Cool story! As a community, we are just beginning to map lipid heterogeneity within cellular membranes & I think there are many discoveries ahead. Exciting times!
New in @jacs.acspublications.org: Brian Chen & @adi-bhatta.bsky.social used photoaffinity labeling to map the localization & interactome of the amphiphilic lipid lysophosphatidic acid & found nanoscale-level heterogeneity within ER membranes! pubs.acs.org/jacsat/artic... @weillinstitute.bsky.social
November 5, 2026 at 6:00 AM
Cool story! As a community, we are just beginning to map lipid heterogeneity within cellular membranes & I think there are many discoveries ahead. Exciting times!
Can lipids alone map the brain? 🧠
A micrometre-scale lipid atlas of the mouse brain reveals 'lipizones' that align with functional anatomy, and lipid remodelling in pregnancy. Congrats to the La Manno lab in Nature 👇🏻
https://doi.org/10.1038/s41586-026-11050-0
A micrometre-scale lipid atlas of the mouse brain reveals 'lipizones' that align with functional anatomy, and lipid remodelling in pregnancy. Congrats to the La Manno lab in Nature 👇🏻
https://doi.org/10.1038/s41586-026-11050-0
November 3, 2026 at 5:52 PM
Can lipids alone map the brain? 🧠
A micrometre-scale lipid atlas of the mouse brain reveals 'lipizones' that align with functional anatomy, and lipid remodelling in pregnancy. Congrats to the La Manno lab in Nature 👇🏻
https://doi.org/10.1038/s41586-026-11050-0
A micrometre-scale lipid atlas of the mouse brain reveals 'lipizones' that align with functional anatomy, and lipid remodelling in pregnancy. Congrats to the La Manno lab in Nature 👇🏻
https://doi.org/10.1038/s41586-026-11050-0
🌊 Global cycles of carbon and phosphorus decouple under intensifying ocean acidification as marine diatoms restructure their lipid membranes and downregulate organic phosphorus scavenging to adapt to the decreasing pH.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sparing use of phosphorus in an acidifying ocean - Nature Geoscience
Global cycles of carbon and phosphorus decouple under intensifying ocean acidification as marine diatoms restructure their lipid membranes and downregulate organic phosphorus scavenging to adapt to th...
www.nature.com
November 6, 2026 at 6:25 AM
🌊 Global cycles of carbon and phosphorus decouple under intensifying ocean acidification as marine diatoms restructure their lipid membranes and downregulate organic phosphorus scavenging to adapt to the decreasing pH.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Disruption of Plasma Membrane Lipid Asymmetry Alters Cellular Energetics
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 4, 2026 at 2:43 PM
Disruption of Plasma Membrane Lipid Asymmetry Alters Cellular Energetics
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
New in @jacs.acspublications.org: Brian Chen & @adi-bhatta.bsky.social used photoaffinity labeling to map the localization & interactome of the amphiphilic lipid lysophosphatidic acid & found nanoscale-level heterogeneity within ER membranes! pubs.acs.org/jacsat/artic... @weillinstitute.bsky.social
November 4, 2026 at 7:42 PM
New in @jacs.acspublications.org: Brian Chen & @adi-bhatta.bsky.social used photoaffinity labeling to map the localization & interactome of the amphiphilic lipid lysophosphatidic acid & found nanoscale-level heterogeneity within ER membranes! pubs.acs.org/jacsat/artic... @weillinstitute.bsky.social
Phosphatidylcholine acyl turnover facilitates thylakoid lipid remodeling and promotes plant survival under heat stress
Dongling Xie, Shasha Wang, Jilian Fan and Changcheng Xu
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience
Dongling Xie, Shasha Wang, Jilian Fan and Changcheng Xu
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience
November 3, 2026 at 7:59 PM
Phosphatidylcholine acyl turnover facilitates thylakoid lipid remodeling and promotes plant survival under heat stress
Dongling Xie, Shasha Wang, Jilian Fan and Changcheng Xu
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience
Dongling Xie, Shasha Wang, Jilian Fan and Changcheng Xu
nph.onlinelibrary.wiley.com/doi/10.1111/...
