These results confirm that also in murine primary cultures one can faithfully replicate the structure of the #AD seeds! The AAV system provides lots of flexibility in these seeding experiments. E.g. one can choose to overexpress either 3R or 4R human tau and seed with 3R or 4R tauopathies.
October 6, 2026 at 10:05 AM
These results confirm that also in murine primary cultures one can faithfully replicate the structure of the #AD seeds! The AAV system provides lots of flexibility in these seeding experiments. E.g. one can choose to overexpress either 3R or 4R human tau and seed with 3R or 4R tauopathies.
Next, is "Differential proteostasis imbalance & the molecular basis of distinct synucleinopathies & tauopathies"
royalsocietypublishing.org/rstb/article...
royalsocietypublishing.org/rstb/article...
October 5, 2026 at 11:56 AM
Next, is "Differential proteostasis imbalance & the molecular basis of distinct synucleinopathies & tauopathies"
royalsocietypublishing.org/rstb/article...
royalsocietypublishing.org/rstb/article...
Seeking a talented postdoc to join the YuToronto lab in Toronto Canada to understand the molecular and cellular mechanisms of sleep and AD.
Postdoctoral Researcher in Proteostasis and Neurodegenerative Diseases @YuTorontoLab
University of Toronto
See the full job description on jobRxiv: https://jo
Postdoctoral Researcher in Proteostasis and Neurodegenerative Diseases @YuTorontoLab
University of Toronto
See the full job description on jobRxiv: https://jo
Postdoctoral Researcher in Proteostasis and Neurodegenerative Diseases
Description The Yu lab at the University of Toronto is seeking a motivated postdoctoral researcher to immediately join a collaborative project investigating proteostasis and impact of risk factors like sleep or vascular impairment in neurodegenerative diseases like Alzheimer’s and other tauopathies.
jobrxiv.org
October 1, 2026 at 1:35 AM
Seeking a talented postdoc to join the YuToronto lab in Toronto Canada to understand the molecular and cellular mechanisms of sleep and AD.
Postdoctoral Researcher in Proteostasis and Neurodegenerative Diseases @YuTorontoLab
University of Toronto
See the full job description on jobRxiv: https://jo
Postdoctoral Researcher in Proteostasis and Neurodegenerative Diseases @YuTorontoLab
University of Toronto
See the full job description on jobRxiv: https://jo
Researchers Joshua Emmerson, Hao Hu, Vivek Savani, David Holtzman, et al. @washumedicine.bsky.social have dvlpd a potential antibody-based approach to reducing #Neurodegeneration in diseases known as tauopathies, including #Alzheimers. Learn More in Neuron | Cell Press 👉 www.cell.com/neuron/fullt...
Peripheral CXCR3 blockade mitigates T cell infiltration and neurodegeneration in a mouse model of tauopathy
Emmerson et al. demonstrate that the CXCR3-CXCL10 chemokine signaling pathway is important
for brain-infiltrating T cells in tau-mediated neurodegeneration. Blocking CXCR3 reduces
T cell entry and pro...
www.cell.com
September 29, 2026 at 12:51 PM
Researchers Joshua Emmerson, Hao Hu, Vivek Savani, David Holtzman, et al. @washumedicine.bsky.social have dvlpd a potential antibody-based approach to reducing #Neurodegeneration in diseases known as tauopathies, including #Alzheimers. Learn More in Neuron | Cell Press 👉 www.cell.com/neuron/fullt...
An antibody that blocked #ImmuneCells from entering the brains of mice reduced #tau -related #neurodegeneration, preserved #brain tissue, and improved #memory, suggesting a potential immune-targeted treatment for #AlzheimersDisease.
