Using micropatterning & thousands of hours on the microscope
@manuelthery.bsky.social and the #CytoMorphoLab reimagined the Musée D’Orsay. Accompanied by an orchestra and poet, their images transported us into the cellular universe. I remembered why I am a cell biologist. All of this is in us. Wow!
@manuelthery.bsky.social and the #CytoMorphoLab reimagined the Musée D’Orsay. Accompanied by an orchestra and poet, their images transported us into the cellular universe. I remembered why I am a cell biologist. All of this is in us. Wow!
January 25, 2026 at 11:03 AM
Using micropatterning & thousands of hours on the microscope
@manuelthery.bsky.social and the #CytoMorphoLab reimagined the Musée D’Orsay. Accompanied by an orchestra and poet, their images transported us into the cellular universe. I remembered why I am a cell biologist. All of this is in us. Wow!
@manuelthery.bsky.social and the #CytoMorphoLab reimagined the Musée D’Orsay. Accompanied by an orchestra and poet, their images transported us into the cellular universe. I remembered why I am a cell biologist. All of this is in us. Wow!
An egg-cellent use of micropatterning 🙌
Not all eggs are hidden in gardens 🥚🔬
Look how fibroblasts beautifully align along a micropatterned fibronectin "egg" created using photopatterning.
There's always room to play in science!
(Thanks @oozguc.bsky.social for the inspo 🙌)
Look how fibroblasts beautifully align along a micropatterned fibronectin "egg" created using photopatterning.
There's always room to play in science!
(Thanks @oozguc.bsky.social for the inspo 🙌)
March 31, 2026 at 11:01 AM
An egg-cellent use of micropatterning 🙌
First attempts at micropatterning in the lab! Tubulin staining in HEK293 cells.
September 22, 2023 at 6:40 AM
First attempts at micropatterning in the lab! Tubulin staining in HEK293 cells.
🎄 𝗜𝘁’𝘀 𝗕𝗲𝗴𝗶𝗻𝗻𝗶𝗻𝗴 𝘁𝗼 𝗟𝗼𝗼𝗸 𝗮 𝗟𝗼𝘁 𝗟𝗶𝗸𝗲 𝗖𝗵𝗿𝗶𝘀𝘁𝗺𝗮𝘀... 𝗨𝗻𝗱𝗲𝗿 𝘁𝗵𝗲 𝗠𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝗲! 🔬
Why buy Christmas trees when you can "grow" one using micropatterning and @alleninstitute.bsky.social cells that come with their own LaminB1 "ornaments"?
Happy #FluorescenceFriday! ✨❄️
Why buy Christmas trees when you can "grow" one using micropatterning and @alleninstitute.bsky.social cells that come with their own LaminB1 "ornaments"?
Happy #FluorescenceFriday! ✨❄️
December 13, 2024 at 9:37 AM
🎄 𝗜𝘁’𝘀 𝗕𝗲𝗴𝗶𝗻𝗻𝗶𝗻𝗴 𝘁𝗼 𝗟𝗼𝗼𝗸 𝗮 𝗟𝗼𝘁 𝗟𝗶𝗸𝗲 𝗖𝗵𝗿𝗶𝘀𝘁𝗺𝗮𝘀... 𝗨𝗻𝗱𝗲𝗿 𝘁𝗵𝗲 𝗠𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝗲! 🔬
Why buy Christmas trees when you can "grow" one using micropatterning and @alleninstitute.bsky.social cells that come with their own LaminB1 "ornaments"?
Happy #FluorescenceFriday! ✨❄️
Why buy Christmas trees when you can "grow" one using micropatterning and @alleninstitute.bsky.social cells that come with their own LaminB1 "ornaments"?
Happy #FluorescenceFriday! ✨❄️
We're already halfway through Day 2 of #EMBOCLEM 🔬 Practical sessions on 'High pressure freezing', 'Freeze substitution', 'Plunge freezing', and 'Micropatterning' are currently underway!
February 10, 2025 at 1:24 PM
We're already halfway through Day 2 of #EMBOCLEM 🔬 Practical sessions on 'High pressure freezing', 'Freeze substitution', 'Plunge freezing', and 'Micropatterning' are currently underway!
🚨 Excited to share our new paper: “Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning”! 🔗 doi.org/10.1038/s414...
