#alphasynuclein
KAUST and Oxford researchers used a transistor-based sensor to read three forms of alpha-synuclein, reaching 90.9% accuracy in a small study.

Link as first comment.

#longevity #geroscience #KAUST #Oxford #alphasynuclein
October 22, 2026 at 10:18 AM
Our new publication about how something as ordinary as freezing and thawing can change how alpha-synuclein aggregates and undergoes liquid–liquid phase separation.

doi.org/10.1016/j.ij...

#LLPS #alphasynuclein #VU #aggregation
October 22, 2026 at 2:12 PM
Researchers have demonstrated that synthetic peptides can inhibit toxic #AlphaSynuclein fibrils & reduce #OxidativeStress. These dual-function peptides offer a promising therapeutic strategy for #Parkinson’s disease.

Read about the study on the blog 🛋️ https://bit.ly/4kUuik0
Alpha Synuclein Inhibition Using Biomimetic Peptides
Dual-function biomimetic peptides inhibited fibrillization & aggregation of alpha synuclein and exhibited antioxidant properties in a Parkinson's disease model.
bit.ly
October 21, 2026 at 11:30 PM
Product Citation: Scientists at the NIA employed StressMarq's #AlphaSynuclein Oligomers, PFFs & Monomers to demonstrate that structurally distinct αSyn polymorphs exhibit varying #neurotoxic effects.

Paper 🔎 https://bit.ly/455xNPX | Alpha Synuclein 🌿 https://bit.ly/48w0J27
October 16, 2026 at 11:17 PM
Could brain amyloids worsen HIV in the CNS?

Research shows ASyn fibrils dramatically boost HIV-1 entry in T cells, macrophages, and microglia, with a bidirectional interplay confirmed. Study conducted using rPeptide's Alpha-Synuclein. 🧠

t.ly/t5fiq

#Neuroscience #AlphaSynuclein #Neurodegeneration
α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia - Nature Communications
Here, Olari et al show that alpha-synuclein enhances HIV-1 entry and replication in human T cells, macrophages and microglia which may contribute to the development of neurodegenerative disease.
t.ly
October 16, 2026 at 8:25 PM
The recombinant Alpha-Synuclein used to generate fibrils in this study is available from rPeptide!

Our ASyn product line includes native and mutant sequences, labeled options, fragments, and preformed fibrils to support a wide range of studies. 🔬

t.ly/ekWJY

#Recombinant #rPeptide #AlphaSynuclein
Alpha-Synuclein
High quality recombinant Alpha-Synuclein, >95% purity. Highly monomeric, batch to batch consistency. Order online today - R&D starts at rPeptide.
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October 16, 2026 at 8:28 PM
A good α-syn antibody pair on recombinant protein may behave differently in biological samples.

P2P2P™ tests candidate pairs beyond standard protein, including in complex samples.

8 α-syn pairs are now available, validated across both.

#AlphaSynuclein #ParkinsonsDisease
October 15, 2026 at 9:25 AM
Product Citation: Histopathological analyses revealed extensive pSer129-αSyn+ neuritic inclusions in a mouse model of #Parkinson's disease, post-injection with StressMarq's Mouse #AlphaSynuclein PFFs.

Paper 💻 https://bit.ly/4f439dh
Product details 🐭 https://bit.ly/2HJyYee
October 12, 2026 at 3:18 PM
🧠 Major breakthrough: Yale scientists identified two neuron surface proteins that control how the toxic protein alpha-synuclein spreads i…

#Alphasynuclein #Neurodegenerativedisease #Neuroinflammation #Parkinsonsdisease #Yaleneuroscience

#Alphasynuclein #Neurodegenerativedisease #Neuroinflammati…
Yale finds how Parkinson's spreads in brain
🧠 Major breakthrough: Yale scientists identified two neuron surface proteins that control how the toxic protein alpha-synuclein spreads i… #Alphasynuclein #Neurodegenerativedisease #Neuroinflammation #Parkinsonsdisease #Yaleneuroscience
news.gmj.ge
October 3, 2026 at 1:26 PM
TGen researchers at City of Hope have uncovered a protein cascade mechanism where amyloid-beta plaques trigger tau and alpha-synuclein accumulatio…

