@bioxcell.bsky.social's resource, RRID:AB_2687730, was just reported to be used in the paper. We value the author's support of reproducibility. #RRID #OpenScience #BetterScience
Peripheral CXCR3 blockade mitigates T cell infiltration and neurodegeneration in a mouse model of tauopathy
Read the full paper: Peripheral CXCR3 blockade mitigates T cell infiltration and neurodegeneration in a mouse model of tauopathy
doi.org
October 2, 2026 at 7:01 AM
@bioxcell.bsky.social's resource, RRID:AB_2687730, was just reported to be used in the paper. We value the author's support of reproducibility. #RRID #OpenScience #BetterScience
RRIDs were included in this in Aging Cell paper. We value the author's support of reproducibility. #OpenScience #BetterScience #ReproducibleResearch
Loss of SMARCAD1 Mitigates Tauopathy
Read the full paper: Loss of SMARCAD1 Mitigates Tauopathy
doi.org
October 1, 2026 at 7:03 AM
RRIDs were included in this in Aging Cell paper. We value the author's support of reproducibility. #OpenScience #BetterScience #ReproducibleResearch
Tau-induced increase in promoter-proximal RNA polymerase II pausing is linked to suppressed expression of long neuronal genes in a Drosophila tauopathy model
#Drosophila
#Drosophila
Tau-induced increase in promoter-proximal RNA polymerase II pausing is linked to suppressed expression of long neuronal genes in a Drosophila tauopathy model
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
September 29, 2026 at 5:23 PM
Tau-induced increase in promoter-proximal RNA polymerase II pausing is linked to suppressed expression of long neuronal genes in a Drosophila tauopathy model
#Drosophila
#Drosophila
Researchers Joshua Emmerson, Hao Hu, Vivek Savani, David Holtzman, et al. @washumedicine.bsky.social have dvlpd a potential antibody-based approach to reducing #Neurodegeneration in diseases known as tauopathies, including #Alzheimers. Learn More in Neuron | Cell Press 👉 www.cell.com/neuron/fullt...
Peripheral CXCR3 blockade mitigates T cell infiltration and neurodegeneration in a mouse model of tauopathy
Emmerson et al. demonstrate that the CXCR3-CXCL10 chemokine signaling pathway is important
for brain-infiltrating T cells in tau-mediated neurodegeneration. Blocking CXCR3 reduces
T cell entry and pro...
www.cell.com
September 29, 2026 at 12:51 PM
Researchers Joshua Emmerson, Hao Hu, Vivek Savani, David Holtzman, et al. @washumedicine.bsky.social have dvlpd a potential antibody-based approach to reducing #Neurodegeneration in diseases known as tauopathies, including #Alzheimers. Learn More in Neuron | Cell Press 👉 www.cell.com/neuron/fullt...
🐭 Tauopathy may involve more than tau. In mice, blocking CXCR3 reduced brain-infiltrating T cells, neurodegeneration and some memory deficits—without lowering bulk tau. Intriguing immune-targeting result, but still preclinical. www.cell.com/neuron/fullt... #Neuroscience #neuroskyence #photography
Peripheral CXCR3 blockade mitigates T cell infiltration and neurodegeneration in a mouse model of tauopathy
Emmerson et al. demonstrate that the CXCR3-CXCL10 chemokine signaling pathway is important
for brain-infiltrating T cells in tau-mediated neurodegeneration. Blocking CXCR3 reduces
T cell entry and pro...
www.cell.com
September 29, 2026 at 1:46 AM
🐭 Tauopathy may involve more than tau. In mice, blocking CXCR3 reduced brain-infiltrating T cells, neurodegeneration and some memory deficits—without lowering bulk tau. Intriguing immune-targeting result, but still preclinical. www.cell.com/neuron/fullt... #Neuroscience #neuroskyence #photography
Up to $1m for AI-enabled research into primary tauopathies. The Rainwater Tau Consortium's new Learning Research Network is open to engineers, data scientists and labs worldwide. LOIs close 30 Oct.
www.dementiaresearcher.nihr.ac.uk/funding/rain...
www.dementiaresearcher.nihr.ac.uk/funding/rain...
