oh shit I get it, this could be like CRISPR but for LLM weights
what the fuck, frontier LLMs can directly interpret and edit the weights of smaller models rikiyat.github.io/blog/weight-...
Sparks of Weight-Space Programming: LLMs can natively read & write neural network weights
We find that frontier LLMs are surprisingly good at natively reading and writing neural network weights, well past what we’d expect from humans or conventional algorithms.
rikiyat.github.io
November 2, 2026 at 10:06 PM
oh shit I get it, this could be like CRISPR but for LLM weights
CRISPR that changes your hair color
October 30, 2026 at 6:26 PM
CRISPR that changes your hair color
Research Highlight: Tracing the origins of CRISPR–Cas www.nature.com/articles/s41...
October 30, 2026 at 3:08 PM
Research Highlight: Tracing the origins of CRISPR–Cas www.nature.com/articles/s41...
Out Now! Planetary-scale metagenomic analysis reveals CRISPR targeting dynamics across ecosystems #MicroSky
Planetary-scale metagenomic analysis reveals CRISPR targeting dynamics across ecosystems
Nature Microbiology, Published online: 29 October 2026; doi:10.1038/s41564-026-02480-7Screening millions of CRISPR spacers across globally distributed metagenomes reveals unexpected dynamics of phage–host interactions, including many cases where phage genomes seem to repeatedly enter non-host cells.
go.nature.com
October 29, 2026 at 3:08 PM
Out Now! Planetary-scale metagenomic analysis reveals CRISPR targeting dynamics across ecosystems #MicroSky
Neues #CRISPR durch #KI entdeckt? #Anthropic berichtete, dass #Claude offenbar eine Entdeckung gemacht hat - was davon zu halten ist, habe ich für die #Zeitfragen recherchiert
www.deutschlandfunkkultur.de/neues-crispr...
www.deutschlandfunkkultur.de/neues-crispr...
Neues CRISPR durch KI entdeckt?
www.deutschlandfunkkultur.de
October 30, 2026 at 7:08 AM
Neues #CRISPR durch #KI entdeckt? #Anthropic berichtete, dass #Claude offenbar eine Entdeckung gemacht hat - was davon zu halten ist, habe ich für die #Zeitfragen recherchiert
www.deutschlandfunkkultur.de/neues-crispr...
www.deutschlandfunkkultur.de/neues-crispr...
Exactly. That’s why he does CRISPR
November 3, 2026 at 6:16 AM
Exactly. That’s why he does CRISPR
Interrogating the Escherichia coli Epitranscriptome Via CRISPR Interference and Nanopore Native RNA Sequencing onlinelibrary.wiley.com/doi/10.1002/...
Interrogating the <i>Escherichia coli</i> Epitranscriptome Via CRISPR Interference and Nanopore Native RNA Sequencing
Epitranscriptomics is understudied in bacteria but has the ability to modulate antimicrobial resistance, virulence and pathogenicity. Pitt et al. implement two cutting-edge techniques: CRISPR interfe...
onlinelibrary.wiley.com
October 31, 2026 at 8:48 PM
Interrogating the Escherichia coli Epitranscriptome Via CRISPR Interference and Nanopore Native RNA Sequencing onlinelibrary.wiley.com/doi/10.1002/...
Non Crispr ne va pas servir uniquement à obtenir des variétés resistantes aux herbicides
Oui le capitalisme va faire son oeuvre et que certains vont capter la ressource
Oui le capitalisme va faire son oeuvre et que certains vont capter la ressource
November 2, 2026 at 5:51 PM
Non Crispr ne va pas servir uniquement à obtenir des variétés resistantes aux herbicides
Oui le capitalisme va faire son oeuvre et que certains vont capter la ressource
Oui le capitalisme va faire son oeuvre et que certains vont capter la ressource
Utilisation de Crispr pour rendre les cacaoyers résistants à la pourriture brune des cabosses par l’université Penn State - licence acquise par une startup américaine
J’en ai un peu marre d’être Cassandre :
J’en ai un peu marre d’être Cassandre :
November 2, 2026 at 5:51 PM
Utilisation de Crispr pour rendre les cacaoyers résistants à la pourriture brune des cabosses par l’université Penn State - licence acquise par une startup américaine
J’en ai un peu marre d’être Cassandre :
J’en ai un peu marre d’être Cassandre :
And 16 months later, the "global CRISPR" story is now in published form \o/
The original thread at the time of this first pre-print (bsky.app/profile/simr...) describes the dataset and analysis, which has not really changed too much.
