.com/articles/d41...
April 17, 2025 at 2:21 PM
One of these trials has been funded by NIH.
The other in Japan (where the Yamanaka work originated); this country made a big bet on iPSCs, leading the world
www.nature.com/articles/d41...
@nature.com editorial on stem cells in this week's issue
www.nature.com/articles/d41...
The other in Japan (where the Yamanaka work originated); this country made a big bet on iPSCs, leading the world
www.nature.com/articles/d41...
@nature.com editorial on stem cells in this week's issue
www.nature.com/articles/d41...
ok i looked into this and what he did was create a sample of ipscs
extremely normal guy voice: I cloned myself so I can become my own blood boy.
July 23, 2026 at 5:42 PM
ok i looked into this and what he did was create a sample of ipscs
Bone Marrow Organoid (BMO)!
BMO generated from human iPSCs can be used to study hematopoiesis. This one pretends to be a heart.
Picture by Savannah Fairley.
🔵DAPI (nuclei)
🌕CD271 (mesenchymal cells)
🔴CD31 (endothelial cells)
www.nature.com/articles/s41...
#FluorescenceFriday #ImmunoSky 🧪
BMO generated from human iPSCs can be used to study hematopoiesis. This one pretends to be a heart.
Picture by Savannah Fairley.
🔵DAPI (nuclei)
🌕CD271 (mesenchymal cells)
🔴CD31 (endothelial cells)
www.nature.com/articles/s41...
#FluorescenceFriday #ImmunoSky 🧪
November 22, 2024 at 3:42 PM
Bone Marrow Organoid (BMO)!
BMO generated from human iPSCs can be used to study hematopoiesis. This one pretends to be a heart.
Picture by Savannah Fairley.
🔵DAPI (nuclei)
🌕CD271 (mesenchymal cells)
🔴CD31 (endothelial cells)
www.nature.com/articles/s41...
#FluorescenceFriday #ImmunoSky 🧪
BMO generated from human iPSCs can be used to study hematopoiesis. This one pretends to be a heart.
Picture by Savannah Fairley.
🔵DAPI (nuclei)
🌕CD271 (mesenchymal cells)
🔴CD31 (endothelial cells)
www.nature.com/articles/s41...
#FluorescenceFriday #ImmunoSky 🧪
Excited to share I’m starting my group in Dublin this September, supported by a Research Ireland Pathway award. We will work on neurulation mechanics using chicken embryos and human iPSCs. Looking forward to this new adventure! #newPI #womeninSTEM
Minister for Further and Higher Education, Research, Innovation and Science, James Lawless, has today announced €23 million in funding to support early-career researchers through the Research Ireland Pathway Programme. Read more: www.researchireland.ie/news/pathways/ #ResearchIreland
June 26, 2025 at 7:56 AM
Excited to share I’m starting my group in Dublin this September, supported by a Research Ireland Pathway award. We will work on neurulation mechanics using chicken embryos and human iPSCs. Looking forward to this new adventure! #newPI #womeninSTEM
Fellow X-scientists! Curious who among you might want human iPSCs stably expressing ASAP-family green fluorescent voltage indicators.
Cardiomyocytes and neurons differentiated from these iPSCs can self-report voltage with <1-ms and <1-mV resolution by standard widefield imaging.
Cardiomyocytes and neurons differentiated from these iPSCs can self-report voltage with <1-ms and <1-mV resolution by standard widefield imaging.
April 12, 2026 at 5:01 PM
Fellow X-scientists! Curious who among you might want human iPSCs stably expressing ASAP-family green fluorescent voltage indicators.
Cardiomyocytes and neurons differentiated from these iPSCs can self-report voltage with <1-ms and <1-mV resolution by standard widefield imaging.
Cardiomyocytes and neurons differentiated from these iPSCs can self-report voltage with <1-ms and <1-mV resolution by standard widefield imaging.
