#AlphaSynuclein
Our paper on disease mechanisms in synucleinopathies, led by Tetiana Serdiuk, is out at Molecular Systems Biology.

#proteomics #structuralproteomics #neurodegeneration #Parkinsons #alphasynuclein #structuralbiology #ethz
@imsb-eth.bsky.social @molsystbiol.org
March 17, 2026 at 6:25 AM
Michel Goedert and myself are looking for two postdocs to work on #cryoEM and #masspec of #alphasynuclein filaments from neurodegenerative disease. Come join our bubbly and friendly team at the @mrclmb.ac.uk in lovely Cambridge, UK.

www.nature.com/naturecareer...
Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12864505
Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M...
www.nature.com
September 15, 2026 at 7:39 AM
Have been reading about the history of toxic oligomers of #alphasynuclein and #Abeta the past few days. As far as I can tell, this whole story originated from observations for in vitro assembly of recombinant protein, which has now been shown to yield disease-irrelevant filaments.
March 14, 2025 at 4:20 PM
🆕🔥#NeuroGastroMotil
#Sex-specific alterations in intestinal neuronal-epithelial interactions between #CGRP & #Goblet cells secondary to elevated enteric #AlphaSynuclein potentially contribute to GI dysfunction in #Parkinson's Disease‼️
👉
onlinelibrary.wiley.com/doi/10.1111/nm…#ANMSocietyt#ESNMNM
May 26, 2025 at 2:14 AM
Words to live by. Especially in my lab where we cover research from RF coils to alphasynuclein to MS to cognition to Abeta. It’s hard to be trans disciplinary. It takes a LOT of reading.
I keep my lab below 10 people (including students, RAs and postdocs) - more than that is beyond my cognitive capacity and multitasking ability
November 25, 2024 at 12:18 PM
Defining synucleinopathies: #AlphaSynuclein aggregates define diseases like Parkinson's, but diagnosis is clinical & postmortem. New insights aim for better early detection! PMID:39885358, Nat Med 2025, @NatureMedicine @Stanford https://doi.org/10.1038/s41591-024-03469-7 🧪
February 27, 2025 at 2:10 AM
Breakthrough at Baylor: tubulin can redirect toxic brain proteins away from harmful clumps in Alzheimer's an…

#Alphasynuclein #Alzheimersdisease #BaylorCollegeofMedicine #Neurodegenerativedisease #Neurologicalresearch

#Alphasynuclein #Alzheimersdisease #BaylorCollegeofMedicine #Neurodegenerativ…
Tubulin stops toxic protein clumps in Alzheimer's, Parkinson's
Breakthrough at Baylor: tubulin can redirect toxic brain proteins away from harmful clumps in Alzheimer's an… #Alphasynuclein #Alzheimersdisease #BaylorCollegeofMedicine #Neurodegenerativedisease #Neurologicalresearch
news.gmj.ge
September 21, 2026 at 9:27 AM
Researchers from #DZNE & partners have developed a method to quantitatively measure pathological #AlphaSynuclein in cerebrospinal fluid, which may facilitate the identification of individuals at elevated risk of #dementia.
👉 www.dzne.de/en/im-fokus/...
New Assay Helps to Identify Elevated Dementia Risk
The approach relies on the detection of pathological alpha-synuclein proteins.
www.dzne.de
February 27, 2026 at 11:36 AM
As part of our inaugural review series!

Targeting protein aggregate co-pathologies in #neurodegeneration: a viable therapeutic strategy?

Silas A. Buck, Sidharth S. Madhavan, Laurie H. Sanders
@dukemedschool.bsky.social #TDP43 #tauopathy #amyloid #alphasynuclein

link.springer.com/article/10.1...
Targeting protein aggregate co-pathologies in neurodegeneration: a viable therapeutic strategy? - Molecular Neurodegeneration Advances
Many neurodegenerative diseases are characterized by pathological protein aggregation in the brain. Alzheimer’s disease displays amyloid-β and tau inclusions in the form of amyloid-β plaques and tau n...
link.springer.com
September 23, 2026 at 3:46 PM
AlphaSynuclein forms condensates via #LLPS before aggregating in Parkinson’s. This study shows #RNA drives them to a more solid-like state, potentially promoting aggregation. #Photonresolvedmicroscopy revealed this RNA-driven shift.
doi.org/10.1093/narm...
@iitalk.bsky.social @narjournal.bsky.social
May 26, 2025 at 3:44 PM
If you are aware of any convincing evidence for the presence of oligomers of #Abeta, #alphasynuclein or #tau in (diseased) human brain, please do reach out. I would be interested in discussing that. If you can isolate such oligomers from brain, we might even want to have a look by #cryoEM.
March 14, 2025 at 4:28 PM
#AlphaSynuclein isn’t just at the synapse it’s also found in the cell nucleus. While most of the protein remains presynaptic, its nuclear presence may reveal new mechanisms behind #ParkinsonsDisease and #LewyBody disorders.

#Neuroscience #BrainHealth #Neurodegeneration #CellBiology
April 23, 2026 at 4:15 PM
Product Citation 🍁

Researchers @westernu.ca utilized StressMarq's #AlphaSynuclein PFFs to create touchscreen cognitive tests that detect early stimulus-response learning deficits in a mouse model of #synucleinopathy.