The original thread at the time of this first pre-print (bsky.app/profile/simr...) describes the dataset and analysis, which has not really changed too much.
Out Now! Planetary-scale metagenomic analysis reveals CRISPR targeting dynamics across ecosystems #MicroSky
Planetary-scale metagenomic analysis reveals CRISPR targeting dynamics across ecosystems
Nature Microbiology, Published online: 29 October 2026; doi:10.1038/s41564-026-02480-7Screening millions of CRISPR spacers across globally distributed metagenomes reveals unexpected dynamics of phage–host interactions, including many cases where phage genomes seem to repeatedly enter non-host cells.
go.nature.com
October 31, 2026 at 1:00 AM
And 16 months later, the "global CRISPR" story is now in published form \o/
The original thread at the time of this first pre-print (bsky.app/profile/simr...) describes the dataset and analysis, which has not really changed too much.
The original thread at the time of this first pre-print (bsky.app/profile/simr...) describes the dataset and analysis, which has not really changed too much.
Our new preprint is out! 🥳
In this study which I co-first-authored with @niafeakes.bsky.social, we explore a new strategy to prevent the spread of antimicrobial resistance (AMR) using a mobile CRISPR-Cas9 system.
www.biorxiv.org/content/10.6...
In this study which I co-first-authored with @niafeakes.bsky.social, we explore a new strategy to prevent the spread of antimicrobial resistance (AMR) using a mobile CRISPR-Cas9 system.
www.biorxiv.org/content/10.6...
www.biorxiv.org
November 2, 2026 at 11:02 AM
Our new preprint is out! 🥳
In this study which I co-first-authored with @niafeakes.bsky.social, we explore a new strategy to prevent the spread of antimicrobial resistance (AMR) using a mobile CRISPR-Cas9 system.
www.biorxiv.org/content/10.6...
In this study which I co-first-authored with @niafeakes.bsky.social, we explore a new strategy to prevent the spread of antimicrobial resistance (AMR) using a mobile CRISPR-Cas9 system.
www.biorxiv.org/content/10.6...
Don't say that too loudly, someone will try to CRispr them in…
October 31, 2026 at 3:18 AM
Don't say that too loudly, someone will try to CRispr them in…
Planetary-scale metagenomic analysis reveals CRISPR targeting dynamics across ecosystems www.nature.com/articles/s41... #jcampubs
Planetary-scale metagenomic analysis reveals CRISPR targeting dynamics across ecosystems - Nature Microbiology
Screening millions of CRISPR spacers across globally distributed metagenomes reveals unexpected dynamics of phage–host interactions, including many cases where phage genomes seem to repeatedly enter n...
www.nature.com
October 29, 2026 at 1:53 PM
Planetary-scale metagenomic analysis reveals CRISPR targeting dynamics across ecosystems www.nature.com/articles/s41... #jcampubs
Innovative thermodynamic DNA primers create a seamless one-pot CRISPR SNP genotyping … PMID:42414323, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-75358-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Thermodynamically programmed one-pot CRISPR platform for point-of-care SNP genotyping | Nature Communications
One-pot CRISPR diagnostics face a fundamental incompatibility: isothermal nucleic acid amplification enables rapid target accumulation, whereas CRISPR activation irreversibly consumes those substrates, destabilizing reaction kinetics. Here we show that reaction order can be programmed into DNA primers through thermodynamic design. Differences in primer-binding strength create two sequential amplification stages, delaying CRISPR activation until enough amplicons have accumulated without physical separation or external control. The design also introduces the protospacer adjacent motif (PAM), a short sequence required for CRISPR recognition, through the primer rather than relying on its presence in the native target, expanding target accessibility while retaining single-nucleotide discrimination. An ordinary differential equation model captures the threshold behavior and establishes a predictable framework for primer design. Building on this principle, we develop Thermodynamically Encoded
doi.org
November 1, 2026 at 3:00 AM
Interestingly, while mating conditions facilitate the transfer of the CRISPR-Cas9 plasmid, this protection works both when the CRISPR-Cas9 system is introduced beforehand and when it is introduced simultaneously with the pathogen.