Rainwater Learning Research Network: AI Tauopathy Funding
Up to $1m for AI-enabled primary tauopathy research from the Rainwater Tau Consortium's new Learning Research Network. Letters of intent close 30 October 2026.
www.dementiaresearcher.nihr.ac.uk
September 28, 2026 at 5:49 PM
Up to $1m for AI-enabled research into primary tauopathies. The Rainwater Tau Consortium's new Learning Research Network is open to engineers, data scientists and labs worldwide. LOIs close 30 Oct.
www.dementiaresearcher.nihr.ac.uk/funding/rain...
www.dementiaresearcher.nihr.ac.uk/funding/rain...
Peripheral CXCR3 blockade mitigates T cell infiltration and neurodegeneration in a mouse model of tauopathy #NeuroDegeneration 🧪🧠
https://www.cell.com/neuron/fulltext/S0896-6273(26)00681-1?rss=yes
https://www.cell.com/neuron/fulltext/S0896-6273(26)00681-1?rss=yes
September 28, 2026 at 4:03 PM
Peripheral CXCR3 blockade mitigates T cell infiltration and neurodegeneration in a mouse model of tauopathy #NeuroDegeneration 🧪🧠
https://www.cell.com/neuron/fulltext/S0896-6273(26)00681-1?rss=yes
https://www.cell.com/neuron/fulltext/S0896-6273(26)00681-1?rss=yes
Washington University in St. Louis researchers found that blocking CXCR3 in tauopathy mice cut brain T-cell infiltration ~50% and reduced brain atrophy ~40%, without lowering tau.
Immune cell trafficking itself helped drive neurodegeneration.
www.cell.com/neuron/fullt...
Immune cell trafficking itself helped drive neurodegeneration.
www.cell.com/neuron/fullt...
Peripheral CXCR3 blockade mitigates T cell infiltration and neurodegeneration in a mouse model of tauopathy
Emmerson et al. demonstrate that the CXCR3-CXCL10 chemokine signaling pathway is important
for brain-infiltrating T cells in tau-mediated neurodegeneration. Blocking CXCR3 reduces
T cell entry and pro...
www.cell.com
September 28, 2026 at 3:47 PM
Washington University in St. Louis researchers found that blocking CXCR3 in tauopathy mice cut brain T-cell infiltration ~50% and reduced brain atrophy ~40%, without lowering tau.
Immune cell trafficking itself helped drive neurodegeneration.
www.cell.com/neuron/fullt...
Immune cell trafficking itself helped drive neurodegeneration.
www.cell.com/neuron/fullt...
Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5 #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
September 28, 2026 at 7:01 AM
Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5 #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5 https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
September 28, 2026 at 4:15 AM
Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5 https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5 https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
September 28, 2026 at 4:15 AM
Seizures and tauopathy following neurotrauma are mediated by prion protein and metabotropic glutamate receptor 5 https://www.biorxiv.org/content/10.64898/2026.09.21.753012v1
The PsychAD cohort included diffuse Lewy body disease, vascular dementia, tauopathy, FTD, schizophrenia, & bipolar disorder. The study replicated findings that the H1 MAPT haplotype is associated with PD susceptibility, & observed that the H1H1 genotype increases PD risk
September 25, 2026 at 9:28 AM
The PsychAD cohort included diffuse Lewy body disease, vascular dementia, tauopathy, FTD, schizophrenia, & bipolar disorder. The study replicated findings that the H1 MAPT haplotype is associated with PD susceptibility, & observed that the H1H1 genotype increases PD risk
As part of our inaugural review series!
Targeting protein aggregate co-pathologies in #neurodegeneration: a viable therapeutic strategy?
Silas A. Buck, Sidharth S. Madhavan, Laurie H. Sanders
@dukemedschool.bsky.social #TDP43 #tauopathy #amyloid #alphasynuclein
link.springer.com/article/10.1...
Targeting protein aggregate co-pathologies in #neurodegeneration: a viable therapeutic strategy?