Paper 🛶 https://go.nature.com/3LPaC5K
Product 🌲 https://bit.ly/2u9YHV2
Impairment in stimulus-response learning as a cognitive biomarker in a model of synucleinopathy - Translational Psychiatry
Translating findings from preclinical assessments of cognitive function relevant to synucleinopathies into successful clinical trials poses significant challenges. In this study, we examined the effectiveness of human-relevant touchscreen cognitive a...
go.nature.com
February 11, 2026 at 12:09 AM
Product Citation: Neuroimmune activation is an early marker of Parkinson’s disease pathology. Exogenous uptake of oligomeric #AlphaSynuclein by cortical microglia was visualized using StressMarq’s Kinetically-Stable #aSyn Oligomers.

Paper ⚡ https://bit.ly/4gW8ZOG
Product ☀️ https://bit.ly/491ImDG
December 21, 2025 at 8:46 PM
We have made a comment on #Alzforum about the hypothesis that the mystery density in #alphasynuclein filaments of MSA could be polyphosphate. Many alternative proposals could pass the tests presented and more evidence is thus needed.
www.alzforum.org/news/researc...
That Mystery “Density” in α-Syn Fibrils: Polyphosphate, Anyone? | ALZFORUM
www.alzforum.org
November 12, 2024 at 8:28 AM
StressMarq will be exhibiting at #ADPD2026 from March 17-21 in Copenhagen!📍

Visit us at Booth No. 70 to learn more about our unique products for #Alzheimers & #Parkinsons disease research. 🧠

Learn more 🍁 https://bit.ly/2II2Jeg
##AlphaSynuclein #Tau #AmyloidBeta #TDP43 #TTR #SOD1
March 18, 2026 at 6:55 PM
StressMarq will be exhibiting at #ADPD2026 from March 17-21 in Copenhagen!📍

Visit us at Booth No. 70 to learn more about our unique products for #Alzheimers & #Parkinsons disease research. 🧠

Learn more 🍁 https://bit.ly/2II2Jeg
##AlphaSynuclein #Tau #AmyloidBeta #TDP43 #TTR #SOD1
March 11, 2026 at 6:55 PM
What if you could clear Alpha-Synuclein aggregates and restore dopamine neurons wirelessly?

This Science Advances research does exactly that using a photothermal nanosystem, studied using rPeptide's Alpha-Synuclein (S-1001). 🧠

t.ly/stiVv

#Neuroscience #ParkinsonsResearch #AlphaSynuclein
A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson’s disease
Nanoparticle-mediated wireless system reverses Parkinson’s disease.
t.ly
September 2, 2026 at 4:06 PM
Check out our Recombinant Alpha-Synuclein (Cat # S-1001) for your research needs!

www.rpeptide.com/product/alph...

Contact Sales@rPeptide.com for a quote or place an order online!

#Neuroscience #AlphaSynuclein #ASyn #LewyBodyDementia #Parkinsons #ResearchReagents #rPeptide
Alpha-Synuclein
High quality recombinant Alpha-Synuclein, >95% purity. Highly monomeric, batch to batch consistency. Order online today - R&D starts at rPeptide.
www.rpeptide.com
March 16, 2026 at 6:00 PM
Spreading #alphasynuclein #oligomers trigger #astrocyte/ #microglial changes and astrocyte-glutamatergic neuron system dysfunction in an age-related manner

Jaehyun LeeBae, Verena Bopp, Alicia Goreth...Karin M. Danzer #Parkinsons

link.springer.com/article/10.1...
Spreading alpha-synuclein oligomers trigger astrocyte/microglial changes and astrocyte-glutamatergic neuron system dysfunction in an age-related manner - Molecular Neurodegeneration Advances
Background Parkinson’s disease (PD) is characterized by the progressive accumulation and spatio-temporal spread of α-synuclein (α-syn) oligomers and a progressive loss of dopaminergic neurons. Many st...
link.springer.com
September 15, 2026 at 9:40 PM
Can a protein aid autism diagnosis? Review suggests α-synuclein links to neurodevelopmental disorders, aiding early detection. #Autism #AlphaSynuclein
www.rimpacts.com/rd/p?c=10077... 📄DOI: doi.org/10.1007/s120...
The Role of Alpha-Synuclein in Neurodevelopmental Diseases
Can a protein aid autism diagnosis? Review suggests α-synuclein links to neurodevelopmental disorders, aiding early detection. #Autism #AlphaSynuclein
www.rimpacts.com
December 22, 2025 at 5:53 AM
Product Citation: Using StressMarq's #AlphaSynuclein A90C Mutant Monomers, researchers implemented a single-molecule confocal microscopy assay to study membrane permeabilisation in #neurodegenerative disease.

Paper 🎈 bit.ly/3GaWOzt
Product 💬 bit.ly/3OZcSpt
April 16, 2025 at 11:46 PM
A preprint using: EGFP-alphasynuclein- (RRID:Addgene_40823) from @addgene.bsky.social was published.

SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #RRID
www.biorxiv.org
December 20, 2025 at 5:25 PM
We usually think of #AlphaSynuclein in the brain, but this protein is found in blood, muscles, and even the gut. Studying it outside the brain may reveal how #ParkinsonsDisease and #LewyBody disorders spread, offering new clues to these diseases.

#Neuroscience #BrainHealth #Neurodegeneration
April 20, 2026 at 4:04 PM
Product Citation 🍎 StressMarq's #AlphaSynuclein Aggregate Antibody was employed by neuroscientists in China to evaluate the effects of chronic intermittent #hypoxia (CIH) on αSyn expression, neuronal function & cognitive ability.

Paper 📕 https://bit.ly/3JFbmcC
Product 🧧 https://bit.ly/3XfzwgR
November 13, 2025 at 12:30 AM