De novo designed oligomers that respond to copper, small molecules, and phosphorylation...
Using a single design strategy? 🧬⚙️
🎉
Excited to share our new bioRxiv preprint—a collaboration between the Khmelinskaia, Correia, Schoeder and a Tinnefeld labs!
www.biorxiv.org/content/10.6...
Using a single design strategy? 🧬⚙️
🎉
Excited to share our new bioRxiv preprint—a collaboration between the Khmelinskaia, Correia, Schoeder and a Tinnefeld labs!
www.biorxiv.org/content/10.6...
A generalizable interface-seeded framework for de novo design of functional oligomers
Protein oligomers are ubiquitous in biological systems and essential for function. However, the de novo design of oligomers that controllably assemble in response to exogenous stimuli remains challeng...
www.biorxiv.org
July 5, 2026 at 6:30 AM
De novo designed oligomers that respond to copper, small molecules, and phosphorylation...
Using a single design strategy? 🧬⚙️
🎉
Excited to share our new bioRxiv preprint—a collaboration between the Khmelinskaia, Correia, Schoeder and a Tinnefeld labs!
www.biorxiv.org/content/10.6...
Using a single design strategy? 🧬⚙️
🎉
Excited to share our new bioRxiv preprint—a collaboration between the Khmelinskaia, Correia, Schoeder and a Tinnefeld labs!
www.biorxiv.org/content/10.6...
Amazing findings in geometry-based immune activation! Two bacterial defence systems detect phage-encoded ring oligomers, assemble high-order molecular complexes, and trigger abortive infection.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 4, 2026 at 6:25 PM
Amazing findings in geometry-based immune activation! Two bacterial defence systems detect phage-encoded ring oligomers, assemble high-order molecular complexes, and trigger abortive infection.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nature research paper: Programmable antisense oligomers for phage functional genomics
go.nature.com/46b1XAQ
go.nature.com/46b1XAQ
Programmable antisense oligomers for phage functional genomics - Nature
Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagation of the nucleus-forming jumbo phage ΦKZ such as the RNase H-like protein ΦKZ155.
go.nature.com
September 12, 2025 at 8:14 AM
Nature research paper: Programmable antisense oligomers for phage functional genomics
go.nature.com/46b1XAQ
go.nature.com/46b1XAQ
No Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social
@uni-wuerzburg.de @helmholtzhzi.bsky.social
published now in @nature.com
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social
@uni-wuerzburg.de @helmholtzhzi.bsky.social
published now in @nature.com
Programmable antisense oligomers for phage functional genomics - Nature
Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagatio...
www.nature.com
September 11, 2025 at 9:10 AM
No Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social
@uni-wuerzburg.de @helmholtzhzi.bsky.social
published now in @nature.com
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social
@uni-wuerzburg.de @helmholtzhzi.bsky.social
published now in @nature.com
Happy to see the first paper from the lab published in the EMBO J today: link.springer.com/article/10.1...
In it, we reconstitute self-assembling cooperative oligomers of human Ndc80 and Ska kinetochore complexes that stabilise microtubule ends, and study these samples using cryoET and TIRF
In it, we reconstitute self-assembling cooperative oligomers of human Ndc80 and Ska kinetochore complexes that stabilise microtubule ends, and study these samples using cryoET and TIRF
Microtubule end stabilisation by cooperative oligomers of Ska and Ndc80 complexes - The EMBO Journal
During mitosis, properly aligned chromosomes stabilise microtubule ends with the help of kinetochores to ensure timely segregation of chromosomes. Microtubule-binding components of the human outer kin...
link.springer.com
March 20, 2026 at 7:18 PM
Happy to see the first paper from the lab published in the EMBO J today: link.springer.com/article/10.1...