Let’s dive into how we used Wnt3a micropatterning to control intestinal epithelial organization. 🧵👇
Let’s dive into how we used Wnt3a micropatterning to control intestinal epithelial organization. 🧵👇
Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning - Nature Communications
Through micropatterning of a soft basement membrane to control Wnt3a protein distribution, the authors demonstrate how the size, shape, and spatial arrangement of intestinal epithelial crypts can be p...
doi.org
January 7, 2025 at 12:07 PM
🚨 Excited to share our new paper: “Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning”! 🔗 doi.org/10.1038/s414...
Let’s dive into how we used Wnt3a micropatterning to control intestinal epithelial organization. 🧵👇
Let’s dive into how we used Wnt3a micropatterning to control intestinal epithelial organization. 🧵👇
Hi I’m @vpmechbio.bsky.social, intrigued by how cells regulate their shape, by means of cytoskeleton and how this influences cellular function. One way to study this mechanism is to impose cells to certain geometric shape. Allow me to welcome you to the world of micropatterning!
August 2, 2025 at 5:07 AM
Hi I’m @vpmechbio.bsky.social, intrigued by how cells regulate their shape, by means of cytoskeleton and how this influences cellular function. One way to study this mechanism is to impose cells to certain geometric shape. Allow me to welcome you to the world of micropatterning!
4/14 A 2024 micropatterning study by the @xaviertrepat.bsky.social lab challenges this simplified leader–follower model. In 1D cell trains, motile leaders can only pull one passive follower—larger groups need coordinated, global organization!
👉 bsky.app/profile/epim...
👉 bsky.app/profile/epim...
April 20, 2025 at 7:32 AM
4/14 A 2024 micropatterning study by the @xaviertrepat.bsky.social lab challenges this simplified leader–follower model. In 1D cell trains, motile leaders can only pull one passive follower—larger groups need coordinated, global organization!
👉 bsky.app/profile/epim...
👉 bsky.app/profile/epim...
Our latest paper made it to the cover of Biomaterials Science! We leverage an efficient method for hydrogel micropatterning (STAMP) to fabricate complex muscle tissues like this #biohybrid iris that actuates in response to light:
pubs.rsc.org/en/content/a...
#TissueEngineering #MyoBlue
pubs.rsc.org/en/content/a...
#TissueEngineering #MyoBlue
June 3, 2025 at 1:08 PM
Our latest paper made it to the cover of Biomaterials Science! We leverage an efficient method for hydrogel micropatterning (STAMP) to fabricate complex muscle tissues like this #biohybrid iris that actuates in response to light:
pubs.rsc.org/en/content/a...
#TissueEngineering #MyoBlue
pubs.rsc.org/en/content/a...
#TissueEngineering #MyoBlue
Check out this amazing video by @julius-w.bsky.social (lead author) summarising our paper out this week!
doi.org/10.1083/jcb....
doi.org/10.1083/jcb....
June 8, 2026 at 2:13 PM
Check out this amazing video by @julius-w.bsky.social (lead author) summarising our paper out this week!
doi.org/10.1083/jcb....
doi.org/10.1083/jcb....
Micropatterning is an amazing tool to provide controlled cell adhesion and shape, enabling studies of structure-function across length scales. Special thanks to @manuelthery.bsky.social, @kriskilian.bsky.social and @xaviertrepat.bsky.social who have contributed greatly in the field!
August 2, 2025 at 5:07 AM
Micropatterning is an amazing tool to provide controlled cell adhesion and shape, enabling studies of structure-function across length scales. Special thanks to @manuelthery.bsky.social, @kriskilian.bsky.social and @xaviertrepat.bsky.social who have contributed greatly in the field!
Do you use #PAAm #hydrogels in your #mechanobiology research? If so, check out our mini review where we discuss advances in cell mechanobiology made using these systems. We discuss protein micropatterning, mechanical patterning, stretching, DNA tension probes, viscoelasticity, and 3D systems!
June 16, 2025 at 6:33 AM
Do you use #PAAm #hydrogels in your #mechanobiology research? If so, check out our mini review where we discuss advances in cell mechanobiology made using these systems. We discuss protein micropatterning, mechanical patterning, stretching, DNA tension probes, viscoelasticity, and 3D systems!
Beautiful study from the Kicheva lab
BMP signalling self-organises neural crest induction & dorsal neural patterning via a temporal relay mechanism involving Lmx1a
Also, useful stencil-based micropatterning technique for studying growing/migrating tissue formation
www.cell.com/developmenta...
BMP signalling self-organises neural crest induction & dorsal neural patterning via a temporal relay mechanism involving Lmx1a
Also, useful stencil-based micropatterning technique for studying growing/migrating tissue formation
www.cell.com/developmenta...