Reprogramming biology: iPSCs and the future of predictive research
How patient-derived stem cells and genomic tools are transforming disease modeling and accelerating cures 🧬🧪🔬🧫
How patient-derived stem cells and genomic tools are transforming disease modeling and accelerating cures 🧬🧪🔬🧫
Reprogramming biology: iPSCs and the future of predictive research
How patient-derived stem cells and genomic tools are transforming disease modeling and accelerating cures
www.jax.org
November 15, 2025 at 8:08 PM
Reprogramming biology: iPSCs and the future of predictive research
How patient-derived stem cells and genomic tools are transforming disease modeling and accelerating cures 🧬🧪🔬🧫
How patient-derived stem cells and genomic tools are transforming disease modeling and accelerating cures 🧬🧪🔬🧫
Very excited for @livcracknell.bsky.social and @eugenia-w.bsky.social to represent our lab at the Keystone Symposia Meeting "iPSCs: Progress, Opportunities and Challenges" in Kyoto, Japan
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
iPSCs: Progress, Opportunities, and Challenges | Keystone Symposia
Join us at the Keystone Symposia on iPSCs: Progress, Opportunities, and Challenges, January 2026, in Kyoto, with field leaders!
www.keystonesymposia.org
January 26, 2026 at 11:27 AM
Very excited for @livcracknell.bsky.social and @eugenia-w.bsky.social to represent our lab at the Keystone Symposia Meeting "iPSCs: Progress, Opportunities and Challenges" in Kyoto, Japan
www.keystonesymposia.org/conferences/...
www.keystonesymposia.org/conferences/...
1/ After 3 years long years, our proteomic analysis of human stem cells is finally out. We reveal key differences between human induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs)—and show why normalisation is crucial. 🧪
Full paper: elifesciences.org/articles/92025
Full paper: elifesciences.org/articles/92025
November 14, 2024 at 5:38 PM
1/ After 3 years long years, our proteomic analysis of human stem cells is finally out. We reveal key differences between human induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs)—and show why normalisation is crucial. 🧪
Full paper: elifesciences.org/articles/92025
Full paper: elifesciences.org/articles/92025
Why do certain genetic mutations impact leukocyte production or function?
With Bone Marrow Organoids (BMOs), we can now explore this question in vitro!
BMOs, derived from human iPSCs, provide a tool to study hematopoiesis.
Yellow: nuclei
Blue: mesenchymal cells
#fluorescencefriday #ImmunoSky 🧪
With Bone Marrow Organoids (BMOs), we can now explore this question in vitro!
BMOs, derived from human iPSCs, provide a tool to study hematopoiesis.
Yellow: nuclei
Blue: mesenchymal cells
#fluorescencefriday #ImmunoSky 🧪
December 13, 2024 at 9:55 AM
Why do certain genetic mutations impact leukocyte production or function?
With Bone Marrow Organoids (BMOs), we can now explore this question in vitro!
BMOs, derived from human iPSCs, provide a tool to study hematopoiesis.
Yellow: nuclei
Blue: mesenchymal cells
#fluorescencefriday #ImmunoSky 🧪
With Bone Marrow Organoids (BMOs), we can now explore this question in vitro!
BMOs, derived from human iPSCs, provide a tool to study hematopoiesis.
Yellow: nuclei
Blue: mesenchymal cells
#fluorescencefriday #ImmunoSky 🧪
Two decades of induced pluripotent stem cell research: From discovery to diverse applications
Two decades of induced pluripotent stem cell research: From discovery to diverse applications
Since the discovery of induced pluripotent stem cells (iPSCs) 20 years ago, iPSC technology has transformed stem cell research and regenerative medicine. This perspective reviews key advances in reprogramming mechanisms and highlights the growing clinical, translational, and societal applications of iPSCs.
dlvr.it
March 9, 2026 at 7:09 PM
Two decades of induced pluripotent stem cell research: From discovery to diverse applications
Happy to share this collaborative work with Ron McKay and Suel Kee Kim, revealing that stable differentiation bias in iPSCs can be linked to transcriptomic signatures unique to individual human's cells: www.cell.com/stem-cell-re...
https://cell.com/stem-cell-repo…
November 25, 2024 at 4:43 PM
Happy to share this collaborative work with Ron McKay and Suel Kee Kim, revealing that stable differentiation bias in iPSCs can be linked to transcriptomic signatures unique to individual human's cells: www.cell.com/stem-cell-re...
My first post here on BlueSky to share our recent work with Claudia Feng and @leopoldparts.bsky.social - a large-scale single cell CRISPR screen to chart out gene regulation and the role of genomic background in iPSCs. Check out the data here: www.sanger.ac.uk/tool/crispri...
Does my mutation have the same impact as yours? Population genetics 🤠 🥸 🤓 🤡 meets single cell CRISPRi ⚡ ! www.biorxiv.org/content/10.1... Led by Claudia Feng, Oliver Stegle, Britta Velten, @sangerinstitute.bsky.social .