Silas A. Buck, Sidharth S. Madhavan, Laurie H. Sanders
@dukemedschool.bsky.social #TDP43 #tauopathy #amyloid #alphasynuclein
link.springer.com/article/10.1...
Targeting protein aggregate co-pathologies in neurodegeneration: a viable therapeutic strategy? - Molecular Neurodegeneration Advances
Many neurodegenerative diseases are characterized by pathological protein aggregation in the brain. Alzheimer’s disease displays amyloid-β and tau inclusions in the form of amyloid-β plaques and tau n...
link.springer.com
September 23, 2026 at 3:46 PM
As part of our inaugural review series!
Targeting protein aggregate co-pathologies in #neurodegeneration: a viable therapeutic strategy?
Silas A. Buck, Sidharth S. Madhavan, Laurie H. Sanders
@dukemedschool.bsky.social #TDP43 #tauopathy #amyloid #alphasynuclein
link.springer.com/article/10.1...
Targeting protein aggregate co-pathologies in #neurodegeneration: a viable therapeutic strategy?
Silas A. Buck, Sidharth S. Madhavan, Laurie H. Sanders
@dukemedschool.bsky.social #TDP43 #tauopathy #amyloid #alphasynuclein
link.springer.com/article/10.1...
Correction to “Emerging Trends and Hot Spots in Tauopathy Research (2003–2025): A Bibliometric Analysis” Br&Beh
Correction to “Emerging Trends and Hot Spots in Tauopathy Research (2003–2025): A Bibliometric Analysis”
Brain and Behavior, Volume 16, Issue 9, September 2026.
dlvr.it
September 23, 2026 at 10:03 AM
Correction to “Emerging Trends and Hot Spots in Tauopathy Research (2003–2025): A Bibliometric Analysis” Br&Beh
Polymorph-Independent Resistance to Generative Protein Design Across Five Tau Fibril Folds: A Cross-Tauopathy Benchmark #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-11108822/latest
https://www.researchsquare.com/article/rs-11108822/latest
September 22, 2026 at 10:02 AM
Polymorph-Independent Resistance to Generative Protein Design Across Five Tau Fibril Folds: A Cross-Tauopathy Benchmark #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-11108822/latest
https://www.researchsquare.com/article/rs-11108822/latest
Region-dependent regulatioin of Tau phosphorylation in a mouse model of tauopathy #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.14.751492v1
https://www.biorxiv.org/content/10.64898/2026.09.14.751492v1
September 21, 2026 at 10:01 PM
Region-dependent regulatioin of Tau phosphorylation in a mouse model of tauopathy #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.14.751492v1
https://www.biorxiv.org/content/10.64898/2026.09.14.751492v1
Region-dependent regulatioin of Tau phosphorylation in a mouse model of tauopathy https://www.biorxiv.org/content/10.64898/2026.09.14.751492v1
September 21, 2026 at 7:25 PM
Region-dependent regulatioin of Tau phosphorylation in a mouse model of tauopathy https://www.biorxiv.org/content/10.64898/2026.09.14.751492v1
Region-dependent regulatioin of Tau phosphorylation in a mouse model of tauopathy https://www.biorxiv.org/content/10.64898/2026.09.14.751492v1
September 21, 2026 at 7:25 PM
Region-dependent regulatioin of Tau phosphorylation in a mouse model of tauopathy https://www.biorxiv.org/content/10.64898/2026.09.14.751492v1
Author Correction: Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model #NeuroDegeneration 🧪🧠
https://www.nature.com/articles/s41467-026-77856-8
https://www.nature.com/articles/s41467-026-77856-8
September 21, 2026 at 1:03 PM
Author Correction: Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model #NeuroDegeneration 🧪🧠
https://www.nature.com/articles/s41467-026-77856-8
https://www.nature.com/articles/s41467-026-77856-8
Check out rPeptide's FITC-labeled Tau-441 used in this study to track microglial Tau uptake, alongside our full Tau product line. 🧠
t.ly/pRT22
#Recombinant #Proteins #Peptides #rPeptide #Tauopathy
t.ly/pRT22
#Recombinant #Proteins #Peptides #rPeptide #Tauopathy
FITC Tau-441
Recombinant FITC Tau-441 from rPeptide. High quality, >90% purity, batch to batch consistency. In stock and ready to ship - order online today.