In it, we reconstitute self-assembling cooperative oligomers of human Ndc80 and Ska kinetochore complexes that stabilise microtubule ends, and study these samples using cryoET and TIRF
In it, we reconstitute self-assembling cooperative oligomers of human Ndc80 and Ska kinetochore complexes that stabilise microtubule ends, and study these samples using cryoET and TIRF
ʙɪɴᴅᴄʀᴀꜰᴛ2 now designs almost any binder format:
• mini & large binders
• linear & cyclic peptides
• VHHs, scFvs & Fabs
• ankyrin repeat proteins (ARPs)
• homo-oligomers & multidomain binders
• induced-fit & fold-switch binders
• mini & large binders
• linear & cyclic peptides
• VHHs, scFvs & Fabs
• ankyrin repeat proteins (ARPs)
• homo-oligomers & multidomain binders
• induced-fit & fold-switch binders
September 21, 2026 at 9:55 AM
ʙɪɴᴅᴄʀᴀꜰᴛ2 now designs almost any binder format:
• mini & large binders
• linear & cyclic peptides
• VHHs, scFvs & Fabs
• ankyrin repeat proteins (ARPs)
• homo-oligomers & multidomain binders
• induced-fit & fold-switch binders
• mini & large binders
• linear & cyclic peptides
• VHHs, scFvs & Fabs
• ankyrin repeat proteins (ARPs)
• homo-oligomers & multidomain binders
• induced-fit & fold-switch binders
Amazing work by the Santiago lab @unil.bsky.social. The malectin-LRR receptor kinase IGP1 senses cello-oligomers to alert the plant immune system & enhance disease resistance. Very nice discovery & mechanism.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 30, 2025 at 2:18 PM
Amazing work by the Santiago lab @unil.bsky.social. The malectin-LRR receptor kinase IGP1 senses cello-oligomers to alert the plant immune system & enhance disease resistance. Very nice discovery & mechanism.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Thrilled to share our latest preprint from @yiechanglin.bsky.social & @ciarawallis.bsky.social showing that AF2-Multimer and AF3 can quickly & accurately predict the oligomeric states & structures of proteins (& maybe can identify multiple biologically relevant oligomeric states 👀)
tiny.cc/oligomers
tiny.cc/oligomers
March 16, 2025 at 6:37 AM
Thrilled to share our latest preprint from @yiechanglin.bsky.social & @ciarawallis.bsky.social showing that AF2-Multimer and AF3 can quickly & accurately predict the oligomeric states & structures of proteins (& maybe can identify multiple biologically relevant oligomeric states 👀)
tiny.cc/oligomers
tiny.cc/oligomers
A systemic screen using programmable antisense oligomers to silence genes of DNA and RNA phages identifies proteins essential for phage propagation. This tool offers potential for optimizing phage therapy. #NBThighlight www.nature.com/articles/s41...
Programmable antisense oligomers for phage functional genomics - Nature
Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagatio...
www.nature.com
September 12, 2025 at 9:40 AM
A systemic screen using programmable antisense oligomers to silence genes of DNA and RNA phages identifies proteins essential for phage propagation. This tool offers potential for optimizing phage therapy. #NBThighlight www.nature.com/articles/s41...
Use antisense oligomers to silence phage genes and discover new biology.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de
print: www.nature.com/articles/s41...
highlight: www.nature.com/articles/s41...
briefing: www.nature.com/articles/d41...
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de
print: www.nature.com/articles/s41...
highlight: www.nature.com/articles/s41...
briefing: www.nature.com/articles/d41...
October 31, 2025 at 8:08 AM
Use antisense oligomers to silence phage genes and discover new biology.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de
print: www.nature.com/articles/s41...
highlight: www.nature.com/articles/s41...
briefing: www.nature.com/articles/d41...
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de
print: www.nature.com/articles/s41...
highlight: www.nature.com/articles/s41...
briefing: www.nature.com/articles/d41...
Proud to share our manuscript:
"How small molecules stabilize oligomers of a phase-separating disordered protein"
www.biorxiv.org/content/10.1...
by Jiaqi Zhu and Tommy Sisk, in collaboration with @borjaml.bsky.social , Stase Bielskute-Garcia & @xsalvatella1.bsky.social
"How small molecules stabilize oligomers of a phase-separating disordered protein"
www.biorxiv.org/content/10.1...
by Jiaqi Zhu and Tommy Sisk, in collaboration with @borjaml.bsky.social , Stase Bielskute-Garcia & @xsalvatella1.bsky.social
November 22, 2025 at 7:11 PM
Proud to share our manuscript:
"How small molecules stabilize oligomers of a phase-separating disordered protein"
www.biorxiv.org/content/10.1...