Self-organized pattern formation in the developing mouse neural tube by a temporal relay of BMP signaling
Lehr and Brückner et al. develop an in vitro differentiation system that produces
self-organized patterns of cell types similar to the ones observed in the dorsal neural
tube. They find that to form t...
www.cell.com
November 29, 2024 at 11:05 AM
Beautiful study from the Kicheva lab
BMP signalling self-organises neural crest induction & dorsal neural patterning via a temporal relay mechanism involving Lmx1a
Also, useful stencil-based micropatterning technique for studying growing/migrating tissue formation
www.cell.com/developmenta...
BMP signalling self-organises neural crest induction & dorsal neural patterning via a temporal relay mechanism involving Lmx1a
Also, useful stencil-based micropatterning technique for studying growing/migrating tissue formation
www.cell.com/developmenta...
A 19 mm coverslip with 80 days of hiPSC-derived cardiomyocytes. Micropatterning proof of concept at our lab (LIAN) in @FleniOficial Argentina. I'm still tweaking some details but it's looking great
Zoom in for more detail...
Zoom in for more detail...
January 19, 2025 at 1:24 PM
A 19 mm coverslip with 80 days of hiPSC-derived cardiomyocytes. Micropatterning proof of concept at our lab (LIAN) in @FleniOficial Argentina. I'm still tweaking some details but it's looking great
Zoom in for more detail...
Zoom in for more detail...
🔈 Thrilled to host Aryeh Warmflash @warmflashlab.bsky.social as an invited speaker at #ICDB2025! Aryeh uses human stem cells and micropatterning to model early embryonic development in vitro—decoding self-organization in real time. 🧬🧫🧪
June 9, 2025 at 3:45 PM
🔈 Thrilled to host Aryeh Warmflash @warmflashlab.bsky.social as an invited speaker at #ICDB2025! Aryeh uses human stem cells and micropatterning to model early embryonic development in vitro—decoding self-organization in real time. 🧬🧫🧪
Happy to see this dynamic micropatterning project taking its beautiful shape as a preprint!
Immune synapse enthusiasts, please take a look 👀 Maybe something to try in your projects too? 🤩
Adapting an amazing tool from @ivaskalab.bsky.social 💥
Immune synapse enthusiasts, please take a look 👀 Maybe something to try in your projects too? 🤩
Adapting an amazing tool from @ivaskalab.bsky.social 💥
I'm very happy to finally be able to show what I have been working on for the last years (with help of @sarahdezperez.bsky.social and Elmeri)!
@mattilalab.bsky.social @inflames-flagship.bsky.social @utu.fi
www.biorxiv.org/content/10.1...
@mattilalab.bsky.social @inflames-flagship.bsky.social @utu.fi
www.biorxiv.org/content/10.1...
Dynamic Micropatterning Reveals Spatial Dynamics of B Cell Receptor Signaling and Immune Synapse Formation
B cell activation by foreign antigens, recognized by the B cell receptor (BCR), is the key prerequisite for cell differentiation for antibody production. B cells typically encounter antigens bound to ...
www.biorxiv.org
August 12, 2025 at 10:36 AM
Happy to see this dynamic micropatterning project taking its beautiful shape as a preprint!
Immune synapse enthusiasts, please take a look 👀 Maybe something to try in your projects too? 🤩
Adapting an amazing tool from @ivaskalab.bsky.social 💥
Immune synapse enthusiasts, please take a look 👀 Maybe something to try in your projects too? 🤩
Adapting an amazing tool from @ivaskalab.bsky.social 💥
I'm very happy to finally be able to show what I have been working on for the last years (with help of @sarahdezperez.bsky.social and Elmeri)!
@mattilalab.bsky.social @inflames-flagship.bsky.social @utu.fi
www.biorxiv.org/content/10.1...
@mattilalab.bsky.social @inflames-flagship.bsky.social @utu.fi
www.biorxiv.org/content/10.1...
Dynamic Micropatterning Reveals Spatial Dynamics of B Cell Receptor Signaling and Immune Synapse Formation
B cell activation by foreign antigens, recognized by the B cell receptor (BCR), is the key prerequisite for cell differentiation for antibody production. B cells typically encounter antigens bound to ...
www.biorxiv.org
August 12, 2025 at 8:55 AM
I'm very happy to finally be able to show what I have been working on for the last years (with help of @sarahdezperez.bsky.social and Elmeri)!
