Could inhaling Xenon be used someday to prevent or treat Alzheimer's disease? An intriguing experimental model study shows its effect on modulating brain microglia and reducing inflammation
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy
Xenon inhalation modulates microglial responses in mice and is a potential therapeutic agent for treating Alzheimer’s disease.
www.science.org
January 15, 2025 at 7:37 PM
Could inhaling Xenon be used someday to prevent or treat Alzheimer's disease? An intriguing experimental model study shows its effect on modulating brain microglia and reducing inflammation
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Congratulations to Sabeen Kazmi & colleagues on their new study showing that gut microbes & microbial metabolites can promote tau aggregation in a mouse model of tauopathy/Alzheimer’s disease. The work identifies microbiome changes linked to tau risk over time as potential therapeutic targets.
Select microbial metabolites promote tau aggregation in a murine tauopathy model - Nature Communications
Here, using a mouse model of tauopathy, the authors reveal that disruption of the gut microbiome drives tau pathology and cognitive decline, and identify five microbial metabolites that directly promo...
www.nature.com
August 11, 2026 at 6:48 PM
Congratulations to Sabeen Kazmi & colleagues on their new study showing that gut microbes & microbial metabolites can promote tau aggregation in a mouse model of tauopathy/Alzheimer’s disease. The work identifies microbiome changes linked to tau risk over time as potential therapeutic targets.
Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia - Nature Immunology
McGavern and colleagues identified a CD8+ T cell population that expresses GZMK in ʽtau-richʼ brains, where it may play a protective role against neurodegeneration.
www.nature.com
June 24, 2025 at 1:24 PM
Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de in STM @science.org! A human #iPSC-derived #Tauopathy model that endogenously develops late-stage Tau pathology. Free personal PDF: www.science.org/eprint/5H5YD....
Here's what we found👇 1/10
Here's what we found👇 1/10
April 10, 2026 at 6:15 AM
🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de in STM @science.org! A human #iPSC-derived #Tauopathy model that endogenously develops late-stage Tau pathology. Free personal PDF: www.science.org/eprint/5H5YD....
Here's what we found👇 1/10
Here's what we found👇 1/10
Check our latest publication! We show that #Lewy body co-pathology is frequent in #Alzheimer disease with important clinical implications.
Work led by Francisco Almeida
Collaboration between
#icvs_uminho
#IcahnMountSinai
#NACCData
doi.org/10.1002/alz....
(1/4)
Work led by Francisco Almeida
Collaboration between
#icvs_uminho
#IcahnMountSinai
#NACCData
doi.org/10.1002/alz....
(1/4)
Lewy body co‐pathology in Alzheimer's disease and primary age‐related tauopathy contributes to differential neuropathological, cognitive, and brain atrophy patterns
INTRODUCTION Alzheimer's disease (AD) co-pathology with Lewy bodies (LB) is frequent and influences clinical manifestations and outcomes. Its significance in primary age-related tauopathy (PART) is ...
doi.org
December 27, 2024 at 11:18 PM
Check our latest publication! We show that #Lewy body co-pathology is frequent in #Alzheimer disease with important clinical implications.
Work led by Francisco Almeida
Collaboration between
#icvs_uminho
#IcahnMountSinai
#NACCData
doi.org/10.1002/alz....
(1/4)
Work led by Francisco Almeida
Collaboration between
#icvs_uminho
#IcahnMountSinai
#NACCData
doi.org/10.1002/alz....
(1/4)
Therapeutic VEGFC treatment protects against traumatic brain injury-driven tauopathy pathogenesis @cp-cellreports.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
November 17, 2025 at 1:55 PM
Therapeutic VEGFC treatment protects against traumatic brain injury-driven tauopathy pathogenesis @cp-cellreports.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Molecular features of human pathological tau distinguish tauopathy-associated dementias www.cell.com/cell/fulltex...
January 29, 2026 at 3:41 PM
Molecular features of human pathological tau distinguish tauopathy-associated dementias www.cell.com/cell/fulltex...
The Genotoxic Stress Sensor ZBP1 Drives Tauopathy and Neurodegeneration
www.mdpi.com/2073-4409/15...
www.mdpi.com/2073-4409/15...
March 26, 2026 at 2:26 PM
The Genotoxic Stress Sensor ZBP1 Drives Tauopathy and Neurodegeneration
www.mdpi.com/2073-4409/15...
www.mdpi.com/2073-4409/15...
Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 24, 2025 at 1:30 PM
Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
June 24, 2025 at 6:04 PM
So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!
White matter degeneration precedes tau aggregation in rats with Alzheimer's-like tauopathy
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
White matter degeneration precedes tau aggregation in rats with Alzheimer's-like tauopathy
Tau pathology is increasingly recognized as a primary driver of white matter (WM) microstructural damage in tauopathies, particularly in Alzheimer's d…
www.sciencedirect.com
November 19, 2025 at 10:00 AM
White matter degeneration precedes tau aggregation in rats with Alzheimer's-like tauopathy
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
AD, PART and CTE share the same 3R/4R-tau+ NFTs, but in a different distribution … what about their proteomes? Excited to share our spatial proteomics study comparing #Alzheimers, #PART and #CTE hippocampi doi.org/10.1002/alz....
#neuropath #neuroscience #neurology #proteomics
#neuropath #neuroscience #neurology #proteomics
Spatial proteomic differences in chronic traumatic encephalopathy, Alzheimer's disease, and primary age‐related tauopathy hippocampi
INTRODUCTION Alzheimer's disease (AD), primary age-related tauopathy (PART), and chronic traumatic encephalopathy (CTE) all feature hyperphosphorylated tau (p-tau)–immunoreactive neurofibrillary deg...
doi.org
December 31, 2024 at 2:21 PM
AD, PART and CTE share the same 3R/4R-tau+ NFTs, but in a different distribution … what about their proteomes? Excited to share our spatial proteomics study comparing #Alzheimers, #PART and #CTE hippocampi doi.org/10.1002/alz....
#neuropath #neuroscience #neurology #proteomics
#neuropath #neuroscience #neurology #proteomics
The PsychAD cohort included diffuse Lewy body disease, vascular dementia, tauopathy, FTD, schizophrenia, & bipolar disorder. The study replicated findings that the H1 MAPT haplotype is associated with PD susceptibility, & observed that the H1H1 genotype increases PD risk
September 25, 2026 at 9:28 AM
The PsychAD cohort included diffuse Lewy body disease, vascular dementia, tauopathy, FTD, schizophrenia, & bipolar disorder. The study replicated findings that the H1 MAPT haplotype is associated with PD susceptibility, & observed that the H1H1 genotype increases PD risk
Study finding Xenon gas could protect against Alzheimer’s disease leads to start of clinical trial
"New research found Xenon gas inhalation reduced neurodegeneration and boosted protection in preclinical models of Alzheimer’s disease"
www.science.org/doi/10.1126/...
"New research found Xenon gas inhalation reduced neurodegeneration and boosted protection in preclinical models of Alzheimer’s disease"
www.science.org/doi/10.1126/...
Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy
Xenon inhalation modulates microglial responses in mice and is a potential therapeutic agent for treating Alzheimer’s disease.
www.science.org
January 22, 2025 at 4:12 AM
Study finding Xenon gas could protect against Alzheimer’s disease leads to start of clinical trial
"New research found Xenon gas inhalation reduced neurodegeneration and boosted protection in preclinical models of Alzheimer’s disease"
www.science.org/doi/10.1126/...
"New research found Xenon gas inhalation reduced neurodegeneration and boosted protection in preclinical models of Alzheimer’s disease"
www.science.org/doi/10.1126/...
Brain on standby — how torpor made ‘tauopathy’ reversible — a Journal Club article by Nina M. Rzechorzek
@dynamicbrain.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
@dynamicbrain.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
Brain on standby — how torpor made ‘tauopathy’ reversible - Nature Reviews Neuroscience
In this Journal Club, Nina Rzechorzek explores a 2003 article showing that, during hibernation, ground squirrels reversibly accumulate highly phosphorylated tau in the brain (a hallmark of Alzheimer’s...
www.nature.com
August 21, 2025 at 9:01 AM
Brain on standby — how torpor made ‘tauopathy’ reversible — a Journal Club article by Nina M. Rzechorzek
@dynamicbrain.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
@dynamicbrain.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
We combined 3R/4R #Tau expression with two synergistic Tauopathy mutations, P301L and S320F, that promote both nucleation and elongation of Tau fibrils. Neither 4R expression nor the mutations alone induced pathology. Only the combination triggered robust #Tauopathy. 4/10
April 10, 2026 at 6:15 AM
We combined 3R/4R #Tau expression with two synergistic Tauopathy mutations, P301L and S320F, that promote both nucleation and elongation of Tau fibrils. Neither 4R expression nor the mutations alone induced pathology. Only the combination triggered robust #Tauopathy. 4/10
Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis in a mouse model www.sciencedirect.com/science/arti...
Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis
Traumatic brain injury (TBI) increases one’s risk of developing Alzheimer’s disease and tauopathy. Yet, the mechanisms linking TBI to neurodegenerativ…
www.sciencedirect.com
November 10, 2025 at 9:40 AM
Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis in a mouse model www.sciencedirect.com/science/arti...
Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice www.nature.com/articles/s41...
Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice - Nature Neuroscience
In PS19 mice, microglia-derived glycoprotein nonmetastatic melanoma protein B promotes mitochondrial extracellular vesicle secretion, enabling mitochondrial transfer to astrocytes. This improves astro...
www.nature.com
May 27, 2026 at 8:47 AM
Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice www.nature.com/articles/s41...
Top #Altmetric 2025: 7️⃣🧪
@pkapahi.bsky.social et al ( @buckinstitute.org ) show that neuronal glycogen feeds the PPP and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.
@pkapahi.bsky.social et al ( @buckinstitute.org ) show that neuronal glycogen feeds the PPP and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.
Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction - Nature Metabolism
Bar et al. show that neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.
bit.ly
December 11, 2025 at 6:31 PM
Top #Altmetric 2025: 7️⃣🧪
@pkapahi.bsky.social et al ( @buckinstitute.org ) show that neuronal glycogen feeds the PPP and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.
@pkapahi.bsky.social et al ( @buckinstitute.org ) show that neuronal glycogen feeds the PPP and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.
Count down: The 5 top accessed research manuscripts of 2024!
#5: KIBRA in tauopathy-related memory loss
https://www.jci.org/articles/view/169064
#5: KIBRA in tauopathy-related memory loss
https://www.jci.org/articles/view/169064
December 27, 2024 at 7:20 PM
Count down: The 5 top accessed research manuscripts of 2024!
#5: KIBRA in tauopathy-related memory loss
https://www.jci.org/articles/view/169064
#5: KIBRA in tauopathy-related memory loss
https://www.jci.org/articles/view/169064
One of the pathological hallmarks of Alzheimer's disease is tauopathy – accumulation of tangles of tau protein, seen here in light blue. www.iflscience.com/new-blood-te...
May 27, 2026 at 9:30 PM
One of the pathological hallmarks of Alzheimer's disease is tauopathy – accumulation of tangles of tau protein, seen here in light blue. www.iflscience.com/new-blood-te...
New Epigenome Technologies Blog!!! u.epigenome.us/S3HTCftT
"Single-Cell Chromatin and Transcriptomic Analyses of Tauopathy-affected Brains Reveal How Glial Cells Contribute"
#Epigenetics #Blog #Chromatin #SingleCell #Tau #Tauopathy #Glia #ChromatinAccessibility
"Single-Cell Chromatin and Transcriptomic Analyses of Tauopathy-affected Brains Reveal How Glial Cells Contribute"
#Epigenetics #Blog #Chromatin #SingleCell #Tau #Tauopathy #Glia #ChromatinAccessibility
August 17, 2026 at 7:25 PM
New Epigenome Technologies Blog!!! u.epigenome.us/S3HTCftT
"Single-Cell Chromatin and Transcriptomic Analyses of Tauopathy-affected Brains Reveal How Glial Cells Contribute"
#Epigenetics #Blog #Chromatin #SingleCell #Tau #Tauopathy #Glia #ChromatinAccessibility
"Single-Cell Chromatin and Transcriptomic Analyses of Tauopathy-affected Brains Reveal How Glial Cells Contribute"
#Epigenetics #Blog #Chromatin #SingleCell #Tau #Tauopathy #Glia #ChromatinAccessibility
p75 neurotrophin receptor signaling through the RhoA/ROCK pathway contributes to Alzheimers Disease tauopathy https://www.biorxiv.org/content/10.64898/2026.02.22.707328v1
February 24, 2026 at 5:15 AM
p75 neurotrophin receptor signaling through the RhoA/ROCK pathway contributes to Alzheimers Disease tauopathy https://www.biorxiv.org/content/10.64898/2026.02.22.707328v1