t.ly
September 18, 2026 at 4:42 PM
Check out rPeptide's FITC-labeled Tau-441 used in this study to track microglial Tau uptake, alongside our full Tau product line. 🧠
t.ly/pRT22
#Recombinant #Proteins #Peptides #rPeptide #Tauopathy
t.ly/pRT22
#Recombinant #Proteins #Peptides #rPeptide #Tauopathy
Could circadian clock disruption drive sex-specific Tau pathology?
Research shows microglial REV-ERBα deletion impairs Tau clearance and worsens tauopathy only in males, using rPeptide's FITC-labeled Tau-441. 🧠
t.ly/NWOV5
#Neuroscience #Tauopathy #AlzheimersResearch
Research shows microglial REV-ERBα deletion impairs Tau clearance and worsens tauopathy only in males, using rPeptide's FITC-labeled Tau-441. 🧠
t.ly/NWOV5
#Neuroscience #Tauopathy #AlzheimersResearch
Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice - Nature Communications
The circadian clock protein REV-ERBα has been implicated in neuroinflammation but mechanisms are poorly understood. Here, the authors show that microglial REV-ERBα regulates inflammatory signaling and...
t.ly
September 18, 2026 at 4:42 PM
Could circadian clock disruption drive sex-specific Tau pathology?
Research shows microglial REV-ERBα deletion impairs Tau clearance and worsens tauopathy only in males, using rPeptide's FITC-labeled Tau-441. 🧠
t.ly/NWOV5
#Neuroscience #Tauopathy #AlzheimersResearch
Research shows microglial REV-ERBα deletion impairs Tau clearance and worsens tauopathy only in males, using rPeptide's FITC-labeled Tau-441. 🧠
t.ly/NWOV5
#Neuroscience #Tauopathy #AlzheimersResearch
🧠🔊 What if our bodies could send an early signal of Alzheimer’s disease? New research by Xiangmin Xu at the UC Irvine Center for Neural Circuit Mapping, found early auditory brainstem dysfunction in mouse models of tauopathy — before detectable behavioral changes.
🔬 Learn more: bit.ly/4rhpl9X
🔬 Learn more: bit.ly/4rhpl9X
September 17, 2026 at 7:01 PM
🧠🔊 What if our bodies could send an early signal of Alzheimer’s disease? New research by Xiangmin Xu at the UC Irvine Center for Neural Circuit Mapping, found early auditory brainstem dysfunction in mouse models of tauopathy — before detectable behavioral changes.
🔬 Learn more: bit.ly/4rhpl9X
🔬 Learn more: bit.ly/4rhpl9X
🧠🔊 Could auditory-circuit changes provide an early signal of Alzheimer’s disease?
New research featuring CNCM Director Dr. Xiangmin Xu found early auditory brainstem dysfunction in mouse models of tauopathy—before detectable behavioral changes.
🔬 Learn more: medschool.uci.edu/news/auditor...
New research featuring CNCM Director Dr. Xiangmin Xu found early auditory brainstem dysfunction in mouse models of tauopathy—before detectable behavioral changes.
🔬 Learn more: medschool.uci.edu/news/auditor...
September 16, 2026 at 6:22 PM
🧠🔊 Could auditory-circuit changes provide an early signal of Alzheimer’s disease?
New research featuring CNCM Director Dr. Xiangmin Xu found early auditory brainstem dysfunction in mouse models of tauopathy—before detectable behavioral changes.
🔬 Learn more: medschool.uci.edu/news/auditor...
New research featuring CNCM Director Dr. Xiangmin Xu found early auditory brainstem dysfunction in mouse models of tauopathy—before detectable behavioral changes.
🔬 Learn more: medschool.uci.edu/news/auditor...