@mattilalab.bsky.social @inflames-flagship.bsky.social @utu.fi
www.biorxiv.org/content/10.1...
@mattilalab.bsky.social @inflames-flagship.bsky.social @utu.fi
www.biorxiv.org/content/10.1...
Asymmetric mitochondrial trafficking balances perinuclear biogenesis to maintain network morphology rupress.org/jcb/article-...
Asymmetric mitochondrial trafficking balances perinuclear biogenesis to maintain network morphology
Winter et al. use substrate micropatterning and photoactivation to define mitochondrial subpopulations in proliferative cells. They find that biased antero
rupress.org
June 3, 2026 at 2:50 PM
Asymmetric mitochondrial trafficking balances perinuclear biogenesis to maintain network morphology rupress.org/jcb/article-...
Just out from the Ivaska lab: Dynamic Micropatterning Reveals Substrate-Dependent Differences in the Geometric Control of Cell Polarization and Migration
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
November 6, 2023 at 12:29 PM
Just out from the Ivaska lab: Dynamic Micropatterning Reveals Substrate-Dependent Differences in the Geometric Control of Cell Polarization and Migration
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
I am absolutely thrilled to share my lab's most recent paper, available on bioRxiv! We combined bioprinting, human pluripotent stem cells, and developmental micropatterning approaches to create reproducible 3D neural tube tissues in high throughput. www.biorxiv.org/content/10.1...
A bioprinting approach for high-throughput production of micropatterned neuroepithelial tissues and modeling TSC2-deficient brain malformations
In vitro human pluripotent stem cell-derived models have been crucial in advancing our understanding of the mechanisms underlying neurodevelopment, though knowledge of the earliest stages of brain for...
www.biorxiv.org
April 7, 2025 at 11:50 PM
I am absolutely thrilled to share my lab's most recent paper, available on bioRxiv! We combined bioprinting, human pluripotent stem cells, and developmental micropatterning approaches to create reproducible 3D neural tube tissues in high throughput. www.biorxiv.org/content/10.1...
About micropatterning
bsky.app/profile/epim...
bsky.app/profile/epim...
Hi I’m @vpmechbio.bsky.social, intrigued by how cells regulate their shape, by means of cytoskeleton and how this influences cellular function. One way to study this mechanism is to impose cells to certain geometric shape. Allow me to welcome you to the world of micropatterning!
August 3, 2025 at 8:22 AM
About micropatterning
bsky.app/profile/epim...
bsky.app/profile/epim...
Micropatterning provides certain adhesive protein islands so we can study mechanism governing cell shape. With triangle patterns of V, T and Y shapes, thick actin fibres are found to distribute on non-adhesive edges indicating increased contractility.
bsky.app/profile/epim...
bsky.app/profile/epim...
August 2, 2025 at 5:07 AM
Micropatterning provides certain adhesive protein islands so we can study mechanism governing cell shape. With triangle patterns of V, T and Y shapes, thick actin fibres are found to distribute on non-adhesive edges indicating increased contractility.
bsky.app/profile/epim...
bsky.app/profile/epim...
Over her project, @icfortunato.bsky.social has become so skilled at micropatterning that her thesis cover is the image of a micropattern🎨👏
November 20, 2024 at 1:03 PM
Over her project, @icfortunato.bsky.social has become so skilled at micropatterning that her thesis cover is the image of a micropattern🎨👏
A really cool little thread about micropatterning cells
Hi I’m @vpmechbio.bsky.social, intrigued by how cells regulate their shape, by means of cytoskeleton and how this influences cellular function. One way to study this mechanism is to impose cells to certain geometric shape. Allow me to welcome you to the world of micropatterning!
August 2, 2025 at 5:45 AM
A really cool little thread about micropatterning cells
Tried dynamic micropatterning last week!
These 3t3s don’t polarise as nicely as the beautiful movies from @ivaskalab.bsky.social but they still look fun! 🍳
More to come next year ! 👀🎄
These 3t3s don’t polarise as nicely as the beautiful movies from @ivaskalab.bsky.social but they still look fun! 🍳
More to come next year ! 👀🎄
December 20, 2024 at 12:44 PM
Tried dynamic micropatterning last week!
These 3t3s don’t polarise as nicely as the beautiful movies from @ivaskalab.bsky.social but they still look fun! 🍳
More to come next year ! 👀🎄
These 3t3s don’t polarise as nicely as the beautiful movies from @ivaskalab.bsky.social but they still look fun! 🍳
More to come next year ! 👀🎄