immunogenicity, and therapeutic efficacy of pT181-Qβ vaccination in patients with AD and related tauopathies. If successful in humans, this approach could complement or even surpass current therapies that only modestly impact disease progression by targeting amyloid beta.
May 5, 2025 at 4:08 PM
immunogenicity, and therapeutic efficacy of pT181-Qβ vaccination in patients with AD and related tauopathies. If successful in humans, this approach could complement or even surpass current therapies that only modestly impact disease progression by targeting amyloid beta.
Our proximity proteomics study introducing Probe‑dependent Proximity Profiling (ProPPr) and applying it for profiling tau pathology‑associated proteins in tauopathies + @drneurochic.bsky.social & others is out now! @cziscience.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....
molecularneurodegeneration.biomedcentral.com/articles/10....
Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies - Molecular Neurodegeneration
Background Tauopathies represent a diverse group of neurodegenerative disorders characterized by the abnormal aggregation of the microtubule-associated protein tau. Despite extensive research, the mec...
molecularneurodegeneration.biomedcentral.com
March 13, 2025 at 10:56 PM
Our proximity proteomics study introducing Probe‑dependent Proximity Profiling (ProPPr) and applying it for profiling tau pathology‑associated proteins in tauopathies + @drneurochic.bsky.social & others is out now! @cziscience.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....
molecularneurodegeneration.biomedcentral.com/articles/10....
This is our paper! Read more here: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
May 16, 2025 at 11:18 PM
This is our paper! Read more here: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies
Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP
doi.org/10.1007/s004...
doi.org/10.1007/s004...
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies - Acta Neuropathologica
Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to in vivo tau P...
doi.org
November 25, 2024 at 7:28 PM
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies
Very excited for our new paper, now out in
@cellcellpress.bsky.social! /🧵
The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...
@cellcellpress.bsky.social! /🧵
The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...
Arc mediates intercellular tau transmission via extracellular vesicles
Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critica…
authors.elsevier.com
June 29, 2026 at 4:49 PM
Very excited for our new paper, now out in
@cellcellpress.bsky.social! /🧵
The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...
@cellcellpress.bsky.social! /🧵
The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...
Great to be at #Tau2025 in London, where @angelikadannert.bsky.social from the lab presents our human #iPSC model of Tauopathies in a packed poster session
April 24, 2025 at 3:11 PM
Great to be at #Tau2025 in London, where @angelikadannert.bsky.social from the lab presents our human #iPSC model of Tauopathies in a packed poster session
Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP
doi.org/10.1007/s004...
doi.org/10.1007/s004...
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies - Acta Neuropathologica
Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to in vivo tau P...
doi.org
November 25, 2024 at 5:59 PM
Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP
doi.org/10.1007/s004...
doi.org/10.1007/s004...
Alzforum has written a piece on our most recent updates to the structure-based classification of tauopathies. 🥳
www.alzforum.org/news/researc...
www.alzforum.org/news/researc...
Filling in the Family Tree—AD, CTE Folds Spotted in Other Tauopathies | ALZFORUM
www.alzforum.org
March 28, 2025 at 2:09 PM
Alzforum has written a piece on our most recent updates to the structure-based classification of tauopathies. 🥳
www.alzforum.org/news/researc...
www.alzforum.org/news/researc...
RFK Jr cannot be confirmed IMHO.
Everything in his resumé disqualifies him. He has no medical knowledge or credentials and was already responsible for 83 deaths from measles. For those who survived measles, it is known that measles infections can cause tauopathies later in life.
Everything in his resumé disqualifies him. He has no medical knowledge or credentials and was already responsible for 83 deaths from measles. For those who survived measles, it is known that measles infections can cause tauopathies later in life.
November 15, 2024 at 4:45 PM
RFK Jr cannot be confirmed IMHO.
Everything in his resumé disqualifies him. He has no medical knowledge or credentials and was already responsible for 83 deaths from measles. For those who survived measles, it is known that measles infections can cause tauopathies later in life.
Everything in his resumé disqualifies him. He has no medical knowledge or credentials and was already responsible for 83 deaths from measles. For those who survived measles, it is known that measles infections can cause tauopathies later in life.
#GanLab #AppelInstitute #neurodegenerationresearch #Neuroscience #NIH #Research #EarlyCareerResearchers #WeillCornellMedicine #BioRxiv #tauopathies
We identified TRAPPC8 as an endogenous brake on UFMylation via direct binding of UBA5. Loss of this brake disrupts lysosomal function and drives tau propagation. Restoration rescues this effect in vivo—revealing it as a potential therapeutic target for tauopathies.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
August 26, 2026 at 2:49 PM
The study has been published in Alzheimer’s & Dementia. YES, it is PEER-REVIEWED.
• alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
• hscnews.unm.edu/news/unm-res...
• alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
• hscnews.unm.edu/news/unm-res...
May 5, 2025 at 4:02 PM
The study has been published in Alzheimer’s & Dementia. YES, it is PEER-REVIEWED.
• alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
• hscnews.unm.edu/news/unm-res...
• alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
• hscnews.unm.edu/news/unm-res...
