Miguel Minaya, Ph.D
@miguelminaya.bsky.social
Assistant Professor @ Washington University in St. Louis
➣ Neurology | Stem Cell Models | Tauopathies | Genomics & Bioinformatics
➣ Neurology | Stem Cell Models | Tauopathies | Genomics & Bioinformatics
1/8 What if your cells are already trying to fight tau aggregation, but a broken gene stops them? 🧠⚡Our new work from @WUSTLmed identifies NINL as a novel regulator of tau aggregation in FTD and AD
Full paper 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Thread 🧵👇
#Neuroscience #WUSM
Full paper 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Thread 🧵👇
#Neuroscience #WUSM
Integrative genomic and functional analyses reveal NINL as a modulator of tau aggregation
INTRODUCTION Proteostasis dysfunction is a hallmark of frontotemporal dementia (FTD) and Alzheimer's disease (AD), yet the genetic and molecular pathways that disrupt protein homeostasis remain poor...
alz-journals.onlinelibrary.wiley.com
May 6, 2026 at 9:49 PM
1/8 What if your cells are already trying to fight tau aggregation, but a broken gene stops them? 🧠⚡Our new work from @WUSTLmed identifies NINL as a novel regulator of tau aggregation in FTD and AD
Full paper 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Thread 🧵👇
#Neuroscience #WUSM
Full paper 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Thread 🧵👇
#Neuroscience #WUSM
1/6 Can a single Tau mutation break the neuron’s recycling system? 🧠🔬
Our new study in Nature Communications links p.R406W Tau to multi-step autophagy failure, and points to a therapeutic path.
#Tauopathies #endFTD #DrugDiscovery #Neuroscience #Lysosomes www.nature.com/articles/s41...
Our new study in Nature Communications links p.R406W Tau to multi-step autophagy failure, and points to a therapeutic path.
#Tauopathies #endFTD #DrugDiscovery #Neuroscience #Lysosomes www.nature.com/articles/s41...
A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia - Nature Communications
Researchers show that a disease-causing Tau mutation disrupts the autophagy-lysosome pathway in human neurons, leading to Tau accumulation, and that enhancing autophagy can partially restore protein c...
www.nature.com
April 6, 2026 at 11:41 PM
1/6 Can a single Tau mutation break the neuron’s recycling system? 🧠🔬
Our new study in Nature Communications links p.R406W Tau to multi-step autophagy failure, and points to a therapeutic path.
#Tauopathies #endFTD #DrugDiscovery #Neuroscience #Lysosomes www.nature.com/articles/s41...
Our new study in Nature Communications links p.R406W Tau to multi-step autophagy failure, and points to a therapeutic path.
#Tauopathies #endFTD #DrugDiscovery #Neuroscience #Lysosomes www.nature.com/articles/s41...
MedicalXpress highlights our new #MolecularPsychiatry paper on lncRNA FAM151B-DT, a key regulator of tau and α-synuclein aggregation. #Neurodegeneration #Tauopathy #Alzheimers #Parkinsons
medicalxpress.com/news/2025-11...
medicalxpress.com/news/2025-11...
Newly discovered RNA molecule could limit protein aggregation and prevent neuronal damage
Neurodegenerative diseases, such as Alzheimer's disease and dementia, are medical conditions that entail the progressive loss of neurons and a decline in brain function. Past studies have found a link...
medicalxpress.com
November 13, 2025 at 9:36 PM
MedicalXpress highlights our new #MolecularPsychiatry paper on lncRNA FAM151B-DT, a key regulator of tau and α-synuclein aggregation. #Neurodegeneration #Tauopathy #Alzheimers #Parkinsons
medicalxpress.com/news/2025-11...
medicalxpress.com/news/2025-11...
Are you planning to use AI in your research? 🤖🧪 AI gives fast answers, but critical thinking still rules the lab! 🧬💡 Trust, but verify the robot. 😜 #AI #Science #Research
🔗 AI in the lab: The power of smarter questions: www.asbmb.org/asbmb-today/...