#Alphasynuclein #Alzheimers #Amyloidbeta #Mixedpathology #Neurodegeneration

#Alphasynuclein #Alzheimers #Amyloidbeta #Mixedpathology #Neurodegenera…
How Amyloid Plaques Trigger Multiple Protein Pathologies
TGen researchers at City of Hope have uncovered a protein cascade mechanism where amyloid-beta plaques trigger tau and alpha-synuclein accumulatio… #Alphasynuclein #Alzheimers #Amyloidbeta #Mixedpathology #Neurodegeneration
news.gmj.ge
September 30, 2026 at 11:26 AM
Could naturally occurring antibodies hold the key to treating Parkinson's Disease?

Research shows autoantibodies targeting Alpha-Synuclein's NAC region can block toxic aggregation, studied using rPeptide's ASyn and defined fragments. 🧠

t.ly/rM9w3

#Neuroscience #ParkinsonsResearch #AlphaSynuclein
Autoantibodies against α-synuclein inhibit its aggregation and cytotoxicity
Aggregates of α-synuclein (α-Syn) are the major component of the Lewy bodies associated with Parkinson's disease. Recently, naturally occurring autoan…
t.ly
September 30, 2026 at 3:32 PM
The Alpha-Synuclein used in this study is available from rPeptide!

Our Synuclein product line includes native and mutant sequences, labeled options, fragments, and preformed fibrils to support a wide range of studies. 🔬

t.ly/Kl17L

#Recombinant #AlphaSynuclein #ParkinsonsResearch #rPeptide
Synuclein Archives
Buy Recombinant Synuclein Proteins – Alpha, Beta, Gamma, Biotin, FITC, Rabbit, Mouse, N15, Mutant, and more for neurodegenerative research.
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September 30, 2026 at 3:37 PM
As part of our inaugural review series!

Targeting protein aggregate co-pathologies in #neurodegeneration: a viable therapeutic strategy?

Silas A. Buck, Sidharth S. Madhavan, Laurie H. Sanders
@dukemedschool.bsky.social #TDP43 #tauopathy #amyloid #alphasynuclein

link.springer.com/article/10.1...
Targeting protein aggregate co-pathologies in neurodegeneration: a viable therapeutic strategy? - Molecular Neurodegeneration Advances
Many neurodegenerative diseases are characterized by pathological protein aggregation in the brain. Alzheimer’s disease displays amyloid-β and tau inclusions in the form of amyloid-β plaques and tau n...
link.springer.com
September 23, 2026 at 3:46 PM
Breakthrough at Baylor: tubulin can redirect toxic brain proteins away from harmful clumps in Alzheimer's an…

#Alphasynuclein #Alzheimersdisease #BaylorCollegeofMedicine #Neurodegenerativedisease #Neurologicalresearch

#Alphasynuclein #Alzheimersdisease #BaylorCollegeofMedicine #Neurodegenerativ…
Tubulin stops toxic protein clumps in Alzheimer's, Parkinson's
Breakthrough at Baylor: tubulin can redirect toxic brain proteins away from harmful clumps in Alzheimer's an… #Alphasynuclein #Alzheimersdisease #BaylorCollegeofMedicine #Neurodegenerativedisease #Neurologicalresearch
news.gmj.ge
September 21, 2026 at 9:27 AM
Spreading #alphasynuclein #oligomers trigger #astrocyte/ #microglial changes and astrocyte-glutamatergic neuron system dysfunction in an age-related manner

Jaehyun LeeBae, Verena Bopp, Alicia Goreth...Karin M. Danzer #Parkinsons

link.springer.com/article/10.1...
Spreading alpha-synuclein oligomers trigger astrocyte/microglial changes and astrocyte-glutamatergic neuron system dysfunction in an age-related manner - Molecular Neurodegeneration Advances
Background Parkinson’s disease (PD) is characterized by the progressive accumulation and spatio-temporal spread of α-synuclein (α-syn) oligomers and a progressive loss of dopaminergic neurons. Many st...
link.springer.com
September 15, 2026 at 9:40 PM
Michel Goedert and myself are looking for two postdocs to work on #cryoEM and #masspec of #alphasynuclein filaments from neurodegenerative disease. Come join our bubbly and friendly team at the @mrclmb.ac.uk in lovely Cambridge, UK.