MAPT Splicing Modulators as a Therapeutic Strategy for Tauopathies https://www.biorxiv.org/content/10.1101/2025.05.06.652428v1
May 11, 2025 at 3:15 AM
MAPT Splicing Modulators as a Therapeutic Strategy for Tauopathies https://www.biorxiv.org/content/10.1101/2025.05.06.652428v1
5/5 In summary, SNHG8 and FAM151B‑DT play complementary roles in tauopathies: SNHG8 limits stress granules that drive tau aggregation, while FAM151B‑DT enhances clearance of toxic proteins, opening new paths for understanding and treating tau-related disease. 🧫🔬🧐
#Neuroscience #Tauopathies #endFTD
#Neuroscience #Tauopathies #endFTD
October 8, 2025 at 11:20 PM
5/5 In summary, SNHG8 and FAM151B‑DT play complementary roles in tauopathies: SNHG8 limits stress granules that drive tau aggregation, while FAM151B‑DT enhances clearance of toxic proteins, opening new paths for understanding and treating tau-related disease. 🧫🔬🧐
#Neuroscience #Tauopathies #endFTD
#Neuroscience #Tauopathies #endFTD
🧠💉 New vaccine targets Alzheimer's protein
A new study tested a vaccine that targets tau protein in Alzheimer's – and it worked in mice & monkeys. It improved memory, reduced brain atrophy, & caused no major side effects.
Human trials are next
🔗 doi.org/10.1002/alz....
#Alzheimers #SciComm 🧪
A new study tested a vaccine that targets tau protein in Alzheimer's – and it worked in mice & monkeys. It improved memory, reduced brain atrophy, & caused no major side effects.
Human trials are next
🔗 doi.org/10.1002/alz....
#Alzheimers #SciComm 🧪
Targeting of phosphorylated tau at threonine 181 by a Qβ virus‐like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques
INTRODUCTION Pathological accumulation of tau (pTau) contributes to various tauopathies, including Alzheimer's disease (AD), and correlates with cognitive decline. A rapid surge in tau-targeted appr...
doi.org
April 26, 2025 at 12:39 PM
🧠💉 New vaccine targets Alzheimer's protein
A new study tested a vaccine that targets tau protein in Alzheimer's – and it worked in mice & monkeys. It improved memory, reduced brain atrophy, & caused no major side effects.
Human trials are next
🔗 doi.org/10.1002/alz....
#Alzheimers #SciComm 🧪
A new study tested a vaccine that targets tau protein in Alzheimer's – and it worked in mice & monkeys. It improved memory, reduced brain atrophy, & caused no major side effects.
Human trials are next
🔗 doi.org/10.1002/alz....
#Alzheimers #SciComm 🧪
Excited to be presenting our work on #Epigenomics of #Tauopathies and related diseases later this week at #Tau2025👇!
Join us along with The Rainwater Charitable Foundation and CurePSP for #Tau2025, Apr. 24-25 in London or online! Be a part of the conversation as leading experts work to address the future of tau research. Register now: alz.org/Tau
Tau Global Conference | Alzheimer’s Association
Leading experts from academia, industry, philanthropy and government will meet to address the future of tau research. Learn more and register.
alz.org
April 21, 2025 at 8:28 PM
Excited to be presenting our work on #Epigenomics of #Tauopathies and related diseases later this week at #Tau2025👇!
We’re proud to support @stephfowler.bsky.social with a major project. Her team will be developing new treatments targeting tether proteins to prevent tau spread. Findings from this study could help diversify treatments for tauopathies.
July 4, 2025 at 12:57 PM
We’re proud to support @stephfowler.bsky.social with a major project. Her team will be developing new treatments targeting tether proteins to prevent tau spread. Findings from this study could help diversify treatments for tauopathies.
“The findings, published on Thursday in the journal Neuron, have implications for a range of so-called tauopathies, diseases marked by an abnormal buildup of tau, such as Alzheimer’s, Huntington’s, and frontotemporal dementia.”
August 6, 2026 at 5:44 PM
“The findings, published on Thursday in the journal Neuron, have implications for a range of so-called tauopathies, diseases marked by an abnormal buildup of tau, such as Alzheimer’s, Huntington’s, and frontotemporal dementia.”
Punchline: might LRRK2 therapeutics in development for PD be useful in Alzheimer's and other tauopathies?
November 27, 2024 at 4:27 PM
Punchline: might LRRK2 therapeutics in development for PD be useful in Alzheimer's and other tauopathies?
A few more days to apply for postdoctoral positions in my group. We investigate :
- tau amyloid formation at a molecular level
- tau LLPS
- tau-spliceosome interaction in tauopathies.
More info here : www.fichou-lab.cnrs.fr/en/home
- tau amyloid formation at a molecular level
- tau LLPS
- tau-spliceosome interaction in tauopathies.
More info here : www.fichou-lab.cnrs.fr/en/home
Home - Yann Fichou
The Fichou Lab focuses on the molecular mechanisms underlying neurodegenerative diseases.
www.fichou-lab.cnrs.fr
March 26, 2025 at 6:31 PM
A few more days to apply for postdoctoral positions in my group. We investigate :
- tau amyloid formation at a molecular level
- tau LLPS
- tau-spliceosome interaction in tauopathies.
More info here : www.fichou-lab.cnrs.fr/en/home
- tau amyloid formation at a molecular level
- tau LLPS
- tau-spliceosome interaction in tauopathies.
More info here : www.fichou-lab.cnrs.fr/en/home
A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology | Science Translational Medicine www.science.org/eprint/5H5YD...
A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology
A human iPSC–derived tauopathy model endogenously recapitulates late-stage pathology and enables translational applications.
www.science.org
April 21, 2026 at 2:11 PM
A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology | Science Translational Medicine www.science.org/eprint/5H5YD...
In this Review, Van Alstyne et al. discuss everything Tau, including the pathogenic mechanisms of neurological tauopathies and advances in tau targeted therapies.
Learn more here:
➡️ tinyurl.com/gd352551
Learn more here:
➡️ tinyurl.com/gd352551
May 6, 2025 at 8:44 PM
In this Review, Van Alstyne et al. discuss everything Tau, including the pathogenic mechanisms of neurological tauopathies and advances in tau targeted therapies.
Learn more here:
➡️ tinyurl.com/gd352551
Learn more here:
➡️ tinyurl.com/gd352551