by Jiaqi Zhu and Tommy Sisk, in collaboration with @borjaml.bsky.social , Stase Bielskute-Garcia & @xsalvatella1.bsky.social
"How small molecules stabilize oligomers of a phase-separating disordered protein"
www.biorxiv.org/content/10.1...
by Jiaqi Zhu and Tommy Sisk, in collaboration with @borjaml.bsky.social , Stase Bielskute-Garcia & @xsalvatella1.bsky.social
Check out our latest article in JACS on circularity in sequence-controlled polymers!
Here, we used enzymes to regioselectively degrade periodic copolyamides to sequence-defined oligomers, and polymerized these oligomers to reproduce the original monomer sequence.
pubs.acs.org/doi/10.1021/...
Here, we used enzymes to regioselectively degrade periodic copolyamides to sequence-defined oligomers, and polymerized these oligomers to reproduce the original monomer sequence.
pubs.acs.org/doi/10.1021/...
Circularity in Sequence-Controlled Copolyamides Enabled by Regioselective Enzymatic Hydrolysis
Sequence-controlled polymers enable precise control over macromolecular structures and function, but both their synthesis and end-of-life management remain fundamental challenges. Achieving high seque...
pubs.acs.org
April 21, 2026 at 3:51 PM
Check out our latest article in JACS on circularity in sequence-controlled polymers!
Here, we used enzymes to regioselectively degrade periodic copolyamides to sequence-defined oligomers, and polymerized these oligomers to reproduce the original monomer sequence.
pubs.acs.org/doi/10.1021/...
Here, we used enzymes to regioselectively degrade periodic copolyamides to sequence-defined oligomers, and polymerized these oligomers to reproduce the original monomer sequence.
pubs.acs.org/doi/10.1021/...
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...
www.science.org
November 26, 2024 at 5:31 PM
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
What is the role of extracellular polymeric substances (EPS) in carbon exchange among microbial species? @sammy-pontrelli.bsky.social &co show that #EPS, formed via #chitin degradation, drives #MicrobialDiversity by acting as a sequentially degraded #CarbonSource @plosbiology.org 🧪 plos.io/3J9kbuu
July 31, 2025 at 9:01 AM
What is the role of extracellular polymeric substances (EPS) in carbon exchange among microbial species? @sammy-pontrelli.bsky.social &co show that #EPS, formed via #chitin degradation, drives #MicrobialDiversity by acting as a sequentially degraded #CarbonSource @plosbiology.org 🧪 plos.io/3J9kbuu
That’s a wrap of the 2nd edition of our one of a kind structural biology block course at the @biozentrum.unibas.ch! In just 6 short weeks students designed protein oligomers; rotated in cryo-ET, cryo-EM SPA, AFM, and NMR labs; and expressed, purified, and structurally characterized their designs
October 25, 2025 at 12:57 PM
That’s a wrap of the 2nd edition of our one of a kind structural biology block course at the @biozentrum.unibas.ch! In just 6 short weeks students designed protein oligomers; rotated in cryo-ET, cryo-EM SPA, AFM, and NMR labs; and expressed, purified, and structurally characterized their designs
questionable standards at @mdpiopenaccess.bsky.social
2 reviews: 1st is repeat offender in review mill that engages in coercive citation. 2nd one throws in the towel after finding authors’ response insulting.
pubpeer.com/publications.... But paper published in “peer reviewed” journal. Ho hum
2 reviews: 1st is repeat offender in review mill that engages in coercive citation. 2nd one throws in the towel after finding authors’ response insulting.
pubpeer.com/publications.... But paper published in “peer reviewed” journal. Ho hum
PubPeer - Exploring the Pathological Effect of Aβ42 Oligomers on Neura...