#Tauopathies
#Tauopathies
Blocking immune cells’ path into brain limits tau-mediated neurodegeneration – BioNews Central
An antibody that blocked immune cells from entering the brains of mice reduced tau-related neurodegeneration, preserved brain tissue, and improved memory, suggesting a potential immune-targeted treatment for Alzheimer’s disease. ...
sbee.link
September 29, 2026 at 3:49 AM
An antibody that blocked #ImmuneCells from entering the brains of mice reduced #tau -related #neurodegeneration, preserved #brain tissue, and improved #memory, suggesting a potential immune-targeted treatment for #AlzheimersDisease.
#Tauopathies
#Tauopathies
Up to $1m for AI-enabled research into primary tauopathies. The Rainwater Tau Consortium's new Learning Research Network is open to engineers, data scientists and labs worldwide. LOIs close 30 Oct.
www.dementiaresearcher.nihr.ac.uk/funding/rain...
www.dementiaresearcher.nihr.ac.uk/funding/rain...
Rainwater Learning Research Network: AI Tauopathy Funding
Up to $1m for AI-enabled primary tauopathy research from the Rainwater Tau Consortium's new Learning Research Network. Letters of intent close 30 October 2026.
www.dementiaresearcher.nihr.ac.uk
September 28, 2026 at 5:49 PM
Up to $1m for AI-enabled research into primary tauopathies. The Rainwater Tau Consortium's new Learning Research Network is open to engineers, data scientists and labs worldwide. LOIs close 30 Oct.
www.dementiaresearcher.nihr.ac.uk/funding/rain...
www.dementiaresearcher.nihr.ac.uk/funding/rain...
Mice retained roughly 40% more tissue in their brain’s memory centers when T-cell entry was limited. Tau buildup remained unchanged. doi.org/hckrnv
Blocking immune cells' path into the brain limits neurodegeneration
There is no treatment available today to stop the death of brain cells in neurodegenerative diseases known as tauopathies, including Alzheimer's disease, in which twisted clumps of a protein called tau accumulate in the brain.
medicalxpress.com
September 28, 2026 at 3:01 PM
Mice retained roughly 40% more tissue in their brain’s memory centers when T-cell entry was limited. Tau buildup remained unchanged. doi.org/hckrnv
New paper out: 4-Repeat Tauopathien – Progressive Supranukleäre Blickparese und kortikobasale Degeneration | 4-Repeat Tauopathies: Progressive Supranuclear Palsy andCorticobasal Degeneration: Palleis, Carla Teresa; Bernhardt, Alexander; Höglinger, Günter… | Thanks for sharing #dzne #papers
4-Repeat Tauopathien – Progressive Supranukleäre Blickparese und kortikobasale Degeneration | 4-Repeat Tauopathies: Progressive Supranuclear Palsy andCorticobasal Degeneration
Palleis, Carla Teresa; Bernhardt, Alexander; Höglinger, Günter
Fortschritte der Neurologie, Psychiatrie Vol. 94, no. 9, p. 389 - 399
dlvr.it
September 25, 2026 at 12:53 PM
Dynamic [18F]PI-2620 recording facilitates prediction of β- #amyloid positivity and simultaneous staging of tau and #neurodegeneration
Johannes Gnörich, Julia Kusche-Palenga, Agnes Kling...Matthias Brendel @lmu.de #neuroimaging #tauopathies
link.springer.com/article/10.1...
Johannes Gnörich, Julia Kusche-Palenga, Agnes Kling...Matthias Brendel @lmu.de #neuroimaging #tauopathies
link.springer.com/article/10.1...
Dynamic [18F]PI-2620 recording facilitates prediction of β-amyloid positivity and simultaneous staging of tau and neurodegeneration - Molecular Neurodegeneration
Background Patients with Alzheimer’s disease (AD) and clinically overlapping neurodegenerative diseases are classified molecularly using the A/T/N classification system. Apart from fluid biomarkers an...
link.springer.com
September 24, 2026 at 2:56 PM
Dynamic [18F]PI-2620 recording facilitates prediction of β- #amyloid positivity and simultaneous staging of tau and #neurodegeneration
Johannes Gnörich, Julia Kusche-Palenga, Agnes Kling...Matthias Brendel @lmu.de #neuroimaging #tauopathies
link.springer.com/article/10.1...