🔗 AI in the lab: The power of smarter questions: www.asbmb.org/asbmb-today/...
AI in the lab: The power of smarter questions
An assistant professor discusses AI's evolution from a buzzw
www.asbmb.org
October 16, 2025 at 12:57 AM
Are you planning to use AI in your research? 🤖🧪 AI gives fast answers, but critical thinking still rules the lab! 🧬💡 Trust, but verify the robot. 😜 #AI #Science #Research
🔗 AI in the lab: The power of smarter questions: www.asbmb.org/asbmb-today/...
🔗 AI in the lab: The power of smarter questions: www.asbmb.org/asbmb-today/...
1/5 Hey friends! Exciting news! Two new studies highlight the role of lncRNAs SNHG8 & FAM151B DT in tau-related brain disorders. These discoveries open new paths for research & therapy. 🔬📚 #Tauopathies #endFTD
Read more:
🔗 pubmed.ncbi.nlm.nih.gov/37730840/
🔗 pubmed.ncbi.nlm.nih.gov/41053434/
Read more:
🔗 pubmed.ncbi.nlm.nih.gov/37730840/
🔗 pubmed.ncbi.nlm.nih.gov/41053434/
October 8, 2025 at 11:20 PM
1/5 Hey friends! Exciting news! Two new studies highlight the role of lncRNAs SNHG8 & FAM151B DT in tau-related brain disorders. These discoveries open new paths for research & therapy. 🔬📚 #Tauopathies #endFTD
Read more:
🔗 pubmed.ncbi.nlm.nih.gov/37730840/
🔗 pubmed.ncbi.nlm.nih.gov/41053434/
Read more:
🔗 pubmed.ncbi.nlm.nih.gov/37730840/
🔗 pubmed.ncbi.nlm.nih.gov/41053434/
Reposted by Miguel Minaya, Ph.D
Nos agarramos a un clavo ardiendo con tal de no cambiar nuestra dependencia de los combustibles fósiles. Uno de esos clavos se llama geoingeniería climática ¿Qué es? ¿Por qué no sirve al menos por ahora?
#geoingenieria #cambioclimatico #fernandovalladares youtu.be/ZqHbcJ0WG00?...
#geoingenieria #cambioclimatico #fernandovalladares youtu.be/ZqHbcJ0WG00?...
GEOINGENIERIA, tecnología climática PELIGROSA y CARA| 196
YouTube video by La salud de la humanidad
youtu.be
November 22, 2024 at 1:48 PM
Nos agarramos a un clavo ardiendo con tal de no cambiar nuestra dependencia de los combustibles fósiles. Uno de esos clavos se llama geoingeniería climática ¿Qué es? ¿Por qué no sirve al menos por ahora?
#geoingenieria #cambioclimatico #fernandovalladares youtu.be/ZqHbcJ0WG00?...
#geoingenieria #cambioclimatico #fernandovalladares youtu.be/ZqHbcJ0WG00?...
Reposted by Miguel Minaya, Ph.D
Hablando de cosas importantes: ¿SE PUEDE PONER YA EL ÁRBOL O NO?
November 20, 2024 at 11:49 PM
Hablando de cosas importantes: ¿SE PUEDE PONER YA EL ÁRBOL O NO?
Reposted by Miguel Minaya, Ph.D
#KernelsofCulture: Maize Around the World (May 3, 2024 – March 31, 2025) @mobotmuseum.bsky.social focuses on the complex story of one of the world’s most important crop plants, maize (Zea mays), which is used by billions of people every day, for food, for animal feed, and as biofuel.
May 6, 2024 at 3:03 PM
#KernelsofCulture: Maize Around the World (May 3, 2024 – March 31, 2025) @mobotmuseum.bsky.social focuses on the complex story of one of the world’s most important crop plants, maize (Zea mays), which is used by billions of people every day, for food, for animal feed, and as biofuel.