Just a reminder that LDL does in fact *cause* heart disease. Here is a summary of the evidence for that:
academic.oup.com/eurheartj/ar...
academic.oup.com/eurheartj/ar...
It is really dangerous when people deny this.
academic.oup.com/eurheartj/ar...
academic.oup.com/eurheartj/ar...
It is really dangerous when people deny this.
Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Co...
AbstractAims. To appraise the clinical and genetic evidence that low-density lipoproteins (LDLs) cause atherosclerotic cardiovascular disease (ASCVD).Metho
academic.oup.com
June 1, 2025 at 2:10 AM
Just a reminder that LDL does in fact *cause* heart disease. Here is a summary of the evidence for that:
academic.oup.com/eurheartj/ar...
academic.oup.com/eurheartj/ar...
It is really dangerous when people deny this.
academic.oup.com/eurheartj/ar...
academic.oup.com/eurheartj/ar...
It is really dangerous when people deny this.
Heart doctors insist there’s no debate: High levels of LDL, or “bad” cholesterol, in the blood can lead to serious heart attack, stroke or death.
Is ‘bad’ cholesterol actually good? Cardiologists set the record straight
Online misinformation about cholesterol-lowering medications and the role LDL, or low-density lipoproteins, play in heart disease is growing.
nbcnews.to
October 5, 2026 at 9:40 PM
Heart doctors insist there’s no debate: High levels of LDL, or “bad” cholesterol, in the blood can lead to serious heart attack, stroke or death.
Slurping down lipoproteins like a freak.
October 1, 2024 at 12:16 AM
Slurping down lipoproteins like a freak.
This thing where people name [male] scientists who discovered something as 'the father of X' is getting out of hand.
January 26, 2026 at 2:32 PM
This thing where people name [male] scientists who discovered something as 'the father of X' is getting out of hand.
Biogenesis and function of archaeal lipoproteins.
This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.
www.nature.com/articles/s41...
This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.
www.nature.com/articles/s41...
Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins - Nature Communications
Lipoproteins are major cell-surface components in archaea, but their functions and the lipidation mechanisms are unclear. Here, Hong et al. identify two proteins required for attachment of proteins to unique archaeal membrane lipids via thioether bonds, and demonstrate their importance in archaeal physiology.
www.nature.com
September 28, 2025 at 10:54 AM
Biogenesis and function of archaeal lipoproteins.
This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.
www.nature.com/articles/s41...
This takes me back. The first papers I published from my new group were on lipoprotein biogenesis in Streptomyces with @proftracypalmer.bsky.social about 15y ago.
www.nature.com/articles/s41...
Hi folks! For those that don't know me, I research brain metabolism, lipids and lipoproteins, and microglia in health and disease. Excited to be part of this shiny new community!
November 19, 2024 at 12:14 PM
Hi folks! For those that don't know me, I research brain metabolism, lipids and lipoproteins, and microglia in health and disease. Excited to be part of this shiny new community!
New in JB: May and Grabowicz describe the most recent research on outer membrane lipoproteins, including targeting these pathways for novel antibiotics.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
February 10, 2025 at 3:00 PM
New in JB: May and Grabowicz describe the most recent research on outer membrane lipoproteins, including targeting these pathways for novel antibiotics.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Of course I like all the papers that we publish, but this is actually a very cool story, a great example of 'bush mechanics' in mycobacteria.
A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis | mBio journals.asm.org/doi/10.1128/...
A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis | mBio journals.asm.org/doi/10.1128/...
A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis | mBio
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains the world’s deadliest bacterial infection, in part because the bacterium’s
unique cell envelope makes it highly resistant to antibioti...
journals.asm.org
December 13, 2025 at 8:28 AM
Of course I like all the papers that we publish, but this is actually a very cool story, a great example of 'bush mechanics' in mycobacteria.
A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis | mBio journals.asm.org/doi/10.1128/...
A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis | mBio journals.asm.org/doi/10.1128/...
Metabolic tagging reveals surface-associated lipoproteins in mycobacteria https://www.biorxiv.org/content/10.1101/2025.01.07.631728v1
January 8, 2025 at 9:20 AM
Metabolic tagging reveals surface-associated lipoproteins in mycobacteria https://www.biorxiv.org/content/10.1101/2025.01.07.631728v1
My latest preprint on the LolB in Bacteroides! Can't delete it, but you can deplete it to basically nothing and cells grow fine, plus lipoproteins still get to the cell surface 🤯
There is still SO much to understand about lipoproteins in Bacteroides!
There is still SO much to understand about lipoproteins in Bacteroides!
www.biorxiv.org
February 9, 2026 at 3:47 PM
My latest preprint on the LolB in Bacteroides! Can't delete it, but you can deplete it to basically nothing and cells grow fine, plus lipoproteins still get to the cell surface 🤯
There is still SO much to understand about lipoproteins in Bacteroides!
