Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)
elifesciences.org
April 2, 2025 at 1:02 PM
Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)
Honored to have Dr. Denise Monack write an @elife.bsky.social Insight article about our latest findings on how inflammasomes control Salmonella in human macrophages! elifesciences.org/articles/106...
April 2, 2025 at 5:01 PM
Honored to have Dr. Denise Monack write an @elife.bsky.social Insight article about our latest findings on how inflammasomes control Salmonella in human macrophages! elifesciences.org/articles/106...
Review @cp-trendsimmuno.bsky.social
Neuronal inflammasomes: balancing immunity, neuroinflammation, and homeostasis
www.cell.com/trends/immun...
Neuronal inflammasomes: balancing immunity, neuroinflammation, and homeostasis
www.cell.com/trends/immun...
December 13, 2025 at 4:35 AM
Review @cp-trendsimmuno.bsky.social
Neuronal inflammasomes: balancing immunity, neuroinflammation, and homeostasis
www.cell.com/trends/immun...
Neuronal inflammasomes: balancing immunity, neuroinflammation, and homeostasis
www.cell.com/trends/immun...
Inflammasomes and Their Role in Microbial Infections - Thailand Medical News
www.thailandmedical.news
January 22, 2025 at 3:28 AM
Most inflammasome mutations in humans are gain of function, which complicates the question of why we have these molecular machines. @sunnyshinlab.bsky.social et al provide strong evidence that we need inflammasomes to prevent Salmonella infection. A must read! elifesciences.org/articles/90107
Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages
Analysis of inflammasome responses in human macrophages reveals that inflammatory caspases and pyroptotic factors control Salmonella replication primarily within the cytosol and also within vacuoles.
elifesciences.org
April 2, 2025 at 10:24 PM
Most inflammasome mutations in humans are gain of function, which complicates the question of why we have these molecular machines. @sunnyshinlab.bsky.social et al provide strong evidence that we need inflammasomes to prevent Salmonella infection. A must read! elifesciences.org/articles/90107
A genetic screen identifies O-antigen as essential for Rickettsia parkeri survival in macrophages by protecting from inflammasomes and interferon-stimulated genes
#MicroSky
#MicroSky
I'm excited to share our recent working using forward genetics to identify virulence determinants in Rickettsia. Check it out!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
A genetic screen identifies O-antigen as essential for Rickettsia parkeri survival in macrophages by protecting from inflammasomes and interferon-stimulated genes
Lipopolysaccharide (LPS) is highly immunostimulatory, yet it is evolutionarily conserved among many obligate intracellular bacteria for unknown reasons. We report a forward genetic screen to identify ...
www.biorxiv.org
June 15, 2026 at 7:34 PM
A genetic screen identifies O-antigen as essential for Rickettsia parkeri survival in macrophages by protecting from inflammasomes and interferon-stimulated genes
#MicroSky
#MicroSky
NETosis is an integral part of the inflammasome youtu.be/-etkTCbnB1w?...
November 11, 2025 at 1:22 AM
NETosis is an integral part of the inflammasome youtu.be/-etkTCbnB1w?...
🔬 Why ARDS is so hard to treat?! Over 10% of ICU patients have ARDS, yet despite being discovered 58 years ago there is still no cure! Blocking inflammasomes works in mice 🐭 but this doesn't translate to human trials – Some research calls for a deeper focus on neutrophils to unlock new therapies. 🧪
Role of inflammasomes in acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) is present in >10% of all people admitted to critical care and is associated with severe morbidity and mortality. Despite more than half a century since its ...
thorax.bmj.com
February 1, 2025 at 11:39 PM
🔬 Why ARDS is so hard to treat?! Over 10% of ICU patients have ARDS, yet despite being discovered 58 years ago there is still no cure! Blocking inflammasomes works in mice 🐭 but this doesn't translate to human trials – Some research calls for a deeper focus on neutrophils to unlock new therapies. 🧪
From the S. Shin lab sunnyshinlab.bsky.social: Hu guanylate-binding protein 1 (GBP1) damages the vesicle around Legionella, revealing the pathogen to the cell by activating inflammasomes. In contrast, murine GBPs can directly attack cytosolic Legionella. doi.org/10.1128/mbio... #mbio #ASM #MicroSky
Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation | mBio
Inflammasomes are essential for host defense against intracellular bacterial pathogens
like Legionella, as they activate caspases, which promote cytokine release and cell death to control
infection. I...
