Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is found across Africa, Asia, and the Middle East where it can cause Haemorrhagic outbreaks with high case fatality rates. Central to the viral life cycl...

Structural studies of Crimean–Congo haemorrhagic fever virus (CCHFV) polymerase reveal the structural basis of CCHFV RNA synthesis and highlight druggable sites for designing both nucleoside antivirals and non-nucleoside antivirals.

Our data demonstrate that our repNP vaccine and NP-specific antibody can protect against CCHFV in non-human primates.

Yang et al. report cryo-EM structures of the CCHFV RNA polymerase across multiple functional states. These structures reveal a promoter-dependent initiation stabilization pathway and a dual-site mechanism of suramin inhibition, providing insights into bunyavirus polymerase regulation and inhibition.

npj Vaccines - Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice

Leveraging cross-reactive monoclonals and next-generation vaccines to address Crimean-Congo hemorrhagic fever virus diversity

Crimean-Congo hemorrhagic fever virus (CCHFV) is the cause of a serious viral hemorrhagic fever in humans. Severe disease and poor outcomes are correlated with little-to-no CCHFV-specific antibody. However, it is unknown if the lack of CCHFV-specific antibody is a direct cause or merely a correlate of a poor outcome. Here, we investigated the contribution of humoral immunity in control of acute CCHFV infection in naive immunocompetent mice. We found that mice develop a rapid, non-neutralizing antibody response that is crucial for control of the acute infection. Further, we found that loss of complement but not activating Fc receptors or the cytoplasmic Fc receptor TRIM21 worsened disease. Together, our findings suggest that lack of CCHFV-specific antibody responses may directly contribute to poor outcomes in CCHFV-infected humans.

Crimean-Congo haemorrhagic fever (CCHF) is a severe, often fatal zoonotic disease caused by the CCHF virus (CCHFV). It is primarily transmitted by Hyalomma ticks, which serve as both reservoir and vec...

Crimean-Congo hemorrhagic fever virus (CCHFV) is a dangerous virus spread by ticks. It transmits Crimean-Congo hemorrhagic fever (CCHF), a serious disease that has been spreading into new regions worl...

Un estudio ha revelado información crucial sobre los patrones de transmisión y los factores de riesgo del virus de la fiebre hemorrágica de Crimea-Congo (CCHFV) en ovejas, un huésped natural ...

Glycoprotein GP38-specific antibodies reduce viral dissemination and GP38-mediated vascular leak in Crimean-Congo hemorrhagic fever virus infection.

Tick-borne diseases pose a growing threat to human and animal health in Europe, with tick-borne encephalitis virus (TBEV) and Crimean-Congo haemorrhagic fever virus (CCHFV), vectored by Ixodes ricinus...

This is the first serosurvey conducted in Spain to suggest possible active circulation of the virus in Africans. Our results suggest the need for more extensive clinical and epidemiological studies in...