There is still SO much to understand about lipoproteins in Bacteroides!
Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins | Nature Communications https://www.nature.com/articles/s41467-025-63625-6
Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins - Nature Communications
Lipoproteins are major cell-surface components in archaea, but their functions and the lipidation mechanisms are unclear. Here, Hong et al. identify two proteins required for attachment of proteins to unique archaeal membrane lipids via thioether bonds, and demonstrate their importance in archaeal physiology.
www.nature.com
September 25, 2025 at 11:25 PM
Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins | Nature Communications https://www.nature.com/articles/s41467-025-63625-6
Nature research paper: Interactions between TTYH2 and APOE facilitate endosomal lipid transfer
https://go.nature.com/4laSnUE
https://go.nature.com/4laSnUE
Interactions between TTYH2 and APOE facilitate endosomal lipid transfer - Nature
The Tweety homologue TTYH2 is identified as the lipid transfer mediator for APOE-containing lipoproteins.
go.nature.com
June 27, 2025 at 7:34 AM
Nature research paper: Interactions between TTYH2 and APOE facilitate endosomal lipid transfer
https://go.nature.com/4laSnUE
https://go.nature.com/4laSnUE
Hi everyone!
To start on 🦋, we will share what we did during this crazy year!! 🤩🎉
To start, our work on the receptor of #CCHFV 🦠: www.nature.com/articles/s41...
And related to that: our review on lipoproteins receptors used by viruses 🚪: www.jbc.org/article/S002...
To start on 🦋, we will share what we did during this crazy year!! 🤩🎉
To start, our work on the receptor of #CCHFV 🦠: www.nature.com/articles/s41...
And related to that: our review on lipoproteins receptors used by viruses 🚪: www.jbc.org/article/S002...
November 24, 2024 at 11:50 AM
Hi everyone!
To start on 🦋, we will share what we did during this crazy year!! 🤩🎉
To start, our work on the receptor of #CCHFV 🦠: www.nature.com/articles/s41...
And related to that: our review on lipoproteins receptors used by viruses 🚪: www.jbc.org/article/S002...
To start on 🦋, we will share what we did during this crazy year!! 🤩🎉
To start, our work on the receptor of #CCHFV 🦠: www.nature.com/articles/s41...
And related to that: our review on lipoproteins receptors used by viruses 🚪: www.jbc.org/article/S002...
You've heard of the father of modern epidemiology (John Snow), the father antiseptic surgery (Joseph Lister) and the father of bacteriology (Robert Koch), but have you heard of the father of... plasma lipoproteins?
January 26, 2026 at 2:43 PM
You've heard of the father of modern epidemiology (John Snow), the father antiseptic surgery (Joseph Lister) and the father of bacteriology (Robert Koch), but have you heard of the father of... plasma lipoproteins?
When the show was over, I heard his cholesterol lipoproteins say, "Wheeeeww. Thank God. We were close to causing an occlusion. We can't keep going on like this."
May 21, 2025 at 10:51 PM
When the show was over, I heard his cholesterol lipoproteins say, "Wheeeeww. Thank God. We were close to causing an occlusion. We can't keep going on like this."
A new imaging method has detailed how the ABCA1 protein uses ATP to transfer lipids, enabling the formation of high-density lipoproteins that help prevent arterial plaque buildup. doi.org/g95cc9
How is good cholesterol made? Imaging method shows production mechanism at molecular level
High-density lipoproteins (HDL), also known as "good cholesterol," remove excess cholesterol from the body's tissues and transport it to the liver.
phys.org
September 29, 2025 at 7:20 PM
A new imaging method has detailed how the ABCA1 protein uses ATP to transfer lipids, enabling the formation of high-density lipoproteins that help prevent arterial plaque buildup. doi.org/g95cc9
Our study on Bacteroides iron piracy is now out in @pnas.org. We show how surface-exposed lipoproteins bind xenosiderophores with different iron-chelating chemistries and propose a mechanism for xenosiderophore import across the outer membrane. Lots of structures (mostly X-ray this time)!
Structural basis of iron piracy by human gut Bacteroides | PNAS
Iron is an essential element that can be growth-limiting in microbial communities,
particularly those present within host organisms. To acquire iro...
doi.org
May 2, 2026 at 9:22 AM
Our study on Bacteroides iron piracy is now out in @pnas.org. We show how surface-exposed lipoproteins bind xenosiderophores with different iron-chelating chemistries and propose a mechanism for xenosiderophore import across the outer membrane. Lots of structures (mostly X-ray this time)!
🫀 Our new study is now out in #EHJ @escardio.bsky.social
📣 Measuring both #apoB and #LipoproteinA provides the most accurate assessment of cardiovascular risk in primary prevention
doi.org/10.1093/eurh...
📣 Measuring both #apoB and #LipoproteinA provides the most accurate assessment of cardiovascular risk in primary prevention
doi.org/10.1093/eurh...