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
January 14, 2025 at 12:42 PM
My first post here on BlueSky to share our recent work with Claudia Feng and @leopoldparts.bsky.social - a large-scale single cell CRISPR screen to chart out gene regulation and the role of genomic background in iPSCs. Check out the data here: www.sanger.ac.uk/tool/crispri...
This review, which features in our collection on the Imbalance of Homeostasis in the nervous system, discusses recent insights into the mechanisms contributing to neurodegenerative disease that have been gained from modelling neuron–glia interactions in human iPSCs.
doi.org/10.1042/BSR2...
doi.org/10.1042/BSR2...
September 25, 2026 at 4:06 PM
This review, which features in our collection on the Imbalance of Homeostasis in the nervous system, discusses recent insights into the mechanisms contributing to neurodegenerative disease that have been gained from modelling neuron–glia interactions in human iPSCs.
doi.org/10.1042/BSR2...
doi.org/10.1042/BSR2...
Like iPSCs have some big problems keeping them from being practical yet but they are already much more practical than embryonic stem cells while having exactly zero ethical complications
September 29, 2025 at 12:07 AM
Like iPSCs have some big problems keeping them from being practical yet but they are already much more practical than embryonic stem cells while having exactly zero ethical complications
We’re hiring! Join the Sivyer Lab at The University of Sydney as a Postdoctoral Research Fellow in Neurodegeneration within the Snow Vision Accelerator, a $50M initiative tackling glaucoma and optic nerve disease. iPSCs, electrophysiology, drug discovery, and gene therapy.
November 4, 2025 at 10:20 AM
We’re hiring! Join the Sivyer Lab at The University of Sydney as a Postdoctoral Research Fellow in Neurodegeneration within the Snow Vision Accelerator, a $50M initiative tackling glaucoma and optic nerve disease. iPSCs, electrophysiology, drug discovery, and gene therapy.
Two decades of iPSCs - a timely overview from Shinya Yamanaka.
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Two decades of induced pluripotent stem cell research: From discovery to diverse applications
Since the discovery of induced pluripotent stem cells (iPSCs) 20 years ago, iPSC technology
has transformed stem cell research and regenerative medicine. This perspective reviews
key advances in repro...
www.cell.com
March 5, 2026 at 4:07 PM
Two decades of iPSCs - a timely overview from Shinya Yamanaka.
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Post 1/3 🧵
Our latest work is out at @natbiomedeng.nature.com!🚀
We present STRAIGHT-IN Dual — a platform for precise, allele-specific integration of two large DNA payloads into human iPSCs, enabling more sophisticated control of complex genetic programs.
Link📝: www.nature.com/articles/s41...
👇
Our latest work is out at @natbiomedeng.nature.com!🚀
We present STRAIGHT-IN Dual — a platform for precise, allele-specific integration of two large DNA payloads into human iPSCs, enabling more sophisticated control of complex genetic programs.
Link📝: www.nature.com/articles/s41...
👇
May 1, 2026 at 1:03 PM
Post 1/3 🧵
Our latest work is out at @natbiomedeng.nature.com!🚀
We present STRAIGHT-IN Dual — a platform for precise, allele-specific integration of two large DNA payloads into human iPSCs, enabling more sophisticated control of complex genetic programs.
Link📝: www.nature.com/articles/s41...
👇
Our latest work is out at @natbiomedeng.nature.com!🚀
We present STRAIGHT-IN Dual — a platform for precise, allele-specific integration of two large DNA payloads into human iPSCs, enabling more sophisticated control of complex genetic programs.
Link📝: www.nature.com/articles/s41...
👇
Well characterized, reliable human iPSCs for (almost) free! Highly recommended
Our #CellLineOfTheWeek is Alpha Actinin 2! 🫀🧫
Our human iPSC lines and plasmids – tagged to illuminate structures – are available for just the cost of shipping to support #cellbiology discovery.
📦 Distributed by Coriell Institute for Medical Research and @addgene.bsky.social
#OpenScience
Our human iPSC lines and plasmids – tagged to illuminate structures – are available for just the cost of shipping to support #cellbiology discovery.
📦 Distributed by Coriell Institute for Medical Research and @addgene.bsky.social
#OpenScience
November 27, 2024 at 2:19 PM
Well characterized, reliable human iPSCs for (almost) free! Highly recommended