Biologist discusses 2 FDA warnings including an odd one for totipotent stem cells and Laennec, noting a past death related to the latter.

Biologist outlines his stem cell and regenerative medicine predictions for the coming year of 2026 including background.

Cheung et al. show that HO-1 expressed by PvTAMs restricts the post-chemotherapy accumulation of stem-like CD8+ T cells in the TME. These cells enter tumors through a CXCR4-dependent pathway associated with chemotherapy-expanded CXCL12+ PvCAFs. Once within the TME, they differentiate into anti-tumor effectors, contributing to durable anti-tumor immunity.

Wu and colleagues establish an epiblast complementation strategy by genetically creating an empty developmental niche in the epiblast, which donor PSCs can then fill. This expands blastocyst complementation and offers a way to test PSC developmental potential and generate animals entirely from PSCs.

Sankaran and colleagues establish DNA methylation-based epigenome editing in human hematopoietic stem cells and their progeny. Targeting ITGB3, they show that silencing persists through self-renewal and megakaryocytic differentiation to alter platelet function and can be reversed through targeted demethylation. Extension to additional platelet genes demonstrates broad applicability.

npj Regenerative Medicine - Human iPSC-derived lens organoids recapitulate lens development and morphogenesis in vitro

The intestine remembers past injury. Arozamena and colleagues reveal that transcriptional and epigenetic memory accelerates future repair, with IFN-gamma encoding inflammatory memory and dedifferentia...

Biologist discusses 2 FDA warnings including an odd one for totipotent stem cells and Laennec, noting a past death related to the latter.