ApoB-containing lipoproteins: count, type, size, and risk of coronary artery disease
AbstractBackground and Aims. Apolipoprotein B concentration reflects the number of atherogenic lipoproteins and is recognized as a key lipid risk marker. W
doi.org
April 28, 2025 at 6:35 AM
🫀 Our new study is now out in #EHJ @escardio.bsky.social
📣 Measuring both #apoB and #LipoproteinA provides the most accurate assessment of cardiovascular risk in primary prevention
doi.org/10.1093/eurh...
📣 Measuring both #apoB and #LipoproteinA provides the most accurate assessment of cardiovascular risk in primary prevention
doi.org/10.1093/eurh...
Excellent commentary from experts about the need for apoB testing by my friends at the NIH Division of Lipids/Lipoproteins/Vascular Biology: Ania Wolski and director Alan Remaley& one and only @dmljmd.bsky.social pubmed.ncbi.nlm.nih.gov/39899636/ @nationallipid.bsky.social @aspcardio.bsky.social
February 4, 2025 at 2:19 PM
Excellent commentary from experts about the need for apoB testing by my friends at the NIH Division of Lipids/Lipoproteins/Vascular Biology: Ania Wolski and director Alan Remaley& one and only @dmljmd.bsky.social pubmed.ncbi.nlm.nih.gov/39899636/ @nationallipid.bsky.social @aspcardio.bsky.social
Imagine you encountered the bacteria E.Coli. It has LPS (lipopolysaccharide), Peptidoglycans, Lipoproteins, Hypomethylated DNA (CpG), double-stranded RNA, and Flagellin. Our cells do not! These PAMPs are how your cells identify if you encountered a fungus, virus or bacteria.
8/10
8/10
December 6, 2024 at 12:17 PM
Imagine you encountered the bacteria E.Coli. It has LPS (lipopolysaccharide), Peptidoglycans, Lipoproteins, Hypomethylated DNA (CpG), double-stranded RNA, and Flagellin. Our cells do not! These PAMPs are how your cells identify if you encountered a fungus, virus or bacteria.
8/10
8/10
bioRxiv preprint (pdf link)
I've always been fascinated by lipoproteins and the diverse roles they play in archaea and bacteria. This work looks at the roles of two Lgt homologues in the archaeon Haloferax volcanii.
www.biorxiv.org/content/10.6...
I've always been fascinated by lipoproteins and the diverse roles they play in archaea and bacteria. This work looks at the roles of two Lgt homologues in the archaeon Haloferax volcanii.
www.biorxiv.org/content/10.6...
www.biorxiv.org
March 16, 2026 at 8:31 AM
bioRxiv preprint (pdf link)
I've always been fascinated by lipoproteins and the diverse roles they play in archaea and bacteria. This work looks at the roles of two Lgt homologues in the archaeon Haloferax volcanii.
www.biorxiv.org/content/10.6...
I've always been fascinated by lipoproteins and the diverse roles they play in archaea and bacteria. This work looks at the roles of two Lgt homologues in the archaeon Haloferax volcanii.
www.biorxiv.org/content/10.6...
Happy New Year to Lipidaholics - First lesson of 2026 providing some basics on Low Density Lipoproteins (LDLs): (1) Structure (2) Properties (3) Particle & cholesterol metrics (4) Changing apoB mass metrics (mg/dL) to particle numbers (nmol/L). @nationallipid.bsky.social @aspcardio.bsky.social
January 1, 2026 at 4:36 PM
Happy New Year to Lipidaholics - First lesson of 2026 providing some basics on Low Density Lipoproteins (LDLs): (1) Structure (2) Properties (3) Particle & cholesterol metrics (4) Changing apoB mass metrics (mg/dL) to particle numbers (nmol/L). @nationallipid.bsky.social @aspcardio.bsky.social
LIPOproteins
(my sponsorship contribution would be 2 Slovenian cookies)
(my sponsorship contribution would be 2 Slovenian cookies)
June 6, 2025 at 4:43 PM
LIPOproteins
(my sponsorship contribution would be 2 Slovenian cookies)
(my sponsorship contribution would be 2 Slovenian cookies)
Cardiologists warn that surging online misinformation falsely claims bad cholesterol provides health benefits. Doctors stress that high levels of low-density lipoproteins directly cause serious heart attacks and strokes, urging patients to ignore viral medical myths.
Is ‘bad’ cholesterol actually good? Cardiologists set the record straight - NBC News
Heart doctors insist there’s no debate: High levels of LDL, or “bad” cholesterol, in the blood can lead to serious heart attack, stroke or death.
www.nbcnews.com
October 7, 2026 at 6:12 PM
Cardiologists warn that surging online misinformation falsely claims bad cholesterol provides health benefits. Doctors stress that high levels of low-density lipoproteins directly cause serious heart attacks and strokes, urging patients to ignore viral medical myths.