#PlantScience
Me getting my lipid panel and PSA
I AM NOT GOING TO LOOK AT YOUR FUCKING NEEDLE YOU CANNOT MAKE ME
November 4, 2026 at 1:12 AM
Me getting my lipid panel and PSA
Prokaryotes bridging the lipid divide academic.oup.com/femsre/advan... #jcampubs
November 2, 2026 at 2:33 PM
Prokaryotes bridging the lipid divide academic.oup.com/femsre/advan... #jcampubs
Adding lipid tails to drug substances is a classic way to change their uptake and distribution. But the effects in different sorts of cells can vary widely:
Lipidation and Its Discontents
www.science.org
November 3, 2026 at 8:08 PM
Adding lipid tails to drug substances is a classic way to change their uptake and distribution. But the effects in different sorts of cells can vary widely:
mRNA’s therapeutic potential was recognized for decades, but lipid nanoparticle research made it a reality. Nature Materials reports how researchers now aim to boost efficacy and reduce side effects to extend these delivery agents beyond vaccines. go.nature.com/4iOlG0y 🧪
November 2, 2026 at 5:08 PM
mRNA’s therapeutic potential was recognized for decades, but lipid nanoparticle research made it a reality. Nature Materials reports how researchers now aim to boost efficacy and reduce side effects to extend these delivery agents beyond vaccines. go.nature.com/4iOlG0y 🧪
Prokaryotes bridging the lipid divide
#microbiology #prokaryotes #lipids #MicroSky
@femsjournals.bsky.social @femsmicro.org
doi.org/10.1093/fems...
#microbiology #prokaryotes #lipids #MicroSky
@femsjournals.bsky.social @femsmicro.org
doi.org/10.1093/fems...
Prokaryotes bridging the lipid divide
Abstract. The fundamental biochemical and stereochemical difference in how cell membrane lipids are built between Archaea on one side, and Bacteria and Euk
doi.org
November 3, 2026 at 8:34 AM
Prokaryotes bridging the lipid divide
#microbiology #prokaryotes #lipids #MicroSky
@femsjournals.bsky.social @femsmicro.org
doi.org/10.1093/fems...
#microbiology #prokaryotes #lipids #MicroSky
@femsjournals.bsky.social @femsmicro.org
doi.org/10.1093/fems...
Finally
The endosomal signalling lipid PI(3)P is crucial for cargo sorting. But how is PI(3)P homeostasis regulated? And how is this coupled to the sorting of cargo through endosomes?
We have uncovered a simple mechanism that couples cargo sorting to membrane identity
www.biorxiv.org/content/10.6...
The endosomal signalling lipid PI(3)P is crucial for cargo sorting. But how is PI(3)P homeostasis regulated? And how is this coupled to the sorting of cargo through endosomes?
We have uncovered a simple mechanism that couples cargo sorting to membrane identity
www.biorxiv.org/content/10.6...
Cargo levels control endosomal PI(3)P homeostasis through direct feedback between SNX17 and MTM1
The sorting of internalised cell surface proteins through the endosomal network is crucial for cellular function. Phosphatidylinositol-3-phosphate (PI(3)P) is a critical lipid identity cue for organis...
www.biorxiv.org
November 3, 2026 at 4:19 PM
Finally
The endosomal signalling lipid PI(3)P is crucial for cargo sorting. But how is PI(3)P homeostasis regulated? And how is this coupled to the sorting of cargo through endosomes?
We have uncovered a simple mechanism that couples cargo sorting to membrane identity
www.biorxiv.org/content/10.6...
The endosomal signalling lipid PI(3)P is crucial for cargo sorting. But how is PI(3)P homeostasis regulated? And how is this coupled to the sorting of cargo through endosomes?
We have uncovered a simple mechanism that couples cargo sorting to membrane identity
www.biorxiv.org/content/10.6...
Eyes like lipid pools...
Goodnight Bob 🫶
Goodnight Bob 🫶
November 3, 2026 at 11:57 PM
Eyes like lipid pools...
Goodnight Bob 🫶
Goodnight Bob 🫶
New Article! Isolation and lipidomic profiling of neuronal lipid droplets to unveil the lipid landscape of neurodegenerative disorders
Isolation and lipidomic profiling of neuronal lipid droplets to unveil the lipid landscape of neurodegenerative disorders
Nature Protocols, Published online: 03 November 2026; doi:10.1038/s41596-026-01451-wThis Protocol describes a robust workflow for pharmacological induction, purification and characterization of mature lipid droplets from primary cortical neurons with minimal detected cytosolic membrane carryover.
dlvr.it
November 3, 2026 at 11:00 PM
New Article! Isolation and lipidomic profiling of neuronal lipid droplets to unveil the lipid landscape of neurodegenerative disorders
7) Regarding the metabolic shift the authors write:
"WASF3 overexpression appears to promote a previously described 'hypometabolic syndrome' state in ME/CFS characterized by depletion of glucose and glycolytic intermediates and decreased lipid metabolism."
"WASF3 overexpression appears to promote a previously described 'hypometabolic syndrome' state in ME/CFS characterized by depletion of glucose and glycolytic intermediates and decreased lipid metabolism."
November 4, 2026 at 9:33 AM
7) Regarding the metabolic shift the authors write:
"WASF3 overexpression appears to promote a previously described 'hypometabolic syndrome' state in ME/CFS characterized by depletion of glucose and glycolytic intermediates and decreased lipid metabolism."