Johannes Gnörich, Julia Kusche-Palenga, Agnes Kling...Matthias Brendel @lmu.de #neuroimaging #tauopathies
link.springer.com/article/10.1...
Traffic lights just published !
onlinelibrary.wiley.com/doi/10.1111/...
#autophagy #neurodegeneration
onlinelibrary.wiley.com/doi/10.1111/...
#autophagy #neurodegeneration
“S‐Tau‐Lled” Lysosomes Disrupt Autophagic Processes in Neurodegeneration
Tauopathies are neurodegenerative diseases characterized by misfolded tau accumulation and lysosomal dysfunction. Pathogenic mutant Tau stalls lysosomes in iPSC-derived neurons upstream of Tau accumu...
onlinelibrary.wiley.com
September 22, 2026 at 12:32 PM
Traffic lights just published !
onlinelibrary.wiley.com/doi/10.1111/...
#autophagy #neurodegeneration
onlinelibrary.wiley.com/doi/10.1111/...
#autophagy #neurodegeneration
RRID:AB_10987115 from @thermofishersci.bsky.social was used by authors in their paper. We value the author's support of reproducibility. #OpenScience #ReproducibleResearch #STMpublishing
Elevated DYRK1A in Primary Tauopathies and Therapeutic Targeting with the Brain-Penetrant Inhibitor DYR533
Neurodegenerative disorders are increasing in prevalence, yet disease-modifying therapies remain limited. Dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) phosphorylates tau and regulates inflammatory signaling, making it a potential therapeutic target for neurodegenerati...
doi.org
September 16, 2026 at 7:36 PM
RRID:AB_10987115 from @thermofishersci.bsky.social was used by authors in their paper. We value the author's support of reproducibility. #OpenScience #ReproducibleResearch #STMpublishing
OBS Neuroimmunology Webinar — Monthly on the 3rd Thu at 12 PM ET
@alzforum Comments
Can Peripheral Antigen-Presenting Cells Hasten Tauopathies?
Article: www.alzforum.org/news/researc...
*Zoom: us02web.zoom.us/meeting/regi...
@alzforum Comments
Can Peripheral Antigen-Presenting Cells Hasten Tauopathies?
Article: www.alzforum.org/news/researc...
*Zoom: us02web.zoom.us/meeting/regi...
September 15, 2026 at 4:04 PM
OBS Neuroimmunology Webinar — Monthly on the 3rd Thu at 12 PM ET
@alzforum Comments
Can Peripheral Antigen-Presenting Cells Hasten Tauopathies?
Article: www.alzforum.org/news/researc...
*Zoom: us02web.zoom.us/meeting/regi...
@alzforum Comments
Can Peripheral Antigen-Presenting Cells Hasten Tauopathies?
Article: www.alzforum.org/news/researc...
*Zoom: us02web.zoom.us/meeting/regi...
New in print: Jessica Fortin, DVM, PhD, of Purdue Veterinary Medicine edited “Translational Research Methods for Tauopathies,” a new volume of laboratory methods for studying tau-related neurodegenerative disease.
https://purdue.vet/XV4XeO
#news /hashtag/VetMed%C2%A0@avmajavma.bsky.social%C2%A0@avmavets.bsky.social" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#VetMed @avmajavma.bsky.social @avmavets.bsky.social.app/profile/did:plc:ka7km2ywsrbn5b5zpcndbqzl" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@avmavets.bsky.social
https://purdue.vet/XV4XeO
#news /hashtag/VetMed%C2%A0@avmajavma.bsky.social%C2%A0@avmavets.bsky.social" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#VetMed @avmajavma.bsky.social @avmavets.bsky.social.app/profile/did:plc:ka7km2ywsrbn5b5zpcndbqzl" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@avmavets.bsky.social
September 14, 2026 at 1:30 PM
New in print: Jessica Fortin, DVM, PhD, of Purdue Veterinary Medicine edited “Translational Research Methods for Tauopathies,” a new volume of laboratory methods for studying tau-related neurodegenerative disease.