www.nature.com/naturecareer...
Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12864505
Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M...
www.nature.com
September 15, 2026 at 7:39 AM
Breakthrough at Baylor: tubulin can redirect toxic brain proteins away from harmful clumps in Alzheimer's an…

#Alphasynuclein #Alzheimersdisease #BaylorCollegeofMedicine #Neurodegenerativedisease #Neurologicalresearch

#Alphasynuclein #Alzheimersdisease #BaylorCollegeofMedicine #Neurodegenerativ…
Tubulin stops toxic protein clumps in Alzheimer's, Parkinson's
Breakthrough at Baylor: tubulin can redirect toxic brain proteins away from harmful clumps in Alzheimer's an… #Alphasynuclein #Alzheimersdisease #BaylorCollegeofMedicine #Neurodegenerativedisease #Neurologicalresearch
news.gmj.ge
September 10, 2026 at 12:42 PM
What if you could clear Alpha-Synuclein aggregates and restore dopamine neurons wirelessly?

This Science Advances research does exactly that using a photothermal nanosystem, studied using rPeptide's Alpha-Synuclein (S-1001). 🧠

t.ly/stiVv

#Neuroscience #ParkinsonsResearch #AlphaSynuclein
A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson’s disease
Nanoparticle-mediated wireless system reverses Parkinson’s disease.
t.ly
September 2, 2026 at 4:06 PM
Product Citation: IHM nanoparticles reprogram diseased microglia to degrade αSyn & reduce #neuroinflammation in #Parkinson's disease. StressMarq's Mouse #AlphaSynuclein PFFs were used to model immune crosstalk.

Paper 🌱 https://bit.ly/3HIG1nU
Product 🍃 https://bit.ly/2HJyYee
September 2, 2026 at 4:58 PM
Check out rPeptide's Alpha-Synuclein (S-1001) and our ready-to-use preformed fibrils, used to support research like this study. 🧠

t.ly/I_T_3

#Recombinant #Proteins #Peptides #rPeptide #AlphaSynuclein
Alpha-Synuclein
High quality recombinant Alpha-Synuclein, >95% purity. Highly monomeric, batch to batch consistency. Order online today - R&D starts at rPeptide.
t.ly
September 2, 2026 at 4:08 PM
Using StressMarq's #BetaSynuclein, #GammaSynuclein & #AmyloidBeta 1-42 PFFs, scientists developed a quiescent seed amplification assay (QSAA) to detect #AlphaSynuclein aggregates in #cerebrospinal fluid & #skin samples.

Read about it on the blog! https://bit.ly/43QvnTN
Optimizing Alpha Synuclein Seed Amplification Assays
Seed amplification assays detect abnormal forms of alpha synuclein. An improved quiescent SAA method streamlines this process and maintains tissue integrity.
bit.ly
September 1, 2026 at 11:09 PM
Product Citation ⏰

Nitrated #AlphaSynuclein may be a key driver of #PD pathology. A nitration-selective antibody reduced #αSyn spreading & aggregation in Parkinson's disease models seeded with StressMarq's αSyn PFFs & Monomers.

Paper 🔖 https://bit.ly/4c7JKYw
αSyn 📭 https://bit.ly/2u9YHV2
August 27, 2026 at 8:41 PM
Product Citation 🌿 #AlphaSynuclein pathology differentially impacts #dopaminergic neuron subtypes in rodent models of Parkinson's disease seeded with StressMarq's αSyn PFFs & Monomers (SPR-322 & SPR-321).

Paper 📫 https://bit.ly/4w6reH9
αSyn 🔖 https://bit.ly/3KcMdGq
##PD #neurodegeneration
August 15, 2026 at 2:00 AM
Check out rPeptide's Alpha-Synuclein (S-1001), used to generate the fibrils featured in this study, along with our full line of preformed fibrils for your research needs. 🧠

t.ly/5WmNP

#Recombinant #Proteins #Peptides #rPeptide #AlphaSynuclein
Alpha-Synuclein
High quality recombinant Alpha-Synuclein, >95% purity. Highly monomeric, batch to batch consistency. Order online today - R&D starts at rPeptide.
t.ly
August 14, 2026 at 3:19 PM