There are comments on PubPeer for publication: Exploring the Pathological Effect of Aβ42 Oligomers on Neural Networks in Primary Cortical Neuron Culture (2023)
pubpeer.com
July 19, 2025 at 6:08 PM
questionable standards at @mdpiopenaccess.bsky.social
2 reviews: 1st is repeat offender in review mill that engages in coercive citation. 2nd one throws in the towel after finding authors’ response insulting.
pubpeer.com/publications.... But paper published in “peer reviewed” journal. Ho hum
2 reviews: 1st is repeat offender in review mill that engages in coercive citation. 2nd one throws in the towel after finding authors’ response insulting.
pubpeer.com/publications.... But paper published in “peer reviewed” journal. Ho hum
Doctor says something is off with my bilirubin levels and it's just like grad school all over again – pyrrole oligomers causing me all sorts of problems.
May 13, 2024 at 1:08 PM
Doctor says something is off with my bilirubin levels and it's just like grad school all over again – pyrrole oligomers causing me all sorts of problems.
Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.
Functional amyloid proteins confer defence against predatory bacteria
Nature - Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a...
rdcu.be
July 2, 2025 at 8:10 PM
Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.
How do transcription factors bind DNA strongly, and in a switch like manner, while remaining sequence specific?
Our new paper on a canonical plant TF suggests the answer is a previously underappreciated assembly state: transcription factor nanoclusters.
www.science.org/doi/10.1126/...
Our new paper on a canonical plant TF suggests the answer is a previously underappreciated assembly state: transcription factor nanoclusters.
www.science.org/doi/10.1126/...
Nanoclustering of a plant transcription factor enables strong yet specific DNA binding
Transcription factor nanoclusters balance the DNA binding trade-off between weakly binding oligomers and nonspecific condensates.
www.science.org
July 25, 2026 at 10:47 AM
How do transcription factors bind DNA strongly, and in a switch like manner, while remaining sequence specific?
Our new paper on a canonical plant TF suggests the answer is a previously underappreciated assembly state: transcription factor nanoclusters.
www.science.org/doi/10.1126/...
Our new paper on a canonical plant TF suggests the answer is a previously underappreciated assembly state: transcription factor nanoclusters.
www.science.org/doi/10.1126/...
My favorite part about reporting this story for @cenmag.bsky.social about using electrochemical potentials to read and write data in oligomers was commiserating with the engineering guy about how finicky organic electrochemistry can be😅
cen.acs.org/materials/po...
cen.acs.org/materials/po...
Researchers use electrochemistry to read data stored in molecules
The technique offers a less expensive approach to oligomer sequencing than mass spectrometry
cen.acs.org
May 16, 2025 at 5:36 PM
My favorite part about reporting this story for @cenmag.bsky.social about using electrochemical potentials to read and write data in oligomers was commiserating with the engineering guy about how finicky organic electrochemistry can be😅
cen.acs.org/materials/po...
cen.acs.org/materials/po...
Our paper has been published! We used in vivo single-particle tracking to demonstrate that the assembly of core FCA oligomers into functional macromolecular condensates.
Thanks to all the authors and colleagues!
Thanks to all the authors and colleagues!
February 28, 2025 at 11:37 AM
Our paper has been published! We used in vivo single-particle tracking to demonstrate that the assembly of core FCA oligomers into functional macromolecular condensates.
Thanks to all the authors and colleagues!
Thanks to all the authors and colleagues!
Strong-Field-Driven Non-Linear Electron Dynamics in Thiophene Oligomers https://arxiv.org/abs/2609.29284
September 25, 2026 at 4:31 AM
Strong-Field-Driven Non-Linear Electron Dynamics in Thiophene Oligomers https://arxiv.org/abs/2609.29284
Let it be known that this EN Arknights Doctor does in fact read. Rhodes Journal Club, anyone?
January 12, 2026 at 7:13 PM
Let it be known that this EN Arknights Doctor does in fact read. Rhodes Journal Club, anyone?
We also modelled Brl1 in curved membranes (a vesicle mimicking the INM shape). Same result: Brl1/Brr6 oligomers stably interacting and promoting lipid mixing within the channel. (11/13)
July 23, 2025 at 11:53 AM
We also modelled Brl1 in curved membranes (a vesicle mimicking the INM shape). Same result: Brl1/Brr6 oligomers stably interacting and promoting lipid mixing within the channel. (11/13)