November 2, 2026 at 11:02 AM
Interestingly, while mating conditions facilitate the transfer of the CRISPR-Cas9 plasmid, this protection works both when the CRISPR-Cas9 system is introduced beforehand and when it is introduced simultaneously with the pathogen.
CRISPR Gene-Edited Strawberries Have Entered the U.S. Food Supply Without Required Labeling www.thefocalpoints.com/p/crispr-gen...
CRISPR Gene-Edited Strawberries Have Entered the U.S. Food Supply Without Required Labeling
The genetically engineered fruit developed by SIMPLOT is being distributed through U.S. wholesale foodservice channels.
www.thefocalpoints.com
November 1, 2026 at 12:23 AM
CRISPR Gene-Edited Strawberries Have Entered the U.S. Food Supply Without Required Labeling www.thefocalpoints.com/p/crispr-gen...
I just published Antimicrobial Resistance: From Resistance Mechanisms to Emerging Research Strategies medium.com/@medchemexpr...
#AntibioticResistance #Microbiology #DrugDiscovery #CRISPR
#AntibioticResistance #Microbiology #DrugDiscovery #CRISPR
November 3, 2026 at 9:45 AM
I just published Antimicrobial Resistance: From Resistance Mechanisms to Emerging Research Strategies medium.com/@medchemexpr...
#AntibioticResistance #Microbiology #DrugDiscovery #CRISPR
#AntibioticResistance #Microbiology #DrugDiscovery #CRISPR
Biosensor-guided genome-wide CRISPR screens enable cis,cis-muconic acid overproduction in yeast https://www.biorxiv.org/content/10.64898/2026.10.31.762157v1
November 3, 2026 at 11:01 AM
Biosensor-guided genome-wide CRISPR screens enable cis,cis-muconic acid overproduction in yeast https://www.biorxiv.org/content/10.64898/2026.10.31.762157v1
Access to CRISPR?
October 30, 2026 at 2:21 AM
Access to CRISPR?
Prevention of Klebsiella pneumoniae antibiotic resistance plasmid dissemination by prophylactic or simultaneous CRISPR-Cas9 treatment. https://www.biorxiv.org/content/10.64898/2026.10.29.762760v1
October 30, 2026 at 11:17 PM
Prevention of Klebsiella pneumoniae antibiotic resistance plasmid dissemination by prophylactic or simultaneous CRISPR-Cas9 treatment. https://www.biorxiv.org/content/10.64898/2026.10.29.762760v1
With fewer cells to screen and hits that are easier to interpret, focused human CRISPR KO libraries let you target the pathway you care about. Addgene’s growing collection of ready-to-use lentiviral preps now includes:
November 2, 2026 at 6:00 PM
With fewer cells to screen and hits that are easier to interpret, focused human CRISPR KO libraries let you target the pathway you care about. Addgene’s growing collection of ready-to-use lentiviral preps now includes:
CRISPR that gives you fur and cat ears.
October 30, 2026 at 6:50 PM
CRISPR that gives you fur and cat ears.
Planetary-scale metagenomic analysis reveals CRISPR targeting dynamics across ecosystems | Nature Microbiology
Planetary-scale metagenomic analysis reveals CRISPR targeting dynamics across ecosystems - Nature Microbiology
Screening millions of CRISPR spacers across globally distributed metagenomes reveals unexpected dynamics of phage–host interactions, including many cases where phage genomes seem to repeatedly enter non-host cells.
www.nature.com
October 30, 2026 at 1:46 AM
Planetary-scale metagenomic analysis reveals CRISPR targeting dynamics across ecosystems | Nature Microbiology