"WASF3 overexpression appears to promote a previously described 'hypometabolic syndrome' state in ME/CFS characterized by depletion of glucose and glycolytic intermediates and decreased lipid metabolism."
Phosphate-responsive ornithine lipid biosynthesis remodels outer membrane composition and contributes to polymyxin tolerance https://www.biorxiv.org/content/10.64898/2026.11.03.764129v1
November 4, 2026 at 7:18 PM
Phosphate-responsive ornithine lipid biosynthesis remodels outer membrane composition and contributes to polymyxin tolerance https://www.biorxiv.org/content/10.64898/2026.11.03.764129v1
University of British Columbia is hiring:
Research Associate in Lipid Nanoparticle Therapeutics
#postdoc #biology #medicine
Research Associate in Lipid Nanoparticle Therapeutics
#postdoc #biology #medicine
November 6, 2026 at 1:18 PM
University of British Columbia is hiring:
Research Associate in Lipid Nanoparticle Therapeutics
#postdoc #biology #medicine
Research Associate in Lipid Nanoparticle Therapeutics
#postdoc #biology #medicine
Formation of Thermally Stable Vesicles from a Cyclic Tetraether Archaeal Lipid pubmed.ncbi.nlm.nih.gov/42975349/ #cryoem
November 5, 2026 at 3:06 AM
Formation of Thermally Stable Vesicles from a Cyclic Tetraether Archaeal Lipid pubmed.ncbi.nlm.nih.gov/42975349/ #cryoem
would generate large amounts of protein in the target tissues. They screened libraries of delivery particles containing both polymer and lipid components, which have been used separately to achieve efficient mRNA delivery. From these screens, they identified one polymer-lipid particle that was
October 30, 2026 at 4:10 PM
would generate large amounts of protein in the target tissues. They screened libraries of delivery particles containing both polymer and lipid components, which have been used separately to achieve efficient mRNA delivery. From these screens, they identified one polymer-lipid particle that was
New Online! Phosphatidylinositol 3,4-bisphosphate is a novel lipid helper for mitochondrial fusion
Phosphatidylinositol 3,4-bisphosphate is a novel lipid helper for mitochondrial fusion
Nature Reviews Molecular Cell Biology, Published online: 02 November 2026; doi:10.1038/s41580-026-01049-wGolgi-derived vesicles that contain phosphatidylinositol 3,4-bisphosphate facilitate mitochondrial fusion at sites marked with mitofusins and endoplasmic reticulum.
dlvr.it
November 2, 2026 at 3:48 PM
New Online! Phosphatidylinositol 3,4-bisphosphate is a novel lipid helper for mitochondrial fusion
'Here we show that the innate and adaptive immune responses elicited by LNPs are linked to their ionizable lipid chemistry. Specifically, we show that the amine headgroups in ionizable lipids drive LNP immunogenicity by binding to Toll-like receptor 4 and CD1d and by promoting lipid-raft formation.'
Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d - Nature Biomedical Engineering
Amine headgroups in ionizable lipids drive the immunogenicity of lipid nanoparticles by binding to Toll-like receptor 4 and CD1d and by promoting lipid-raft formation.
www.nature.com
November 2, 2026 at 9:32 AM
'Here we show that the innate and adaptive immune responses elicited by LNPs are linked to their ionizable lipid chemistry. Specifically, we show that the amine headgroups in ionizable lipids drive LNP immunogenicity by binding to Toll-like receptor 4 and CD1d and by promoting lipid-raft formation.'
Online now: Lipid homeostasis and cellular metabolism in neurodegenerative diseases: A maturing framework to guide therapeutic development
Lipid homeostasis and cellular metabolism in neurodegenerative diseases: A maturing framework to guide therapeutic development
Isacson et al. describe a paradigm shift in understanding Alzheimer’s disease, Lewy body dementia, and Parkinson’s disease, moving beyond proteinopathy-centered observations toward primary lipid and metabolic disturbances. The perspective explores how deeper insights into cell biology and brain health may enable innovative therapeutic interventions against neurodegeneration.
dlvr.it
November 5, 2026 at 8:19 PM
Online now: Lipid homeostasis and cellular metabolism in neurodegenerative diseases: A maturing framework to guide therapeutic development
ORB-TXTL: Cell-Free Expression of Membrane Proteins on Lipid Bilayer-Coated Beads pubs.acs.org/asbcd6/artic...
ORB-TXTL: Cell-Free Expression of Membrane Proteins on Lipid Bilayer-Coated Beads
Abstract. Membrane proteins achieve a remarkable range of cellular functions, yet their characterization at high throughputs remains difficult with standar
pubs.acs.org
November 3, 2026 at 10:17 AM
ORB-TXTL: Cell-Free Expression of Membrane Proteins on Lipid Bilayer-Coated Beads pubs.acs.org/asbcd6/artic...