https://purdue.vet/XV4XeO
#news /hashtag/VetMed%C2%A0@avmajavma.bsky.social%C2%A0@avmavets.bsky.social" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#VetMed @avmajavma.bsky.social @avmavets.bsky.social.app/profile/did:plc:ka7km2ywsrbn5b5zpcndbqzl" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@avmavets.bsky.social
https://purdue.vet/XV4XeO
#news /hashtag/VetMed%C2%A0@avmajavma.bsky.social%C2%A0@avmavets.bsky.social" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#VetMed @avmajavma.bsky.social @avmavets.bsky.social.app/profile/did:plc:ka7km2ywsrbn5b5zpcndbqzl" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@avmavets.bsky.social
New preprint from our group: site-specific lysine glycation can decouple nucleation, cellular uptake, and templated propagation.
chemrxiv.org/doi/full/10....
chemrxiv.org/doi/full/10....
Site-specific lysine glycation decouples tau nucleation, uptake, and templated propagation | ChemRxiv
Tau aggregation is a defining molecular feature of Alzheimer’s disease and related
tauopathies, but how non-enzymatic chemical modifications tune tau assembly, cellular
uptake, and templated propagati...
chemrxiv.org
September 11, 2026 at 2:51 PM
New preprint from our group: site-specific lysine glycation can decouple nucleation, cellular uptake, and templated propagation.
chemrxiv.org/doi/full/10....
chemrxiv.org/doi/full/10....
PhD project at Cambridge developing in silico models to predict clinical severity and progression in neurodegenerative tauopathies. Closing date: 8th December
www.dementiaresearcher.nihr.ac.uk/job/phd-math...
www.dementiaresearcher.nihr.ac.uk/job/phd-math...
PhD: Mathematical Modelling of Neurodegenerative Tauopathies
Cambridge offers a PhD project developing in silico models to predict clinical severity and progression in neurodegenerative tauopathies.
www.dementiaresearcher.nihr.ac.uk
September 9, 2026 at 3:41 PM
PhD project at Cambridge developing in silico models to predict clinical severity and progression in neurodegenerative tauopathies. Closing date: 8th December
www.dementiaresearcher.nihr.ac.uk/job/phd-math...
www.dementiaresearcher.nihr.ac.uk/job/phd-math...
Cell type- and tau lesion-specific accumulation of phospho-Ser65 ubiquitin in primary tauopathies #NeuroDegeneration 🧪🧠
https://link.springer.com/10.1186/s40478-026-02426-4
https://link.springer.com/10.1186/s40478-026-02426-4
September 4, 2026 at 4:05 PM
Cell type- and tau lesion-specific accumulation of phospho-Ser65 ubiquitin in primary tauopathies #NeuroDegeneration 🧪🧠
https://link.springer.com/10.1186/s40478-026-02426-4
https://link.springer.com/10.1186/s40478-026-02426-4
🧠This review highlights glycosylation as a critical regulator of Alzheimer’s disease and related tauopathies, demonstrating how alterations in glycosylation influence tau aggregation, amyloid-β processing, neuroinflammation, and synaptic dysfunction.
www.mdpi.com/2227-9059/13...
www.mdpi.com/2227-9059/13...
September 3, 2026 at 9:05 AM
🧠This review highlights glycosylation as a critical regulator of Alzheimer’s disease and related tauopathies, demonstrating how alterations in glycosylation influence tau aggregation, amyloid-β processing, neuroinflammation, and synaptic dysfunction.
www.mdpi.com/2227-9059/13...
www.mdpi.com/2227-9059/13...