doi.org
November 13, 2024 at 12:32 PM
From the S. Shin lab sunnyshinlab.bsky.social: Hu guanylate-binding protein 1 (GBP1) damages the vesicle around Legionella, revealing the pathogen to the cell by activating inflammasomes. In contrast, murine GBPs can directly attack cytosolic Legionella. doi.org/10.1128/mbio... #mbio #ASM #MicroSky
Bacteria encode homologs of the human NACHT proteins that form inflammasomes and use them to defend against phage #infection. @amyconte.bsky.social @aaronwhiteley.bsky.social &co show that bNACHT25 detects diverse phages indirectly through interaction with the host chaperone DnaJ. 🧪
plos.io/4koXP60
plos.io/4koXP60
DnaJ mediates phage sensing by the bacterial NLR-related protein bNACHT25
Bacteria encode homologs of the human NACHT proteins that form inflammasomes, and use them to defend against phage infection. This study shows that the NLR-related protein bNACHT25 detects diverse pha...
plos.io
June 4, 2025 at 9:17 AM
Bacteria encode homologs of the human NACHT proteins that form inflammasomes and use them to defend against phage #infection. @amyconte.bsky.social @aaronwhiteley.bsky.social &co show that bNACHT25 detects diverse phages indirectly through interaction with the host chaperone DnaJ. 🧪
plos.io/4koXP60
plos.io/4koXP60
From Hasselt University and Queen’s University Belfast, researchers reviewed over 100 studies and found that inflammasomes were once thought to act only in innate immunity may play a key role in MS by driving inflammation across many cell types.
www.cell.com/trends/immun...
www.cell.com/trends/immun...
Beyond the innate immune system: rethinking inflammasomes in multiple sclerosis
Inflammasomes have emerged as central regulators of (auto)immune pathology, including
multiple sclerosis (MS). Once exclusively considered in the domain of myeloid cells,
both canonical and noncanonic...
www.cell.com
January 16, 2026 at 2:37 AM
From Hasselt University and Queen’s University Belfast, researchers reviewed over 100 studies and found that inflammasomes were once thought to act only in innate immunity may play a key role in MS by driving inflammation across many cell types.
www.cell.com/trends/immun...
www.cell.com/trends/immun...
Beyond excited that two of my brilliant students, Kirsten and Manasa, submitted their PhD theses in the last few weeks! Congratulations ladies! The future of science is in great hands. #inflammasomes #PhDone #ProudPI
February 27, 2026 at 6:24 AM
Beyond excited that two of my brilliant students, Kirsten and Manasa, submitted their PhD theses in the last few weeks! Congratulations ladies! The future of science is in great hands. #inflammasomes #PhDone #ProudPI
What do David Bowie, Queen & #inflammasomes have in common? Read our new review to find out! Deep dive into #NLRP1, #Inflammasomes, and innate immunity — covering activation, regulation & disease links. Great work from lab members Jeremy Yap & Kinga Duszyc!
authors.elsevier.com/a/1ly0C3vVUP...
authors.elsevier.com/a/1ly0C3vVUP...
authors.elsevier.com
November 24, 2025 at 3:59 AM
What do David Bowie, Queen & #inflammasomes have in common? Read our new review to find out! Deep dive into #NLRP1, #Inflammasomes, and innate immunity — covering activation, regulation & disease links. Great work from lab members Jeremy Yap & Kinga Duszyc!
authors.elsevier.com/a/1ly0C3vVUP...
authors.elsevier.com/a/1ly0C3vVUP...
🔓 Our open-access review on inflammasomes in ARDS
🏥 ARDS treatments are limited
🫁 Multiple inflammasomes drive ARDS via IL-1β/18
💊 Their modulation offers potential therapies
🔬Further human-specific research is needed
@charlottesummers.bsky.social
@vpd-hlri.bsky.social
tinyurl.com/mt76tcan
🏥 ARDS treatments are limited
🫁 Multiple inflammasomes drive ARDS via IL-1β/18
💊 Their modulation offers potential therapies
🔬Further human-specific research is needed
@charlottesummers.bsky.social
@vpd-hlri.bsky.social
tinyurl.com/mt76tcan
January 31, 2025 at 8:05 AM
🔓 Our open-access review on inflammasomes in ARDS
🏥 ARDS treatments are limited
🫁 Multiple inflammasomes drive ARDS via IL-1β/18
💊 Their modulation offers potential therapies
🔬Further human-specific research is needed
@charlottesummers.bsky.social
@vpd-hlri.bsky.social
tinyurl.com/mt76tcan
🏥 ARDS treatments are limited
🫁 Multiple inflammasomes drive ARDS via IL-1β/18
💊 Their modulation offers potential therapies
🔬Further human-specific research is needed
@charlottesummers.bsky.social
@vpd-hlri.bsky.social
tinyurl.com/mt76tcan
Gastrointestinal microbiota and inflammasomes interplay in health and disease: a gut feeling
gut.bmj.com/content/earl...
gut.bmj.com/content/earl...
June 16, 2025 at 3:55 PM
Gastrointestinal microbiota and inflammasomes interplay in health and disease: a gut feeling
gut.bmj.com/content/earl...
gut.bmj.com/content/earl...
Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to dissect inflammasome responses to #poxvirus infections in human #PrimaryCells
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells - The EMBO Journal
The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investig...
link.springer.com
January 21, 2026 at 1:27 AM
Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to dissect inflammasome responses to #poxvirus infections in human #PrimaryCells
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
Please check out our latest publication where we find that caspase-3, which mediates what is thought to be an immunologically silent form of cell death is important for protecting against bacterial infections. Congrats to the whole team for making this possible.
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages
Author summary The immune system uses specialized sensors called inflammasomes to detect infection and trigger protective responses. These responses are carried out by enzymes known as caspases, which...
journals.plos.org
May 6, 2026 at 3:23 PM
Please check out our latest publication where we find that caspase-3, which mediates what is thought to be an immunologically silent form of cell death is important for protecting against bacterial infections. Congrats to the whole team for making this possible.
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis.
Happy to share here: www.nature.com/articles/s41...
Happy to share here: www.nature.com/articles/s41...
A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis - Nature Immunology
Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.
www.nature.com
January 6, 2025 at 12:29 AM
Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis.
Happy to share here: www.nature.com/articles/s41...
Happy to share here: www.nature.com/articles/s41...
Hello! The Autoinflammatory Alliance has joined Blue sky. #autoinglammatory #immunedysregulation #cytokines #inflammasomes #rheumatology #immunology
November 17, 2024 at 8:31 AM
Hello! The Autoinflammatory Alliance has joined Blue sky. #autoinglammatory #immunedysregulation #cytokines #inflammasomes #rheumatology #immunology
Now online - research briefing from @inflammasomelab.bsky.social Mercedes Monteleone on our recent @natimmunol.bsky.social publication on how pyroptotic cell corpses signal to dendritic cells from beyond the grave! #inflammasomes #pyroptosis #CellDeath #CLEC9A
Link: rdcu.be/d30EL
Link: rdcu.be/d30EL
December 19, 2024 at 3:53 AM
Now online - research briefing from @inflammasomelab.bsky.social Mercedes Monteleone on our recent @natimmunol.bsky.social publication on how pyroptotic cell corpses signal to dendritic cells from beyond the grave! #inflammasomes #pyroptosis #CellDeath #CLEC9A
Link: rdcu.be/d30EL
Link: rdcu.be/d30EL
Bacteria encode homologs of the human NACHT proteins that form inflammasomes and use them to defend against phage #infection. @amyconte.bsky.social @aaronwhiteley.bsky.social &co show that bNACHT25 detects diverse phages indirectly through interaction with the host chaperone DnaJ. 🧪
plos.io/4koXP60
plos.io/4koXP60
DnaJ mediates phage sensing by the bacterial NLR-related protein bNACHT25
Bacteria encode homologs of the human NACHT proteins that form inflammasomes, and use them to defend against phage infection. This study shows that the NLR-related protein bNACHT25 detects diverse pha...
plos.io
June 3, 2025 at 3:19 PM
Bacteria encode homologs of the human NACHT proteins that form inflammasomes and use them to defend against phage #infection. @amyconte.bsky.social @aaronwhiteley.bsky.social &co show that bNACHT25 detects diverse phages indirectly through interaction with the host chaperone DnaJ. 🧪
plos.io/4koXP60
plos.io/4koXP60
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells - The EMBO Journal
The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investig...
link.springer.com
January 21, 2026 at 7:29 PM
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Bacteria encode homologs of the human NACHT proteins that form inflammasomes and use them to defend against phage #infection. @amyconte.bsky.social @aaronwhiteley.bsky.social &co show that bNACHT25 detects diverse phages indirectly through interaction with the host chaperone DnaJ. 🧪
plos.io/4koXP60
plos.io/4koXP60
DnaJ mediates phage sensing by the bacterial NLR-related protein bNACHT25
Bacteria encode homologs of the human NACHT proteins that form inflammasomes, and use them to defend against phage infection. This study shows that the NLR-related protein bNACHT25 detects diverse pha...
plos.io
June 4, 2025 at 4:46 PM
Bacteria encode homologs of the human NACHT proteins that form inflammasomes and use them to defend against phage #infection. @amyconte.bsky.social @aaronwhiteley.bsky.social &co show that bNACHT25 detects diverse phages indirectly through interaction with the host chaperone DnaJ. 🧪
plos.io/4koXP60
plos.io/4koXP60
So proud of the new Dr @emmamckay.bsky.social for smashing her PhD viva! Huge thank you to her examiners @kesslerbenedikt001.bsky.social @gunnarns.bsky.social for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised with Prof Ben Collins 😊
October 1, 2025 at 2:07 PM
So proud of the new Dr @emmamckay.bsky.social for smashing her PhD viva! Huge thank you to her examiners @kesslerbenedikt001.bsky.social @gunnarns.bsky.social for great discussions on NLRP3 inflammasomes and proteomics - first student co-supervised with Prof Ben Collins 😊